个人简历

王适之 Shizhi Wang
No.87 DingJiaQiao, Nanjing, China, 210009

副教授，博士生导师，东南大学“仲英青年学者”。主要致力于探索以生物标志物为基础的环境污染物致疾病和器官毒性的分子流行病学与机制研究。主持完成国家（81302502）和江苏省自然科学基金青年基金（BK20130641）各1项、教育部博士点专项科研基金1项（20130092120063），目前主持在研国家（81872684）和江苏省自然科学基金面上基金项目（BK20171367）各1项。研究成果发表在《International Journal of Cancer》、《Molecular Carcinogenesis》、《Carcinogenesis》等高水平专业期刊杂志上。目前共发表学术论文30余篇，其中第一作者（通讯作者）SCI收录论文19篇，单篇最高被引21次。相关研究成果获江苏省抗癌协会“江苏肿瘤医学科学技术奖励”三等奖。获聘南京预防医学会“环境卫生专业委员会”委员、江苏省抗癌协会“第一届肿瘤病因学及流行病学委员会”青年委员、中国毒理学会毒理学替代法与转化毒理学专业委员会青年委员、《中华疾病控制杂志》第五届编委会青年委员。
教育经历
1. 2007/09 - 2012/06，南京医科大学，劳动卫生与环境卫生学系，博士（硕博连读）
2. 2002/09 - 2007/06，南京医科大学，预防医学系，学士

科研与学术工作经历
1. 2017/04 - 至今，东南大学，劳动卫生与环境卫生学系，副教授，博士生导师
2. 2012/09 – 2017/04，东南大学，劳动卫生与环境卫生学系，讲师

主持或参加科研项目（课题）及人才计划项目情况
1. 东南大学“仲英青年学者”，2020/01-2022/12，30万元，在研，主持
2. 国家自然科学基金面上项目，81872684，MiR-143/145宿主基因CARMN低表达参与宫颈癌遗传易感及其机制研究，2019/01-2022/12，57万元，在研，主持
3. 江苏省自然科学基金面上项目，BK20171367，LncRNA MIR143HG及其遗传变异与宫颈癌易感性的机制研究，2017/07-2020/06，10万元，在研，主持
4. 国家自然科学青年基金项目，81302502，miR-143基因启动子区遗传变异影响基因转录调控机制及与宫颈癌发生危险性的研究，2014/01-2016/12，23万元，已结题，主持
5. 江苏省自然科学青年基金项目，BK20130641，miR-21基因启动子区多态变异与宫颈癌遗传易感性及其机制探讨，2013/07-2016/6，20万元，已结题，主持
6. 教育部博士点基金（新教师类），20130092120063，miR-143基因启动子区多态变异与宫颈癌遗传易感性的研究，2014/01-2016/12，4万元，已结题，主持

研究领域

近年来在环境与肿瘤领域形成了以环境、遗传/表遗传与肿瘤发生发展及其机制为稳定的研究方向，较系统地开展了胃癌、宫颈癌、神经胶质瘤等肿瘤的遗传易感性及其分子机制研究，形成了人群生物标志物与机制研究密切结合的特色""

