徐彦辉
近期热点
资料介绍
个人简历
清华大学博士,普林斯顿大学博士后。现任全国生物物理学会理事。主要研究领域:表观遗传修饰酶的结构生物学研究。研究成果发表在高水平国际刊物,包括Cell(1篇),MolCell(1篇),ProcNatlAcadSci(1篇),Genes&Dev(2篇),CellResearch(4篇),JBiolChem(2篇)等。近五年以共同通讯或通讯作者发表SCI论文16篇,总影响因子136,被SCI他引150次,单篇最高SCI他引47次。徐彦辉研究员为中国生物物理学会理事。获得“明治生命科学奖”(杰出奖)等奖励。获得中组部“万人计划-青年拔尖人才”,教育部“新世纪优秀人才支持计划”,上海市“优秀学术带头人”,“浦江人才计划”及“曙光学者”等人才计划的支持。获得科技部重大科学研究计划“973”2项(子课题负责人,子课题项目骨干),主持国家自然科学基金重点1项,面上项目3项。共计科研经费1200万元。研究领域
Structuralstudiesoftheenzymesthatareinvolvedinepigeneticregulations.Weareinterestedinthemolecularmechanismsforcatalysis,substraterecognitionandregulationofenzymaticactivitiesofepigeneticregulatorsforDNAmethylation/demethylationandhistonemethylation/demethylation."代表性成果:系统的阐明了DNA甲基化和组蛋白甲基化修饰关键酶催化,底物识别和酶活性调节的分子机制。表观遗传在整个生命发育过程及多种疾病发生发展中起到至关重要的作用,对其分子机制的研究是生物医药研究取得进展的重要前提。在DNA甲基化修饰酶的研究中,阐明了TET2氧化DNA甲基化及识别DNA底物的分子机制(Cell,唯一通讯作者),揭示了UHRF1识别组蛋白甲基化修饰以指导DNA甲基化维持(CellRes近期论文
1.Hu,L.#,Li,Z.#,Cheng,J.#,Rao,Q.,Gong,W.,Liu,M.,Shi,YG.,Zhu,J.,Wang,P.andXu,Y.*CrystalStructureofTET2-DNAComplex:InsightintoTET-Mediated5mCOxidation,Cell155,1545-1555,20132.Fang,R.#,Chen,F.#,Dong,Z.,Hu,D.,Barbera,A.J.,Clark,E.A.,Fang,J.,Yang,Y.,Mei,P.,Rutenberg,M.,Li,Z.,Zhang,Y.,Xu,Y.,Yang,H.,Wang,P.,Simon,M.D.,Zhou,Q.,Li,J.,Marynick,M.P.,Li,X.,Lu,H.,Kaiser,U.B.,Kingston,R.E.,Xu,Y.*,andShi,Y.G.*LSD2/KDM1BanditscofactorNPAC/GLYR1endowastructuralandmolecularmodelforregulationofH3K4demethylation,Molecularcell49,558-570,20133.Chen,F.#,Yang,H.#,Dong,Z.#,Fang,J.,Wang,P.,Zhu,T.,Gong,W.,Fang,R.,Shi,Y.G.,Li,Z.*,andXu,Y.*StructuralinsightintosubstraterecognitionbyhistonedemethylaseLSD2/KDM1b,Cellresearch23,306-309,20134.Cheng,J.,Yang,Y.,Fang,J.,Xiao,J.,Zhu,T.,Chen,F.,Wang,P.,Li,Z.,Yang,H.,andXu,Y.*StructuralinsightintocoordinatedrecognitionoftrimethylatedhistoneH3lysine9(H3K9me3)bytheplanthomeodomain(PHD)andtandemtudordomain(TTD)ofUHRF1(ubiquitin-like,containingPHDandRINGfingerdomains,1)protein,TheJournalofbiologicalchemistry288,1329-1339,20135.Ma,H.#,Chen,H.#,Guo,X.#,Wang,Z.,Sowa,M.E.,Zheng,L.,Hu,S.,Zeng,P.,Guo,R.,Diao,J.,Lan,F.,Harper,J.W.,Shi,Y.G.,Xu,Y.*,andShi,Y.*MphasephosphorylationoftheepigeneticregulatorUHRF1regulatesitsphysicalassociationwiththedeubiquitylaseUSP7andstability,ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica109,4828-4833,20126.Yang,Y.#,Hu,L.#,Wang,P.#,Hou,H.,Lin,Y.,Liu,Y.,Li,Z.,Gong,R.,Feng,X.,Zhou,L.,Zhang,W.,Dong,Y.,Yang,H.,Lin,H.,Wang,Y.,Chen,C.D.*,andXu,Y.*Structuralinsightsintoadual-specificityhistonedemethylaseceKDM7AfromCaenorhabditiselegans,Cellresearch20,886-898,20107.Hu,L.#,Li,Z.#,Wang,P.,Lin,Y.,andXu,Y.*CrystalstructureofPHDdomainofUHRF1andinsightsintorecognitionofunmodifiedhistoneH3arginineresidue2,Cellresearch.21(9):1374-8,20118.Gong,R.#,Li,L.#,Liu,Y.#,Wang,P.,Yang,H.,Wang,L.,Cheng,J.,Guan,K.L.,andXu,Y.*CrystalstructureoftheGtr1p-Gtr2pcomplexrevealsnewinsightsintotheaminoacid-inducedTORC1activation,Genes&development25,1668-1673,20119.Li,Z.#,Zhao,B.#,Wang,P.,Chen,F.,Dong,Z.,Yang,H.,Guan,K.L.*,andXu,Y.*StructuralinsightsintotheYAPandTEADcomplex,Genes&development24,235-240,2010 相关热点