个人简历

教育背景 2010.01–2013.02，日本京都大学，博士后，导师：KeijiMaruoka教授\r
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2007.07 –2009.12， 香港浸会大学，博士后，导师：姜志宏教授\r
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2004.09–2007.07，中山大学，博士，导师：许遵乐教授\r
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2002.09–2004.07，中山大学，硕士，导师：汪波教授\r
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工作经历 2013/01–至今轻工化工学院，副教授，硕士生导师\r
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2013.03–2013.05，法国CNRS-LCC，访问学者，导师：Bernard Meunier教授\r
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2010.01–2013.02，日本京都大学，博士后，导师：Keiji Maruoka教授\r
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2007.07 –2009.12， 香港浸会大学，博士后，导师：姜志宏教授

研究领域

""1、新型抗老年痴呆药物研究；2、不对称催化、有机方法学；3、基于靶点的新药设计及药理活性和作用模式研究。""""

近期论文

1. Liu, Yan, Ma, L., Chen. W.-H., Park, S.,Ke, Z., Wang, B. Binding Mechanism and Synergetic Effects of XanthoneDerivatives as Noncompetitive α-Glucosidase Inhibitors: A Theoretical andExperimental Study. J. Phys. Chem. B 2013, 117, 13464−13471.\r
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2. Liu, Yan, Shirakawa, S., Maruoka, K.*Phase-Transfer-Catalyzed Asymmetric Conjugate Cyanation of Alkylidenemalonateswith KCN in the Presence of Brønsted Acid Additive. Org. Lett., 2013, 15,1230−1233.\r
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3. Liu, Yan, Usui, A., Shirakawa, S.,Maruoka, K.* Catalytic Asymmetric Synthesis of 3-Substituted ProlineDerivatives via Phase-Transfer-Catalyzed Conjugate Addition. Asian. J. Org.Chem. 2012, 1, 180–186.\r
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4. Liu, Yan, Ke, Z., Liu, S., Chen, W.-H.,Jiang, S.; Jiang, Z.-H.* An Amphilic Conjugate Approach toward the Design andSynthesis of Betulinic Acid-Polyphenol Conjugates as inhibitors of the HIV-1gp41 Fusion Core Formation. ChemMedChem, 2011, 6, 1654-1664.\r
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5. Liu, Yan, Shirakawa, S., Usui, A.,Maruoka, K.* Efficient Asymmetric Synthesis of Bicyclic Amino Acid as a CoreStructure of Telaprevir. ChemCatChem, 2012, 4, 980-982.\r
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6. Su, Q., Liu, Yan, Cai, Y.-C., Sun,Y.-L., Wang. B.,* Xian,L.-J.* Anti-tumour effects of xanthone derivatives andthe possible mechanisms of action, Invest. New Drugs, 2011, 29, 1230-1240.\r
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7. Dong, H., Liu, Yan, Jiang Z.-H. et al.Molecule The in Vitro Structure-Related Anti-Cancer Activity of Ginsenosidesand Their Derivatives. MOLECULES 2011, 16, 10619-10630.\r
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8. Liu, Yan, Ke, Z., Cui, J., Chen, W.-H.,Ma, L., Wang, B.* Synthesis, inhibitory activities, and QSAR study of xanthonederivatives as alpha-glucosidase inhibitors. Bioorg. Med. Chem. 2008, 16,7185-7192.\r
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9. Liu, Yan, Ma, L., Chen, W.-H., Wang,B.*, Xu, Z. Synthesis of xanthone derivatives with extended pi-systems asalpha-glucosidase inhibitors: Insight into the probable binding mode. Bioorg.Med. Chem. 2007, 15, 2810-2814.\r
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10. Liu, Yan, Zou, L., Ma, L., Chen, W.-H.,Wang, B.*, Xu, Z.L. Synthesis and pharmacological activities of xanthonederivatives as alpha-glucosidase inhibitors. Bioorg. Med. Chem. 2006, 14,5683-5690.\r
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11. Shan, H., Liu, Yan, Wang, Bo., Xian,L.-J. et al. Cytotoxicity of cantharidin analogues targeting proteinphosphatase 2A ；Anti-Cancer Drug 2006, 17, 905-911.