个人简历

2006年7月， 湖南中医药大学药学院药学专业获理学学士学位， 2009年7月， 四川大学华西药学院，获药物化学专业理学硕士学位，2014年4月， 西班牙加泰罗尼亚化学研究所 (ICIQ) & Rovira I Virgili 大学，化学工程与技术专业获理学博士学位。 2014年7月至2016年4月，德国哥廷根大学有机与生物分子化学所博士后。2016年9月以广东省高水平大学建设项目引入广州医科大学药学院。迄今共发表SCI收录论文10余篇，其中以第一作者发表在J. Am. Chem. Soc.， Angew. Chem. Int. Ed.，等论文共计4篇，他引近500多次。目前主要从事有机小分子以及过渡金属催化剂配体的设计、合成及在手性先导药物不对称合成中的应用。

研究领域

手性先导药物不对称催化合成

近期论文

1. Tian X, Yang FZ, Rasina D, Ferlin F, Vaccaro L, Ackermann L. C–H Arylations of 1,2,3-Triazoles by Reusable Heterogeneous Palladium Catalysts in Biomass-Derived γ-Valerolactone. Chem. Commun. 2016; 62: 9777-9780. 2. Tian X, Hofmann N, Melchiorre P. Asymmetric Vinylogous Diels–Alder Reactions Catalyzed by a Chiral Phosphoric Acid. Angew. Chem. Int. Ed. 2014; 53: 2997-3000. Highlighted in Synfacts 2014, 4, 433. 3. Tian X, Melchiorre P. Control of Remote Stereochemistry in the Synthesis of Spirocyclic Oxindoles: Vinylogous Organocascade Catalysis. Angew. Chem. Int. Ed. 2013; 52: 5360-5363. 4. Bastide D, Liu YK, Tian X, Escudero-Adán, E, Melchiorre P. Asymmetric Vinylogous Aldol Reaction via H-Bond-Directing Dienamine Catalysis. Org. Lett. 2013; 15: 220-223. 5. Tian X, Liu YK, Melchiorre P. Aminocatalytic Enantioselective 1,6 Additions of Alkyl Thiols to Cyclic Dienones: Vinylogous Iminium Ion Activation. Angew. Chem. Int. Ed. 2012; 51: 6439-6442. Highlighted in Synfacts 2012, 8, 905. 6. Tian X, Cassani C, Liu YK, Moran A, Urakawa A, Galzerano P, Arceo E, Melchiorre P. Diastereodivergent Asymmetric Sulfa-Michael Additions of α-Branched Enones using a Single Chiral Organic Catalyst. J. Am. Chem. Soc. 2011; 133: 17934-17941. Highlighted in Science 2011, 334, 569. Highlighted in Synfacts 2012, 2, 213. 7. Cassani C, Tian X, Escudero-Adán E, Melchiorre P. Multiple Approaches to Enantiopure Spirocyclic Benzofuranones using Organocatalytic Cascade Reactions. Chem. Commun.2011; 47:233-235. 8. Fabio Pesciaioli, Xu Tian, Giorgio Bencivenni, Giuseppe Bartoli, Paolo Melchiorre. “Organocatalic Asymmetric Conjugate Additions of Oxindoles and Benzofuranones to Cyclic Enones”. Synlett 2010, 11, 1704-1708. 9. Bo Han, Qing-Ping Liu, Rui Li, Xu Tian, Xiao-Feng Xiong, Jin-Gen Deng, Ying-Chun Chen. “Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Setereselective Nitro-Mannich Reaction of α–substituted Nitroacetates”. Chem. Eur. J. 2008, 14, 8094-8097. 10. Xu Tian, Kun Jiang, Jing Peng, Wei Du, Ying–Chun Chen. “Organocatalytic Stereoselective Mannich Reaction of 3-Substituted Oxindoles”. Org. Lett. 2008, 10, 3583-3586.