个人简历

工作经历
研究员，复旦大学，生物医学研究院，（2010.5-今）
博士后，美国哈佛大学，（2005.5-2010.5）
博士后，美国耶鲁大学，（2004.10-2005.5）
助教/讲师，第二军医大学，（1997.9-2001.7）
教育经历
理学博士，中国科学院，上海生化细胞所，（2001.9-2004.7）
医学硕士，第二军医大学/军事医学科学院，（1994.9-1997.7）
医学学士，第二军医大学，海军医学系，（1988.9-1994.7）
所获人才项目
新世纪优秀人才，国家教育部，2012年
上海高校特聘教授（跟踪计划），上海市教委，2014年
上海高校特聘教授，上海市教委，2011年
浦江人才计划，上海市科委，2011年
获科技部“973”项目和重大专项，基金委重大研究计划培育和集成项目以及面上项目，上海市科委科技支撑和基础研究领域项目等资助。迄今为止，申报或获颁美国/国际专利7项、国内专利2项，并在国外学术刊物上发表论文30余篇，包括NatureMedicine,Circulation,Blood,CirculationResearch,CancerResearch,JournalofImmunology,JBC,FASEBJ,Oncogene,StemCellReports等。

近期论文

1.ZhangL,WangQ,ZhouY,OuyangQ,DaiW,ChenJ,DingP,LiL,ZhangX,ZhangW,LvX,LiL,ZhangP,CaiG,HuW*.OverexpressionofMTA1inhibitsthemetastaticabilityofZR-75-30cellsinvitrobypromotingMTA2degradation.CellCommunSignal.2019;17(1):4.
2.GeX,ChenJ,LiL,DingP,WangQ,ZhangW,LiL,LvX,ZhouD,JiangZ,ZengH,XuY,HouY*,HuW*.MidostaurinpotentiatesrituximabantitumoractivityinBurkitt'slymphomabyinducingapoptosis.CellDeathDis.2018;10(1):8.
3.ZhouY,WangQ,ChuL,DaiW,ZhangX,ChenJ,ZhangL,DingP,ZhangX,GuH,ZhangP,LiL,ZhangW,LiL,LvX,ZhouD,CaiG,ChenL,ZhaoK,HuW*.FOXM1cpromotesoesophagealcancermetastasisbytranscriptionallyregulatingIRF1expression.CellProlif.2018:e12553.
4.HuC,LiL,DingP,LiL,GeX,ZhengL,WangX,WangJ,ZhangW,WangN,GuH,ZhongF,XuM,RongR,ZhuT*,HuW*.ComplementInhibitorCRIg/FHAmelioratesRenalIschemiaReperfusionInjuryviaActivationofPI3K/AKTSignaling.JImmunol.2018;201(12):3717-3730.
5.ZhouY,ChuL,WangQ,DaiW,ZhangX,ChenJ,LiL,DingP,ZhangL,GuH,LiL,LvX,ZhangW,ZhouD,ZhangP,CaiG,ZhaoK*,HuW*.CD59isapotentialbiomarkerofesophagealsquamouscellcarcinomaradioresistancebyaffectingDNArepair.CellDeathDis.2018;9(9):887.
6.ZhangX,ZhangL,DuY,ZhengH,ZhangP,SunY,WangY,ChenJ,DingP,WangN,YangC,HuangT,YaoX,QiaoQ,GuH,CaiG,CaiS,ZhouX,HuW*.AnovelFOXM1isoform,FOXM1D,promotesepithelial-mesenchymaltransitionandmetastasisthroughROCKsactivationincolorectalcancer.Oncogene.2017;36(6):807-819.
7.ChenJ,DingP,LiL,GuH,ZhangX,ZhangL,WangN,GanL,WangQ,ZhangW,HuW*.CD59RegulationbySOX2IsRequiredforEpithelialCancerStemCellstoEvadeComplementSurveillance.StemCellReports.2017January10;8(1):140–151.StemCellReports_Bestof2016-2017
8.YangC,DingP,WangQ,ZhangL,ZhangX,ZhaoJ,XuE,WangN,ChenJ,YangG,HuW*,ZhouX*.InhibitionofComplementRetardsAnkylosingSpondylitisProgression.ScientificReports.2016Oct4;6:34643.
9.QiaoQ,TengX,WangN,LuR,GuoL,ZhangX,DuY,WangW,ChenS,WuQ,HeG,WangY,HuW*.AnovelCRIg-targetedcomplementinhibitorprotectscellsfromcomplementdamage.FASEBJ.2014,28(11):4986-99.
