卢智刚
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个人简历
工作经历研究员复旦大学生物医学研究院,复旦大学附属上海市第五人民医院兼职教授(2017.09-今)助理教授美国西南医学研究中心,(2016.12-2017.9)讲师美国西南医学研究中心,(2015.8-2016.12)研究助理美国西南医学研究中心,(2012.2-2015.7)副教授北京大学深圳研究生院,(2005.10-2012.1)博士后北京大学,(2003.10-2005.9)教育经历博士北京大学,生命科学学院,(1998.9–2003.9)学士北京大学,生命科学学院,(1994.9–1998.7)所获奖项1.国家自然科学二等奖,第五完成人,20102.教育部自然科学一等奖,第九完成人,2006研究领域
课题组主要从事造血干细胞及白血病方面的研究:1)开发出针对急性淋系白血病(ALL)和急性髓系白血病(AML)的新靶点和药物,并推动相关策略向临床进行转化;2)研究造血干细胞(HSC)的自我更新和定向分化的分子机制,并进一步优化HSC体外扩增体系,为造血干细胞移植治疗的细胞来源瓶颈提供技术解决手段。近期论文
1.LuZ#,XieJ,WuG,ShenJ,CollinsR,ChenW,KangX,LuoM,ZouY,HuangLJ,AmatrudaJF,SloneT,WinickN,SchererPE,ZhangCC#.Fastingselectivelyblocksacutelymphoblasticleukemiadevelopmentvialeptinreceptorupregulation.NatureMedicine.2017.23(1):79-90.(共同通讯作者)2.Nakada,Y.,CansecoD.C.,ThetS.,AbdisalaamS.,AsaithambyA.,SantosC.X.,ShahA.,ZhangH.,FaberJ.E.,KinterM.T.,SzwedaL.I.,XingC.,DeberardinisR.,OzO.,LuZ.,ZhangC.C.,KimuraW.andSadekH.A..Hypoxiainducesheartregenerationinadultmice.Nature.2017.541(7636):222-227.3.LuoM.,WangH.,WangZ.,CaiH.,LuZ.,HuangG.,ChenX.,PorembkaM.,FrankelA,ChenZJ,GaoJ.ASTING-activatingnanovaccineforcancerimmunotherapy.NatNanotechnoloty.doi:10.1038/nnano.2017.52.2017.4.Kimura,W.,XiaoF.,CansecoD.C.,MuralidharS.,ThetS.,ZhangH.M.,AbderrahmanY.,ChenR.,GarciaJ.A.,SheltonJ.M.,RichardsonJ.A.,AshourA.M.,AsaithambyA.,LiangH.,XingC.,LuZ.,ZhangC.C.andSadekH.A:Hypoxiafatemappingidentifiescyclingcardiomyocytesintheadultheart.Nature,2015,523(7559):226-230.5.KangX,LuZ,CuiC,DengM,FanY,DongB,HanX,XieF,TynerJW,ColiganJE,CollinsRH,XiaoX,YouMJ,ZhangC.C:TheITIM-containingreceptorLAIR1isessentialforacutemyeloidleukaemiadevelopment.NatureCellBiology,2015;17(5):665–677.6.DengM*,LuZ*,ZhengJ,WanX,ChenX,HirayasuK,SunH,LamY,ChenL,WangQ,SongC,HuangN,GaoG.F,JiangY,AraseH,andZhangC.C.AmotifinLILRB2criticalforAngptl2bindingandactivation.Blood.2014.924-935.(共同第一作者)7.ZhengJ.*,LuZ.*,KocabasF.,BottcherR.T.,CostellM.,KangX.,LiuX.,DeberardinisR.J.,WangQ.,ChenG.,SadekH.,ZhangC.C.Profilin1isessentialforretentionandmetabolismofmousehematopoieticstemcellsinbonemarrow.Blood.2014.123(7):992-1001.(共同第一作者)8.LuoM.,LingT.,XieW.,SunH.,ZhouY.,ZhuQ.,ShenM.,ZongL.,LyuG.,ZhaoY.,YeT.,GuJ.,TaoW.#,LuZ.#,GrummtI#.NuRDblocksreprogrammingofmousesomaticcellsintopluripotentstemcells.StemCells.2013;31:1278-1286.(共同通讯作者)9.LingT.,XieW.,LuoM.,ShenM.,ZhuQ.,ZongL.,ZhouT.,GuJ.,LuZ.#,ZhangF.#,TaoW#.CHD4/NuRDmaintainsdemethylationstateofrDNApromotersthroughinhibitingtheexpressionoftherDNAmethyltransferaserecruiterTIP5.BiochemBiophysResCommun.2013;437:101-107.(共同通讯作者)10.LuQ*.,LuZ.*,LiuQ.*,GuoL.,RenH.,FuJ.,JiangQ.,ClarkeP.R.,ZhangC.Chromatin-boundNLSproteinsrecruitmembranevesiclesandnucleoporinsfornuclearenvelopeassemblyviaimportin-alpha/beta.CellRes.2012;22:1562-1575.(共同第一作者)11.MengS,LuoM,SunH,YuX,ShenML,ZhangQC,ZhouRD,JuXF,TaoW,LiuD#,DengHK#,LuZ#.IdentificationandcharacterizationofBmi-1respondingelementwithinthehumanp16promoter.JournalofBiologicalChemistry.285,33219-33229.2010.(共同通讯作者)12.LuoM,LuZY,SunH,YuanKH,ZhangQC,MengS,WangFX,GuoHC,JuXF,LiuYQ,YeT,LuZ#,ZhaiZ.Nuclearentryofactivecaspase-3isfacilitatedbyitsp3-recognition-basedspacificcleavageactivity.CellResearch.20:211-222.2010.(通讯作者)13.LuZ,ZhangCM,ZhaiZ.Nucleoplasminregulateschromatincondensationduringapoptosis.Proc.Natl.Acad.Sci.USA.102(8):2778-2783.200514.LuZ,ZhangCM,ZhaiZ.LDFF,thelarge-sizeDNAfragmentationfactor,isresponsibleforthelargemolecularweightDNAdegradationduringapoptosisinXenopuseggextracts.CellResearch,14,134-140.2004.15.LuZ,YangW,CaoQ,TaoW,H.J.andZhaiZ.IdentificationofinhibitorofapoptosisspecificDNaseinXenopuseggextract.ChineseScienceBulletin,46,1449-1453.2001.16.ZhaoY,LuZ,WuM,etal.Effectsofphosphocreatineonapoptosisinacell-freesystem.JBIOLCHEM,276(37):34573-34578.2001. 相关热点