个人简历

杨青，教授，博士生导师。国家杰出青年基金获得者。担任Current Pharmaceutical Design、Biofuels, Biopructs and Biorefining和Applied Biochemistry and Biotechnology等国际期刊编委。任中国生物化学与分子生物学学会理事，中国昆虫学会昆虫生物化学与分子生物学专业委员会副主任等职务。长期从事绿色农药分子靶标研究，针对病原菌、有害昆虫等均以几丁质作为结构成分的特点，运用结构生物学和化学生物学等方法系统研究这些生物的几丁质合成、降解以及修饰的关键酶，开发新的、人/畜安全的农药分子靶标以及农化产品。先后主持国家杰出青年基金、国家自然科学基金重点项目和国家重点研发计划项目子课题等。近五年作为通讯作者在Biotechnology Advances, Journal of Biological Chemistry（7篇）, Journal of Agriculture and Food Chemistry（5篇）等领域内重要刊物发表论文30余篇，出版英文专著1部\r
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教育经历\r
1985.91998.6 湘潭市一中无\r
1999.102002.4 大连理工大学生物化工博士\r
1988.91992.7 华东理工大学生物化工学士\r
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工作经历\r
1995.7至今 大连理工大学

研究领域

""1）昆虫表皮及外骨骼形成的分子机制\r
2）昆虫酶的结构生物学及抑制剂设计\r
3）病害、虫害的小分子调控""""

近期论文

Chu, Fangmeng,Wang, Di,Liu, Tian,Han, Hongyu,Yu, Yike,Yang, Qing.An optimized cocktail of chitinolytic enzymes to produce N,N '-diacetylchitobiose and N-acetyl-...[J],INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,133:1029-1034\r
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Liu, Lin,Zhou, Yong,Qu, Mingbo,Qiu, Yu,Guo, Xingming,Zhang, Yuebin,Liu, Tian,Yang, Jun,Yang, Qing.Structural and biochemical insights into the catalytic mechanisms of two insect chitin deacetyl...[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2019,294(15):5774-5783\r
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Liu Lin,Qu Mingbo,Liu Tian,Chen Qi,Guo Xingming,Yang Jun,Yang Qing.Biochemical characterization of three midgut chitin deacetylases of the Lepidopteran insect Bomby...[J],Journal of insect physiology,2019,113:42-48\r
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Shen, Shengqiang,Dong, Lili,Chen, Wei,Zeng, Xiangdi,Lu, Huizhe,Yang, Qing,Zhang, Jianjun.Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhib...[J],ACS MEDICINAL CHEMISTRY LETTERS,2018,9(12):1241-1246\r
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Duan, Yanwei,Liu, Tian,Zhou, Yong,Dou, Tongyi,Yang, Qing.Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berb...[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2018,293(40):15429-15438\r
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Muthukrishnan, Subbaratnam,Arakane, Yasuyuki,Yang, Qing,Zhang, Chuan-Xi,Zhang, Jianzhen,Zhang, Wenqing,Moussian, Bernard.Future questions in insect chitin biology: A microreview[J],ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY,2018,98(2):e21454\r
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Liu, Tian,Zhu, Weixing,Wang, Jing,Zhou, Yong,Duan, Yanwei,Qu, Mingbo,Yang, Qing.The deduced role of a chitinase containing two nonsynergistic catalytic domains[J],ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY,2018,74(Pt 1):30-40\r
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Liu L,Qu M,Yang J,Yang Q.The physiological differentiation along the midgut of Bombyx mori - inspirations from proteomics ...[J],Insect molecular biology,2017,27(2):247-259\r
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Qu, M.,Ren, Y.,Liu, Y.,Yang, Q..Studies on the chitin/chitosan binding properties of six cuticular proteins analogous to peritr...[J],INSECT MOLECULAR BIOLOGY,2017,26(4):432-439\r
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Liu, Tian,Chen, Lei,Zhou, Yong,Jiang, Xi,Duan, Yanwei,Yang, Qing.Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2017,292(6):2080-2088\r
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Jiang, Xi,Kumar, Ashutosh,Liu, Tian,Zhang, Kam Y. J.,Yang, Qing.A Novel Scaffold for Developing Specific or Broad-Spectrum Chitinase Inhibitors[J],JOURNAL OF CHEMICAL INFORMATION AND MODELING,2016,56(12):2413-2420\r
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Zhu, Weixing,Wang, Di,Liu, Tian,Yang, Qing.Production of N-Acetyl-D-glucosamine from Mycelial Waste by a Combination of Bacterial Chitinas...[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(35):6738-6744\r
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Bai, Jing,Yang, Jun,Zhou, Yong,Yang, Qing.Structural basis of Escherichia coli nitroreductase NfsB triple mutants engineered for improved...[J],PROCESS BIOCHEMISTRY,2015,50(11):1760-1766\r
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Wang, Yongan,Liu, Wei,Yang, Qing,Yu, Mingxi,Zhang, Zhou.Di (2-ethylhexyl) phthalate exposure during pregnancy disturbs temporal sex determination regul...[J],TOXICOLOGY,2015,336:10-16\r
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Kong, Hanchu,Chen, Wei,Lu, Huizhe,Yang, Qing,Dong, Yanhong,Wang, Daoquan,Zhang, Jianjun.Synthesis of NAG-thiazoline-derived inhibitors for beta-N-acetyl-D-hexosaminidases[J],CARBOHYDRATE RESEARCH,2015,413:135-144\r
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Bai, Jing,Zhou, Yong,Chen, Qi,Yang, Qing,Yang, Jun.Altering the Regioselectivity of a Nitroreductase in the Synthesis of Arylhydroxylamines by Str...[J],CHEMBIOCHEM,2015,16(8):1219-1225\r
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Bai, Jing,Yang, Jun,Liu, Peiyu,Yang, Qing.Transformation pathway of 2,4,6-trinitrotoluene by Escherichia coli nitroreductases and improve...[J],PROCESS BIOCHEMISTRY,2015,50(5):705-711\r
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Meng, Yingying,Jiang, Junpeng,Wang, Haitao,Cao, Xupeng,Xue, Song,Yang, Qing,Wang, Weiliang.The characteristics of TAG and EPA accumulation in Nannochloropsis oceanica IMET1 under differe...[J],BIORESOURCE TECHNOLOGY,2015,179:483-489\r
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Liu, Tian,Xia, Meng,Zhang, Haitao,Zhou, Hao,Wang, Jing,Shen, Xu,Yang, Qing.Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic beta-acetylglucosami...[J],FEBS LETTERS,2015,589(1):110-116\r
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Liu, Tian,Guo, Peng,Zhou, Yong,Wang, Jing,Chen, Lei,Yang, Huibin,Qian, Xuhong,Yang, Qing.A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity b...[J],SCIENTIFIC REPORTS,2014,4:6188