个人简历

陈敬华，男，1978年10月生，理学博士，教授，博士生导师。担任教育部科技发展中心科研基金和科技奖励评审专家、教育部博士后基金面上项目评审专家、教育部学位与研究生教育评估专家、福建省医药卫生科技评审专家、福建省安全生产事故隐患排查专家。福建省杰出青年科学基金获得者，入选福建省高校领军人才青年拔尖人才、福建省卫生系统中青年骨干人才，福建省高等学校新世纪优秀人才和福建省高校杰出青年科研人才。2017年获福州市青年科技奖，2016年获福建省运盛青年科技奖，2012年获福建省优秀博士论文一等奖，2012年获得福建省自然科学优秀学术论文二等奖。2007年（第二完成人）和2009年（第四完成人）获得福建省科学技术二等奖。一直从事分析化学和药物分析等领域的科研与教学工作。先后主持国家自然科学基金项目2项和省（部）级科研课题十余项。迄今，在《Analytical Chemistry》、《Chemistry Communications》、《Biosensors and Bioelectronics》等国内外学术期刊上发表学术论文百余篇，其中SCI收录论文80余篇，获国家授权专利4项。

研究领域

"""""主要从事纳米生物传感技术等领域的研究工作。研究方向涉及外泌体分离与内容物检测、核酸适配体、DNA自组装和DNA纳米机器、功能化纳米材料制备以及多通道阵列式生物传感技术。基于上述研究开发纳米生物传感器用于肿瘤标志物检测；食品、农产品及中药材安全分析；环境监测等。"

