个人简历

主要从事肝纤维化的基础研究工作，先后主持了与肝纤维化研究相关的国家自然科学基金课题3项、省级课题3项；以通讯或第一作者发表SCI论文29篇（总的影响因子为90.93，被引用435次，IF5.0以上有3篇）、中文核心期刊论文26篇；获得国家授权发明专利3项；获得广西自然科学奖二等奖1项（排名第2）、广西科技进步奖三等奖1项（排名第3）、中国药学会科学技术奖三等奖1项（排名第3）。

科研项目：
近5年主持的纵向省级以上科研课题6项，经费200万元。
1.Raf激酶抑制蛋白在肝纤维化发生机制中的调控作用，国家自然科学基金，批准号：81260505，55万元，主持。
2.从TGF-β1/Smads、ERK信号途径探讨山芝麻酸甲酯抗肝纤维化的作用机制，国家自然科学基金，批准号：81473431，73万元，主持。
3.基于PI3K/Akt信号通路探讨鹅不食草心菊内酯抑制肝纤维化的作用机制，国家自然科学基金，批准号：81660693，直接经费36万元，主持。
4.鹅不食草心菊内酯抗肝纤维化的作用及其机制研究，广西自然科学基金重点项目，批准号：2016GXNSFDA380025，经费30万无，主持。
5.山芝麻酸甲酯介导ERK信号传导通路对肝纤维化的抑制作用机制，广西自然科学基金面上项目，批准号：2014GXNSFAA118154，经费5万无，主持。
6.基于Raf-1/MEK/ERK1,2信号通路研究RKIP在肝纤维化中的调控作用，广西自然科学基金面上项目，批准号：2013GXNSFAA019150，经费5万无，主持。
获得专利
（1）山芝麻提取物在制备抗肝纤维化药物中的应用，专利号：ZL201010154207.6，授权公告：2013.05（专利权人：林兴）。
（2）山芝麻提取物在制备抗乙型肝炎药物中的应用，专利号：ZL201110102153.3，授权公告：2013.07（专利权人：林兴）。
（3）满天星异荭草苷在制备治疗酒精性肝损伤药物中的应用，授权专利号：ZL201310190276.6，授权公告：2015.01（专利权人：黄权芳，林兴）。

