个人简历

黎相广，男，1987年生，广东湛江人，广东工业大学“青年百人计划”引进人才。主要从事干细胞驱动的肠黏膜更新、肠道疾病发病机制与调控的研究工作。2016年12月至2017年12月国家公派到美国俄亥俄州立大学医学院访问学习，合作导师为麻建杰教授。

教育背景：
2016.12－2017.12 俄亥俄州立大学，医学院，国家公派联合培养博士
2014.09－2017.06 华南农业大学，动物科学学院，博士
2010.09－2013.06 华南农业大学，动物科学学院，硕士
2006.09－2010.06 华南农业大学，动物科学学院，学士

工作经历
2018.01—至今 广东工业大学，生物医药学院， 讲师
2013.07—2014.08 华南农业大学，动物科学学院，科研助理


知识产权：
近年申请和授权的专利
[1] 黎相广, 王喆, 王修启, 高春起, 严会超, 傅厚龙, 翟振亚, 陈明霞. 一种猪肠道干细胞的分离培养方法（专利号：ZL201510082966.9）
[2] 王喆, 王修启, 黎相广, 高春起, 严会超, 傅厚龙, 陈明霞, 翟振亚, 范宏博. 一种猪肠道隐窝的分离液及其分离方法（专利号：ZL201510080396.X）
[3] 黎相广, 王修启, 高春起, 严会超, 朱敏, 周加义. 一种促进猪肠道隐窝细胞体外扩增的培养基及其培养方法（申请号：201610826211.X）

科研项目：
[1] 广东工业大学“青年百人计划”科研启动项目：难辨梭状芽胞杆菌IgY的制备，2018/01-2023/01，10万元，在研，主持
[2] 广州市国际合作项目：EAAT3介导谷氨酸转运促进仔猪肠上皮发育的机制（705241209049），2018/04-2020/03，100万元，在研，参加
[3] 广东省自然科学基金项目：猪肠道上皮特异转录因子CDX2基因克隆及其对靶基因的调控（2015A030310524），2015/8-2018/8，10万元，已结题，参加
[4] 国家自然科学基金重点项目：仔猪小肠上皮隐窝绒毛轴更新与蛋白质代谢的分子机制（31330075），2014/01-2018/12，287万元，已结题，参加
[5] 973项目：“猪利用氮营养素的机制及营养调控”子课题“小肠黏膜结构、功能与氮营养素吸收利用”（ 2013CB127302），2013/01-2017/12，96万元，已结题，参加

教学活动：
主要承担《药食同源与健康》的教学任务

研究领域

干细胞与肠道疾病治疗""

近期论文

[1] Xiang-Guang Li, Min Zhu, Ming-Xia Chen, Hong-Bo Fan, Hou-Long Fu, Jia-Yi Zhou, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway. Toxicology Letters (Revised)
[2] Xiang-Guang Li, Zhe Wang, Rong-Qiang Chen, Hou-Long Fu, Chun-Qi Gao, Hui-Chao Yan, Guang-Xu Xing, Xiu-Qi Wang*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/β-catenin signaling. International Journal of Molecular Sciences. 2018, 19(4): 1036.
[3] Xiang-Guang Li, Gao-Feng Xu, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Qian-Yun Xi, Wu-Tai Guan, Song-Bo Wang, Xiu-Qi Wang*. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016, 7(21): 30597–30609.
[4] Xiang-Guang Li, Wei-Guo Sui, Chun-Qi Gao, Hui-Chao Yan, Yu-Long Yin, Hai-Chang Li, Xiu-Qi Wang*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science. 2016, 94(4):1541–1549.
[5] Xiang-Guang Li, Wei-Guo Sui, Hui-Chao Yan, Qing-Yan Jiang, Xiu-Qi Wang*. The in ovo administration of l-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks. Animal. 2014, 8(10): 1677–1683.
[6] Xiang-Guang Li, Xue-Ling Chen, Xiu-Qi Wang*. Changes in relative organ weights and intestinal transporter gene expression in embryos from White Plymouth Rock and WENS Yellow Feather Chickens. Comparative Biochemistry and Physiolgy A-Molecular & Integrative Physiology. 2013, 164(2): 368–375.
[7] Ming-Xia Chen #, Xiang-Guang Li #, Hui-Chao Yan, Xiu-Qi Wang*, Chun-Qi Gao*. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia). Poultry Science. 2016, 95(6):1425–1432. (# Co-first authors)
[8] Ming-Xia Chen #, Xiang-Guang Li #, Jun-Xian Yang, Chun-Qi Gao, Bin Wang, Xiu-Qi Wang*, Hui-chao Yan*. The growth of embryo and gene expression of nutrient transporters in the small intestine of domestic pigeon (Columba livia). Journal of Zhejiang University-SCIENCE B. 2015, 16(6): 511–523. (# Co-first authors)
[9] Pei-Ling Zeng #, Xiang-Guang Li #, Xiu-Qi Wang*, De-Xiang Zhang, Gang Shu, Qing-Bin Luo. The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration. Poultry Science. 2011, 90(11): 2548–2556. (# Co-first authors)
[10] Jin-Ling Ye #, Chun-Qi Gao #, Xiang-Guang Li #, Cheng-Long Jin, Dan Wang, Gang Shu, Wen-Ce Wang, Xiang-Feng Kong, Kang Yao, Hui-Chao Yan, Xiu-Qi Wang*. EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells. Oncotarget. 2016, 7(25): 38681–38692. (# Co-first authors)
[11] Mi Li, Haichang Li, Xiang-Guang Li, Hua Zhu, Zihui Xu, Lianqing Liu, Jianjie Ma*, Mingjun Zhang*. A bioinspired alginate-gum arabic hydrogel with micro-/nanoscale structures for controlled drug release in chronic wound healing. ACS Applied Materials & Interfaces. 2017, 9 (27): 22160–22175.
[12] Hong-Bo Fan, Zhen-Ya Zhai, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Zhe-Sheng Chen, Xiu-Qi Wang*. CDX2 stimulates the proliferation of porcine intestinal epithelial cells by activating the mTORC1 and Wnt/β-catenin signaling pathways. International Journal of Molecular Sciences. 2017, 18(11): 2447.
[13] Li-Na Wang, Xue-Ling Chen, Xiang-Guang Li, Gang Shu, Hui-ChaoYan, Xiu-Qi Wang*. Evaluation of adrenocorticotropin regulated glucocorticoid synthesis pathway in adrenal of different breeds of pigs. Livestock Science. 2014, 169: 185–191.
[14] Jing-E Ma, Qian-Qian Lang, Feng-Fang Qiu, Li Zhang, Xiang-Guang Li, Wen Luo, Juan Wang, Xing Wang, Xi-Ran Lin, Wen-Sheng Liu, Qing-Hua Nie, Xi-Quan Zhang. Negative glucocorticoid response-like element from the first intron of the chicken growth hormone gene represses gene expression in the rat pituitary tumor cell line. International Journal of Molecular Sciences. 2016, 17(11): E 1863.