简要介绍：Dr Chen graduated from Fudan university with a Ph.D. in bioinformatics, and did her postdoctoral research in University of California, Berkeley. Dr Chen joined ISTBI Fudan in Janurary, 2019. Dr Chen mainly studies the roles of the noncoding genome in neurological and psychiatric diseases, by integrating multi-omics data and designing new analyzing pipelines and tools. Dr Chen is also interested in the genome interpretation and clinical diagnosis of rare brain-related diseases, by identifying novel disease-causing noncoding SNPs and structural variants through whole-genome sequencing.
研究领域
生物信息学 脑疾病非编码 基因组研究""
近期论文
J Chen.A Fully‐automated Event‐based Variant Prioritizing Solution to the CAGI5 Intellectual Disability Gene Panel Challenge. Hum Mutat.doi:10.1002/humu.23781(2019)J Chenand W Tian.Explaining the disease phenotype of intergenic SNP through predicted long range regulation. Nucleic Acids Res44, 8641-8654, doi:10.1093/nar/gkw519 (2016)J Chen, M Ma, J Xi, and W Tian.Integration of cancer gene co-expression network and metabolic network to uncover potential cancer drug targets. J Proteome Res12, 2354-2364, doi:10.1021/pr400162t (2013)T Cheng,J Chen, H Wan, B Tang, W Tian, L Liao and Z Qiu. Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Sci Rep7, 42790, doi:10.1038/srep42790 (2017)Q Zhou, S Zhang, Q Wang, H Shen, W Tian,J Chen, G Acharya and X Li.China's community-based strategy of universal preconception care in rural areas at a population level using a novel risk classification system for stratifying couples preconception health status. BMC Health Serv Res16, 689, doi:10.1186/s12913-016-1930-4 (2016).
