窦庆平
近期热点
资料介绍
个人简历
窦庆平,男,1956年06月出生,博士研究生,广州医科大学基础学院特聘教授,美国韦恩州立大学医学院教授,本课题组依托广州医科大学蛋白质修饰与降解实验室,长期从事泛素-蛋白酶体蛋白降解系统的研究工作,侧重于研发蛋白酶体抑制剂,并研究其在肿瘤中的应用。发表论文170余篇,申请及获得专利10余项,发表著作1本(Resistance to Proteasome Inhibitors in Cancer,主编,2014年),担任数十本国际杂志的审稿人。学习和工作经历:1.2017年03月-至今,广州医科大学 基础学院,特聘教授; 2.2003年09月-至今,美国Wayne State University School of Medicine,教授; 3.1998年09月-2003年09月,美国University of South Florida College of Medicine,副教授;4.1993年09月-1998年08月,美国University of Pittsburgh School of Medicine,助理教授;5.1988年10月-1993年08月,美国Dana-Farber Cancer Institute, Harvard Medical School,生物分子药理学,博士后; 6.1982年09月-1988年06月,美国 Rutgers University,化学,博士,导师:Kuang Yu Chen;7.1978年09月-1982年06月,山东大学,化学,学士。承担课题:国家自然科学基金面上项目,RAP1在非小细胞肺癌细胞顺铂耐药中的作用,2018/01-2021/12,53万,在研,主持。研究领域
泛素-蛋白酶体蛋白降解系统近期论文
(1) Peng, Tao,Dou, Q Ping. Everolimus Inhibits Growth of Gemcitabine-Resistant Pancreatic Cancer Cells via Induction of Caspase-Dependent Apoptosis and G2 /M Arrest. J Cell Biochem,2017.2.6,118(9): 2722-2730.(2) Arkwright, Richard,Pham, Tri Minh,Zonder, Jeffrey A,Dou, Q Ping. The preclinical discovery and development of bortezomib for the treatment of mantle cell lymphoma. Expert Opin Drug Discov,2017.2.01,12(2):225~235.(3) Deshmukh, Rahul R,Kim, Seongho,Elghoul, Yasmine,Dou, Q Ping. P-Glycoprotein Inhibition Sensitizes Human Breast Cancer Cells to Proteasome Inhibitors.J Cell Biochem, 2016.11.4,118(5): 1239-1248.(4) Ahmed, Reda Saber Ibrahim,Liu, Gang,Renzetti, Andrea,Farshi,Pershang,Yang, Huanjie,Soave, Claire,Saed, Ghassan,El-Ghoneimy, Ashraf Ahmed,El-Banna, Hossny Awad,Foldes, Robert,Chan, Tak-Hang,Dou, Q Ping. Biological and Mechanistic Characterization of Novel Prodrugs of Green Tea Polyphenol Epigallocatechin Gallate Analogs in Human Leiomyoma Cell Lines. J Cell Biochem,2016.10.01,117(10):2357~2369.(5) Schmitt, Sara M,Neslund-Dudas, Christine,Shen, Min,Cui,Cindy,Mitra, Bharati,Dou, Q Ping.Involvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal alpha2 Subunits. J Cell Biochem,2016.1.01,117(1):144~151.(6) Deshmukh, Rahul R,Dou, Q Ping. Proteasome inhibitors induce AMPK activation via CaMKKbeta in human breast cancer cells. Breast Cancer Res Treat, 2015.8.01, 153(1):79~88.(7) Zhang, Zhongyu,Bi, Caifeng,Fan, Yuhua,Zhang, Nan,Deshmukh,Rahul,Yan, Xingchen,Lv, Xiuwen,Zhang, Pengfei,Zhang, Xia,Dou, Q Ping. L-Ornithine Schiff base-copper and -cadmium complexes as new proteasome inhibitors and apoptosis inducers in human cancer cells. J Biol Inorg Chem,2015.1.01,20(1):109~121. 相关热点