黄鑫欣
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资料介绍
个人简历
工作经历青年研究员复旦大学生物医学研究院(2019.6-今)研究助理教授美国印第安纳大学医学院(2018.12-2019.6)博士后美国印第安纳大学医学院(2012.7-2018.11)博士后北京生命科学研究所(2010.7-2012.6)教育经历博士北京生命科学研究所/北京师范大学联合培养(2006.9-2010.6)学士北京师范大学生命科学学院(2002.9-2006.6)研究领域
课题组研究方向为生物治疗和干细胞治疗,主要从事造血干细胞基础和临床的相关研究,重点探究如何通过调控细胞的表观遗传和代谢途径增进造血干细胞的移植效率,运用分子生物学,细胞生物学,生物信息学,小鼠遗传学等方法研究造血干细胞的调控,注重基础研究和临床应用的密切结合,研究成果将更广泛的为各种血液病、遗传病患者服务。近期论文
1.XuD,YangM,CapitanoM,GuoB,LiuS,WanJ,BroxmeyerHE#,HuangX#.(#corresponding)Pharmacologicalactivationofnitricoxidesignalingpromoteshumanhematopoieticstemcellhomingandengraftment.Leukemia.2020.3online.2.HuangX#,BroxmeyerHE.(#corresponding)Progresstowardsimprovinghomingandengraftmentofhematopoieticstemcellsforclinicaltransplantation.CurrOpinHematol.2019Jul26(4):266-272.3.HuangX*,GuoB*,LiuS,WanJ,BroxmeyerHE.(*co-equalcontribution)NeutralizingnegativeepigeneticregulationbyHDAC5enhanceshumanhematopoieticstemcellhomingandengraftment.NatureCommunications.2018Jul16;9(1):2741.4.GuoB*,HuangX*,LeeMR,LeeSA,BroxmeyerHE.(*co-equalcontribution)AntagonizingPPARγ-FBP1axisrepressedglycolysisexpandshumanhematopoieticstemandprogenitorcells.NatureMedicine.2018Mar;24(3):360-367.5.HuangXandBroxmeyerHE.m6AreadersuppressionbolstersHSCexpansion.CellResearch.2018Sep;28(9):875-8766.HuangX.TrinhT,AljoufiA,BroxmeyerHE.Hypoxiasignalingpathwayinstemcellregulation:goodandevil.CurrStemCellReports.2018Jun.4(2):149-157.7.HuangX,LeeMR,CooperS,HangocG,HongKS,ChungHMandBroxmeyerHE.ActivationofOCT4enhancesexvivoexpansionofhumancordbloodhematopoieticstemandprogenitorcellsbyregulatingHOXB4expression.Leukemia,2016Jan;30(1):144-153.8.GuoB*,HuangX*,ZhangP,QiL,LiangQ,ZhangX,HuangJ,FangB,HouW,HanJ,ZhangH.(*co-equalcontribution)Genome-widescreenidentifiessignalingpathwaysthatregulateautophagyduringC.elegansdevelopment.EMBORep.2014June;15(6):705-713.9.HuangX,ZhangH,ZhangH.Theautosomalsignalelementsea-2regulateslarvaldevelopmentaltimingandadultlifespaninC.elegans.Development.2011May;138(10):2059-2068.10.HuangX,TianE,XuY,ZhangH.TheC.elegansengrailedhomologceh-16regulatestheself-renewalexpansiondivisionofstemcell-likeseamcells.DevBiol.2009Sep15;333(2):337-347.11.CapitanoML,Mor-VakninN,SahaAK,CooperS,LegendreM,GuoH,Contreras-GalindoR,KappesF,SartorMA,LeeCT,HuangX,MarkovitzDM,BroxmeyerHE.SecretednuclearproteinDEKregulateshematopoiesisthroughCXCR2signaling.JClinInvest.2019May20;130.12.CapitanoM,ZhaoL,CooperS,ThorsheimC,SuzukiA,HuangX,DentAL,MarksMS,AbramsCS,BroxmeyerHE.PhosphatidylinositoltransferproteinsregulatemegakaryocyteTGF-β1secretionandhematopoiesisinmice.Blood.2018Sep6;132(10):1027-1038.13.GuoB,HuangX,CooperS,BroxmeyerHE.Glucocorticoidhormone-inducedchromatinremodelingenhanceshumanhematopoieticstemcellhomingandengraftment.NatureMedicine.2017Apr;23(4):424-428.14.MantelCR,O'LearyHA,ChittetiBR,HuangX,CooperS,HangocG,BrustovetskyN,SrourEF,LeeMR,Messina-GrahamS,HaasDM,FalahN,KapurR,PelusLM,BardeesyN,FitamantJ,IvanM,KimKS,BroxmeyerHE.Enhancinghematopoieticstemcelltransplantationefficacybymitigatingoxygenshock.Cell.2015Jun161(7):1553-1565 相关热点