个人简历

From 2017.6 复旦大学化学系青年研究员，博士生导师 \r
2016.4-2017.6 美国哈佛大学医学院，Dana-Farber癌症研究所， 博士后\r
2013.8-2016.3 美国Rice大学，博士后\r
2012.9-2013.7 美国Scripps研究所（La Jolla, CA），博士后\r
2007.9-2012.7 中国科学院上海有机化学研究所，博士\r
2003.9-2007.7 华东理工大学药学院，本科

研究领域

"""""不对称催化反应\r
活性天然产物和药物分子合成\r
药物化学及化学生物学研究"

近期论文

Enantioselective Synthesis of Axially Chiral Biaryls by Diels−Alder/Retro-Diels−Alder Reaction of 2‑Pyrones with Alkynes. Xu, M.-M.; You. X-Y.; Zhang, Y.-Z.; Lu, Y.; Tan, K.; Yang, L.*; Cai, Q.* J. Am. Chem. Soc. 2021, DOI: 10.1021/jacs.1c04759.\r
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Asymmetric Inverse-Electron-Demand Diels-Alder Reactions of 2-Pyrones by Lewis Acid Catalysis. Si, X.-G.; Zhang, Z.-M.; Cai, Q.*Synlett 2021, 32, 947-954.\r
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Enantioselective Synthesis of cis-Decalin Derivatives by the Inverse-Electron-Demand Diels–Alder Reaction of 2-Pyrones. Si, X.G.; Zhang, Z.-M.; Zheng, C.-G.; Li, Z.-T.; Cai, Q.*Angew. Chem. Int. Ed.2020, 59, 18412-18417.\r
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Enantioselective Synthesis of Arene cis-Dihydrodiols from 2-Pyrones. Liang, X.-W.; Zhao, Y.; Si, X.-G.; Xu, M.-M.; Tan, J.-H.; Zhang, Z.-M.; Zheng, C.-G.; Zheng, C.; Cai, Q.*Angew. Chem. Int. Ed.2019, 58, 14562-14567.\r
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The [4+2] Cycloaddition of 2-Pyrone in Total Synthesis. Cai, Q.*Chin. J. Chem.2019, 37, 946-976.\r
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Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. T. B. Faust, H. Yoon, R. P. Nowak, K. A. Donovan, Z. Li, Q. Cai, N. A. Eleuteri, T. Zhang, N. S. Gray, E. S. Fischer* Nat. Chem. Biol.2020, 16, 7-14.\r
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Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. M. C. Sliva, F. M. Ferguson, Q. Cai, K. A. Donovan, G. Nandi, D. Patnaik, T. Zhang, H.-T. Huang, D. E. Lucente, B. C. Dickerson, T. J. Mitchison, E. S. Fischer, N. S. Gray*, S. J. Haggarty* eLife 2019, e45457.\r
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K. C. Nicolaou*, Pengxi Chen,† Shugao Zhu,† Quan Cai,† Rohan D. Erande, Ruofan Li, Hongbao Sun, Kiran Kumar Pulukuri, Stephen Rigol, Monette Aujay, Joseph Sandoval, Julia Gavrilyuk. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. J. Am. Chem. Soc. 2017, 139, 15467.(co-first author except the corresponding author)\r
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K. C. Nicolaou*, Quan Cai, Hongbao Sun, Bo Qin, Shugao Zhu. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C and C7ˊˊ-epi-C and Full Structural Assignment of Trioxacarcin C. J. Am. Chem. Soc. 2016, 138, 3118.\r
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K. C. Nicolaou*, Quan Cai, Bo Qin, Mette T. Peterson, Remi J. T. Mikkelsen, Philipp Heretsch. Total Synthesis of Trioxacarcin DC-45-A2. Angew. Chem. Int. Ed.2015, 54, 3074.\r
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Quan Cai, Qin Yin, Shu-Li You*. Chiral Amine Catalyzed Asymmetric Bromocyclization of Trptamine Derivatives. Asian. J. Org. Chem.2014, 3, 408.\r
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K. C. Nicolaou*, Ruocheng Yu, Lei Shi, Quan Cai, Min Lu, Phillip Heretsch. General Synthetic Approach to Functionalized Dihydrooxepines. Org. Lett. 2013, 15, 1994.\r
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Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Shu-Li You*. An olefin isomerization/asymmetric Pictet–Spengler cascade via sequential catalysis of ruthenium alkylidene and chiral phosphoric acid. Org. Biomol. Chem.2013, 11, 1602.\r
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Jun-Wei Zhang, Quan Cai, Qin Gu, Xiao-Xin Shi, Shu-Li You*. Enantioselective Synthesis of Benzofurans and Benzoxazines via an Olefin Cross-Metathesis/Intramolecular Oxo-Michael Reaction. Chem. Commun. 2013, 49, 7750.\r
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Quan Cai, Xiao-Wei Liang, Shou-Guo Wang, Jun-Wei Zhang, Xiao Zhang, Shu-Li You*. Ring-Closing Metathesis/Isomerization/Pictet–Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis. Org. Lett. 2012, 14, 5022.\r
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Quan Cai, Chuan Liu, Xiao-Wei Liang, Shu-Li You*. Enantioselective Construction of Pyrroloindolines via Chiral Phosphoric Acid Catalyzed Cascade Michael Addition–Cyclization of Tryptamines. Org. Lett.2012, 14, 4588.\r
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Quan Cai, Shu-Li You*. Organocatalyzed Enantioselective Formal [4 + 2] Cycloaddition of 2,3-Disubstituted Indole and Methyl Vinyl Ketone. Org. Lett.2012, 14, 3040.\r
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Quan Cai, Chao Zheng, Jun-Wei Zhang, Shu-Li You*. Enantioselective Michael/Mannich Polycyclization Cascade of Indolyl Enones Catalyzed by Quinine-Derived Primary Amines. Angew. Chem. Int. Ed.2011, 50, 8665.\r
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Jun-Wei Zhang, Quan Cai, Xiao-Xin Shi, Wei Zhang, Shu-Li You*. Enantioselective Synthesis of Tetrahydropyrano[3,4-b] Indoles Catalyzed by Chiral N-Triflyl Phosphoramide via Intramolecular Friedel-Crafts Alkylation Reaction. Synlett 2011, 1239.\r
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Quan Cai, Chao Zheng, Shu-Li You*. Enantioselective Intramolecular Aza-Michael Addition of Indoles Catalyzed by Chiral Phosphoric Acid. Angew. Chem. Int. Ed.2010, 49, 8666.