个人简历

工作经历
研究员，复旦大学，生物医学研究院及附属肿瘤医院-肿瘤研究所（2014.01-至今）
研究员，上海市肿瘤研究所，癌基因及相关基因国家重点实验室（2008.12-2013.12）
副研究员，上海市肿瘤研究所，癌基因及相关基因国家重点实验室（2006.04-2008.11）
博士后，美国UTMD安德森癌症中心，分子与细胞肿瘤学系（2003.08-2006.04）
助理研究员，上海市肿瘤研究所，免疫室（1998.07-2000.08）
教育经历
博士，复旦大学，上海医学院（2000-2003）
硕士，华东师范大学，生物系（1995-1998）
学士，华东师范大学，生物系（1991-1995）
所获人才项目
国家杰出青年科学基金，国家自然科学基金，2011
中青年科技创新领军人才，科技部，2016
新世纪优秀人才，教育部，2010
上海市优秀学术带头人，上海市科委，2011
曙光学者，上海市教委，2011
浦江人才计划，上海市科委，2006
上海市医学领军人才，上海市卫计委，2015
上海市卫计委优秀学科带头人，上海市卫计委，2011
所获奖项
自然科学二等奖（第一完成人），教育部，2012
医学科技奖二等奖（第一完成人），上海市医学会，2011
第五届吴孟超医学科技奖（一等奖），吴孟超医学科技基金会，2011
第十三届银蛇奖（二等奖），上海市卫计委，2011
明治生命科学奖（优秀奖），国家人类基因组南方研究中心，2011
课题组长何祥火主持和参与多项国家和省部级项目，包括科技部重大研究计划、国家自然科学基金重大项目、重大研究计划、面上项目、上海市科委重点项目等。迄今为止，已在国内外学术刊物上发表论文90余篇，包括NatureCellBiology,Gastroenterology,Hepatology,CellResearch,NatureCommunications,NucleicAcidsResearch,CancerResearch,ClinicalCancerResearch,Oncogene,ScienceSignaling等；论文被引3944次（至2017-12）

研究领域

研究领域为肿瘤分子生物学，主要从事消化系恶性肿瘤发生与转移的分子机理研究，研究方向包括：1.非编码RNA功能及分子机制；2.RNA可变剪接异常及调控机制；3.转录重编程及表观调控机制。

