个人简历

已在Nature、Science、Cancer Cell和J. Am. Chem. Soc等国际知名学术期刊发表SCI论文30余篇，申请中国发明专利8项，美国发明专利1项，授权发明专利3项。成为国际著名期刊特约审稿人，累计审稿近百余篇，包括英国皇家化学会RSC、德国Wiley-VCH、荷兰Elsevier等出版社的多个学术期刊。目前主持国家自然科学基金2项，主持完成或在研省级课题5项，作为主要完成人分别完成国家自然基金科研课题5项及美国NIH基金3项。参与的“创新合成策略的发展与系列生理活性天然产物的全合成”获2016年度高等学校科学研究优秀成果奖（科学技术）自然科学奖一等奖。2017年度获贵州省第十四届青年科技奖。

研究领域

""（1）中药民族药作用靶点及相关机制的研究； （2）靶向药物的研究与开发； （3）药物化学生物学研究。""""

近期论文

1. Identification of a cellularly active SIRT6 allosteric activator. Nat. Chem. Biol. 2018, https://doi.org/10.1038/s41589-018-0150-0. 2. The mimics of Nε-acyl-lysine derived from cysteine as sirtuin inhibitors. Bioorg. Med. Chem. Lett. 2018, 28(14), 2375-2378. 3. SIRT4 is the last puzzle of mitochondrial sirtuins. Bioorg. Med. Chem. 2018, 26(14), 3861-3865. 4. Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorg. Med. Chem. Lett. 2017, 27(14), 5404-5408. 5. Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure. Cell Chem. Biol. 2017, 24, 1-7. 6. Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety. Molecules 2017, 22, 238(1-10). 7. HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine. ACS Chem. Biol. 2016, 11 (10), 2685-2692. 8. SIRT2 reverses 4-oxononanoyl lysine modification on histones. J. Am. Chem. Soc. 2016, 138(38), 12304-12307. 9. A SIRT2-Selective Inhibitor Promotes c-Myc Oncoprotein Degradation and Exhibits Broad Anticancer Activity. Cancer Cell 2016, 29(3), 297-310. 10. A mini-review on Sirtuin activity assays. Biochem. Bioph. Res. Co. 2015, 467(3), 459-466. 11. A FRET-based assay for screening SIRT5 specific modulators. Bioorg. Med. Chem. Lett. 2015, 25(8), 1671-1674. 12. A FRET-based assay for screening SIRT6 modulators. Eur. J. Med. Chem. 2015, 96, 245-249. 13. Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies. Sci. Rep. 2015, 5(8529), 1-8. 14. Thiomyristoyl peptides as cell-permeable Sirt6 inhibitors. Org. Biomol. Chem. 2014, 12(38), 7498-7502. 15. SIRT6 regulates TNF-a secretion through hydrolysis of long-chain fatty acyl lysine. Nature 2013, 496(7443), 110-113. 16. Thiosuccinyl Peptides as Sirt5-Specific Inhibitors. J. Am. Chem. Soc. 2012, 134(4), 1922-1925. 17. Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase. Science 2011, 334(6057), 806-809.