个人简历

美国TheMethodistHospitalResearchInstitute基因组医学中心（CenterforGenomicMedicine）和糖尿病研究中心(CenterforDiabetesResearch)的研究员（Scientist）。美国胃肠病协会(AGA)会员，美国肝脏病研究协会（AASLD）会员，美国内分泌学会（TheEndocrineSociety）会员。担任《Gastroenterology》、《Hepatology》、《Gut》、《AmericanJournalofPhysiology》、《AJP-GastrointestinalandLiverPhysiology》、《DigestiveandLiverDisease》等杂志审稿人。1998-2002年于美国贝勒医学院（BaylorCollegeofMedicine）完成PostdoctoralAssociate培训，曾担任德州大学休士顿医学院（UniversityofTexasHealthScienceCenteratHouston）医学系讲师(Instructor)和助理教授（AssistantProfessor）。已经培养博士研究生2名和博士后研究生8名。兰州大学萃英讲习教授和广州医科大学特聘教授。主持完成课题9项，参与美国国立卫生研究所（NIH）项目5项，继续承担NIH课题和美国国防部课题2项，合作科研项目2项，发表ProcNatlAcadSciUSA,Cell,JClinInvest,Oncogene,CircRes,JBiolChem及Heptology有等高水平学术期刊论文40余篇，曾多次受邀在A&MUniversitySystemHealthScienceCenter、MDAndersonCancerCenter,UniversityofHouston、中南大学、广州医科大学、华东师范大学、温州医科大学、兰州大学及其他科研机构做专题报告，并多次参加国际会议交流并大会发言，论文获大会颁奖。2011年作为特邀嘉宾在东方内分泌-糖尿病论坛和中华内分泌年会大会报告。

