个人简历

燕秋
职务: Professor, Director
专业: 生物化学与分子生物学
Education/Professional Experience
1981-1978 Bethune Medical University Medicine BS
1987-1990 Bethune Medical University Biochemistry and Molecular Biology MS
1995-1998 Dalian Medical University Biochemistry and Molecular Biology PhD Visiting scholar and professor in Sweden, USA and Japan

Research Projects/Grants
1.NSFC: Structures and Functions of endometrial LeY/sLeX glycoproteinsin embryo implantation（2011-2013）
2. NSFC: Annotation of O-glycosylation in embryo development and implantation (2013-2016)
3. Regulation of reproductive hormones on glycosylation in PCOS (2017-2020)
4. 973 grant: Tumor chemistry and Glycobiology (2012-2016)
Admission Plan/Requirements
Admission Plan
1-2 PhD candidates
1-2 Master candidates
Requirements
Bichemistry,Biotechnogy or Immune background

研究领域

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近期论文

Tian L, Shen D, Li X, Shan X, Wang X, Yan Q, Liu J. Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4. Oncotarget. 2016 Jan 12;7(2):1619-32. doi: 10.18632/oncotarget.6451. PubMed PMID: 26636541. IF:6.359.
Aziz F, Wang X, Liu J, Yan Q. Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions. Toxicol In Vitro. 2016 Mar;31:158-66. doi: 10.1016/j.tiv.2015.09.025. Epub 2015 Sep 30. PubMed PMID: 26427350. IF:2.903.
Liu S, Zheng Q, Cui XY, Dai KX, Yang XS, Li FS, Yan Q. Expression of uPAR in human trophoblast and its role in trophoblast invasion. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14325-34. eCollection 2015. PubMed PMID: 26823748; PubMed Central PMCID: PMC4713534. IF:1.891.
Gao J, Liu X, Yang F, Liu T, Yan Q, Yang X. By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis. Oncotarget. 2015 Sep 29;6(29):27187-98. doi: 10.18632/oncotarget.4551. PubMed PMID: 26356670; PubMed Central PMCID: PMC4694982. IF:6.359.
Gao, Wei; Liang, Jin-Xiao; Yan, Qiu. Exposure to radiation therapy is associated with female reproductive health among childhood cancer survivors: a meta-analysis study. J Assist Reprod Genet. 2015 Aug;32(8):1179-86. doi: 10.1007/s10815-015-0490-6. Epub 2015 May 5.PubMed PMID:25940112. IF:1.718.
Yan X, Lin Y, Liu S, Aziz F, Yan Q. Fucosyltransferase IV (FUT4) as an effective biomarker for the diagnosis of breast cancer. Biomed Pharmacother. 2015 Mar;70:299-304. doi: 10.1016/j.biopha.2014.12.048. Epub 2015 Jan 14. PubMed PMID: 25776515. IF:2.023.
Shan X, Aziz F, Tian LL, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3-induced EGFR/MAPK pathway deactivation inhibits melanoma cell proliferation by decreasing FUT4/LeY expression. Int J Oncol. 2015 Apr;46(4):1667-76. doi: 10.3892/ijo.2015.2886. Epub 2015 Feb 10. PubMed PMID: 25672851. IF:3.025.
Aziz F, Yang X, Wang X, Yan Q. Anti-LeY antibody enhances therapeutic efficacy of celecoxib against gastric cancer by downregulation of MAPKs/COX-2 signaling pathway: correlation with clinical study. J Cancer Res Clin Oncol. 2015 Jul;141(7):1221-35. doi: 10.1007/s00432-014-1892-z. Epub 2014 Dec 20. PubMed PMID: 25527419. IF:3.081.
Shan, Xiu; Tian, Li Li; Zhang, Yu Mei; Wang, Xiao Qi; Yan, Qiu; Liu, Ji Wei. Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-kappa B/p65 signaling pathway to promote melanoma cell death. Int J Oncol Int J. 2015 Aug;47(2):701-9. doi: 10.3892/ijo.2015.3057. Epub 2015 Jun 18. PubMed PMID: 26094873. IF:3.025.
Aziz, Faisal; Yang, Xuesong; Wen, Qingping; Yan, Qiu. A method for establishing human primary gastric epithelial cell culture from fresh surgical gastric tissues. Mol Med Rep. 2015 Aug;12(2):2939-44. doi: 10.3892/mmr.2015.3692. Epub 2015 Apr 28. PubMed PMID:25937205. IF:1.554.
Zhang, Yu-Mei; Zhang, Yuan-Yuan; Bulbul, Ahmmed; Shan, Xiu; Wang, Xiao-Qi; Yan, Qiu. Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway. FEBS Lett.2015 May 8;589(11):1225-33. doi: 10.1016/j.febslet.2015.04.011. Epub 2015 Apr 17. PubMed PMID: 25896022. IF:3.169.
Gao, Wei; Liang, Jin-Xiao; Liu, Shuai; Liu, Chang; Liu, Xiao-Fang; Wang, Xiao-Qi; Yan, Qiu. Oxidative damage of DNA induced by X-irradiation decreases the uterine endometrial receptivity which involves mitochondrial and lysosomal dysfunction. Int J Clin Exp Med. 2015 Mar 15;8(3):3401-10. eCollection 2015. PubMed PMID: 26064230. IF:1.277.
