杜志云
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个人简历
杜志云,四川省南部县人,广东工业大学制药工程,广东省“千百十”省级人才。2006年7月中山大学生物化学专业博士毕业,2006年7月到广东工业大学轻工化工学院制药工程专业从事教学与科研工作,已毕业研究生45名,合带博士研究生12名,正在指导硕士研究生13名,博士3名;承担硕士生“中药现代化”等课程。已申请专利47项,授权32项,发表论文170多篇,其中SCI收录论文119余篇。先后到法国巴黎狄德罗大学ITODYS实验室,新加坡国立大学化学系,美国罗格斯(Rutegers)大学药学院从事过访问研究。主持国家自然科学基金2项、广东省部产学研项目13项、市厅项目4项和和企业横向项目11项。主要研究药食同源类天然产物物质基础(小分子、多糖、多肽)及其生物活性(炎症与免疫相关老年性疾病靶点),以此应用到新药创制、医学转化应用、功能食品及功能化妆品中。主持的科研项目:1.基于天然产物骨架和药物特征片段设计、合成新型ALR2抑制剂及抗炎作用研究,80万,国家自然科学基金委员会,2013-2016。21272043. (主持)结题(基金号:21272043)2.具有选择性及后修饰敏化作用的新型ALR2抑制剂设计合成及抗炎作用研究,10万,国家自然科学基金委员会,2011。(主持)结题。(基金号:21042003)3.联合阿托伐他汀和塞来昔布抑制前列腺癌的机理研究,70万,国家自然科学基金委员会,2013-2016。(第三)结题4.广东省药食同源资源综合利用工程技术中心,100万, 广东省科技厅, 2015-2017(主持)在研(项目编号:2015KQNCX024)5.芍药规范化种植与产地加工技术研究与优化、100万、四川省科技厅,2014-2017(主持)在研6.“植物黄金”姜黄深加工及系列功能食品保健品开发, 100万, 广东省省部产学研重点项目, 广东省科技厅,2013-2016。(主持)结题7.三维仿组织肿瘤药敏检测试剂盒研制,30万,广东省科技厅,2013-2015。(主持)结题8.基于三维仿组织培养技术对肿瘤个体化系统的开发应用,20万,广州市产学研国际合作项目,广州市科信委,2013-2015。(主持)结题9.新型ALR2选择性抑制剂设计、合成及生物活性研究,7万,北京大学天然药物及仿生药物国家重点实验室开放基金,2012-2013。(主持)结题10.甲基环戊酮分离及下游产品开发(2011B090400573),20万,广东省省部产学研,2011-2013。(主持) 结题11.新型二苯烯酮类醛糖还原酶抑制剂的合成及其抗炎机理(S20110100004967),3万元,广东省自然科学基金委,2012-2013。(主持) 结题12.酪氨酸酶生物传感器对有机磷类残留快速检测应用(2007A020300007-10),5万,广东省科学技术厅,2007-2009。(主持)结题13.饮料工业安全控制关键技术研究与示范, 100万元,广东省科学技术厅,2009-2011。(参与)结题14.超临界流体技术在防霉和杀虫中的应用研究,2.5万,广东省自然科学基金委,2008-2011。(参与)结题15.富勒烯C60双功能聚合物的设计、合成和光电性质研究(07300884),3万,广东省自然科学基金管理委员会,2008-2010。(第二)结题16.功能化酸性离子液体的设计合成与应用(2006B13801007),10万,广东省科学技术厅,2007-2009。(第二)结题17.基于ALR2具有多功能作用的姜黄素及类似物的设计、合成与机制的研究,15万,广东工业大学,2009-2012. (主持) 结题18.应用纳米微球固定乙醇脱氢酶联用HPLC对多组分协同抑制作用的筛选(063026),2万,广东工业大学, 2006-2008。(主持)结题19.离子液体催化连续酯化技术(2005JI-C0231),11万,广州市科学技术局,2006-2008。(第二)结题20.模拟过氧化物掺杂改性沸石在低温漂白体系中的应用,12万元,广州市番禺区科技局,2011-09。(第三)结题21.G6PD/NADPH调控皮肤氧化还原新机理的研究及抗氧化活性物质开发,无限极(中国)有限公司,308万,项目编号:16HK0365, 2015-2018(本项目负责人主持)(主持)在研22.3D皮肤培养技术及产品功效与感官评价,100万,佛山市康伲爱伦生物技术有限公司,2016-2020.