个人简历

工作经历
研究员复旦大学，生物医学研究院(2019.08-今)
研究员上海交通大学医学院(2015.12-2019.07)
副研究员上海交通大学医学院(2012.01-2015.11)
博士后比利时弗拉芒生物技术研究所（2010.07-2011.12）
医师同济大学附属第十人民医院普外科（2005.08-2006.08）
教育经历
博士布鲁塞尔自由大学，生命科学工程(2006.09-2010.06)
学士、硕士哈尔滨医科大学，临床医学（七年制）(1998.09-2005.07)
所获人才项目
国家“万人计划”青年拔尖人才,2015
国家自然科学基金优青，2013
仲英青年学者，2016
上海市曙光学者，2015
上海高校特聘教授，2013
上海市浦江人才，2013
欧盟优秀博士后奖励计划，2010
上海市青年科技启明星，2006
所获奖项
上海市卫生系统银蛇奖二等奖2015
国家科学技术进步奖二等奖（第四完成人）2018
上海市科学技术进步奖一等奖（第三完成人）2014

近期论文

1.Xu,J*.(2020).RegulationofCancerImmuneCheckpoints:MolecularandCellularMechanismsandTherapy(HardcoverBook).SpringerNature.ISBN9811532656(*书籍主编)
2.Wang,Huanbin(#);Yao,Han;Li,Chushu;Shi,Hubing;Lan,Jiang;Li,Zhaoli;Zhang,Yao;Liang,Lunxi;Fang,Jing-Yuan;Xu,Jie(*),HIP1RtargetsPD-L1tolysosomaldegradationtoalterTcell-mediatedcytotoxicity.NatureChemicalBiology,2019.1,15(1):42~50
3.HanYao(#);JiangLan(#);ChushuLi(#);HubingShi(#);Jean-PhilippeBrosseau;HuanbinWang;HaojieLu;CaiyunFang;YaoZhang;LunxiLiang;XiaolinZhou;ChaojunWang;YuXue;YunCui;JieXu(*),InhibitingPD-L1palmitoylationenhancesT-cellimmuneresponsesagainsttumours,NatureBiomedicalEngineering,2019May;3(5):414
4.LiangL(#),WangH(#),ShiH,LiZ,YaoH,BuZ,SongN,LiC,XiangD,ZhangY,WangJ,HuY,XuQ,MaY,ChengZ,WangY,ZhaoS,QianJ,ChenY,FangJY,Xu,J(*),ADesignedPeptideTargetsTwoTypesofModificationsofp53withAnti-cancerActivity,CellChemicalBiology,2018.06.21,25(6):761~774
5.Wang,Huanbin(#);Yao,Han(#);Li,Chushu;Liang,Lunxi;Zhang,Yao;Shi,Hubing;Zhou,Chongzhi;Chen,Yingxuan;Fang,Jing-Yuan;Xu,Jie(*),PD-L2expressionincolorectalcancer:Independentprognosticeffectandtargetabilitybydeglycosylation,Oncoimmunology,2017,6(7):e1327494
6.Zhang,Y.(#);Hu,Y.(#);Wang,J-L;Yao,H.;Wang,H.;Liang,L.;Li,C.;Shi,H.;Chen,Y.;Fang,J-Y;Xu,J.(*),ProteomicidentificationofERP29asakeychemoresistantfactoractivatedbytheaggregatingp53mutantArg282Trp,Oncogene,2017.9.28,36(39):5473~5483
7.Yao,Han(#);Wang,Huanbin;Li,Chushu;Fang,Jing-Yuan;Xu,Jie;Xu,J(*),CancerCell-intrinsicPD-1andimplicationsinCombinatorialimmunotherapy,FrontiersinImmunology,2018.07.30,9(1774):0~1774
8.WangH(#);LiangL;FangJY;XuJ(*),Somaticgenecopynumberalterationsincolorectalcancer:newquestforcancerdriversandbiomarkers,Oncogene,2015.01.01,35(304):2011~2019
9.Xie,Yuan-Hong(#);Gao,Qin-Yan;Zou,Tian-Hui;Chen,Hui-Min;Yu,Si-Yi;Qiu,Yi-Wen;Gu,Wei-Qi;Chen,Xiao-Yu;Cui,Yun;Sun,Danfeng;Xu,Jie;Chen,Ying-Xuan;Fang,Jing-Yuan;Cai,Guo-Xiang;Cai,San-Jun;Sun,Xiao-Ming;Liu,Zhan-Ju;Cai,SJ(*);Xu,J(*);Chen,YX(*);Fang,JY(*),FecalClostridiumsymbiosumforNoninvasiveDetectionofEarlyandAdvancedColorectalCancer:TestandValidationStudies,EBioMedicine,2017.11,25:32~40
10.Qian,Jin(#);Kong,Xuan(#);Deng,Niantao;Tan,Patrick;Chen,Haoyan;Wang,Jilin;Li,Zhaoli;Hu,Ye;Zou,Weiping;Xu,Jie(*);Fang,Jing-Yuan(*),OCT1isadeterminantofsynbindin-relatedERKsignallingwithindependentprognosticsignificanceingastriccancer,Gut,2015.1.01,64(1):37~48
11.LiangL(#);FangJY(*);XuJ(*),Gastriccancerandgenecopynumbervariation:emergingcancerdriversfortargetedtherapy,Oncogene,2015.01.01,35(12):1475~1482
12.Wang,Jilin(#);Qian,Jin(#);Hu,Ye;Kong,Xuan;Chen,Haoyan;Shi,Qinghua;Jiang,Long;Wu,Chenming;Zou,Weiping;Chen,Yingxuan;Xu,Jie(*);Fang,Jing-Yuan(*),ArhGAP30promotesp53acetylationandfunctionincolorectalcancer,NatureCommunications,2014.08.26,5:5735
13.Hu,Ye(#);Wang,Jilin;Qian,Jin;Kong,Xuan;Tang,Jieting;Wang,Yingchao;Chen,Haoyan;Hong,Jie;Zou,Weiping;Chen,Yingxuan;Xu,Jie(*);Fang,Jing-Yuan(*),LongNoncodingRNAGAPLINCRegulatesCD44-DependentCellInvasivenessandAssociateswithPoorPrognosisofGastricCancer,CancerResearch,2014.12.1,74(23):6890~6902
14.XuanKong,JinQian,Li-ShaChen,Ying-ChaoWang,Ji-LinWang,HaoyanChen,Yu-RongWeng,Shu-LiangZhao,JieHong,Ying-XuanChen,WeipingZou,JieXu(*),Jing-YuanFang(*),SynbindininExtracellularSignal-RegulatedProteinKinaseSpatialRegulationandGastricCancerAggressiveness,JNCI:JournaloftheNationalCancerInstitute,2013,105(22):1738-49
15.XuJ(*),ZhouX,WangJ,LiZ,KongX,QianJ,HuY,FangJY(*).RhoGAPsattenuatecellproliferationbydirectinteractionwithp53tetramerizationdomain.CellReports,2013.3(5):1526-1538
16.XuJ,ReumersJ,CouceiroJR,DeSmetF,GallardoR,RudyakS,CornelisA,RozenskiJ,ZwolinskaA,MarineJC,LambrechtsD,SuhYA,RousseauF(*),SchymkowitzJ(*).Gainoffunctionofmutantp53bycoaggregationwithmultipletumorsuppressors.NatureChemicalBiology.2011May;7(5):285-95