近期论文

1.XiaX,JungD,WebbP,ZhangA,ZhangB,LiL,AyersSD,GabbieC,UenoY,GustafssoneJ,AlpiniG,MooreDD,LeSageGD.LiverXReceptorβandPeroxisomeProliferator-ActivatedReceptorδregulatecholesteroltransportincholangiocytes.Hepatology.2012Jun22.doi:10.1002/hep.25919.[Epubaheadofprint]
2.YuB,LinH,YangL,ChenK,LuoH,LiuJ,GaoX,XiaX,HuangZ.GeneticvariationinNRF2-AREpathwayassociateswithdefectivespermatogenesisinhumans.JMolMed(Berl).2012May31.[Epubaheadofprint]
3.WangF,YuB,YangW,LiuJ,LuJ,XiaX.Polycysticovarysyndromeresemblinghistopathologicalalterationsinovariesfromprenatalandrogenizedfemalerats.JOvarianRes.2012May18;5(1):15.[Epubaheadofprint]
4.LiL,ZhangX,ZhaoL,XiaX,WangW.ComparisonofDNAapoptosisinmouseandhumanblastocystsaftervitrificationandslowfreezing.MolReprodDev.2012Feb1,79:229-236
5.ZhouY,TozziF,ChenJ,FanF,XiaL,WangJ,GaoG,ZhangA,XiaX,BrasherH,WidgerW,EllisLM,WeihuaZ.IntracellularATPlevelsareapivotaldeterminantofchemoresistanceincoloncancercells.CancerRes.2012Jan1;72(1):304-14.
6.SandulacheVC,SkinnerHD,OwTJ,ZhangA,XiaX,LuchakJM,WongLJ,PickeringCR,ZhouG,MyersJN.Individualizinganti-metabolictreatmentstrategiesforheadandnecksquamouscellcarcinomabasedonTP53mutationalstatus.Cancer.2012Feb1;118(3):711-21.
7.DengT,SieglaffDH,ZhangA,LyonCJ,AyersSD,CvoroA,GupteAA,XiaX,BaxterJD,WebbP,HsuehWA.Aperoxisomeproliferatoractivatedreceptor(PPAR)/PPARcoactivator1βautoregulatoryloopinadipocytemitochondrialfunction.JBiolChem.2011Sep2;286(35):30723
8.CollinsAR,LyonCJ,XiaX,LiuJZ,TangiralaRK,YinF,BoyadjianR,BikineyevaA,PraticòD,HarrisonDG,HsuehWA.Age-acceleratedatherosclerosiscorrelateswithfailuretoupregulateantioxidantgenes.CircRes.2009Mar27;104(6):e42-54.
9.ZhongX,LiuH,PuA,XiaX,ZhouX.Mcellsareinvolvedinpathogenesisofhumancontactlens-associatedgiantpapillaryconjunctivitis.ArchImmunolTherExp(Warsz).2007May;55(3):173-7.
10.ZhangW,XiaX,ReisenauerMR,VallonV,LangF,KuhlD,KoneBC.Aldosterone-inducedSGK1PhosphorylatesAF9andRelievesDot1a-AF9-MediatedTranscriptionalRepressionofENaCalpha.JClinInvest.2007Mar;117(3):773-83.
11.ZhangW,XiaX,ReisenauerMR,HemenwayCS,KoneBC.DOT1a-AF9complexmediateshistoneH3K79hypermethylationandrepressionofENaCαinanaldosterone-sensitivemanner.JBiolChem.2006Jun30;281(26):18059-68.
12.MaW,XiaX,StaffordLJ,YuC,WangF,LeSageG,LiuM.ExpressionofGCIPintransgenicmicedecreasessusceptibilitytochemicalhepatocarcinogenesis.Oncogene.2006Jul13;25(30):4207-16.
13.ZhangW,XiaX,JalalDI,KuncewiczT,XuW,LeSageGD,KoneBC.Aldosterone-sensitiverepressionofENaCαtranscriptionbyahistoneH3lysine-79methyltransferase.AmJPhysiolCellPhysiol.2006Mar;290(3):C936-46.
14.AlpiniG,GlaserS,BaiocchiL,FrancisH,XiaX,LeSageG.SecretinactivationoftheapicalNa(+)-dependentbileacidtransporterisassociatedwithcholehepaticshuntinginrats.Hepatology.2005May;41(5):1037-45.
15.YuZ,XiaX,KoneB.ExpressionProfileofaHumanInducibleNitricOxideSynthasePromoter-ReporterInTransgenicMiceDuringEndotoxemia.AmJPhysiolRenalPhysiol.2005Jan;288(1):F214-20.
16.XiaX,RoundtreeM,MerikhiA,LuX,ShentuS,LeSageG.DegradationoftheApicalSodium-dependentBileAcidTransporter(ASBT)bytheUbiquitin-ProteasomePathwayinCholangiocytes.JBiolChem.2004279(43):44931-44937.
17.ZhangW,XiaX,ZouL,XuX,LeSageGD,andKoneBC.InVivoExpressionProfileofanH+-K+-ATPase2SubunitPromoter-reporterTransgene.JPhysiolRenalPhysiol.2004Jun;286(6):F1171-77.
18.QyangY,ChambersSM,WangP,XiaX,ChenX,GoodellMA,ZhengH.Myeloproliferativediseaseinmicewithreducedpresenilingenedosage:effectofgamma-secretaseblockage.Biochemistry.2004May11;43(18):5352-9.
19.KangDE,SorianoS,XiaX,EberhartCG,DeStrooperB,ZhengH,KooED.Presenilincouplesthepairedphosphorylationofbeta-cateninindependentofaxin:implicationsforbeta-cateninactivationintumorigenesis.Cell.2002Sep20;110(6):751-62.
20.XiaX,WangP,SunX,SorianoS,ShumWK,YamaguchiH,TrumbauerME,TakashimaA,KooEH,ZhengH.Theaspartate-257ofpresenilin1isindispensableformousedevelopmentandproductionofbeta-amyloidpeptidesthroughbeta-catenin-independentmechanisms.ProcNatlAcadSciUSA.2002Jun25;99(13):8760-5.
21.MoehlmannT,WinklerE,XiaX,EdbauerD,MurrellJ,CapellA,KaetherC,ZhengH,GhettiB,HaassC,SteinerH.Presenilin-1mutationsofleucine166equallyaffectthegenerationoftheNotchandAPPintracellulardomainsindependentoftheireffectonAbeta42production.ProcNatlAcadSciUSA.2002Jun11;99(12):8025-30.
22.DineleyKT,XiaX,BuiD,SweattJD,ZhengH.Acceleratedplaqueaccumulation,associativelearningdeficits,andup-regulationofalpha7nicotinicreceptorproteinintransgenicmiceco-expressingmutanthumanpresenilin1andamyloidprecursorproteins.JBiolChem.2002Jun21;277(25):22768-80.
23.XiaX,QianS,SorianoS,WuY,FletcherAM,WangXJ,KooE,WuX,ZhengH.Lossofpresenilin1isassociatedwithenhancedbeta-cateninsignalingandskintumorigenesis.ProcNatlAcadSciUSA.2001Sep11;98(19):10863-8.
Books,BookChaptersandReviews
1.XiaX,FrancisH,GlaserS,AlpiniG,LeSageG.Bileacidinteractionswithcholangiocytes.WorldJGastroenterol.2006;12(22):3553-3563.
2.XiaX,DeMorrowS,MarzioniM,FavaG,FrancisH,AlpiniG,GlaserS,LeSageG.CholangiocyteInjuryandDuctopenicSyndromes.SeminLiverDis.2007Nov;27(4):401-12.
3.XiaX,AlpiniG,LeSageG.“ExtrahepatocyticTransportofBileAcids:TheRoleoftheCholangiocyte”.In:KepplerD,BeuersU,LeuschnerU,StiehlA,TraunerM,PaumgartnerG,eds.Bileacids:biologicalactionsandclinicalrelevance.ProceedingsoftheFalkSymposium155;2006Oct6-7;Freiberg(Germany).Dordrecht(TheNetherlands):Springer;2007:71-75
4.XiaX,LeSageG.,“Bileacidsandcholangiocytebiology”inPathophysiologyoftheIntrahepaticBiliaryEpithelium.2008:ISBN:978-81-7895-337-3TransworldResearchNetwork37/661(2),FortP.O.,Trivandrum-695023,Kerala,India2009:1-20