个人简历

工作经历
教授，复旦大学，化学系，(2005.4-今)
访问学者，香港科技大学，生物化学系，(2002.2-2003.8)
副教授，复旦大学，化学系，(2000.12-2005.4)
讲师，复旦大学，化学系，(1996.4-2000.12)
博士后，日本国立分子科学研究所，(1995.12-1996.3)
教育经历
博士，复旦大学，化学系，(1990-1995)
学士，复旦大学，化学系，(1986-1990)
所获人才项目
曙光学者，上海市教委，2004
香港求槎基金会内地青年学者，香港求槎基金会，2003

近期论文

Zhu,J.,Wen,W.,Zheng,Z.,Shang,Y.,Wei,Z.,Xiao,Z.,Pan,Z.,DuQ.*,WangW.*,ZhangM.*(2011)“LGN/mInscandLGN/NuMAcomplexesstructuressuggestdistinctfunctionsinasymmetriccelldivisionforthePar3/mInsc/LGNandGai/LGN/NuMApathways”,Mol.Cell,43,418-431.(IF=14.714)
Jia,M.,Shan,Z.,Yang,Y.,Liu,C.,Li,J.,Luo,Z.,Zhang,M.,CaiY.*,WenW.*,WangW.*(2015)“ThestructuralbasisofMiranda-mediatedStaufenlocalizationduringDrosophilaneuroblastasymmetricdivision”Nat.Commun.6:8381.(IF=12.124)
Wang,W.*,Weng,J.,Zhang,X.,Liu,M.,Zhang,M.*(2009)“Creatingconformationalentropybyincreasinginter-domainmobilityinligandbindingregulation:arevisittoN-terminaltandemPDZdomainsofPSD-95”,J.Am.Chem.Soc.131,787-796.(IF=13.858)
Feng,Y.,Zhang,L.,Wu,S.,Gao,X.,Liu,J.*,Huang,X.*,Wang,W.*(2016)“ConformationalDynamicsofapo-GlnBPRevealedbyExperimentalandComputationalAnalysis”Angew.Chem.Int.Ed.Engl.55,13990-13994.(IF=11.994)
WuS.,WangD.,LiuJ.,FengY.,WengJ.,GaoX.,LiuJ.*,WangW.*(2017)“TheDynamicMultisiteInteractionsbetweenTwoIntrinsicallyDisorderedProteins”Angew.Chem.Int.Ed.Engl.56:7515-7519.(IF=11.994)
Reviewedby:Facultyof1000
Yao,C.,Wei,C.,Huang,Z.,Lu,Y.,El-Toni,AM,Ju,D.,Zhang,X.,Wang,W.*,Zhang,F.*(2016)“PhosphorylatedPeptidesFunctionalizationofLanthanideUpconversionNanoparticlesforTuningtheNanomaterial-CellInteraction”ACSAppl.Mater.Interfaces,8,6935-6943.
Ma,W.,Shang,Y.,Wei,Z.,Wen,W.,Wang,W.*,Zhang,M.*(2010)“PhosphorylationofDCCbyERK2isFacilitatedbyDirectDockingoftheReceptorP1DomaintotheKinase”Structure,18,1502-1511.
Pan,Z.,Zhu,J.,Shang,Y.,Wei,Z.,Jia,M.,Xia,C.,Wen,W.,WangW.*,ZhangM.*(2013)“Anauto-inhibitedconformationofLGNrevealsadistinctinteractionmodebetweenGoLocomotifsandTPRmotifs”Structure,21,1007-1017.
Weng,J.,Fan,K.Wang,W.*(2010)“TheconformationaltransitionpathwayofATPbindingcassettetransporterMsbArevealedbyatomisticsimulations”J.Biol.Chem.285,3053-3063.
Jia,M.,Li,J.,Zhu,J.,Wen,W.,Zhang,M.,Wang,W.*(2012)“CrystalStructuresofthescaffoldingproteinLGNrevealthegeneralmechanismbywhichGoLocobindingmotifsinhibitthereleaseofGDPfromGaisubunitsinG-coupledheterotrimericproteins”,J.Biol.Chem.,287,36766-36776.
Zuo,Z.,Wang,B.,Weng,J.*,Wang,W.*(2015)“StepwisesubstratetranslocationmechanismrevealedbyfreeenergycalculationsofdoxorubicininthemultidrugtransporterAcrB.”Sci.Rep.5:13905.
Weng,J.,Ma,J.,Fan,KN,Wang,W.*(2008)“TheConformationalCoupling.andTranslocationMechanismofVitaminB12ATP-bindingCassette(ABC)TransporterBtuCD”,Biophys.J.,94,612-62.
Weng,J.,Ma,J.Fan,K.,andWang,W.*(2009)“AsymmetricconformationalflexibilityintheATP-BindingCassettetransporterHI1470/1”Biophys.J.96,1918-1930.
Weng,J.,Gu,S.,Gao,X.,Huang,X.*,Wang,W.*(2017)“MaltoseBindingProteinEffectivelyStabilizesthePartiallyClosedConformationoftheATP-bindingCassetteTransporterMalFGK2”Phys.Chem.Chem.Phys.19,9366-9373.
Wang,B.,Weng,J.*,Wang,W.*(2015)“SubstratebindingacceleratestheconformationaltransitionsandsubstratedissociationinmultidrugeffluxtransporterAcrB”Front.Microbiol.6,302.
WuS.,WangD.,LiuJ.,FengY.,WengJ.,GaoX.,LiuJ.*,WangW.*(2017)“TheDynamicMultisiteInteractionsbetweenTwoIntrinsicallyDisorderedProteins”Angew.Chem.Int.Ed.Engl.56:7515-7519.