个人简历

1993年于韩国高丽大学生物学专业获理学学士学位，1995年于韩国高丽大学生物学专业获理学硕士学位，2003年于加拿大麦吉尔大学生物化学专业获理学博士学位，2009年于美国哈佛大学医学院贝斯以色列女执事医疗中心博士后流动站出站。2017年入选福建省“外专百人计划”，2019年获福建省引进人才B类荣誉。现任福建医科大学基础医学院转化医学研究院教授，长期从事神经系统疾病研究，在衰老和阿尔兹海默病（AD）的研究领域已有许多重要的新发现，特别是关于Pin1及其调节因子DAPK1的研究，不仅揭示了新的病理机制，同时也为治疗AD提供新的策略。近年来，在Nature，NatCellBio,MolCell,NatMed,JCI等SCI收录的高影响因子期刊上发表学术论文30余篇。

研究领域

神经退行性疾病

近期论文

t4mediatesboneandsofttissuetumourigenesisbyactivatingfibroblastgrowthfactor-4.TheFederationofEuropeanBiochemicalSocietiesJournal,2019(IF:4.739)
2、NamiKim,DongmeiChen,XiaoZhenZhou*andTaeHoLee*.Death-AssociatedProteinKinase1PhosphorylationinNeuronalCellDeathandNeurodegenerativeDisease.InternationalJournalofMolecularSciences,2019,20(13)(IF:4.183)
3、DongmeiChen,XiaoZhenZhou*andTaeHoLee*.Death-AssociatedProteinKinase1asaPromisingDrugTargetinCancerandAlzheimer'sDisease.RecentPatentsonAnti-CancerDrugDiscovery,2019,14(2):144-157(IF:2.121)
4、Mi-HyeonYou,ByeongMoKim,Chun-HauChen,MichaelJ.Begley,LewisC.CantleyandTaeHoLee*.Death-associatedproteinkinase1phosphorylatesNDRG2andinducesneuronalcelldeath.CellDeathandDifferentiation,2017,24(2):238-250(IF:8.339)
5、ByeongMoKim#,Mi-HyeonYou#,Chun-HauChen,JaehongSuh,RudolphE.TanziandTaeHoLee*.Inhibitionofdeath-associatedproteinkinase1attenuatesthephosphorylationandamyloidogenicprocessingofamyloidprecursorprotein.HumanMolecularGenetics,2016,25(12):2498-2513(IF:5.34)
6、TaeHoLee#,SunghaPark#,Mi-HyeonYou,Ji-HongLim,Sang-HyunMin,ByeongMoKim*.ApotentialtherapeuticeffectofSaikosaponinCasanoveldual-targetanti-Alzheimeragent.JournalofNeurochemistry,2016,136(6):1232-1245(IF:4.083)
7、ByeongMoKim,Mi-HyeonYou,Chun-HauChen,SeunghoonLee,YonggeunHong,AdiKimchi,XiaoZhenZhou,andTaeHoLee*.Death-associatedproteinkinase1playsacriticalroleinaberranttauproteinregulationandfunction.CellDeath&Disease,2014,5:e1237(IF:5.965)
8、TaeHoLee,JihoonChang,ByeongMoKim*.SaikosaponinCinhibitslipopolysaccharide-inducedapoptosisbysuppressingcaspase-3activationandsubsequentdegradationoffocaladhesionkinaseinhumanumbilicalveinendothelialcells.BiochemicalandBiophysicalResearchCommunications,2014,445(3):615-621(IF:2.472)
9、Chun-HauChen#,Che-ChangChang#,TaeHoLee#,ManLiLuo,PengyuHuang,Pei-HsinLiao,ShuoWei,Fu-AnLi,Ruey-HwaChen,XiaoZhenZhou,Hsiu-MingShihandKunPingLu*.SENP1deSUMOylatesandregulatesPin1proteinactivityandcellularfunction.CancerResearch,2013,73(13):3951-3962(IF:9.122)
10、TaeHoLee#,LuciaPastorino#andKunPingLu*.Peptidyl-prolylcis-transisomerasePin1inaging,cancerandAlzheimer’sdisease.ExpertReviewsinMolecularMedicine,2011,13:e21(IF:4.405)
11、TaeHoLee#,Chun-HauChen#,FutoshiSuizu,PengyuHuang,CordeliaSchiene-Fischer,SebastianDaum,YanJessieZhang,AlisonGoate,Ruey-HwaChen,XiaoZhenZhouandKunPingLu*.Deathassociatedproteinkinase1phosphorylatesPin1andinhibitsitsprolylisomeraseactivityandcellularfunction.MolecularCell,2011,42(2):147-159(IF:14.714)
12、TaeHoLee,AdrianTun-Kyi,RongShi,JormayLim,ChristinaSoohoo,GregFinn,MartinBalastik,LuciaPastorino,GerburgWulf,XiaoZhenZhou*andKunPingLu*.EssentialroleofPin1intheregulationofTRF1stabilityandtelomeremaintenance.NatureCellBiology,2009,11(1):97-105(IF:20.06)