个人简历

在哈佛大学医学院完成博士后研究，获国家优秀青年科学基金、上海市浦江人才、复旦大学“卓越2025”卓识人才及上海市卫生系统青年人才最高荣誉奖银蛇奖

研究领域

1）基于CRISPR/Cas9基因编辑的遗传性耳聋基因治疗及转化；2）内耳毛细胞再生和听觉保护"据WHO估计，超过全世界人口的5%，也就是4.66亿人，患有残疾性听力损失（4.32亿成人和3400万儿童），课题组的工作围绕如下开展：1）基于CRISPR/Cas9基因编辑的遗传性耳聋基因治疗；2）内耳毛细胞再生和听觉保护。发表SCI文章36篇，其中第一/通讯作者27篇，建立和发现了遗传性耳聋基因治疗内耳导入新路径和新载体，得到广泛应用；首次以CRISPR/Cas9蛋白系统对活体内耳感觉细胞进行基因编辑；发现成年哺乳动物内耳支持细胞和毛细胞增殖转分化再生；发现自噬在耳毒性药物耳聋听觉保护过程中起到重要调控作用。主持包括国自然优青、面上、青年、上海市科委政府间合作（芬兰）、上海浦江人才、市科委自然科学探索类、复旦大学“卓越2025”卓识人才项目等9项纵向课题。"

近期论文

1.YilaiShu#,WenyanLi#,MingqianHuang#,Yi-ZhouQuan#,YongTao,XuezhongLiu,KonradHochedlinger,ZhengminWang,HuaweiLiandZheng-YiChen*，Renewedproliferationinadultmousecochleaandregenerationofhaircells,Naturecommunication.2019Dec4;10(1):5530.doi:10.1038/s41467-019-13157-7.
2.YilaiShu#,LijunWang#,XiaotingCheng,ChayadaTangshewinsirikul,WeiliShi,YashengYuan,ZhiqiangYang,HuaweiLi,JunShen*,BingChen*,WeiguoZou*Thep.Pro170LeuVariantinNOGImpairsNogginSecretionandCausesAutosomalDominantCongenitalConductiveHearingLossDuetoStapesAnkylosis,JournalofGeneticsandGenomics,2019Sep20;46(9):445-449.
3.JinghanWang#,JunShen#,LuoGuo,ChengCheng,RenjieChai,YilaiShu*HuaweiLi*.AhumanizedmousemodeldemonstratedthatapparentlyautosomaldominantdeafnesscausedbyMYO6p.C442Yisinheritedinasemi-dominantpattern.Hearingresearch,2019Aug;379:79-88.doi:10.1016/j.heares.2019.04.014.Epub2019Apr26.
4.ZurisJA,ThompsonDB,ShuY,GuilingerJP,BessenJL,HuJH,MaederML,JoungJK,ChenZY,LiuDR*.Cationiclipid-mediateddeliveryofproteinsenablesefficientprotein-basedgenomeeditinginvitroandinvivo.NatureBiotechnology.2015Jan;33(1):73-80.
5.XiGu#,RenjieChai,LuoGuo,BiaoDong,WenyanLi,YilaiShu*,XinshengHuang1*HuaweiLi*.TransductionofAdeno-AssociatedVirusVectorsTargetingHairCellsandSupportingCellsintheNeonatalMouseCochlea.FrontiersinCellularNeuroscience.2019.doi:10.3389/fncel.2019.00008.
6.XiaotingCheng#,YanqingFang,YilaiShu*,Duo-DuoTao,YangwenyiLiu,BingWang,YashengYuan,JohnJ.Galvin,Qian-JieFu,BingChen*MusictrainingcanimprovemusicandspeechperceptioninpediatricMandarin-speakingcochlearimplantusers.TrendsinHearing，20189:2331216518759214,doi:10.1177/2331216518759214.
7.YilinShen,BinYe,PenghuiChen,QuanWang,CuiFan,YilaiShu*,MingliangXiang*.CognitiveDecline,Dementia,Alzheimer’sdiseaseandPresbycusis:ExaminationofthePossibleMolecularMechanism,FrontiersinNeuroscience,2018Jun8;12:394.doi:10.3389/fnins.2018.00394.
8.GaoX,TaoY,LamasV,HuangM,YehWH,PanB,HuYJ,HuJH,ThompsonDB,ShuY,LiY,WangH,YangS,XuQ,PolleyDB,LibermanMC,KongWJ,HoltJR,ChenZY*,LiuDR*.Treatmentofautosomaldominanthearinglossbyinvivodeliveryofgenomeeditingagents.Nature.2018Jan11;553(7687):217-221.
9.HeZ#,GuoL#,ShuY#,FangQ,ZhouH,LiuY,LiuD,LuL,ZhangX,DingX,LiuD,TangM,KongW,ShaS,LiH,GaoX,ChaiR.Autophagyprotectsauditoryhaircellsagainstneomycin-induceddamage.Autophagy.2017Oct2:1-21.13(11):1884-1904.
10.ShuY#,TaoY,WangZ,TangY,LiH,DaiP,GaoG,ChenZY*.IdentificationofAdeno-associatedviralvectors(AAV)thattargetneonatalandadultmammalianinnerearcellsubtypes.HumanGeneTherapy.27(9):687-99.2016Jun24.(Coverstory)
11.ShuY#,TaoY,LiW,ShenJ,WangZ,ChenZY.AdenovirusVectorsTargetSeveralCellSubtypesofMammalianInnerEarInVivo.NeuralPlast.2016;2016:9409846.doi:10.1155/2016/9409846
12.LiM,TaoY,ShuY,LaRochelleJR,SteinauerA,ThompsonD,SchepartzA,ChenZY,LiuDR*.Discoveryandcharacterizationofapeptidethatenhancesendosomalescapeofdeliveredproteinsinvitroandinvivo.JAmChemSoc.2015Nov11;137(44).