个人简历

复旦大学教授、博士生导师，基础医学院副院长、药理学系主任。1999年在日本留学获博士学位，任日本学术振兴会JSPS博士后、大阪生命科学研究所研究员，研究副部长；2005年12月加盟复旦大学。获国家杰出青年科学基金、上海市领军人才、上海市优秀学科带头人称号

研究领域

""分子行为药理学、睡眠与失眠机制，镇静催眠药物开发""""

近期论文

Luo YJ#, Li YD#, Wang L#, Yang SR, Yuan XS, Wang J, Cherasse Y, Lazarus M, Chen JF, Qu WM, and Huang ZL*. Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors.Nature Communications, 2018 Apr 20;9(1):1576. doi: 10.1038/s41467-018-03889-3.
Wu YE, Enoki R*, Oda Y, Huang ZL*, et al. Ultradian Calcium Rhythms in the Paraventricular Nucleus and Subparaventricular Zone in the Hypothalamus. Proc Natl Acad Sci USA. 2018; 115(40):E9469-E9478. doi: 10.1073/pnas.1804300115.
Yang SR*, Hu ZZ, Luo YJ, Zhao YN, Sun HX, Yin D, Wang CY, Yan YD, Wang DY, Yuan XS, Ye CB, Guo W, Qu WM, Cherasse Y, Lazarus M, Ding YQ, Huang ZL*. The rostromedial tegmental nucleus is essential for non-rapid eye movement sleep. PLoS Biology, 2018 Apr 13;16(4):e2002909. doi: 10.1371/journal.pbio.2002909.
Oishi Y#, Xu Q#, Wang L#, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schifmann S, de Kerchove d'Exaerde A, Urade Y, Qu WM, Huang ZL*, and Lazarus M*. Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nature Communications, 2017 Sep 29;8(1):734. doi: 10.1038/s41467-017-00781-4.
Yuan XS#, Wang L#, Dong H#, Qu WM, Yang SY, Cherasse Y, Lazarus M, Schifmann S, de Kerchove d'Exaerde A, Li RX* and Huang ZL*. Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus. eLife, 2017, 2017 Oct 12;6. pii: e29055. doi: 10.7554/eLife.29055.
Zhang Z#, Wang HJ#, Wang DR, Qu WM* and Huang ZL*.Red light alters sleep-wake behavior at intensities above 10 lx in mice. Light: Science & Applications. 2017, DIO:10.1038/lsa.2016.231. (IF: 13.6).
Oishi Y, Huang ZL*,et al. Adenosine in the tuberomammillary nucleus inhibitsthe histaminergic system via A1 receptors andpromotes non-rapid eye movement sleep. Proc Natl Acad Sci USA, 2008, 105(50):19992-19997.
Huang ZL, Mochizuki T, Qu WM, Hong ZY, Watanabe T, Urade Y and Hayaishi O. Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci USA 2006, 103(12): 4687-4692.
Huang ZL, Qu WM, Eguchi, N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y and Hayaishi O. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 2005; 8(7): 858-859.
Huang ZL, QuWM, LiWD, MochizukiM, EguchiN, WatanabeT, UradeY and HayaishiO. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci USA2001; 98(17): 9965-9970.