个人简历
1990参加工作，2002,6毕业于哈尔滨医科大学医学遗传学专业，获医学博士学位。2006.9–2006.12德国马格德堡大学医学院高级访问学者。2008.3-2008.9香港大学医学院Research Fellow。
研究领域
消化系统肿瘤的表观遗传现象与肿瘤表观遗传标志物的筛查与应用研究
近期论文
Hu JJ, Song W, Zhang SD, Shen XH, Qiu XM, Wu HZ, Gong PH, Lu S, Zhao ZJ, He ML*, Fan H*. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling.Sci Rep. 2016;6:23521. Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells. Fan H*, Zhao Z, Cheng Y, Cui H, Qiao F, Wang L, Hu J, Wu H, Song W. Tumour Biol. 2016 ;37:877-85 Cui H, Zhao C, Gong P, Wang L, Wu H, Zhang K, Zhou R, Wang L, Zhang T, Zhong S,Fan H*. DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18(INK4C) in gastric carcinogenesis. Sci Rep. 2015;5:13781. Zhao Z, Wang L, Song W, Cui H, Chen G, Qiao F, Hu J, Zhou R,Fan H*.Reduced miR-29a-3p expression is linked to the cell proliferation and cell migration in gastric cancer.World J Surg Oncol. 2015;13:101. Cui H, Wang L, Gong P, Zhao C, Zhang S, Zhang K, Zhou R, Zhao Z,Fan H*.Deregulation between miR-29b/c and DNMT3A Is Associated with Epigenetic Silencing of the CDH1 Gene, Affecting Cell Migration and Invasion in Gastric Cancer.PLoS One. 2015;10:e0123926. Wu HZ, Zhang K, Pihai Gong PH, Qiao FC, Wang L, Cui H, Sui XY, Gao JF, Fan H* A novel functional tagSNP rs7560488 in the DNMT3A1 promoter is associated with susceptibility to gastric cancer by modulating promoter activity.PLoS One. 2014；25：9:e92911 Qiao F, Zhang K, Gong P, Wang L, Hu J, Lu S, Fan H*. Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.Mol Biol Rep. 2014 ;41:5693-700. Qiu XM, Zhang LH, Lu S, Song YW, Lao Y B, Hu JJ, Fan H* . Upregulation of DNMT1 mediated by HBx suppresses RASSF1A expression independent of DNA methylation. Oncol Rep. 2014；31: 202-208 Lao YB, Wu HZ, Zhao CC, Wu QY, Qiao FC,Fan H*. Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma. Biomedical Reports. 2013;1: 771-775. Zhao CC, Yan F, Wu HZ, Qiao FC, Qiu XM, Fan H*. DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma. Biomedical Reports. 2013;1:664-668. Qiu X, Dong S, Qiao F, Lu S, Song Y, Lao Y, Li Y, Zeng T, Hu J, Zhang L, Zhang L, Fan H*. HBx-mediated miR-21 upregulation represses tumor-suppressor function of PDCD4 in hepatocellular carcinoma.Oncogene. 2013; 32, 3296 – 3305 Wu Q, Lu S, Wang L, Hu J, Qiao F, Qiu X, Zhao C, Lao Y, Song Y, Fan H*. DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.Mol Biol Rep. 2012;39:10949-55. Fan H*, Chen L, Zhang F, Quan Y, Su X, Qiu X, Zhao Z, Kong KL, Dong S, Song Y, Chan TH, Guan XY. MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.Oncogene. 2012;31:2298-308. Qiao F, Su X, Qiu X, Qian D, Peng X, Chen H, Zhao Z, Fan H*. Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells.Oncol Rep. 2012;28:1475-81 Zhao Z, Li C, Song Y, Wu Q, Qiao F, Fan H*. Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.Oncol Lett. 2012;3:450-454. Liu H, Jiao Y, Guan Y, Lao Y, Zhao C, Fan H*.The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer.Exp Ther Med. 2012;3:525-529. Zhao ZJ,Wu QX,Chen J, Qiu XM,Zhang JQ, Fan H*. Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cells. J Biomed Biotech. 2010;2010:737535. Fan H, Liu DS, Qiu XM, Qiao FC, Wu QX, Su XW, Zhang F, Song YW, Zhao ZJ, Xie W A functional polymorphism in the DNA methyltransferase 3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.BMC Medicine. 2010 ；Feb 3;8:12 Su XW, Lv CY, Qiao FC, Qiu XM, Huang WB, Wu QX, Zhao ZJ,Fan H. Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma. Oncol Rep.2010; 23:819-26.
