个人简历

学习经历 2009.3 至2012.9 巴黎第六大学，分子化学专业，获理学博士学位 2008.9 至2009.1 北京语言大学，法语培训，获结业证书 2002.9 至2005.7 贵州大学，有机化学专业，获理学硕士学位 1999.3 至1999.7 中国科学院昆明植物研究所，植物化学、仪器分析培训 1994.9 至1998.7 贵州大学（化学系），分析化学专业，获理学学士学位 工作经历 2012.10 至 今 贵州省中国科学院天然产物化学重点实验室，副研究员 2005.7 至2009.3 贵州省中国科学院天然产物化学重点实验室，助理研究员 1998.7 至2002.7 贵州省中国科学院天然产物化学重点实验室，研究实习员

研究领域

药物设计与合成、天然产物全合成与结构修饰

近期论文

[1] Luca Unione[┼], Bixue Xu[┼], Dolores Dίaz, Sonsoles Martίn-Santamarίa, Ana Poveda, João Sardinha, Amelia Pilar Rauter, Yves Blériot, Yongmin Zhang, F. Javier CaÇada, Matthieu Sollogoub,* and Jesus Jim nez-Barbero*. Chemistry A European Journal, 2015, 21, 1 – 10（not the final page numbers!）【SCI, IF 5.7 (2014)】（[┼]共同第一作者） [2] Hongju Chen, Zhanxing Hu, Jianxin Zhang, Guangyi Liang*, Bixue Xu*. A modified fluoro-Pummerer reaction with DAST and NIS for synthesis of β-amino-α-fluoro- sulfides from corresponding β-amino-sulfides [J]. Tetrahedron [J]. 2015, 71, 2089-2094. 【SCI收录, IF 2.8】（通讯作者） [3] BixueXu, Luca Unione, João Sardinha, Shaoping Wu, Mélanie Ethève-Quelquejeu, Amelia Pilar Rauter, Yves Blériot, Yongmin Zhang, Sonsoles Martín-Santamaría, Dolores Dίaz, Jesus Jiménez-Barbero, MatthieuSollogoub*. Gem-difluoro- carbadisaccharides: restoring the exo-anomeric effect [J]. Angewandte Chemie International Edition, 2014, 53(36): 9597-9602.【SCI, IF 11.3 (2013)】（第一作者） [4] Bixue Xu, Ning Wang, Weidong Pan, Jingying Qiu, Peixue Cao, Meifen Zhu, Yibin Feng, Guangyi Liang*. Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives [J]. Bioorganic Chemistry, 2014, 56, 34–40. 【SCI, IF 1.73】（通讯作者） [5] Bixue Xu, Zhengming Huang, Changxiao Liu, Zegui Cai, Weidong Pan, Peixue Cao, Xiaojiang Hao, Guangyi Liang*. Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives [J]. Bioorganic & Medicinal Chemistry, 2009, 17(8), 3118–3125. (SCI, IF: 2.9). （第一作者） [6] 梁光平，曹佩雪，杨秀虾，黄正明，刘青川，梁光义*，徐必学*. NO供体型马蹄金素衍生物的合成及其初步的抗乙肝病毒活性[J]. 有机化学, 2014, 05: 973-979. 【SCI, IF 0.74】（通讯作者） [7] 梁光平, 胡占兴, 刘青川, 黄正明, 张建新, 梁光义*, 徐必学*. 马蹄金素杂环衍生物的合成及抗乙肝病毒活性[J]. 高等学校化学学报, 2014, 35 (11): 2353-2359.【SCI, IF 0.95 (2013)】（通讯作者） [8] Zhan-Xing Hu, Yan-Gong Zhang, Qiao An, Bi-Xue Xu, Wei-Dong Pan, Pei-Xue Cao, Chang-Xiao Liu, Zheng-Ming Huang, Wen Xia, Jing-Ying Qiu*, Guang-Yi Liang*. Development of a practical and scalable synthesis of anti-HBV drug Y101 [J]. Tetrahedron. 2014, 70, 9592-9600. 【SCI, IF 2.8】 [9] Katherine A. Patzel, Tal Yardeni, Erell Le Poëc-Celic, Petcharat Leoyklang, Heidi Dorward, Dominic S. Alonzi, Nikolay V. Kukushkin, Bixue Xu, Yongmin Zhang, Matthieu Sollogoub, Yves Blériot, William A. Gahl, Marjan Huizing*, Terry D. Butters*. Non-specific accumulation of glycosphingolipids in GNE myopathy [J]. Journal of Inherited Metabolic Disease, 2014, 37, 297–308. (SCI, IF: 4.0). [10] Zhanxing Hu, Qiao An, Kunfeng Li, Yangong Zhang, Jingying Qiu, Bixue Xu, Weidong Pan, Peixue Cao, Changxiao Liu, Zhengming Huang, Wen Xia, and Guangyi Liang*. Identification, Synthesis, and Strategy for Minimization of Potential Impurities in the Preclinical Anti-HBV Drug Y101 [J]. Org. Process Res. Dev. 2013, 17, 1156−116. Articles ASAP (As Soon As Publishable) (SCI, IF: 2.7). [11] Jingying Qiu, Bixue Xu, Zhengming Huang, Weidong Pan, Peixue Cao, Changxiao Liu, Xiaojiang Hao, Baoan Song, Guangyi Liang*. Synthesis and biological evaluation of Matijing-Su derivatives as potent anti-HBV agents[J]. Bioorganic & Medicinal Chemistry, 2011, 19(18), 5352–5360. (SCI, IF: 2.9). [12] Guangyi Liang*, Bixue Xu, Weidong Pan, Peixue Cao, Yong Zhang, Yang Lu, Yunshan Wuand Xiaojiang Hao. A novel iridoid from Torricellia angulata var intermedia[J]. Natural Product Research, 2009, 23 (1), 1–4. (SCI, IF: 1.0). [13] Weidong Pan, Yongmin Zhang*, Bixue Xu, Peixue Cao, Guangyi Liang*. Two new naturally occurring optical polyacetylene compounds from Torricellia angulata var intermedia and the determination of their absolute configurations[J]. Natural product research, 2006, 20 (12), 1098-1104. (SCI, IF: 1.0).