(主持)在研23.祛粉刺系列功能食品及化妆品开发,50万,(2014-2017)广州市六风旭正生物技术有限公司,(主持)在研24.护肤品感官测试专业平台建设项目,100万,无限极(中国)有限公司,2014-2016。(主持)结题25. NBCP产品功效可视化呈现3D仿真皮肤,22万,无限极(中国)有限公司,2014-2016(主持)结题26. 基于天然有效成分的功能化妆品及保健品研发,200万,完美(中国)公司,2011-2017 (主持)结题27. 产品技术咨询服务,100万,完美(中国)公司,2011-2013 (主持)结题28. 氨基酸口服液杂质分析技术开发,5万,广东利泰制药股份有限公司,2013-2014,(主持)结题29.三维放组织细胞培养技术研究与开发,6万,(2014-2017)广州一杰医药科技有限公司。(主持)结题30.皮肤及粘膜消毒杀菌系列产品开发,50万,广州一杰医药科技有限公司,2009-2014.(主持) 结题31. 水基纳米粉散香精技术研发,10万,广州市坤豪日用品有限公司,2007-2008,(主持)结题32.2015省级教改项目-研究生助教资源开发应用及系统运行有效性研究试点,5万,(主持) 结题 33.2015省级教改项目-广东工业大学-立白集团工程实践教育中心。30万,(主持)结题33.2014省级教改项目-“共赢”驱动下化工卓越计划“校企联合”人才培养模式实践与探索。2万 (主持)结题34. 就业导向的个性发展需求与规模培养柔性对接的本科教学模式研究 0.7万,广东工业大学,2012-2014。(主持)结题35. 就业导向与项目组织柔性对接的“3+1”模式实践教学改革的研究与实践探索, 3 万,广东工业大学本科质量工程重点项目,2010-2012。(主持) 结题36. 就业导向与项目组织柔性对接的“3+1”模式实践教学改革的研究与实践探索,广东省教育厅教学成果培育,2011-2016。(主持)结题37.培育英才-教学改革-配套经费,广东省教育厅教学成果培育,2014-2016。8万,(主持)结题 38.化学反应工程,1.5万,广东工业大学,2014-2016(主持)结题近5年授权和申请的专利:1.张晓娣, 杜志云. 一种预防保健科用上臂固定装置. CN 108283747 A. 2018. 公开2.陈惠雄, 鄢龙家, 张万正, 黎永刚, 杜志云. 一种吩噻嗪衍生物、其制备方法和应用. CN 108191789 A. 2018. 实审3.梁烽, 汤亚东, 蓝兴梓, 杜志云等. 一种具有聚合物纤维的细胞培养板及其制备方法. CN 108118447 A. 2018. 实审4.梁烽, 汤亚东, 蓝兴梓, 杜志云等. 一种具有微柱阵列的细胞培养板及其制备方法. CN 108285870 A. 2018. 实审5.杜志云, 黎鹏辉, 招敏聪等. 一种喹啉衍生物的制备及其在抗炎中的应用: CN, CN 106588909 A[P]. 2017. 实审 6.杜志云, 柏利霞, 黎永良, 赵俊峰, 文哲, 周渭, 张焜, 郑希, 陈惠雄, 董长治. 一种含天然NO源的果蔬饮料及其制备方法. CN 106261220 A实审7.杜志云, 彭奕, 梁邱闯, 汤亚东, 周渭, 张蓝月, 郑希, 方岩雄. 一种酵母氧化应激代谢物在抗炎产品中的应用:CN 10221617 A. 实审8.林丽, 谢玲娜, 郑希, 杜志云. 一种含姜黄油的免洗型去屑止痒护发素. CN 107007490 A.实审9.林丽, 郑雅婷, 杜志云, 郑希. 一种黑色素转运抑制率的快速检测方法. CN 107688004 A. 实审10.陈惠雄, 张万正, 杜志云等. 一种姜黄素衍生物及其制备方法与应用. CN 107473978 A. 实审11.杜志云, 陈敏, 张琨, 周渭等. 芳姜黄酮的应用. CN 107349190 A . 在审-公开12.杜志云, 黎鹏辉, 江宏, 张文进等. 一种咔唑衍生物、其制备方法及在抗肿瘤中的应用. CN 107698579 A . 实审13.杜志云, 黎鹏辉, 江宏, 张文进等. 一种苯丙咪唑类衍生物、其制备方法及在抗肿瘤中的应用. CN 107698577 A.实审14.杜志云, 黎永良, 黄博鑫, 林丽, 郑希, 周渭, 张蓝月, 张焜. 