个人简历

教育工作经历：
2009.9-2014.9 厦门大学药学院 理学博士
2011.9-2012.9 美国Sanford-Burnham Medical Research Institute交流访学
2005.9-2009.7 福建师范大学生命科学学院理学学士

教学简介：
目前参与承担本科生《遗传学实验》、《细胞生物学实验》课程以及研究生《基因组学》课程的教学工作。

科研简介：
在国际刊物发表高水平研究论文数篇，包括Nature杂志子刊Nature Communications、Cell杂志子刊Chemistry & Biology、European Journal of Medicinal Chemistry、Med. Chem. Commun、PLoS ONE、Oncogene、The FASEB Journal等，申请国家发明专利一项。曾参与多项国家自然科学基金重点项目、面上项目、教育部科学技术研究重大项目的研究。现主持国家自然科学基金青年科学基金一项，福建省自然科学基金面上项目一项。

科研项目：
1. 癌蛋白tRXRα与PI3K/AKT信号通路的调节亚基p85α相互作用的分子机制研究、国家自然科学基金青年基金、31500616、项目主持人、在研。
2. 核受体RXRα参与调控PI3K/AKT信号通路的分子机制研究、福建省自然科学基金面上项目、2017J01445、项目主持人、在研。
3. 基于荧光定量PCR技术的Nur77启动子的功能研究、福建省教育厅中青年科技项目、JA15093、项目主持人、在研。

研究领域

主要从事细胞生物学、化学生物学、基因组学及蛋白组学的研究工作。""

近期论文

代表性论文：（*为通讯作者）
1. Liqun Chen#, Alexander E. Aleshin#, Gulimiran Alitongbieke, Yuqi Zhou, Xindao Zhang, Xiaohong Ye,Mengjie Hu, Gaoang Ren, Ziwen Chen, Yue Ma, Duo Zhang, Shuai Liu, Weiwei Gao, Lijun Cai, Lingjuan Wu, Zhiping Zeng, Fuquan Jiang, Jie Liu, Hu Zhou, Gregory Cadwell, Robert C. Liddington,Ying Su*,Xiao-kun Zhang*, Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα, Nature Communications, 2017, 8:16066.
2. Liqun Chen#, Zhi-Gang Wang#, Alexander E. Aleshin, Fan Chen, Jiebo Chen, Fuquan Jiang,Gulimiran Alitongbieke, Zhiping Zeng,Yue Ma, Mingfeng Huang, Hu Zhou, Gregory Cadwell, Jian-Feng Zheng, Pei-Qiang Huang, Robert C. Liddington, Xiao-kun Zhang*, Ying Su*, Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site, Chemistry & Biology, 2014, 21(5):596-607
3. Zhi-Gang Wang#, Liqun Chen#, Jiebo Chen, Jian-Feng Zheng, Weiwei Gao, Zhiping Zeng,Hu Zhou, Xiao-kun Zhang, Pei-Qiang Huang*, Ying Su*, Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation, European Journal of Medicinal Chemistry, 2013, 62:632-648
4. Zhiping Zeng#, Zhe Sun#, Mingfeng Huang, Weidong Zhang, Jie Liu, Liqun Chen, Fan Chen, Yuqi Zhou, Jiacheng Lin, Fengyu Huang, Lin Xu, Zixing Zhuang, Shangjie Guo, Gulimiran Alitongbieke, Guobin Xie, Yang Xu, Bingzhen Lin, Xihua Cao, Ying Su, Xiao-kun Zhang*, Hu Zhou*, Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-kappaB, Cancer Research, 2015, 75(10):2049-2060
5. Xiao-kun Zhang#*, Ying Su, Liqun Chen, Fan Chen, Jie Liu, Hu Zhou, Regulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sites, Acta pharmacologica Sinica, 2015, 36(1):102-112
6. Zebin Xia#,Xihua Cao#, Elizabeth Rico-Bautista, Jinghua Yu, Liqun Chen, Jiebo Chen, Andrey Bobkov, Dieter A. Wolf, Xiao-Kun Zhang and Marcia I. Dawson*, Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability, MedChemComm, 2013, 4(2):332-339
7. Zhe Sun#, Xihua Cao, Miao-miao Jiang, Yingkun Qiu, Hu Zhou, Liqun Chen, Bin Qin, Hua Wu, Fuquan Jiang, Jiebo. Chen, Jie Liu, Yi Dai, Haifeng Chen, Qiong-ying Hu, Zhen Wu, Jinzhang Zeng, Xin-sheng Yao, Xiaokun Zhang*, Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77, Oncogene, 2012, 31(21):2653-2667