近期论文

Yu Gao, Ye Ding, Haiying Chen, Haijun Chen* and Jia Zhou*. Targeting krüppel-like factor 5 (KLF5) for cancer therapy. Current Topics in Medicinal Chemistry. DOI: 10.2174/1568026615666150302105052 (IF = 3.453)
Yu Gao*, Zhihong Li, Chaoqun Wang, Jiali You, Biyu Jin, Fan Mo, Jianzhong Chen, Yunquan Zheng, Haijun Chen*. Self-assembled chitosan/rose bengal derivative nanoparticles for targeted sonodynamic therapy: preparation and tumor accumulation. RSC Advances, 5 (2015) 17915 - 17923 (IF = 3.708)
Yu Gao*, Zhihong Li, Xiaodong Xie, Chaoqun Wang, Jiali You, Fan Mo, Biyu Jin, Jianzhong Chen, Jingwei Shao, Haijun Chen, Lee Jia*. Dendrimeric anticancer prodrugs for targeted delivery of ursolic acid to folate receptor-expressing cancer cells: synthesis and biological evaluation. Eur. J. Pharm. Sci. 70 (2015) 55-63 (IF = 3.005)
Haijun Chen#, Yu Gao# (co-first author), Ailan Wang, Xiaobin Zhou, Yunquan Zheng, Jia Zhou*. Evolution in Medicinal Chemistry of Ursolic Acid Derivatives as Anticancer Agents. Eur. J. Med. Chem. 92 (2015) 648-655 (IF = 3.432)
Jingjing Xie, Yusheng Lu, Haiyan Dong, Rongli Zhao, Hongning Chen, Weiyu Shen, Patrick J. Sinko, Yewei Zhu, Jichuang Wang, Jingwei Shao*, Yu Gao, Fangwei Xie, and Lee Jia*. Enhanced Specifi city in Capturing and Restraining Circulating Tumor Cells with Dual Antibody–Dendrimer Conjugates. Adv. Funct. Mater. 25 (2015) 1304–1313. (IF = 10.439)
Suhong Yu, Xingtian Yang, Yewei Zhu, Fangwei Xie, Yusheng Lu, Ting Yu, Cuicui Yan, Jingwei Shao, Yu Gao, Fan Mo, Guoneng Cai, Patrick J. Sinko, Lee Jia*. Systems pharmacology of mifepristone (RU486) reveals its 47 hub targets and network: Comprehensive analysis and pharmacological focus on FAK-Src-Paxillin complex. Sci. Rep. 5 (2015) 7830. (IF = 5.078)
Haiyan Dong, Xiang Yang, Jingjing Xie, Liping Xiang, Yuanfang Li, Minrui Ou, Ting Chi, Zhenhua Liu, Suhong Yu, Yu Gao, Jianzhong Chen, Jingwei Shao, Lee Jia. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochemical Pharmacology 93 (2015) 151–162. (IF = 4.650)
Rong-Jie Zeng, Yu Li, Jian-Zhong Chen*, Gui-Xin Chou*, Yu Gao, Jing-Wei Shao, Lee Jia, Sheng-Dong Wu, Shui-Sheng Wu. A novel UPLC-MS/MS method for sensitive quantitation of boldine in plasma, a potential anti-inflammatory agent: application to a pharmacokinetic study in rats. Biomedical Chromatography 29 (2015) 459–464 (IF = 1.662)
Haijun Chen, Xiaobin Zhou, Ailan Wang, Yunquan Zheng, Yu Gao, Jia Zhou*. Evolutions in Fragment-Based Drug Design: Deconstruction-Reconstruction Approach. Drug Discovery Today 1 (2015) 105-113. (IF = 5.964)
Yu Gao, Jingjing Xie, Haijun Chen, Songen Gu, Rongli Zhao, Jingwei Shao, Lee Jia*. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnology Advances 32(2014)761-777. (IF = 8.905)
Yu Gao, Jingwei Shao, Zhou Jiang, Songen Gu, Suhong Yu, Ke Zheng, Lee Jia*. Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics. Drug Discovery Today 19(2014)326-340. (IF = 5.964)
Haijun Chen1, Yu Gao1 (co-first author), Jianlei Wu, Yingyu Chen, Buyuan Chen, Jianda Hub*, Jia Zhou*. Exploring Therapeutic Potentials of Baicalin and Its Aglycone Baicalein for Hematological Malignancies. Cancer Letters. 354(2014):5-11. (IF = 5.016)
Haijun Chen*, Guihua He, Cailong Li, Longrong Dong, Xiaobo Xie, Yu Gao, Jia Zhou*. Development of a Concise Synthetic Approach to Access Oroxin A. RSC Advances. 4 (2014) 45151-45154. (IF = 3.708)
Jianzhong Chen, Jichuang Wang, Jingwei Shao, Yu Gao, Jianguo Xu, Suhong Yu, Zhenhua Liu, Lee Jia*. The unique pharmacological characteristics of Mifepristone (RU486): from terminating pregnancy to preventing cancer metastasis. Medicinal Research Reviews, 34 (2014) 979-1000 (IF = 8.131)
Haijun Chen*, Xiaobin Zhou, Yu Gao, Biyuan Zheng, Fengxiang Tang, Jiandong Huang*. Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discovery Today 19(2014)502-509. (IF = 5.964)
Yusheng Lu, Ting Yu, Haiyan Liang, Jichuang Wang, Jingjing Xie, Jingwei Shao, Yu Gao, Suhong Yu, Shuming Chen, Lie Wang & Lee Jia. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade. Sci Rep 4(2014)4344. (IF = 5.078)
Jian-Zhong Chen, Ji-Chuang Wang, Yu Gao, Rong-Jie Zeng, Zhou Jiang,Ye-Wei Zhu, Jing-Wei Shao, Lee Jia. A novel UPLC/MS/MS method for rapid determination of metapristonein rat plasma, a new cancer metastasis chemopreventive agentderived from mifepristone (RU486). Journal of Pharmaceutical and Biomedical Analysis 95 (2014) 158–163. (IF = 2.829)