个人简历

工作经历
1998年7月及2003年7月在重庆医科大学分别获得医学学士学位及医学博士学位。2003年8月至2009年10月先后在复旦大学附属肿瘤医院、美国凯斯西储大学(CaseWesternReserveUniversity)、德州大学安德森肿瘤中心(UniversityofTexasM.D.AndersonCancerCenter)及乔治华盛顿大学(GeorgeWashingtonUniversity)从事博士后研究工作。
教育经历
2009年11月起任乔治华盛顿大学生物化学及分子生物学系Faculty及AssistantResearchProfessor，并于2013年7月升职为AssociateResearchProfessor。2013年8月底回国任复旦大学生物医学研究院及肿瘤研究所PI，入选2013年上海高校特聘教授。
在CancerCell、MolCell、CellRep、Hepatology、JCellBiol、NatCommun、PNAS、Autophagy、NucleicAcidsRes、CancerRes以及CellDeathDiffer等国际期刊上发表SCI论文50余篇。目前担任CancerResearch等杂志编委以及CancerResearch等多个杂志的审稿人。

研究领域

致力于肿瘤侵袭转移及治疗耐药的分子机制研究，为寻找干预肿瘤转移和治疗耐药的候选药物靶标提供线索

近期论文

1.LiuHY,LiuYY,YangF,ZhangL,ZhangFL,HuX*,ShaoZM*,LiDQ*(2020).AcetylationofMORC2byNAT10regulatescell-cyclecheckpointcontrolandresistancetoDNA-damagingchemotherapyandradiotherapyinbreastcancer.NucleicAcidsRes[PMID:32112098]
2.ZhangL,LiDQ*(2019).MORC2regulatesDNAdamageresponsethroughaPARP1-dependentpathway.NucleicAcidsRes,47(16):8502-8520
3.ZhangFL,CaoJL,XieHY,SunR,YangLF,ShaoZM*,LiDQ*(2018).Cancer-associatedMORC2-mutantM276IregulatesanhnRNPM-mediatedCD44splicingswitchtopromoteinvasionandmetastasisintriple-negativebreastcancer.CancerRes,78(20):5780-5792
4.SunR,XieHY,QianJX,HuangYN,YangF,ZhangFL*,ShaoZM*,LiDQ*(2018).FBXO22possessesbothprotumorigenicandantimetastaticrolesinbreastcancerProgression.CancerRes,78(18):5274-5286
5.YangLF,YangF,ZhangFL,XieYF,HuZX,HuangSL*,ShaoZM*,LiDQ*(2020).DiscretefunctionalandmechanisticrolesofCDYL2transcriptvariantsinbreastcancergrowthandmetastasis.Theranostics(accepted)
6.YangF,XieHY,YangLF,ZhangL,ZhangFL,LiuHY,LiDQ*,ShaoZM*(2020).StabilizationofMORC2byestrogenandantiestrogensthroughGPER1-KAPCA-CMApathwaycontributestoestrogen-inducedproliferationandendocrineresistanceofbreastcancercells.Autophagy(PublishedOnline:06Sep2019)
7.YangYL,ZhangY,LiDD,ZhangFL,LiuHY,LiaoXH,XieHY,LuQ,ZhangL,HongQ,DongWJ,LiDQ*,ShaoZM*(2020).RNF144Afunctionsasatumorsuppressorinbreastcancerthroughubiquitinligaseactivity-dependentregulationofstabilityandoncogenicfunctionsofHSPA2.CellDeathDiffer,27(3):1105-1118
8.LiDQ*,PakalaSB*,ReddySD,PengS,Balasenthil1S,LeeCC,ReaMA,KumarR.Metastasis-associatedprotein1isanintegralcomponentofthecircadianmolecularmachinery.NatCommun,2013;4:2545(*Contributedequally)
9.LiDQ*,NairSS,OhshiroK,KumarA,NairVS,PakalaSB,ReddySD,GajulaRP,EswaranJ,AravindL,KumarR*.MORC2signalingintegratesphosphorylation-dependent,ATPase-coupledchromatinremodelingduringtheDNAdamageresponse.CellRep,2012;2:1657–1669(*Co-correspondingauthors)
10.LiDQ,PakalaSB,ReddySD,OhshiroK,ZhangJX,WangL,ZhangY,deAlboránIM,PillaiMR,EswaranJ,KumarR.Bidirectionalautoregulatorymechanismofmetastasisassociatedprotein1-alternativereadingframepathwayinoncogenesis.ProcNatlAcadSciUSA,2011;108:8791-8796
11.LiDQ,OhshiroK,ReddySD,PakalaSB,LeeMH,ZhangY,RayalaSK,KumarR.E3ubiquitinligaseCOP1regulatesthestabilityandfunctionsofMTA1.ProcNatlAcadSciUSA,2009;106:17493-17498
12.ZhangJX*,LiDQ*,HeAR,MotwaniM,VasiliouV,EswaranJ,MishraL,KumarR.Synergisticinhibitionofhepatocellularcarcinomagrowthbycotargetingchromatinmodifyingenzymesandpoly(ADP-ribose)polymerases.Hepatology,2012;55:1840-1851(*Contributedequally)
13。MolliPR*,LiDQ*,Bagheri-YarmandR,PakalaSB,KatayamaH,SenS,IyerJ,ChernoffJ,TsaiMY,NairSS,KumarR.Arpc1b,acentrosomalprotein,isbothanactivatorandsubstrateofAuroraA.JCellBiol,2010;190:101-114(CommentinNatRevMolCellBiol,2010;11:542)(*Contributedequally)
14.MiaoH,LiDQ,MukherjeeA,GuoH,PettyA,CutterJ,BasilionJP,SedorJ,WuJ,DanielpourD,SloanAE,CohenML,WangB.EphA2mediatesligand-dependentinhibitionandligand-independentpromotionofcellmigrationandinvasionviaareciprocalregulatoryloopwithAkt.CancerCell,2009;16:9-20(FeaturedinNature,2009;461:149underResearchHighlights)
15.NairSS,LiDQ,KumarR.Acorechromatinremodelingfactorinstructsglobalchromatinsignalingthroughmultivalentreadingofnucleosomecodes.MolCell,2013;49:704–718