个人简历
贵州医科大学药物化学教研室主任，药物化学学科组负责人，药学院党委委员，贵州省第九批优秀青年科技人才培养对象，贵州省优秀教师，中组部第十批“西部之光”访问学者，国家职业资格鉴定高级考评员，国家自然科学基金通讯函评专家，科学出版社药学本科《药物化学》“十三五”规划教材副主编。国际著名学术期刊Journal of Medicinal Chemistry, Medicinal Chemistry Research, Journal of Pharmacy and Pharmacology , Current Medicinal Chemistry杂志审稿人。
研究领域
1、基于主动转运机理的黄酮类天然活性成分的结构修饰、生物活性及其构效关系研究； 2、基于脑靶向性转运性质的黄酮类天然活性成分设计、合成、生物活性及其构效关系研究； 3、基于肝靶向性增强与毒性降低的核苷类抗病毒药物研究； 4、具有主客体包合作用特性与特定释放规律的药物-瓜环（Cucurbit[n]uril）分子药物胶囊的设计与合成；
近期论文
1. Yongxi Dong, Li Dong,Jinglei Chen, Min Luo, Xiaozhong Fu*, Chunhua Qiao Synthesis and biological evaluation of N-alkyl-1,4-dihydroquinoline prodrugs of scutellarin methyl ester as neuroprotective agents. Med Chem Res. 2018, 27, 1111-1121. 2. Zhao, Y.-L.*; Tang, Y.-Q., Fei, X.-H.; Xiao, T.; Lu, Y.-D.; Fu, X.-Z.; He, B.; Zhou, M; Li, C; Xu, P.-F.* Yang, Y.-Y.*. Palladium-Catalyzed Direct C(sp3)-H Arylation of Indole-3-ones with Aryl Halides: A Novel and Efficient Method for the Synthesis of Nucleophilic 2-Monoarylated Indole-3-ones. RSC Adv. 2018, 8, 25292- 25297. 3. Ya Chen, Wen Zheng Zhang, Jing Li, Tao Xiao, Jiang Xia Liu, Min Luo, Hang Su, Xiao-Zhong Fu*, Ting Liu, Yong-Xi Dong, Yong-Long Zhao, Bin He, Yong-Jun Li. Novel adefovir mono L-amino acid ester, mono bile acid ester derivatives: Design, synthesis, biological evaluation, and molecular docking study. Med Chem Res. 2017, 26, 1812-1821 4.Yu Ou, Min Luo, Yong-Xi Dong, Hang Su, Xiao-Zhong Fu*, Yu-Feng Cha,Shun Zhang, Yong-Long Zhao, Yong-Jun Li, Yong-Lin Wang.Permeability of novel 4′-N-substituted (aminomethyl) benzoate-7- substituted nicotinic acid ester derivatives of scutellarein in Caco-2 cells and in an invitro model of the blood-brain barrier. Med Chem Res. 2016, 25,2205-2213. 5.Yu-Feng Cha, Shun Zhang, Hang Su, Yu Ou, Xiao-Zhong Fu*, Feng-Jie Jiang,Yong-Long Zhao, Yong-Xi Dong, Min Luo, Yong Huang,Yan-Yu Lan, Ai-Min Wang, Yong-Lin Wang. L-Aminoacid carbamate prodrugs of scutellarin: synthesis, physiochemical property,Caco-2 cell permeability, and In Vivo anti-oxidative activity Med Chem Res. 2015, 24, 2238-2246. 6. Ze-Qin Dai, Hang Su, Min Luo, Yu Ou, Xiao-Zhong Fu*,Yu-Feng Cha, Shun Zhang, Yong Huang, Yong-Lin Wang. Applicationof N-substituted (aminomethyl) benzoate Strategy in Design of ScutellareinDerivatives with Improved Caco-2 Cell Permeability and In vitro AntioxidativeActivity Bull K Chem Soc 2015, 36,1959-1965. 7. Xiaozhong Fu*, FengjieJiang, Yu Ou, Sheng Fu, Yufeng Cha, Shun Zhang, Zongyuan Liu, Wen Zhou,Yonglin Wang* Synthesis and anti-HBV evaluation of mono L-amino acidester, mono non-steroid anti-inflammation drug carboxylic ester derivatives ofacyclonucleoside phosphonates. Chin Chem Lett 2014，25，115-118 7.FengjieJiang, Xiaozhong Fu*, Shanwu Wang, Yong Huang, Wen Zhou, Aimin Wang and Yonglin Wang*.Synthesis and physiochemical property evaluationof carbamate derivatives of scutellarin methyl ester Chin Chem Lett 2013, 24, 338-340 8.Xiao-Zhong Fu, Yu Ou,Jian-Ying Pei,Ying Liu, Jing Li, Wen Zhou, Yan-Yu Lan, Ai-Min Wang and Yong-Lin Wang *. Synthesis, anti-HBV activityand renal cell toxicity evaluation of mixed phosphonate prodrugs ofadefovir Eur J Med Chem 2012, 49,211-218. 9.Xiao Zhong Fu, Yu Ou, Jian Xin, Yu She Yang*. Design,synthesis and in vivo evaluation of mono (2,2,2- tri- fluoroethyl) esters, monoL-amino acid ester prodrugs of acyclic nucleoside phosphonates as anti-HBVagents Chin Chem Lett 2011, 22,1387-1390. 10.Xiao-ZhongFu, Feng-Jing Xing, Yan-Yu Lan, Ai-Min Wang, Yong-Lin Wang,* Jing Li, Wen Zhou, Wei Zhang, Ying Liu. Synthesis and in vitroanti-oxidative activity studies of 4’-N-substituted (amino methyl) benzoatederivativesof Scutellarein. Chin J Org Chem, 2011,31(7) : 1043-1048. 11.Xiao-Zhong Fu*, Ying Huang, Zhu Tao, Sai-Feng Xue, Chun Luo, Yu Ou, Jian-XinZhang. Investigation of Complex of Cucurbit[6, 7, 8]urils with AdefovirBis(L-amino acid) Ester Prodrug and Its Anti-HBV Activity. Chin J Org Chem 2010, 30 (5):675-683. 12. Xiaozhong Fu, SaihongJiang, Chuan Li, Jian Xin, Yushe Yang*, Ruyun Ji. Design and synthesis of novelbis(L-amino acid) ester prodrugs of 9-[2- (phosphono methoxy) ethyl] adenine(PMEA) with improved anti-HBV activity. Bioorg. Med Chem Lett 2007, 17(2): 465-470. 13.Xiaozhong Fu, Sai Hong Jiang, Jian Xin, Yushe Yang*. Design,synthesis and in vitro Evaluation of L-amino acid esters prodrugs of acyclicnucleoside phosphonates as anti-HBV agent. Chin Chem Lett 2007,18(7): 817-819. 14. Xiaozhong Fu, SaihongJiang, Peng Lu, Yushe Yang*, Ruyun Ji. An improved synthetic process for YF-6,A promising anti-HBV drug candidate. Org Prep Proced In 2008, 40 (5): 467-470. 15.Xiaozhong Fu, Sai Hong Jiang, Jian Xin, Yushe Yang*. Design,synthesis and in vitro Evaluation of L-amino acid esters prodrugs of acyclicnucleoside phosphonates as anti-HBV agent. Chin Chem Lett 2007,18(7): 817-819.