一种精准修复与护理面膜的制备方法: CN 105596222 A. 实审15.杜志云, 刘文锋,郑希,月圆,张焜,董宇琴,张秋炎,陈迁,卢宇靖,王华倩. 一种含厚朴酚以及和厚朴酚类似物与羧酸类非甾体抗炎药酯化衍生物的制备方法与应用:, CN 105884614 A[P]. 2016. 实审16. 黄华容, 郑希, 杜志云, 黄华容, 郑希, 杜志云, 张焜, 林卫萍, 吴晓凤, 王艳磊. 一种联合布雷非德菌素A的抗癌复方药物:, CN105456255A. 实审17.吴晓凤,郑希,黄华容,杜志云,何燕,张焜,方岩雄,喻林,林卫萍. 一种组合物及其在抗肿瘤中的应用:, CN106075452A. 实审18.董长治, 盛钊君, 张焜, 杜志云. 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用:, CN 105585583 . 授权19.张焜, 李冬利, 杜志云, 郑希. 簕菜提取物抑制α-葡萄糖苷酶的应用:, CN104922173A. 实审20.方岩雄, 杜志云, ,张海涛, 卢宇靖, 李宇辉, 谭伟, 张维刚. 一种芳烃抽余油磺酸或其盐及其制备方法和应用: CN, CN103724235A. 授权21.郑希, 杜志云, 张焜, 苏博云, 王华倩, 艾伦·康尼, 卢宇靖, 赵肃清, 郑杰, 黄华容, 谭伟, 周丽华, 陈迁, 刘艳,郑俊霞, 丁金龙. 一种联合他汀类降胆固醇药与噻嗪类抗高血压药物的复方抗癌药物: CN, CN103494822A. 授权22.卢宇靖, 张焜, 黄宝华, 杜志云, 庄子翀, 雷琳, 付成杰, 胡冬萍, 邓强, 王郑亚 常山碱衍生物及其在制备抗耐药.菌药物中的应用:, CN 103980251 A. 授权23.杜志云, ,薛贵华,黎永良, 王婷, 关书杰, 张焜, 郑希, 苏博云, 贾乾发, 汪舰, 曾华强, 艾伦·康尼. 一种医用消毒超声凝胶组合物及其制备方法:, CN 102580124 B. 授权24.杜志云, 何燕,马诗经,吕惠彬,梁学良,钟燕琼,刘美祺,张焜,李晨悦,郑希,艾伦·康尼. 一种姜黄素和沙棘组成的保健饮料及其制备方法:, CN103271393A[P]. 2013. 授权25.马诗经, 杜志云, ,何燕, 吕惠彬, 梁学良, 钟燕琼, 刘美祺, 张焜, 李晨悦, 郑希, 艾伦·康尼. 一种姜黄素保健硬糖及其制备方法:, CN103229884A. 授权26.张焜, 杜志云, 苏薄云, 等. Hair-care cosmetic containing acanthopanax trifoliatus extract:, CN 102949308 A. 授权27.郑希, 杜志云, 艾伦.康尼, 张焜, 苏博云. 一种仿真三维细胞培养器及培养方法, CN 102399693 B. 授权28.马诗经, 杜志云, 何燕,吕惠彬, 张焜, 李晨悦, 梁学良, 钟燕琼, 刘美祺, 郑希, 艾伦·康尼. 一种姜黄素保健颗粒剂及其制备方法:, CN103230422A. 授权29.张焜, 杜志云, 李晨悦, 胡瑞连, 王辉, 卢宇靖, 王华倩, 郑俊霞, 黄华容, 方岩雄, 赵肃清, 郑希, 汪舰, 曾华强,艾伦·康尼 一种含簕菜乙醇提取物的肤用化妆品: CN, CN102961275A. 授权30.张焜, 胡瑞连, 王华倩, 杜志云, 郑希, 李晨悦, 郑俊霞, 卢宇靖, 吴盼盼, 黄华容, 方岩雄, 赵肃清, 汪舰, 曾华强. 一种簕菜提取物及其制备方法和应用:, CN102920759A 授权31.张焜, 胡瑞连, 江森, 杜志云, 郑希, 李晨悦, 王华倩, 郑俊霞, 卢宇靖, 吴盼盼, 黄华容, 方岩雄, 赵肃清. 一种簕菜凉茶饮料及其制备方法:, CN102919436A. 授权成果及所获奖励√ 科技成果方面:1.国家创新促进委员会,国家产学研创新合作促进一等奖;中草药高通量筛选的关键技术及皮肤调控机制与产业化应用;杜志云、刘晓英、车飙、阿吉.艾克拜尔艾萨、唐健、张焜、刘光荣、方岩雄、林丽、郑雅婷2.广东省化妆品学会,特等奖;分子印记技术富集色浅的光甘草定40关键技术及其产业化应用;刘晓英、杜志云、车飙、唐健、林丽、刘光荣、阿吉.艾克拜尔艾萨、郑雅婷。3.广东省化妆品学会,一等奖;美白技术研究及产业化应用;杜志云、刘晓英、车飙、唐健、刘光荣、张琨、阿吉.