研究领域

研究方向：
1.民族药抗肝纤维化研究
2.中药活性成分抗脂肪肝的研究

近期论文

1.BaiF,HuangQF,WeiJB,LvSJ,ChenYX,LiangCH,WeiL,LuZP,LinX*.Gypsophilaelegansisoorientin-2″-O-α-L-arabinopyranosylamelioratesporcineserum-inducedimmuneliverfibrosisbyinhibitingNF-κBsignalingpathwayandsuppressingHSCactivation.InternationalImmunopharmacology.2018,54:60-67(IF2.956)(通讯作者)
2.HuangQF,BaiF,NieJ,LuS,LuC,ZhuX,ZhuoL,LuZ,LinX*.DidyminameliorateshepaticinjurythroughinhibitionofMAPKandNF-κBpathwaysbyup-regulatingRKIPexpression.InternationalImmunopharmacology.2017,42:130-138(IF2.956)(通讯作者)
3.WeiJ1,HuangQF1,BaiF,LinJ,NieJ,LuS,LuC,HuangR,LuZ,LinX*.Didymininducesapoptosisthroughmitochondrialdysfunctionandup-regulationofRKIPinhumanhepatomacells.Chemico-BiologicalInteractions.2017,261(5):118-126(IF3.143)(通讯作者)
4.BaiF,HuangQF,NieJL,LuSJ,LuCY,ZhuXS,WangYX,ZhuoL,LuZP,LinX*.TrollineAmelioratesLiverFibrosisbyInhibitingtheNF-κBPathway,PromotingHSCApoptosisandSuppressingAutophagy.CellularPhysiologyandBiochemistry.2017,44:436-446(IF5.104)(通讯作者)
5.LinX,WeiJB,ChenYX,HeP,LinJ,TanSM,NieJL,LuSJ,HeM,LuZP,HuangQF*,IsoorientinfromGypsophilaelegansinducesapoptosisinlivercancercellsviamitochondrial-mediatedpathway.JournalofEthnopharmacology.2016,187:187–194(IF2.981)(第一作者)
6.HuangQF,WeiL,LiangC,NieJ,LuS,LuC,TanS,LvS,ZhuoL,LuZ,LinX*.LossofRafkinaseinhibitorproteinisassociatedwithmalignantprogressioninhepaticfibrosis.Biomedicine&Pharmacotherapy.2016,82:669-676(IF2.759)(通讯作者)
7.HuangQF,LiangC,WeiL,NieJ,LuS,LuC,TanS,LvS,ZhuoL,LuZ,LinX*.Rafkinaseinhibitoryproteindown-expressionexacerbateshepaticfibrosisInVivoandInVitro.CellularPhysiologyandBiochemistry.2016,40:49-61(IF5.104)(通讯作者)
8.LinX,BaiF,NieJ,LuS,LuC,ZhuX,WeiJ,LuZ,HuangQF*.DidyminalleviateshepaticfibrosisthroughinhibitingERKandPI3K/AktpathwaysviaregulationofRafkinaseinhibitorprotein.CellularPhysiologyandBiochemistry.2016,40:1422-1432(IF5.104)(第一作者)
9.WeiL,LvSJ,HuangQF,WeiJB,ZhangSJ,HuangRB,LuZP,LinX*.PratenseinattenuatesAβ-inducedcognitivedeficitsinrats:Enhancementofsynapticplasticityandcholinergicfunction.Fitoterapia.2015,101:208-217(IF2.698)(通讯作者)
10.LiangCH,TanSM,HuangQF,LinJ,LuZP,LinX*.Pratenseinamelioratesβ-amyloid-inducedcognitiveimpairmentinratsviareducingoxidativedamageandrestoringsynapseandBDNFlevels.NeuroscienceLetters.2015,592:48–53(IF2.18)(通讯作者)
11.LinX,ChenY,LvS,TanS,ZhangS,HuangR,ZhuoL,LiangS,LuZ,HuangQF*.GypsophilaelegansisoorientinattenuatesCCl4-inducedhepaticfibrosisinratsviamodulationofNF-κBandTGF-β1/Smadsignalingpathways.Internationalimmunopharmacology.2015Jun25,28(1):305-312.(IF2.956)(第一作者)
12.LinX1,HuangZS1,ChenXY,RongYP,ZhangSJ,JiaoY,HuangQF,HuangRB*.ProtectiveeffectofMillettiapulchrapolysaccharideoncognitiveimpairmentinducedbyd-galactoseinmice.Carbohydratepolymers.2014,101:533-543(IF4.811)(并列第一作者)
13.LinX,ZhangSJ,HuangRB,TanS,LiangS,WuX,ZhuoL,HuangQF*.ProtectiveeffectoftormenticacidfromPotentillachinensisagainstlipopolysaccharide/D-galactosamineinducedfulminanthepaticfailureinmice.InternationalImmunopharmacology,2014,19：365-372(IF2.956)(第一作者)
14.LinX,ZhangSJ,HuangRB,WeiL,LiangC,ChenY,LvS,LiangS,WuX,HuangQF*.ProtectiveEffectofGenisteinonLipopolysaccharide/D-galactosamine-inducedHepaticFailureinMice.Biologicalandpharmaceuticalbulletin.2014,37(4):1-8(IF1.574)(第一作者)
15.LinX,ZhangSJ,HuangRB,WeiL,TanS,LiangS,TianYC,WuXY,LuZP,HuangQF*.Helenalinattenuatesalcohol-inducedhepaticfibrosisbyenhancingethanolmetabolism,inhibitingoxidativestressandsuppressingHSCactivation.Fitoterapia.2014,95:203-213(IF2.698)(第一作者)