近期论文

Yaokun Xia, Liangliang Wang, Juan Li, Xiangqi Chen, Jianming Lan, An Yan, Yun Lei, Sheng Yang*, Huang-Hao Yang*, and Jing-Hua Chen*, A Ratiometric Fluorescent Bioprobe Based on Carbon Dots and Acridone Derivate for Signal Amplification Detection Exosomal microRNA. Analytical Chemistry, 2018, 90 (15): 8969-8976. \r
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Jing Zhang*, Liang-Liang Wang, Mei-Feng Hou, Li-Pei Luo, Yi-Juan Liao, Yao-Kun Xia, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen*, Label-free fluorescent and electrochemical biosensors based on defective Gquadruplexes. Biosensors and Bioelectronics, 2018, 118, 1-8. \r
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Jing Zhang, Liang-Liang Wang, Mei-Feng Hou, Yao-Kun Xia, Wen-Hui He, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen*, A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction, Biosensors and Bioelectronics, 2018, 102, 33-40.\r
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Xiaosong Chen*, Jianming Lan, Yingxin Liu, Li Li, Liu Yan, Yaokun Xia, Fang Wu, Chunyan Li, Shirong Li, Jinghua Chen*, A paper-supported aptasensor based on upconversion luminescence resonance energy transfer for the accessible determination of exosomes, Biosensors and Bioelectronics, 2018, 102, 582-588.\r
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Yaokun Xia, Mengmeng Liu, Liangliang Wang, An Yan, Wenhui He, Mei Chen, Jianming Lan, Jiaoxing Xub,c, Lunhui Guan*, Jinghua Chen*, A Visible and Colorimetric Aptasensor Based on DNA-capped Single-Walled Carbon Nanotubes for Detection of Exosomes, Biosensors and Bioelectronics, 2017, 92, 8-15.\r
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Fang Wu, Mei Chen, Jianming Lan, Yaokun Xia, Mengmeng Liu, Wenhui He, Chunyan Li, Xiaosong Chen∗, Jinghua Chen∗，A universal locked nucleic acid-integrated X-shaped DNA probedesign for amplified fluorescence detection of single-nucleotide variant, Sensors and Actuators B, 2017, 241: 123-128.\r
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Jianming Lan, Li Li, Yingxin Liu, Liu Yan, Chunyan Li , Jinghua Chen*, Xiaosong Chen, Upconversion luminescence assay for the detection of the vascular endothelial growth factor, a biomarker for breast cancer, Microchim. Acta, 2016, 183(12): 3201-3208. \r
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Jing Zhang∗, Yao-Kun Xia, Mei Chen, Dong-Zhi Wu, Shu-Xian Cai, Meng-Meng Liu,Wen-Hui He, Jing-Hua Chen*, A fluorescent aptasensor based on DNA-scaffolded silver nanoclusterscoupling with Zn(II)-ion signal-enhancement for simultaneous detection of OTA and AFB1. Sensors and Actuators B, 2016, 235: 79-85. \r
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Shuxian Cai, Mei Chen, Mengmeng Liu, Wenhui He, Zhijing Liu, Dongzhi Wu, Yaokun Xia, Huanghao Yang, Jinghua Chen*, A signal amplification electrochemical aptasensor for the detection of breast cancer cell via free-running DNA walker, Biosensors and Bioelectronics, 2016, 85, 184-189.\r
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Wei-Ming Sun, Xiang-Hui Li, Ying Li, Di Wu*, Chun-Yan Li, Jing-Hua Chen*, Zhi-Ru Li, Can Fluorinated Molecular Cages Be Utilized as Building Blocks of Hyperhalogens? Chem Phys Chem, 2016, 17,1468-1474.\r
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Jing Zhang, Dong-Zhi Wu, Shu-Xian Cai, Mei Chen, Yao-Kun Xia, Fang Wu, Jing-Hua Chen*, An immobilization-free electrochemical impedance biosensor based on duplex-specific nuclease assisted target recycling for amplified detection of microRNA, Biosensors and Bioelectronics, 2016, 75, 452–457.\r
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Chunyan Li, Zhijing Liu, Shuxian Cai, FadiWen, DongzhiWu, Yingxin Liu, Fang Wu, Jianming Lan, Zhizhong Han, Jinghua Chen*, An electrochemicalmicroRNA biosensor based on protein p19 combining an acridone derivate as indicator and DNA concatamers for signal amplification, Electrochemistry Communications, 2015, 60:185-189.\r
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Jing Zhang, Dongzhi Wu, QiuXiang Chen, Mei Chen, Yaokun Xia, Shuxian Cai, Xi Zhang, Fang Wu, Jinghua Chen*, Label-Free MicroRNA Detection based on Terbium and Duplex-Specific Nuclease Assisted Target Recycling. Analyst, 2015, 140, 5082-5089.\r
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Xi Zhang, Dongzhi Wu, Zhijing Liu, Shuxian Cai, Yanping Zhao, Mei Chen, Yaokun Xia, Chunyan Li, Jing Zhang* and Jinghua Chen*, An ultrasensitive Label-Free Electrochemical Biosensor for MicroRNA-21 Detection based on 2’-O-methyl modified DNAzyme and Duplex-Specific Nuclease Assisted Target Recycling. Chemical Communications, 2014, 50, 12375--12377.\r
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Jinghua Chen, Xi Zhang, Shuxian Cai, Dongzhi Wu, Mei Chen, Shihua Wang*, Jing Zhang*, A Fluorescent Aptasensor based on DNA-Scaffolded Silver-Nanocluster for Ochratoxin A Detection, Biosensors and Bioelectronics, 2014,57, 226-231.\r
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Jinghua Chen, Jia Lin, Xi Zhang, Shuxian Cai, Dongzhi Wu, Chunyan Li, Sheng Yang*, Jing Zhang*, Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection, Anal Chim Acta. 2014, 817:42-47. \r
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Jing Zhang, XiaoYan Wu, WeiJuan Yang, JingHua Chen*, FengFu Fu*, Ultra-sensitive electrochemical detection of single nucleotide polymorphisms based on an electrically controllable magnetic gold electrode, Chem. Commun. 2013，49, 10, 996-998. \r
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Xian Chen, Cheng-Yi Hong, Ya-Hui Lin, Jing-Hua Chen*, Guo-Nan Chen, Huang-Hao Yang*, Enzyme-free and label-free ultrasensitive electrochemical detection of human immunodeficiency virus DNA in biological samples based on long-range self-assembled DNA nanostructures, Analytical chemistry. 2012, 84(19): 8277-8283.\r
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Jinghua Chen, Jing zhang, Juan Li, Huanghao Yang, Fengfu Fu, Guonan Chen*, An ultrasensitive electrochemical biosensor for detection of DNA species related to oral cancer based on nuclease-assisted target recycling and amplification of DNAzyme, Chem. Commun., 2011, 47(28): 8004-8006. \r
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Jinghua Chen, Jing Zhang, Kun Wang, Xinhua Lin, Liying Huang, Guonan Chen*, Electrochemical Biosensor for Detection of BCR/ABL Fusion Gene Using Locked Nucleic Acids on 4-Aminobenzenesulfonic Acid-Modified Glassy Carbon Electrode. Anal. Chem., 2008, 80(21): 8028-8034.