艾克拜尔艾萨、林丽、郭清泉、郑雅婷、黎永良、张蓝月,汤亚东,周渭、贺飞、韩萍、朱林静;4.超微粉碎联合酶法破壁技术在功能性防脱乌发育发中药有效成分提取工艺的研究 省级科技鉴定『2007』 183号 (第四)5.白云区人民政府2006-2007年度科学技术进步奖 广州市白云区人民政府(第三)√ 教学成果1.第九届校级教学成果一等奖(2016),以协同创新为导向的化工类应用型创新型人才培养模式研究与实践,方岩雄、杜志云、郑育英、余林、郝志峰、黄宝华、潘湛昌、郭清泉、孙明、杨楚芬、叶飞、孙大雷、谭伟2.第九届校级教学成果二等奖(2016),面向需求的化工与制药类应用创新型人才培养体系探索与实践,杜志云、方岩雄、余林、郑育英、赵肃清、郑杰、郑俊霞3.国家级教学成果二等奖(2014),大众化教育背景下多样性本科人才培养机制的创新与实践,陈新、章云、何汉武、万频、肖小亭、杜志云、张成科、杨文斌、张育广、杨燕4.第八届校级教学成果一等奖(2012),校企协同应用型本科人才培养的教学体系构建与运行实践,何汉武、章云、万频、成思源、杜志云5.第八届校级教学成果二等奖(2012),需求导向下化工类专业人才柔性培养模式,杜志云、李永峰、余林、潘湛昌、英建文6.第八届校级教学成果二等奖(2012),产业转型升级背景下的化工类本科人才工程能力提升模式与实践,余林、杜志云、孙明、余倩、郝志峰√ 指导学生获奖情况:1. 2013年荣获第三届“国药工程杯”全国大学生制药工程设计竞赛一等奖;2012、2015年荣获“国药工程杯”全国大学生制药工程设计竞赛二等奖;2011年荣获“国药工程杯”全国大学生制药工程设计竞赛三等奖 2.2013、2015年荣获“挑战杯”二等奖 3.2012年11月,荣获“东富龙杯”第二届全国大学生制药工程设计竞赛二等奖(指导老师,第一)4.2011年12月,荣获“东富龙杯”第一届全国大学生制药工程设计竞赛三等奖(指导老师,第一)5.2011年8月,荣获全国“三井杯”化工设计创业竞赛三等奖(指导老师,第三)6.2008年5月,广东工业大学轻化学院第三届青年教师授课竞赛一等奖7.2007年9月,荣获华南地区首届大学生化工设计创业大赛“优秀指导教师奖(指导老师,第一)√ 个人荣誉:1.荣获2016年度广东工业大学先进科技工作者称号2.荣获2015年度广东工业大学先进科技工作者称号3荣获2014年度广东工业大学椰氏奖教金4.荣获2012年度广东工业大学先进科技工作者称号5.荣获2011年度广东工业大学先进科技工作者称号6.荣获2010年度广东工业大学先进科技工作者称号7.荣获2007-2008 学毕业生就业工作先进个人8.荣获2008-2009学毕业生就业工作先进个人9.荣获2006-2007学年度教学优秀二等奖10.荣获2006-2007学年度优秀班主任称号11.参编的教材《药物制剂工程技术与设备》荣获中国石油和化学工业优秀教材一等奖研究领域
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Industrial Crops and Products, 103, 274-282. (通讯作者, IF=3.181, 1区).4.Lanyue Zhang, Zhiwen Yang, Feng Chen, Ping Su, Dingkang Chen, Wanyi Pan, Yanxiong Fang, Changzhi Dong, Xi Zheng and Zhiyun Du*. Essential Oil Variation in Curcuma longa L. Collected from Twenty Locations in China. Industrial Crops and Products, 109, 60-73. (通讯作者, IF=3.181, 1区).5.Ma YY, Zhao DG, Zhou AY, Zhang Y, Du Z*, Zhang K*..a-Glucosidase Inhibition and Antihyperglycemic Activity of Phenolics from the Flowers of Edgeworthia gardneri. J Agric Food Chem. 2015 Sep 4. (通讯作者, IF=3.154,1区)6.Wenfeng Liu, Yonglian Li , Xi Zheng, Kun Zhang*, Zhiyun Du*. Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimulby12-O-tetradecanoylphorbol-13-acetate [J]. Food & Function, 2015. (通讯作者, IF=3.247,1区)7.Li PH,Jiang, H,Zhang, WJ, Li, YL Zhao MC,Zhou, W Zhang, LY Tang, YD Dong, CZ Huang, ZS Chen, HX,Du, ZY*Synthesis of Carbazole Derivatives Containing Chalcone Analogs as Non-intercalative Topoisomerase II Catalytic Inhibitors and Apoptosis Inducers.Eur. J. Med. Chem 2018 Feb 10. doi: 10.1016/j.ejmech.2018.01.010. (通讯作者, IF=4.519, 2区).8.Yue Y, Liu W, Zhou W, Min Chen, Boxin Huang, Lanyue Zhang, Zhenshi Wang, Yan He, Kun Zhang, Xi Zheng and Zhiyun Du*. Synergistic inhibitory effects of naproxen in combination with magnolol on TPA-induced skin inflammation in mice[J]. Rsc Advances, 2016, 6(44):38092-38099. (通讯作者, IF=3.108, 2区)9.Yang G, Jia Q, Chen L, Du Z*, Wang J*. ChemInform Abstract: Direct Access to Pyrimidines Through Organocatalytic Inverse-Electron-Demand Diels-Alder Reaction of Ketones with 1,3,5-Triazine.[J]. Rsc Advances, 2016, 47(6):76759-76763. (通讯作者, IF=3.108, 2区)10.Yan He*, Zhiyun Du*, Shijing Ma, Yue Liu, Dongli Li, Huarong Huang, Sen Jiang, Shupeng Cheng, Wenjing Wu, Kun Zhang, and Xi Zheng. Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo[J]. International journal of nanomedicine, 2016, 11: 1879. (通讯作者,IF=4.300, 2区)11.Z Du, H Lv, Q Jia, Z Tang, X Zheng, K Zhang, F ZhaoGreen synthesis of silver nanoparticles by Chrysanthemum morifolium Ramat. extract and their application in clinical ultrasound gel Y He, International journal of nanomedicine 8, 1809. (IF=4.3, 2区)12.Li P, Li Y, Jiang H, Xu Y, Liu X, Che B, Tang J, Liu G, Tang Y, Zhou W, Zhang L, Dong C, Chen H, Zhang K, Du Z*.Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice. Int. Immunonpharmacol. 