Shan X, Fu YS, Aziz F, Wang XQ, Yan Q, Liu JW. Ginsenoside Rg3 inhibits melanoma cell proliferation through down-regulation of histone deacetylase 3 (HDAC3) and increase of p53 acetylation. PLoS One. 2014 Dec 18;9(12):e115401. doi: 10.1371/journal.pone.0115401. eCollection 2014. PubMed PMID: 25521755. IF:3.234.
Liang JX, Ning Z, Gao W, Ling J, Wang AM, Luo HF, Liang Y, Yan Q, Wang ZY. Ubiquitinspecific protease 22induced autophagy is correlated with poor prognosis of pancreatic cancer. Oncol Rep. 2014 Dec;32(6):2726-34. doi: 10.3892/or.2014.3508. Epub 2014 Sep 22. PubMed PMID: 25241857. IF:2.301.
Ning, Zhen; Wang, Aman; Liang, Jinxiao; Xie, Yunpeng; Liu, Jiwei; Feng, Lu; Yan, Qiu; Wang, Zhongyu. USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via beta-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma. Int J Oncol. 2014 Oct;45(4):1594-608. doi: 10.3892/ijo.2014.2531. Epub 2014 Jul 3. PubMed PMID: 24993031. IF:3.025.
Liu, S.; Wang, J.; Qin, H-M; Yan, X-M; Yang, X-S; Liu, C.; Yan, Q. LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal-maternal interface.Cell Death Dis. 2014 Aug 28;5:e1396. doi: 10.1038/cddis.2014.335. PubMed PMID: 25165882. IF:5.014.
Aziz, Faisal; Chen, Xin; Yang, Xuesong; Yan, Qiu. Prevalence and Correlation with Clinical Diseases of Helicobacter pylori cagA and vacA Genotype among Gastric Patients from Northeast China. Biomed Res Int. 2014;2014:142980. doi: 10.1155/2014/142980. Epub 2014 May 13. PubMed PMID:24949419. IF:1.579.
Wang, Jiao; Liu, Shuai; Qin, Hua-Min; Zhao, Yue; Wang, Xiao-Qi; Yan, Qiu. Pregnancy-associated plasma protein A up-regulated by progesterone promotes adhesion and proliferation of trophoblastic cells. Int J Clin Exp Pathol. 2014 Mar 15;7(4):1427-37. eCollection 2014. PubMed PMID: 24817938. IF:1.891.
Aziz, Faisal; Qiu, Yan. The Role of Anti-LeY Antibody in the Downregulation of MAPKs/COX-2 Pathway in Gastric Cancer. Curr Drug Targets. 2014 Apr;15(4):469-76. PubMed PMID: 24533777. IF:3.021.
Yang, Xuesong; Wang, Jiao; Liu, Shuiai; Yan, Qiu. HSF1 and Sp1 Regulate FUT4 Gene Expression and Cell Proliferation in Breast Cancer Cells. J Cell Biochem. 2014 Jan;115(1):168-78. doi: 10.1002/jcb.24645. PubMed PMID: 23959823. IF:3.263.
Yan Q, Bach DQ, Gatla N, Sun P, Liu JW, Lu JY, Paller AS, Wang XQ. Deacetylated GM3 promotes uPAR-associated membrane molecular complex to activate p38 MAPK in metastatic melanoma. Mol Cancer Res. 2013 Jun;11(6):665-75. doi: 10.1158/1541-7786.MCR-12-0270-T. Epub 2013 Mar 22. PubMed PMID: 23525268. IF:4.380.
Yang, X.; Liu, S.; Yan, Q. Role of fucosyltransferase IV in epithelial-mesenchymal transition in breast cancer cells. Cell Death Dis. 2013 Jul 25;4:e735. doi: 10.1038/cddis.2013.241. PubMed PMID: 23887626. IF:5.014.
Yang XS, Liu SA, Liu JW, Yan Q. Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-κB pathways in A431 cells. Asian Pac J Cancer Prev. 2012;13(4):1657-62. PubMed PMID: 22799384. IF:2.514.
Wei X, Liu S, Wang X, Yan Q. CD82 expression alters with human endometrial cycles and affects the uterine endometrial receptivity in vitro. Exp Biol Med (Maywood). 2012 Mar;237(3):254-62. doi: 10.1258/ebm.2011.011309. Epub 2012 Mar 5.PubMed PMID: 22393164. IF:2.165.
Liu S, Yang X, Wang J, Wei J, Zhang D, Wang X, Yan Q. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. Cell Biol Int. 2012 May 1;36(5):469-74. doi: 10.1042/CBI20100644. PubMed PMID: 22145955. IF:1.933.
Yang X, Liu Y, Liu J, Wang X, Yan Q. Cyclophosphamide-induced apoptosis in A431 cells is inhibited by fucosyltransferase IV. J Cell Biochem. 2011 May;112(5):1376-83. doi: 10.1002/jcb.23054. PubMed PMID: 21337384. IF:3.263.
Liu S, Yang X, Liu Y, Wang X, Yan Q. sLeX/L-selectin mediates adhesion in vitro implantation model. Mol Cell Biochem. 2011 Apr;350(1-2):185-92. doi: 10.1007/s11010-010-0697-x. Epub 2011 Jan 1. PubMed PMID: 21197561. IF:2.393.
Zheng Q, Dai K, Cui X, Yu M, Yang X, Yan B, Liu S, Yan Q ,Leukemia inhibitory factor promote trophoblast invasion via urokinase-type plasminogen activator receptor in preeclampsia. Biomed Pharmacother. 2016 May;80:102-8
Liu S, Zheng Q, Cui XY, Dai KX, Yang XS, Li FS, Yan Q,.Expression of uPAR in human trophoblast and its role in trophoblast invasion.Int J Clin Exp Pathol. 2015 Nov 1;8(11):14325-34. eCollection 2015.