个人简历

工作经历\r
教授，复旦大学，化学系，生物医学研究院（2008.9-至今）\r
副教授，复旦大学，化学系（2004.9-2008.7）\r
讲师，复旦大学，化学系（2003.9-2004.7）\r
访问学者，美国加州大学洛杉矶分校（UCLA）医学院（2006.9-2007.9）\r
博士后，中科院上海有机化学研究所（2001.9-2003.7）\r
\r
教育经历\r
博士，中科院兰州化物所（1996-2001）\r
学士，厦门大学，化学系（1992-1996）

研究领域

"""""课题组研究兴趣是基于生物质谱的蛋白质组学新技术新方法建立与应用研究。与疾病相关的蛋白质往往是丰度较低的蛋白质并和蛋白质翻译后修饰有关，这些重要的蛋白质由于本身存在的量极少或修饰的量极少而很难得以有效鉴定。低丰度蛋白质和蛋白质翻译后修饰的精准质谱定性和定量分析作为一个艰巨的前沿研究任务，适合质谱鉴定的样品处理方法和相应的质谱分析方法对实现该任务起着首要和关键作用。课题组建立了一系列复杂背景干扰下低丰度蛋白质和翻译后修饰蛋白质的高灵敏鉴定和高准确定量新方法，在重大疾病蛋白质标志物高灵敏鉴定和高准确验证关键环节获系列重要成果。"

近期论文

Yuan, W., Zhang, Y., Xiong, Y., Tao, T., Wang, Y., Yao, J., Zhang, L., Yan, G., Bao, H., Lu, H.* (2017) Highly Selective and Large Scale Mass Spectrometric Analysis of 4-Hydroxynonenal Modification via Fluorous Derivatization and Fluorous Solid-Phase Extraction. Analytical chemistry 89, 3093-3100.\r
\r
Xiong, Y., Zhang, Y., Yao, J., Yan, G., Lu, H.* (2017) Direct digestion of living cells via a gel-based strategy for mass spectrometric analysis. Chemical communications (Cambridge, England) 53, 1421-1424.\r
\r
Li, L., Jiao, J., Cai, Y., Zhang, Y.*, Lu, H.* (2015) Fluorinated carbon tag derivatization combined with fluorous solid-phase extraction: a new method for the highly sensitive and selective mass spectrometric analysis of glycans. Analytical chemistry 87, 5125-5131.\r
\r
Liu, M., Fang, C., Pan, X., Jiang, H., Zhang, L., Zhang, L., Zhang, Y., Yang, P., Lu, H.* (2015) Positive enrichment of C-terminal peptides using oxazolone chemistry and biotinylation. Analytical chemistry 87, 9916-9922.\r
\r
Zhang, Y., Zhang, C., Jiang, H., Yang, P., Lu, H.* (2015b) Fishing the PTM proteome with chemical approaches using functional solid phases. Chemical Society reviews 44, 8260-8287.\r
\r
Zhang, L., Jiang, H., Yao, J., Wang, Y., Fang, C., Yang, P., Lu, H.* (2014a) Highly specific enrichment of N-linked glycopeptides based on hydrazide functionalized soluble nanopolymers. Chemical communications (Cambridge, England) 50, 1027-1029.\r
\r
Zhang, Y., Kuang, M., Zhang, L., Yang, P., Lu, H.* (2013a) An accessible protocol for solid-phase extraction of N-linked glycopeptides through reductive amination by amine-functionalized magnetic nanoparticles. Analytical chemistry 85, 5535-5541.\r
\r
Liu, M., Zhang, L., Zhang, L., Yao, J., Yang, P., Lu, H.* (2013) Approach for identification and quantification of C-terminal peptides: incorporation of isotopic arginine labeling based on oxazolone chemistry. Analytical chemistry 85, 10745-10753.\r
\r
Wang, D., Fang, C., Zong, N., Liem, D., Cadeiras, M., Scruggs, S., Yu, H., Kim, A., Yang, P., Deng, M., Lu, H.*, Ping, P.* (2013) Regulation of acetylation restores proteolytic function of diseased myocardium in mouse and human. Molecular & cellular proteomics 12, 1-8.\r
\r
Ma, W., Zhang, Y., Li, L., You, L., Zhang, P., Zhang, Y., Li, J., Yu, M., Guo, J., Lu, H.*, Wang, C.* (2012) Tailor-Made Magnetic Fe3O4@mTiO2 Microspheres with a Tunable Mesoporous Anatase Shell for Highly Selective and Effective Enrichment of Phosphopeptides. ACS nano 6, 3179.\r
\r
Xiong, H., Guan, X., Jin, L., Shen, W., Lu, H.*, Xia, Y.* (2008) Surfactant-free synthesis of SnO2@PMMA and TiO2@PMMA core-shell nanobeads designed for peptide/protein enrichment and MALDI-TOF MS analysis. Angewandte Chemie (International ed in English) 47, 4204-4207.\r
\r
Lu, H., Zong, C., Wang, Y., Young, G., Deng, N., Souda, P., Li, X., Whitelegge, J., Drews, O., Yang, P., Ping, P*. (2008) Revealing the dynamics of the 20 S proteasome phosphoproteome: a combined CID and electron transfer dissociation approach. Molecular & cellular proteomics : MCP 7, 2073-2089.\r
\r
Xu, Y., Zhang, L., Lu, H.*, Yang, P. (2008) Mass spectrometry analysis of phosphopeptides after peptide carboxy group derivatization. Analytical chemistry 80, 8324-8328.\r
\r
Shen, W., Xiong, H., Xu, Y., Cai, S., Lu, H.*, Yang, P. (2008) ZnO-poly(methyl methacrylate) nanobeads for enriching and desalting low-abundant proteins followed by directly MALDI-TOF MS analysis. Analytical chemistry 80, 6758-6763.\r
\r
Jia, W., Chen, X., Lu, H.*, Yang, P.* (2006) CaCO3-poly(methyl methacrylate) nanoparticles for fast enrichment of low-abundance peptides followed by CaCO3-core removal for MALDI-TOF MS analysis. Angewandte Chemie (International ed in English) 45, 3345-3349.