个人简历

2013年毕业于西北农林科技大学，同年就职于贵州医科大学药学院有机化学教研室，主持贵州省科技厅、贵州省教育厅、贵州省卫生厅等各类基金项目5项，发表论文19篇，其中SCI论文12篇，申请国家专利4项。

研究领域

活性先导化合物及其结构优化

近期论文

[1] Lingling Fan，Jianta Wang，Xiao Ma，Wan Xiao，Zhiyan Li，Gang Zhong，Lei Tang*，Haoshu Wu*. Design, synthesis and biological evaluation of GY3-based derivatives for anti-type 2 diabetes activity[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25(7): 1500-1505. [2] Lingling Fan, Xiaoyan Zhi, Zhiping Che, Hui Xu*. Insight into 2α-chloro-2′(2′,6′)-(di)halogenopicropodophyllotoxins reacting with carboxylic acids mediated by BF3·Et2O[J]. Scientific Reports, 2015, 5: 16285. [3] Lingling Fan，Yong Guo, Xiaoyan Zhi, Xiang Yu, Hui Xu*, Stereoselective synthesis of 2alpha-chloropicropodophyllotoxins and insecticidal activity of their esters against oriental armyworm, Mythimna separate walker[J]. Journal of Agricultural and Food Chemistry，2014，62(17)：3726-3733. [4] Lingling Fan, Zhi-ping Che, Rui Zhang, Xiang Yu, Xiao-yan Zhi, Hui Xu*. Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl-aryl coupling reaction[J]. Molecular Diversity, 2012, 16(2): 415-421. [5] LingLing Fan, Ning Huang, Ruige Yang, Shuzhe He, Liumeng Yang, , Hui Xu*. Yongtang Zheng. Discovery of 5,6-Dihydro-indolo[1,2-a]quinoxaline Derivatives as New HIV-1 Inhibitors In Vitro[J]. Letters in Drug Design & Discovery, 2012, 9(1): 44-47. [6] Hui Xu *, LingLing Fan. Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives[J]. European Journal of Medicinal Chemistry, 2011, 46(5): 1919-1925. [7] Hui Xu*, LingLing Fan. Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole [1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro[J]. European Journal of Medicinal Chemistry, 2011, 46(1): 364-369. [8] Lingling Fan, Wuqing Liu, Hui Xu*, Liumeng Yang, Min Lv, Yongtang Zheng. Anti human immunodeficiency virus-1 (HIV-1) agents 3. synthesis and in vitro anti-HIV-1 activity of some N-arylsulfonylindoles[J]. Chemical & Pharmaceutical Bulletin, 2009, 57(8): 797-800. [9] Lingling Fan, Wuqing Liu, Hui Xu*, Liumeng Yang, Min Lv, Yongtang Zheng. Anti HIV-1 Agents 2. Discovery of Dibenzofurans as New HIV-1 Inhibitors In Vitro. Letters in Drug Design & Discovery, 2009, 6(3): 178-190. [10 Hui Xu*, LingLing Fan. One-pot N-arylation of indoles directly from N-arylsulfonylindoles via consecutive deprotection and SNAr reactions with activated aryl halides[J]. Chemical & Pharmaceutical Bulletin, 2009, 57(3): 321-323. (IF:1.7） [11] Hui Xu*, LingLing Fan. Synthesis of dibenzofurans directly from aryl halides and ortho-bromophenols via one-pot consecutive SNAr and intramolecular palladium-catalyzed aryl-aryl coupling reactions[J]. Chemical & Pharmaceutical Bulletin, 2008, 56(10): 1496-1498.