鲁伯埙
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男,研究员,主要从事神经兴奋性分子机制以及神经退行性疾病研究,揭示了遗传性神经退行性疾病的代表性疾病亨廷顿病的多个潜在药靶及疾病分子机制,系列成果以第一作者或最终通讯作者在Nature、Cell、eLife、Nature Neuroscience、Neuron等期刊发表研究领域
神经退行性疾病治疗药靶及药物近期论文
Yao Y,Cui X,Al-Ramahi l,Sun X,Li B, Hou J,Diflglia M,Palacino J,Wu ZY,Ma L,Botas J, Lu B*(2015).A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.eLife, 4:4..Lu B*,Al-Ramahi l,Valencia A,Wang Q,Berenshteyn F,Yang H,Gallego-Flores,Ichcho S,lacoste A,Hild M,Difigia M,Botas J,Palacino J*(2013).Identification of NUB1 as a Suppressor of Mutant Huntingtin Toxicity via Enhanced Protein Clearance.Nat Neurosci,16(5):562-570.Yu S,Liang Y,Palacino J,Difiglia M, Lu B*(2014).Drugging unconventional targets: insights from Huntington's disease.Trends Pharmacol Sci,35(2):53-62.Lu B,Su Y,Das S,Wang H,Wang Y,Liu J, Ren D*(2009).Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.Nature,457(7230):741-744.Lu B,Su Y,Das S,Liu J,Xia J, Ren D*(2007).The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell,129(2):371-383.标签: 复旦大学 医学神经生物学国家重点实验室
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