近期论文

1.ZhangJ,LiZ,LiuL,WangQ,LiS,ChenD,HuZ,YuT,DingJ,LiJ,YaoM,HuangS,ZhaoY*,HeX.*LongnoncodingRNATSLNC8isatumorsuppressorthatinactivatestheinterleukin-6/STAT3signalingpathway.Hepatology.2018Jan;67(1):171-187.
2.YuT,ZhaoY,HuZ,LiJ,ChuD,ZhangJ,LiZ,ChenB,ZhangX,PanH,LiS,LinH,LiuL,YanM,HeX.*YaoM*.MetaLnc9FacilitatesLungCancerMetastasisviaaPGK1-ActivatedAKT/mTORPathway.CancerRes.2017Nov1;77(21):5782-5794.
3.LiS,ZhangJ,HuangS*,HeX.*Genome-wideanalysisrevealsthatexonmethylationfacilitatesitsselectiveusageinthehumantranscriptome.BriefBioinform.2017Feb16.doi:10.1093/bib/bbx019.
4.ZhengQ,BaoC,GuoW,LiS,ChenJ,ChenB,LuoY,LyuD,LiY,ShiG,LiangL,GuJ,HeX,*HuangS*.CircularRNAprofilingrevealsanabundantcircHIPK3thatregulatescellgrowthbyspongingmultiplemiRNAs.NatCommun.2016Apr6;7:11215.
5.QiuZ,GuoW,WangQ,ChenZ,HuangS,ZhaoF,YaoM,ZhaoY*,HeX.*MicroRNA-124reducesthepentosephosphatepathwayandproliferationbytargetingPRPS1andRPIAmRNAsinhumancolorectalcancercells.Gastroenterology.2015Nov;149(6):1587-1598.e11.
6.BaoC,LiY,HuanL,ZhangY,ZhaoF,WangQ,LiangL,DingJ,LiuL,ChenT,LiJ,YaoM,HuangS*,HeX.*NF-κBsignalingrelievesnegativeregulationbymiR-194inhepatocellularcarcinomabysuppressingthetranscriptionfactorHNF-1α.SciSignal.2015Jul28;8(387):ra75.
7.ChenZ,WangZ,GuoW,ZhangZ,ZhaoF,ZhaoY,JiaD,DingJ,WangH,YaoM,HeX.*TRIM35InteractswithpyruvatekinaseisoformM2tosuppresstheWarburgeffectandtumorigenicityinhepatocellularcarcinoma.Oncogene.2015Jul23;34(30):3946-56.
8.LiY,ZhengQ,BaoC,LiS,GuoW,ZhaoJ,ChenD,GuJ,HeX,*HuangS*.CircularRNAisenrichedandstableinexosomes:apromisingbiomarkerforcancerdiagnosis.CellRes.2015Aug;25(8):981-4.
9.GuoW,QiuZ,WangZ,WangQ,TanN,ChenT,ChenZ,HuangS,GuJ,LiJ,YaoM,ZhaoY*,HeX.*MiR-199a-5pisnegativelyassociatedwithmalignanciesandregulatesglycolysisandlactateproductionbytargetinghexokinase2inlivercancer.Hepatology.2015Oct;62(4):1132-44.
10.JiaD,DongR,JingY,XuD,WangQ,ChenL,LiQ,HuangY,ZhangY,ZhangZ,LiuL,ZhengS,XiaQ,WangH*,DongK*,HeX.*ExomesequencingofhepatoblastomarevealsnovelmutationsandcancergenesintheWntpathwayandubiquitinligasecomplex.Hepatology.2014Nov;60(5):1686-96.
11.GaoQ,ZhaoYJ,WangXY,GuoWJ,GaoS,WeiL,ShiJY,ShiGM,WangZC,ZhangYN,ShiYH,DingJ,DingZB,KeAW,DaiZ,WuFZ,WangH,QiuZP,ChenZA,ZhangZF,QiuSJ,ZhouJ*,HeXH*,FanJ*.ActivatingmutationsinPTPN3promotecholangiocarcinomacellproliferationandmigrationandareassociatedwithtumorrecurrenceinpatients.Gastroenterology.2014May;146(5):1397-407.
12.WangQ,HuangZ,GuoW,NiS,XiaoX,WangL,HuangD,TanC,XuQ,ZhaR,ZhangJ,ShengW,HeX,*DuX*.microRNA-202-3pinhibitscellproliferationbytargetingADP-ribosylationfactor-like5Ainhumancolorectalcarcinoma.ClinCancerRes.2014Mar1;20(5):1146-57.
13.JiaD,JingY,ZhangZ,LiuL,DingJ,ZhaoF,GeC,WangQ,ChenT,YaoM,LiJ,GuJ,HeX.*AmplificationofMPZL1/PZRpromotestumorcellmigrationthroughSrc-mediatedphosphorylationofcortactininhepatocellularcarcinoma.CellRes.2014Feb;24(2):204-17.