2018 Jun. 59,243-251. (通讯作者,IF=3.118, 3区)13.Huang S, Han Y, Chen M, Hu K, Qi Y, Sun P, Wang M, Wu H, Li G, Wang Q, Du Z*, Zhang K, Zhao S, Zheng X. Radiosynthesis and biological evaluation of 18F-labeled 4-anilinoquinazoline derivative (18F-FEA-Erlotinib) as a potential EGFR PET agent. Bioorganic and Medicinal chemistry letters. 2018 Apr 1. 28(6): 1143-1148. (IF=2.442, 3区)14.Yadong Tang, Boxin Huang, Yuqin Dong, Wenlong Wang, Xi Zheng, Wei Zhou, Kun Zhang & Zhiyun Du*. Three-dimensional prostate tumor model based on a hyaluronic acid-alginate hydrogel for evaluation of anti-cancer drug efficacy[J]. Journal of Biomaterials Science, Polymer Edition, 2017 (just-accepted): 1-23. (通讯作者, IF=1.8999, 3区)15.Zhao D G, Ma Y Y, Peng W, Zhou A, Zhang Y, Ding L,Du Z*&Zhang K*.Total synthesis and cytotoxic activities of longamide B, longamide B methyl ester, hanishin, and their analogues[J]. 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(通讯作者, IF=1.683, 4区)24. DY Zhou, N Ding, ZY Du*, XX Cui, H Wang, XC Wei, AH Conney, K Zhang*, .Curcumin analogues with high activity for inhibiting human prostate cancer cell growth and androgen receptor activation. Molecular medicine reports 10 (3), 1315-1322. (通讯作者,IF=1.692, 4区)25.Yang G, Chen L, Wang J*, Jia Q, Wei J, Du Z*. Facile synthesis of pyrimidines via iminium catalyzed [4+2] reaction of α,β-unsaturated ketones with 1,3,5-triazines[J]. Tetrahedron Letters, 2015, 56(43):5889-5891. (通讯作者, IF=2.193, 3区)26.Y Jiang, Z Du*, G Xue, Q Chen, Y Lu, X Zheng,Allan H. Conney and K Zhang 1,*. Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinase inhibitors, AH Conney, K Zhang. Molecules 18 (4), 3948-3961 . (通讯作者, IF=2.861, 3区)27.Chen D, Du Z*, Lin Z, Su P, Huang H, Ou Z, Pan W, Huang S, Zhang K, Zheng X, Lin L, Zhang L. The chemical compositions of Angelica pubescens oil and its prevention of UV-B radiation-induced cutaneous photoaging. 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