个人简历

工作经历
青年研究员，复旦大学，生物医学研究院（2014.11至今）
博士后，美国加州大学圣迭戈分校（2009.09-2014.08）
教育经历
博士，中国科学院上海生化细胞所（2002-2009）
学士，中国科技大学生命科学学院（1998-2002）
所获人才项目
上海市人才发展资金（2019）
国家自然科学基金面上项目3项（2020，2018，2016）
“发育编程及其代谢调节”国家重点研发计划（2019）
“艾滋病和病毒性肝炎等重大传染病防治”国家科技重大专项（2017）

近期论文

1.LiX,WangTX,HuangX,LiY,SunT,ZangS,GuanKL,XiongY,LiuJ*,YuanHX*.Targetingferroptosisalleviatesmethionine-cholinedeficient(MCD)-dietinducedNASHbysuppressingliverlipotoxicity.LiverInt.2020Mar7.doi:10.1111/liv.14428.(*co-corresponding)
2.WangTX,LiangJY,ZhangC,XiongY,GuanKLandYuanHX.Theoncometabolite2-hydroxyglutarateproducedbymutantIDH1sensitizescellstoferroptosis.CellDeathDis.2019,10:755.
3.LiFL,LiuJP,BaoRX,YanG,FengX,XuYP,SunYP,YanW,LingZQ,XiongY,GuanKLandYuanHX.AcetylationaccumulatesPFKFB3incytoplasmtopromoteglycolysisandprotectscellsfromcisplatin-inducedapoptosis.NatCommun2018,9:508.
4.LiuMX,JinL,SunSJ,LiuP,FengX,ChengZL,LiuWR,GuanKL,ShiYH*,YuanHX*andXiongY*.MetabolicreprogrammingbyPCK1promotesTCAcataplerosis,oxidativestressandapoptosisinlivercancercellsandsuppresseshepatocellularcarcinoma.Oncogene2018,37:1637-1653.(*co-corresponding)
5.MoY,LinR,LiuP,TanM,XiongY,GuanKL,YuanHX.SIRT7deacetylatesDDB1andsuppressestheactivityoftheCRL4E3ligasecomplexes.FEBSJ.2017284:3619-3636.
6.WangZ,LiuP,ZhouX,WangT,FengX,SunYP,XiongY*,YuanHX*,GuanKL*.EndothelinpromotescolorectaltumorigenesisbyactivatingYAP/TAZ.CancerRes.2017,77:2413-2423.(*co-corresponding)
7.FengX,LiuP,ZhouX,LiMT,LiFL,WangZ,MengZP,SunYP,YuY,XiongY*,YuanHX*,andGuanKL*.ThromboxaneA2ActivatesYAP/TAZtoInduceVascularSmoothMuscleCellProliferationandMigration.JBiolChem.2016,291:18947-18958.(*co-corresponding)
8.YuanHX*andGuanKL*.StructuralinsightsofmTORcomplex1.CellRes.2016,26:267-268.(*co-corresponding)
9.YuanHX,WangZ,YuFX,LiF,RussellRC,JewellJL,andGuanKL.NLKphosphorylatesRaptortomediatestress-inducedmTORC1inhibition.GeneDev.2015,29:2362-2376.
10.YuanHXandGuanKL.TheSIN1-PHDomainConnectsmTORC2toPI3K.CancerDiscov.2015,5:1127-1129.
11.YuanHX,RussellRC,andGuanKL.RegulationofPIK3C3/VPS34complexesbyMTORinnutrientstress-inducedautophagy.Autophagy2013,9:1983-1995.
12.YuanHX,XiongY,andGuanKL.Nutrientsensing,metabolism,andcellgrowthcontrol.MolCell.2013,49:379-387.
13.YuanH#,ZhangH#,WuX,ZhangZ,DuD,ZhouW,ZhouS,BrakebuschC,andChenZ.Hepatocyte-specificdeletionofCdc42resultsindelayedliverregenerationafterpartialhepatectomyinmice.Hepatology2009,49:240-249.(#co-first)
14.YuanH,ZhangL,LiuA,ZhouH,WangY,ZhangH,WangG,ZengR,ZhangY,andChenZ.Proteomicprofilingofregionalizedproteinsinratepididymisindicatesconsistencybetweenspecializeddistributionandproteinfunctions.JProteomeRes.2006,5:299-307.