个人简历

个人简历：
吴龙火，男，汉族，中共党员，福建漳州人，教授。硕士研究生导师。现研究方向：骨与软骨疾病研究、天然产物活性成分研究。江西省青年井冈学者，江西省百千万人才工程人选。制药工程、药物化学教研室主任，生药学重点学科带头人。2010年毕业于华侨大学学校，取得博士学位。2015-2016获国家公派到美国常青藤联盟高校布朗大学进修访问1年。承担课题情况：主持国家自然基金课题3项，主持江西省科技厅、教育厅科技项目4项。发表SCI30余篇，申请授权专利4项。
附：
研究课题
1.miR-29a在骨关节炎软骨细胞中调控Wnt/β-catenin信号通路的分子机制及九里香酮的干预作用。国家自然科学基金（NO.81660371）——课题负责人。
2.基于GSK-3β研究内质网应激诱导的软骨细胞凋亡机制及九里香的干预作用。国家自然科学基金（NO.81360277）——课题负责人。
3.基于PGE2研究九里香叶防治膝骨关节炎的药效物质基础及其作用机制。国家自然科学基金（NO.81102797）——课题负责人。
4.基于GSK-3β调控的氧化应激研究TMF抑制软骨细胞凋亡的分子机制。江西省教育厅科技项目（GJJ180792）——课题负责人。
5.九里香总黄酮抑制糖尿病性骨关节炎中β-catenin信号通路的分子作用机制。江西省教育厅科技项目（GJJ150959）——课题负责人。
6.九里香酮抑制骨关节炎软骨细胞凋亡的分子机制。江西省科技厅自然科学基金（20142BAB215047）——课题负责人。
7.基于EP-G蛋白-cAMP研究九里香药效物质基础的抗骨关节炎作用机制。江西省教育厅科技项目（GJJ13669）——课题负责人。

研究领域

骨与软骨疾病研究、天然产物活性成分研究

近期论文

1.RuiZhang,WeimeiShi,LinfuLi,XianhuaHuang,DaohuaXu,LonghuoWu*.Thebiologicalactivityofpsoralidincontributestohealth.Pharmazie.2019,74(2):67-72.
2.QilaiCheng,MeixiangLiao,HongliangLi,LonghuoWu*.Asiaticacid(AA)sensitizesA549/DDPmultidrug-resistanthumanlungadenocarcinomacellstocisplatin(DDP)viadownregulationofP-glycoprotein(P-gp)anditsregulatedtargets.CellPhysiolBiochem2018;47:279-292.
3.WeimeiShi,LinfuLi,YechunDing,KaiYang,ZhixiChen,XiaonaFan,ShanJiang,YingjieGuan,ZhipingLiu,DaohuaXu,LonghuoWu*.Thecriticalroleofepigallocatechingallateinregulatingmitochondrialmetabolism.FutureMedChem.2018,10(7):795-809.
4.LonghuoWu*,HaiqingLiu,LinfuLi,DaohuaXu,YunGao,YingjieGuan,QianChen.5,7,3’,4’-TetramethoxyflavoneprotectschondrocytesfromERstress-inducedapoptosisthroughregulationoftheIRE1αpathway.ConnectTissueRes.2018,59(2):157-166.
5.YuanbingWu,XinqiangWu,LonghuoWu,XiangcaiWang,ZhipingLiu.Theanti-cancerfunctionsofRIG-Ilikereceptors,RIG-IandMDA5,andtheirapplicationsincancertherapy.TranslationalResearch.2017.190:51-60.
6.XiaomeiXiao,LiangmeiHe,YayunChen,LonghuoWu,LinWang,ZhipingLiu.Anti-inflammatoryandantioxidativeeffectsofCamelliaoleiferaAbelcomponents.FutureMedChem.2017.9(17):2069-2079.
7.KaiYang,ZhixiChen,JuanjuanGao,WeimeiShi,LinfuLi,ShanJiang,HaiboHu,ZhipingLiu,DaohuaXu,LonghuoWu*.ThekeyrolesofGSK-3βinregulatingmitochondrialactivity.CellularPhysiologyandBiochemistry.2017.44(4):1445-1459.
8.HongliangLi,QishengLi,ZhaowenLiu,KaiYang,ZhixiChen,QiLaiCheng,LonghuoWu*.Theversatileeffectsofdihydromyricetininhealth.Evid-BasedComplAlt.2017,2017,1053617.
9.LiangmeiHe,XiaomeiXiao,XiYang,ZixiangZhang,WuLonghuo*,ZhipingLiu*.STINGsignalingintumorigenesisandcancertherapy:Afriendorfoe?CancerLett.2017,402:2013-212.
10.YuanXiaoliang,LiuHaiqing,LinfuLi,HaiLiu,JianqiongYang,WeimeiShi,LonghuoWu*.Therolesofendoplasmicreticulumstressinthepathophysiologicaldevelopmentofcartilageandchondrocytes.CurrPharmDes.2017,23(11):1693-1704.
11.DaohuaXu,YunGao,NanHu,LonghuoWu,QianChen.MiR-365AmelioratesDexamethasone-InducedSuppressionofOsteogenesisinMC3T3-E1CellsbyTargetingHDAC4.InternationalJournalofMolecularSciences.2017,18(5):977.
12.LonghuoWu,ZhipingLiu.Themolecularmechanismsofpreventingapoptosisofcartilagechondrocytetotargetosteoarthritis.FutureMedChem.2017,9(6):537-540.
13.XiaoliangYuan,LinfuLi,WeimeiShi,HaiLiu,XianhuaHuang,ZhipingLiu,LonghuoWu*.TMFprotectschondrocytesfromERstress-inducedapoptosisbydown-regulatingGSK-3β.Biomedicine&Pharmacotherapy.2017,89:1262-1268.
14.YechunDing,YuantongTian,ZhaoyiZeng,PingShuai,HaiyingLan,XianshenZhu,YiZhong,LonghuoWu,XiaonaFan*.YCl3PromotesNeuronalCellDeathbyInducingApoptoticPathwaysinRats.BioMedResearchInternational.2017;2017:2183658.
15.LinfuLi,HaiqingLiu,WeimeiShi,HaiLiu,JianqiongYang,DaohuaXu,HaoHuang,andLonghuoWu*.InsightsontheactionmechanismsofTraditionalChineseMedicineinosteoarthritis.Evid-BasedComplAlt.2017,2017,5190986.
16.JianqiongYang,HaiqingLiu,LinfuLi,HaiLiu,WeimeiShi,XiaoliangYuan,LonghuoWu*.StructuralinsightsintoIRE1functionsintheunfoldedproteinresponse.CurrMedChem.2016,23(41):4706-4716.
17.HaoHuang,LinfuLi,WeimeiShi,HaiLiu,JianqiongYang,XiaoliangYuan,LonghuoWu*.ThemultifunctionaleffectsofNobiletinanditsmetabolitesinvivoandinvitro.Evid-BasedComplAlt.2016,2016,2918796.
18.HaiLiu,JianqiongYang,LinfuLi,WeimeiShi,XiaoliangYuan,LonghuoWu*.Thenaturaloccurringcompoundstargetingendoplasmicreticulumstress.Evid-BasedComplAlt.2016,2016,7831282.
19.YuanXiaoliang,LiuHaiqing,HuangHao,LiuHai,LiLinfu,YangJianqiong,ShiWeimei,LiuWeiyou,WuLonghuo*.ThekeyroleofcanonicalWnt/β-cateninsignalingincartilagechondrocytes.CurrDrugTargets.2016,17(4):475-484.