个人简历
广东省优秀青年教师培养对象，广州医科大学。2010年进入广州医科大学药理学教研室承担药理学教学与科研工作。2012年12月-2014年12月赴美国罗彻斯特大学医学院进行博士后研究。主要研究方向糖尿病心肌损伤调控的分子机制。《International Journal of Biological Science》、《Drug design, development and therapy》 和《中国组织工程研究》杂志审稿人。近五年以第一作者在Circulation-Heart Failure、Cardiovascular Research等杂志发表SCI论文多篇。主持及参与国家、省市级项目多项。获得国家发明专利2项。
研究领域
糖尿病心肌病发病机制与防治
近期论文
(1) Hou N, Wen Y, Yuan X, Xu H, Wang X, Li F*, Ye B*. Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy. Exp Mol Pathol. Exp Mol Pathol. 2017, 103(3):267-275. (2) Hou N#, Cai B#, Ou CW#, Zhang ZH, Liu XW, Yuan M, Zhao GJ, Liu SM, Xiong LG, Luo JD, Luo CF* and Chen MS*. Puerarin-7-O-glucuronide, a water-soluble puerarin metabolite, prevents angiotensin II-induced cardiomyocyte hypertrophy by reducing oxidative stress. Naunyn Schmiedebergs Arch Pharmacol. 2017, 390(5):535–545. (3) Hou N, Ye B, Li X, Margulies KB, Xu H, Wang X and Li F*. Transcription Factor 7-like 2 Mediates Canonical Wnt/beta-Catenin Signaling and c-Myc Upregulation in Heart Failure. Circ Heart Fail. 2016; 9(6): e003010. (4) Hou N,Ye B, Xiao L, Xu Y, Xu H and Li F*. Dynamic monitoring of oxidative DNA double-strand break and repair in cardiomyocytes. Cardiovasc Pathol. 2016;25:93-100. (5) Ye B#, Hou N#, Xiao L, Xu Y, Boyer J, Xu H and Li F*. APC controls asymmetric Wnt/beta-catenin signaling and cardiomyocyte proliferation gradient in the heart. J Mol Cell Cardiol. 2015;89:287-296. Co-first author (6) Xiao Q#, Hou N#, Wang YP, He LS, He YH, Zhang GP, Yi Q, Liu SM, Chen MS* and Luo JD*. Impaired sonic hedgehog pathway contributes to cardiac dysfunction in type 1 diabetic mice with myocardial infarction. Cardiovasc Res. 2012, 95:507-16. Co-first author (7) Luo CF#, Cai B#, Hou N#, Yuan M, Liu SM, Ji H, Xiong LG, Xiong W, Luo JD and Chen MS*. UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for puerarin metabolism in human liver microsomes. Arch Toxicol. 2012, 86:1681-1690. Co-first author (8) Hou N and Luo JD*. Leptin and cardiovascular diseases. Clin Exp Pharmacol Physiol. 2011;38:905-13. (9) Hou N, Luo MS, Liu SM, Zhang HN, Xiao Q, Sun P, Zhang GS, Luo JD* and Chen MS*. Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor alpha pathway in cultured neonatal rat cardiomyocytes. Clin Exp Pharmacol Physiol. 2010;37:1087-95. (10) Qin Y, He YH, Hou N, Zhang GS, Cai Y, Zhang GP, Xiao Q, He LS, Li SJ, Yi Q, Luo JD.Sonic hedgehog improves ischemia-induced neovascularization by enhancing endothelial progenitor cell function in type 1 diabetes. Mol Cell Endocrinol. 2016 Mar 5;423:30-39. (11) Jie Li, Wenxia Ma, Huizhong Li, Ning Hou, Xuejun Wang, Il-Man Kim, Faqian Li and Huabo Su. NEDD8 Ultimate Buster-1 Long (NUB1L) Protein Suppresses Atypical Neddylation and Promotes Proteasomal Degradation of Misfolded Proteins. J Biol Chem. 2015, 290(39):23850-23862. (12) Yuan X, Xiao YC, Zhang GP, Hou N, Wu XQ, Chen WL, Luo JD, Zhang GS. Chloroquine improves left ventricle diastolic function in streptozotocin-induced diabetic mice. Drug Des Devel Ther. 2016,10:2729-2737. (13) Luo CF, Hou N, Tian J, Yuan M, Liu SM, Xiong LG, Luo JD# and Chen MS. Metabolic profile of puerarin in rats after intragastric administration of puerarin solid lipid nanoparticles. International journal of nanomedicine. 2013;8:933-940.