近期论文

1. Xia Qianqian#, Jin Hua #, Zhang Xing, Yan Wenjing, Meng Dan, Ding Bo, Cao Jian,Li Dake*, Wang Shizhi*. Prognosis prediction signature of seven immune genes based on HPV statusin cervical cancer. International Immunopharmacology. 2020; 88:106935
2. Zhang Yan, Zhang Xing, Zhu Haixia, Liu Yang, Cao Jian, Li Dake, Ding Bo, Yan Wenjing, Jin Hua*, Wang Shizhi*. Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer. Cancer Management and Research. 2020;12: 719-730.
3. Wang Shizhi*, Zhu Haixia, Ding Bo, Feng Xinrui, Zhao Wenxuan, Cui Mengjing, Xu Yuling, Shi Minxing, Chen Jian, Jin Hua*. Genetic variants in microRNAs are associated with cervical cancer risk. Mutagenesis. 2019 May 29;34(2):127-133.
4. Gu Bin, Li Meng, Zhang Yan, Li Lingyun, Yao Kun, Wang Shizhi*. DR7 encoded by human herpesvirus 6 promotes glioma development and progression. Cancer Management and Research. 2019 Mar 12;11:2109-2118.
5. Li Xiuting, Dong Qiu, Wang Boshen, Song Haiyan, Wang Shizhi*, Zhu Baoli*. The Influence of Occupational Noise Exposure on Cardiovascular and Hearing Conditions among Industrial Workers. Scientific Reports. 2019;9:11524
6. Gu Bin, Li Lingyun, Li Meng, Wang Jinfeng, Zhang Guofeng, Yao Kun, Wang Shizhi*. U94/rep of human herpesvirus 6 inhibits proliferation, invasion, and angiogenesis of glioma. Cancer Management and Research. 2018 Nov 20;10:5991-6001.
7. Jin Hua#, Lu Xiaoyun#, Ni Jing#, Sun Jinfang, Gu Bin, Ding Bo, Zhu Haixia, Ma Chao, Cui Mengjing, Xu Yuling, Zhang Zhengdong, Lercher Martin, Chen Jian*, Gao Na*, Wang Shizhi*, HOTAIR rs7958904 polymorphism is associated with increased cervical cancer risk in a Chinese population [J]. Scientific Reports. 2017, 7(1):3144.
8. Meng Qingtao#, Wang Shizhi#, Tang Weiyan#, Wu Shenshen, Gao Nao, Zhang Chengcheng, Cao Xiaoli, Li Xiaobo, Zhang Zhengdong, Aschner Michael,Jin Hua*, Huang Yue*, Chen Rui*. XRCC1 mediated the development of cervival cancer througha novel Sp1/Krox-20 swich. Oncotarget. 2017 Sep 16;8(49):86217-86226.
9. WuShenshen#, WangShizhi#, FuYou, TangWeiyan, JinHua, MengQingtao, Zhang Chengcheng, CuiMengjing, CaoXiaoli, LiXiaobo, ZhangZhengdong, ChenRui*, A novel mechanism of rs763110 polymorphism contributing to cervical cancer risk by affecting the binding affinity of C/EBPbeta and OCT1 complex to chromatin [J]. Int J Cancer, 2017, 140(4): 756-763.
10. WangShizhi#, MaGaoxiang#, ZhuHaixia#, LvChunye#, ChuHaiyan, TongNa, Wu Dongmei, QiangFulin, GongWeida, ZhaoQinghong, TaoGuoquan, ZhouJianwei, Zhang Zhengdong*, WangMeilin*, miR-107 regulates tumor progression by targeting NF1 in gastric cancer [J]. Scientific Reports, 2016, 6: 36531.
11. WangShizhi*, CaoXiaoli, DingBo, ChenJinfeng, CuiMengjing, XuYuling, Lu Xiaoyun, ZhangZhengdong, HeAiqin, JinHua*, The rs767649 polymorphism in the promoter of miR-155 contributes to the decreased risk for cervical cancer in a Chinese population [J]. Gene, 2016, 595(1): 109-114.
12. WangShizhi, WuShenshen, ZhuHaixia, DingBo, CaiYunlang, NiJing, WuQiang, MengQingtao, ZhangXin, ZhangChengcheng, LiXiaobo, WangMeilin, ChenRui*, Jin Hua*, ZhangZhengdong*, PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population [J]. Scientific reports, 2016, 6: 23465.
13. Wang Shizhi, Wu Shenshen, Meng Qingtao, Li Xiaobo, Zhang Jinchun, Chen Rui*, Wang Meilin*, FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin, Scientific reports, 2016, 6: 19229.
14. Wang Shizhi, Lv Chunye, Jin Hua, Xu Ming, Kang Meiyun, Chu Haiyan, Tong Na, Wu Dongmei, Zhu Haixia, Gong Weida, Zhao Qinghong, Tao Guoquan, Zhou Jianwei, Zhang Zhengdong*, Wang Meilin, A common genetic variation in the promoter of miR-107 is associated with gastric adenocarcinoma susceptibility and survival, Mutation research, 2014, 769: 35-41.
15. Wang Shizhi, Chen Lulu, Zhao Qinghong, Rong Huan, Wang Meilin, Gong Weida, Zhou Jianwei, Wu Dongmei, Zhang Zhengdong*, Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy, Cancer Chemother Pharmacol, 2013, 71(4): 1073-1082.
16. Wang Shizhi, Tao Guoquan, Wu Dongmei, Zhu Haixia, Gao Yan, Tan Yongfei, Wang Meilin, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, A functional polymorphism in MIR196A2 is associated with risk and prognosis of gastric cancer, Mol Carcinog, 2013, 52 Suppl 1: E87-95.
17. Shi Danni#, Wang Shizhi#, Gu Dongying#, Wu Dongmei, Wang Meilin, Chu Haiyan, Tong Na, Ma Lan, Zhong Dongyan, Zhang Zhengdong*, The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis, J Cancer Res Clin Oncol, 2012, 138(8): 1339-1345.
18. Wang Shizhi, Tian Yuanyuan, Wu Dongmei, Zhu Haixia, Luo Dewei, Gong Weida, Zhou Yan, Zhou Jianwei, Zhang Zhengdong*, Genetic variation of CTNNB1 gene is associated with susceptibility and prognosis of gastric cancer in a Chinese population, Mutagenesis, 2012, 27(6): 623-630.
19. Wang Shizhi, Tang Jialin, Wang Meilin, Yuan Lin, Zhang Zhengdong*, Genetic variation in PSCA and bladder cancer susceptibility in a Chinese population, Carcinogenesis, 2010, 31(4): 621-624.
#& * indicate co-first author and co-corresponding author, respectively.