14.DingJ,HuangS,WangY,TianQ,ZhaR,ShiH,WangQ,GeC,ChenT,ZhaoY,LiangL,LiJ,HeX.*Genome-widescreeningrevealsthatmiR-195targetstheTNF-α/NF-κBpathwaybydown-regulatingIκBkinasealphaandTAB3inhepatocellularcarcinoma.Hepatology.2013Aug;58(2):654-66.
15.KeG,LiangL,YangJM,HuangX,HanD,HuangS,ZhaoY,ZhaR,HeX,*WuX*.MiR-181aconfersresistanceofcervicalcancertoradiationtherapythroughtargetingthepro-apoptoticPRKCDgene.Oncogene.2013Jun20;32(25):3019-27.
16.ZhengB,LiangL,HuangS,ZhaR,LiuL,JiaD,TianQ,WangQ,WangC,LongZ,ZhouY,CaoX,DuC,ShiY*,HeX.*MicroRNA-409suppressestumourcellinvasionandmetastasisbydirectlytargetingradixiningastriccancers.Oncogene.2012Oct18;31(42):4509-16.
17.GaoQ,ZhaoYJ,WangXY,QiuSJ,ShiYH,SunJ,YiY,ShiJY,ShiGM,DingZB,XiaoYS,ZhaoZH,ZhouJ*,HeXH,*FanJ*.CXCR6upregulationcontributestoaproinflammatorytumormicroenvironmentthatdrivesmetastasisandpoorpatientoutcomesinhepatocellularcarcinoma.CancerRes.2012Jul15;72(14):3546-56.
18.YingQ,LiangL,GuoW,ZhaR,TianQ,HuangS,YaoJ,DingJ,BaoM,GeC,YaoM,LiJ,HeX.*Hypoxia-induciblemicroRNA-210augmentsthemetastaticpotentialoftumorcellsbytargetingvacuolemembraneprotein1inhepatocellularcarcinoma.Hepatology.2011Dec;54(6):2064-75.
19.ZhengB,LiangL,WangC,HuangS,CaoX,ZhaR,LiuL,JiaD,TianQ,WuJ,YeY,WangQ,LongZ,ZhouY,DuC,HeX,*ShiY*.MicroRNA-148asuppressestumorcellinvasionandmetastasisbydownregulatingROCK1ingastriccancer.ClinCancerRes.2011Dec15;17(24):7574-83.
20.JiaD,WeiL,GuoW,ZhaR,BaoM,ChenZ,ZhaoY,GeC,ZhaoF,ChenT,YaoM,LiJ,WangH,GuJ,HeX.*Genome-widecopynumberanalysesidentifiednovelcancergenesinhepatocellularcarcinoma.Hepatology.2011Oct;54(4):1227-36.
21.HuangZ,HuangS,WangQ,LiangL,NiS,WangL,ShengW,HeX,*DuX*.MicroRNA-95promotescellproliferationandtargetssortingNexin1inhumancolorectalcarcinoma.CancerRes.2011Apr1;71(7):2582-9.
22.ZhaoY,WangX,WangT,HuX,HuiX,YanM,GaoQ,ChenT,LiJ,YaoM,WanD,GuJ*,FanJ*,HeX.*Acetylcholinesterase,akeyprognosticpredictorforhepatocellularcarcinoma,suppressescellgrowthandinduceschemosensitization.Hepatology.2011Feb;53(2):493-503.
23.LiangL,WongCM,YingQ,FanDN,HuangS,DingJ,YaoJ,YanM,LiJ,YaoM,NgIO,HeX.*MicroRNA-125bsuppressesedhumanlivercancercellproliferationandmetastasisbydirectlytargetingoncogeneLIN28B2.Hepatology.2010Nov;52(5):1731-40.
24.HuangS,WuS,DingJ,LinJ,WeiL,GuJ,HeX.*MicroRNA-181amodulatesgeneexpressionofzincfingerfamilymembersbydirectlytargetingtheircodingregions.NucleicAcidsRes.2010Nov;38(20):7211-8.
25.DingJ,HuangS,WuS,ZhaoY,LiangL,YanM,GeC,YaoJ,ChenT,WanD,WangH,GuJ,YaoM,LiJ,TuH,HeX.*GainofmiR-151onchromosome8q24.3facilitatestumourcellmigrationandspreadingthroughdownregulatingRhoGDIA.NatCellBiol.2010Apr;12(4):390-9.
26.WuS,HuangS,DingJ,ZhaoY,LiangL,LiuT,ZhanR*,HeX.*MultiplemicroRNAsmodulatep21Cip1/Waf1expressionbydirectlytargetingits3'untranslatedregion.Oncogene.2010Apr15;29(15):2302-8.
27.YaoJ,LiangL,HuangS,DingJ,TanN,ZhaoY,YanM,GeC,ZhangZ,ChenT,WanD,YaoM,LiJ,GuJ,HeX.*MicroRNA-30dpromotestumorinvasionandmetastasisbytargetingGalphai2inhepatocellularcarcinoma.Hepatology.2010Mar;51(3):846-56.