个人简历

林旭，1970年4月出生。教授，博士生导师。复旦大学上海医学院博士，美国国立卫生研究院（NIH）博士后。消化道恶性肿瘤教育部重点实验室、福建省肿瘤微生物学重点实验室主任，福建省高校“感染与肿瘤”科技创新团队负责人。从事医学微生物学教学与科研工作20余年，研究方向为肿瘤微生物学，主要包括乙型肝炎病毒与肝癌、乳头瘤病毒与胃癌。现为中华医学会微生物与免疫学分会常委、福建省医学微生物学与免疫学会主任委员、福建省微生物学会副理事长。为《EmergingMicrobesandInfections》、《中华微生物学与免疫学杂志》、《中国人兽共患病学报》及《中华医学科研管理》等杂志编委。先后主持国家自然科学基金项目（5项）、“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项子课题（7项）、全国优博专项基金、教育部博士点博导类基金等国家、省部级科研课题20余项，以第一/通讯作者发表学术论文近100篇，其中SCI收录论文近50篇。编著国家规划教材5部。为全国优秀博士论文作者、全国优秀教师、教育部新世纪优秀人才、国务院特殊津贴及省五一劳动奖章获得者、省科技创新领军人才。

研究领域

乙型肝炎病毒致病机制

近期论文

1.ChenH,ZhangY,YeS,WuQ,LinY,ShengK,ChenW,LinX,LinX*（林旭）.ChromatinremodellingfactorBAF155protectshepatitisBvirusXprotein(HBx)fromubiquitin-independentproteasomaldegradation.EmergMicrobesInfect2019;8(1):1393-1405.
2.JingZT,LiuW,XueCR,WuSX,ChenWN,LinXJ,LinX*（林旭）.AKTactivatorSC79protectshepatocytesfromTNF-alpha-mediatedapoptosisandalleviatesd-Gal/LPS-inducedliverinjury.AmericanjournalofphysiologyGastrointestinalandliverphysiology2019;316(3):G387-G396.
3.LiY,YanX,ShiJ,HeY,XuJ,LinL,ChenW,LinX,LinX*（林旭）.AberrantlyexpressedmiR-188-5ppromotesgastriccancermetastasisbyactivatingWnt/beta-cateninsignaling.BMCCancer2019;19(1):505.
4.LiuW,JingZT,XueCR,WuSX,ChenWN,LinXJ,LinX*（林旭）.PI3K/AKTinhibitorsaggravatedeathreceptor-mediatedhepatocyteapoptosisandliverinjury.Toxicologyandappliedpharmacology2019;381:114729.
5.WuYL,HeY,ShiJJ,ZhengTX,LinXJ,LinX*（林旭）.Microcystin-LRpromotesnecroptosisinprimarymousehepatocytesbyoverproducingreactiveoxygenspecies.Toxicologyandappliedpharmacology2019;377:114626.
6.WuSX,ChenWN,JingZT,LiuW,LinXJ,LinX*（林旭）.HepatitisBSplicedProtein(HBSP)SuppressesFas-MediatedHepatocyteApoptosisviaActivationofPI3K/AktSignaling.JournalofVirology.2018;92(23).pii:e01273-18.doi:10.1128/JVI.01273-18
7.JingZT,LiuW,WuSX,HeY,LinYT,ChenWN,LinXJ,LinX*（林旭）.HepatitisBVirusSurfaceAntigenEnhancestheSensitivityofHepatocytestoFas-MediatedApoptosisviaSuppressionofAKTPhosphorylation.JournalofImmunology.2018;201(8):2303-2314.
8.LiuW,JingZT,WuSX,HeY,LinYT,ChenWN,LinXJ,LinX*（林旭）.ANovelAKTActivator,SC79,PreventsAcuteHepaticFailureInducedbyFas-MediatedApoptosisofHepatocytes.TheAmericanJournalofPathology.2018;188(5):1171-1182.
9.SuZJ,CaoJS,WuYF,ChenWN,LinX,WuYL*,LinX*（林旭）.DeubiquitylationofhepatitisBvirusXprotein(HBx)byubiquitin-specificpeptidase15(USP15)increasesHBxstabilityanditstransactivationactivity.ScientificReports.2017;7:40246.
10.YeJ,HuangJ,XuJ,HuangQ,WangJ,ZhongW,LinX,LiY,LinX*（林旭）.ERp29controlsinvasionandmetastasisofgastriccarcinomabyinhibitionofepithelial-mesenchymaltransitionviaPI3K/Aktsignalingpathway.BMCCancer2017;17(1):626.
11.YeJ,XuJ,LiY,HuangQ,HuangJ,WangJ,ZhongW,LinX,ChenW,LinX*（林旭）.DDAH1mediatesgastriccancercellinvasionandmetastasisviaWnt/beta-cateninsignalingpathway.Molecularoncology2017;11(9):1208-1224.
12.WuYL,PengXE,ZhuYB,YanXL,ChenWN,LinX*（林旭）.HepatitisBVirusXProteinInducesHepaticSteatosisbyEnhancingtheExpressionofLiverFattyAcidBindingProtein.JournalofVirology.2016;90(4):1729-1740.
13.ZhengH,ZhangF,LinX,HuangC,ZhangY,LiY,LinJ,ChenW,LinX*（林旭）.MicroRNA-1225-5pinhibitsproliferationandmetastasisofgastriccarcinomathroughrepressinginsulinreceptorsubstrate-1andactivationofbeta-cateninsignaling.Oncotarget2016;7(4):4647-4663.
14.ZhengH,ZhangF,LinX,HuangC,ZhangY,LiY,LinJ,ChenW,LinX*（林旭）.MicroRNA-1225-5pinhibitsproliferationandmetastasisofgastriccarcinomathroughrepressinginsulinreceptorsubstrate-1andactivationofbeta-cateninsignaling.Oncotarget2016;7(4):4647-4663.
15.LiX,CaiH,ZhengW,TongM,LiH,AoL,LiJ,HongG,LiM,GuanQ,YangS,YangD,LinX*（林旭）,GuoZ.Anindividualizedprognosticsignatureforgastriccancerpatientstreatedwith5-Fluorouracil-basedchemotherapyanddistinctmulti-omicscharacteristicsofprognosticgroups.Oncotarget.2016;7(8):8743-55.
16.ChenWN,LiuLL,JiaoBY,LinWS,LinXJ,LinX*（林旭）.HepatitisBvirusXproteinincreasestheIL-1beta-inducedNF-kappaBactivationviainteractionwithevolutionarilyconservedsignalingintermediateinTollpathways(ECSIT).VirusResearch.2015;195:236-45.
17.ShenXB,HuangL,ZhangSH,WangDP,WuYL,ChenWN,XuSH*,LinX*（林旭）.TranscriptionalregulationoftheapolipoproteinF(ApoF)genebyETSandC/EBPalphainhepatomacells.Biochimie.2015;112:1-9.
18.LiuW,LinYT,YanXL,DingYL,WuYL,ChenWN,LinX*（林旭）.HepatitisBviruscoreproteininhibitsFas-mediatedapoptosisofhepatomacellsviaregulationofmFas/FasLandsFasexpression.FASEBJ.2015;29(3):1113-1123.
现为中华医学会微生物与免疫学分会常委、福建省医学微生物学与免疫学会主任委员、福建省微生物学会副理事长。为《EmergingMicrobesandInfections》、《中华微生物学与免疫学杂志》、《中国人兽共患病学报》及《中华医学科研管理》等杂志编委