16.LinX,ZhangSJ,HuangRB,WeiL,TanS,LiangC,LvS,ChenY,LiangS,TianY,LuZ,HuangQF*.ProtectiveeffectofmadecassosideagainstcognitiveimpairmentinducedbyD-galactoseinmice.Pharmacology,BiochemistryandBehavior.2014,124:343-442(IF2.537)(第一作者)
17.HuangQF,HuangRB,WeiL,ChenY,LvS,LiangC,ZhangX,YinF,LiHT,ZhuoL,LinX*.AntiviralactivityofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)againsthepatitisBvirus.Antiviralresearch.100(2):373-381,2013(IF4.909)(通讯作者)
18.HuangQF,HuangRB,ZhangZJ,LinJ,WeiL,HeM,ZhuoL,LinX*.ProtectiveeffectofgenisteinisolatedfromHydrocotylesibthorpioidesonhepaticinjuryandfibrosisinducedbychronicalcoholinrats.ToxicologyLetters.217(2):102-110,2013(IF3.522)(通讯作者)
19.HuangQF,ZhangSJ,HuangRB,WeiL,ChenY,LvS,LiangC,TanS,ZhuoL,LinX*.Isolationandidentificationofananti-hepatitisBviruscompoundfromHydrocotylesibthorpioidesLam.Journalofethnopharmacology.150(2):568-575,2013(IF2.981)(通讯作者)
20.LinX,HuangRB,ZhangSJ,WeiL,ZhuoL,WuX,TangA,HuangQF*.Beneficialeffectsofasiaticosideoncognitivedeficitsinsenescence-acceleratedmice.Fitoterapia.87:69-77,2013(IF2.698)(第一作者)
21.WeiJ,HuangQF,HuangRB,ChenY,LvS,WeiL,LiangC,LiangS,ZhuoL,LinX*.AsiaticacidfromPotentillachinensisattenuateethanol-inducedhepaticinjuryviasuppressionofoxidativestressandKupffercellactivation.Biological&pharmaceuticalbulletin.36(12):1980-1989,2013(IF1.574)(通讯作者)
22.HuangQF,ZhangSJ,ZhengL,LiaoM,HeM,HuangRB,ZhuoL,LinX*.Protectiveeffectofisoorientin-2″-O-α-L-arabinopyranosylisolatedfromGypsophilaelegansonalcoholinducedhepaticfibrosisinrats.Foodandchemicaltoxicology.50(6):1992-2001,2012(IF3.778)(通讯作者)
23.HuangQF,ZhangSJ,ZhengL,HeM,HuangR.B,LinX*.HepatoprotectiveeffectsofTotalSaponinsIsolatedfromTaraphochlamysaffinisagainstcarbontetrachlorideinducedliverinjuryinrats.Foodandchemicaltoxicology.50,713-718,2012(IF3.778)(通讯作者)
24.LinX,HuangRB,ZhangSJ,ZhengL,WeiL,HeM,ZhouY,ZhuoL,HuangQF*.MethylhelicterateprotectsagainstCCl4-inducedliverinjuryinratsbyinhibitingoxidativestress,NF-κBactivation,Fas/FasLpathwayandcytochromeP4502E1level.Foodandchemicaltoxicology.50(10):3413-3420,2012(IF3.778)(第一作者)
25.HuangQF,LiYW,ZhangSJ,HuangRB,ZhengL,WeiL,HeM,LiaoM,LiL,ZhuoL,LinX*.EffectandmechanismofmethylhelicterateisolatedfromHelicteresangustifolia(Sterculiaceae)onhepaticfibrosisinducedbycarbontetrachlorideinrats.JournalofEthnopharmacology.143(3):889-895,2012(IF2.981)(通讯作者)
26.LinX,ZhangSJ,HuangQF,WeiL,ZhengL,ChenZ.N,JiaoY,HuangJC,FuSJ,HuangRB*.ProtectiveeffectofFufang-Liu-Yue-Qing,atraditionalChineseherbalformula,onCCl4inducedliverfibrosisinrats.JournalofEthnopharmacology.142(2):548-56,2012(IF2.981)(第一作者)
27.ZhuoL,MingM,ZhengL,HeM,HuangQF,WeiL,HuangRB,ZhangZJ,LinX*.Combinationtherapywithtaurine，epigallocatechingallateandgenisteinforprotectionagainsthepaticfibrosisinducedbyalcoholinrats.BiologicalandPharmaceuticalBulletin.35(10),1802-1810,2012(IF1.574)(通讯作者)
28.LinX1,LiuX1,HuangQF,ZhangSJ,ZhengL,WeiL,HeM,JiaoY,HuangJC,FuSJ,ChenZN,LiYW,ZhuoL,HuangRB*.HepatoprotectiveeffectsofthepolysaccharideisolatedfromTarphochlamysaffinis(Acanthaceae)againstCCl4-inducedhepaticinjury.BiologicalandPharmaceuticalBulletin.35(9),1574-1580,2012(IF1.574)(并列第一作者)
29.Chen1ZN,Lin1X,ZhangZ.W,HuangJC,FuSJ,HuangRB*.EXO70proteininfluencesdenguevirussecretion.MicrobesandInfection,13(2):143-150,2011(IF2.291，并列第一作者）