10.DuY,TengX,WangN,ZhangX,ChenJ,DingP,QiaoQ,WangQ,ZhangL,YangC,YangZ,ChuY,DuX,ZhouX*,HuW*.NF-κBandenhancer-bindingCREBproteinscaffoldedbyCREB-bindingprotein(CBP)/p300proteinsregulateCD59proteinexpressiontoprotectcellsfromcomplementattack.JBiolChem.2014;289(5):2711-24.
11.HuW*,GeX,YouT,XuT,ZhangJ,WuG,PengZ,ChorevM,AktasBH,HalperinJA,BrownJR,andQinX*.HumanCD59inhibitorsensitizesrituximab-resistantlymphomacellstocomplement-mediatedcytolysis.CancerResearch.2011,71(6):2298-307.
12.ZhangJ,HuW,XingW,YouT,QinX,PengZ*.TheprotectiveroleofCD59andpathogenicroleofcomplementinhepaticischemiaandreperfusioninjury.AmericanJournalofPathology.2011,179(6):2876-84.
13.GeX,WuL,HuW,FernandesS,WangC,LiX,BrownJR,QinX*.rILYd4,aHumanCD59InhibitorEnhancesComplementDependentCytotoxicityofOfatumumabagainstRituximab-resistantB-cellLymphomaCellsandChronicLymphocyticLeukemia.ClinicalCancerResearch.2011,17(21):6702-11.
14.HuW#,JinR#,ZhangJ,YouT,BronsonRT,PengZ,GeX,LoscalzoJ,andQinX*.TheMechanismsofFatalPulmonaryArterialHypertensioninaUniqueRapidHemolysisModel.Blood.2010,116(9):1613-22.
15.HuW#,YuQ#,HuN,ByrdD,ShikumaC,ShiramizuB,HalperinJA,QinX*.AhighaffinityinhibitorofhumanCD59enhancescomplement-mediatedvirolysisofHIV-1:ImplicationsfortreatmentofHIV-1/AIDS.JournalofImmunology.2010,184(1):359-368.
16.WuG,ChenT,ShahsafaeiA,HuW,BronsonRR,ShiGP,HalperinJA,andQinX*.ComplementregulatorCD59protectsagainstangiotensinII-inducedabdominalaorticaneurysmsinmice.Circulation.2010,121(11):1338-1346.
17.QinX#,HuW#,SongW,GrubissichL,SongY,WuG,HuX,FerrisS,DobarroM,BauerS,FeelischM,LeopoldJA,LoscalzoJ,HalperinJA*.Balancingroleofnitricoxideincomplement-mediatedplateletactivationofmCd59aandmCd59bdoubleknockoutmice.AmericanJournalofHematology.2009,84(4):221-7.
18.WuG,HuW,ShahsafaeiA,SongW,DobarroM,SukhovaGK,BronsonRR,ShiGP,RotherRP,HalperinJA,andQinX*.ComplementregulatorCD59protectsagainstatherosclerosisbyrestrictingtheformationofthecomplementmembraneattackcomplex.CirculationResearch.2009,104(4):550-8.
19.HuW,FerrisS,TwetenRK,WuG,GaoB,BronsonRT,HalperinJAandQinX*.Conditional,rapidandtargetedablationofcellsexpressinghumanCD59intransgenicmicebyintermedilysin.NatureMedicine.2008;14(1):98-103.
20.ZhouX#,HuW#,QinX*.TheRoleofComplementintheMechanismofActionofRituximabforB-CellLymphoma:ImplicationsforTherapy.TheOncologist.2008;13:954-966.