个人简历

个人简介\r
Personal Profile\r
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我们的研究主要利用生物大分子模拟、生物信息学（包含人工智能技术）、化学生物学、药物设计及药物化学等方法与各种体内外先进的实验技术方法相结合，研究重大疾病及重要生命过程的发生发展机制，发现相关调控靶点并设计开发创新药物以及诊疗手段等。近5年以第一及通讯作者（含共同）在Nature Medicine (IF = 30.64)、J. Med Chem. (IF = 6.29)、Angew Chem Int Ed (IF = 12.25)、J Clin Invest (IF = 12.28)、Chem Sci (IF = 9.55)以及Clin Cancer Res (IF = 8.91)等生物医药领域重要期刊发表SCI论文30余篇（影响因子大于10的论文3篇、影响因子大于5的论文9篇）, 篇均影响因子7分，h-index指数为15(谷歌学术）。我们的研究工作在2018年被国家自然科学基金委官网（NSFC）专门撰文报道、在2015年被科技部官方媒体《科技日报》头版报道。近年来获得辽宁省科技进步二等奖一项、辽宁省自然科学学术成果一等奖一项，并主持国家自然科学基金及省部级项目多项。我们开发的基于人工智能全局信息共享优化搜索算法的分子识别及对接工具FIPSDock被全世界多个国家的科研机构及制药公司使用。\r
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教育经历\r
2001.9 2006.6 美国纽约州立大学石溪分校 化学系 博士\r
1997.9 2001.6 武汉大学 化学理科 学士\r
1994.6 1997.7 辽宁抚顺一中 无\r
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专利 \r
嘧啶胺类化合物在制备乙酰胆碱酯酶抑制剂中的应用 \r
著作成果 \r
Editorial: Rational drug design with the aid of molecular modeling and bioinformatics \r
科研项目 \r
细胞核输出调节剂的计算设计和实验验证研究, 省、市、自治区科技项目, 2013/01/01, 完成 \r
基于生物信息学寻找用于胃癌诊断及预后判断的唾液标记物, 国家自然科学基金项目, 2010/09/25-2013/12/31, 完成 \r
新型CRM1抑制剂的设计和制备以及对ENKTL淋巴瘤治疗机制与效果的研究, 国家自然科学基金项目, 2018/08/16, 进行 \r
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科研奖励 \r
优秀教学成果奖 \r
辽宁省科技进步二等奖

研究领域

""1）生物信息学; 2）知识图谱; 3）药物发现。""""

近期论文

[1]高久蕉,张琦,杨永亮.莱菔素通过阻断STAT3信号通路杀伤三阴性乳腺癌细胞MDA-MB-468和MDA-MA-231[J],中国肿瘤生物治疗杂志,2019,26(8):837-844 \r
[2]Cui Bai,Luo Xi,Yin Liu,Cheng Wei,An Fan,He Bin,Liang Dapeng,Wu Sijin,Chu Peng,Song Luyao,Liu Xinyu,Luo Yuanyuan,Luo Huandong,Xu Jie,Pan Yujia,Wang Yang,Li Dangsheng,Huang Peng,Yang Qingkai,Zhang Lingqiang,Zhou Binhua P,Liu Suling,Tian Pengfei,Xu Guowang,Lam Eric W-F,Kelley Keith W,Liu Quentin,Peng Fei,Lu Jinxin,Yang Yongliang,Su Qitong,Liu Bing,Yu Jiachuan.Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells[J],The Journal of clinical investigation,2019,129(3):1030-1046 \r
[3]Liu, Caigang,Zaidi, Mone,New, Maria I.,Yuen, Tony,Guo, Qiyong,Sun, Lisha,Yang, Jie,Liu, Tong,Yang, Yongliang,Kim, Se-Min,Ou, Xunyan,Wang, Yining,Sun, Li.FSIP1 regulates autophagy in breast cancer[J],PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OFAMERICA,2018,115(51):13075-13080 \r
[4]Feng, Lei,Long, Feida,Wang, Wei,Ma, Xiaochi,Yang, Yongliang,Huo, Xiaokui,Tian, Xiangge,Feng, Yujie,Yuan, Hanwen,Zhao, Lijian,Wang, Chao,Chu, Peng.Highly Selective NIR Probe for Intestinal beta-Glucuronidase and High-Throughput Screening Inhibitors to Therapy Intestinal Damage[J],ACS SENSORS,2018,3(9):1727-1734 \r
[5]Feng, Lan,Wang, Yipeng,Yu, Haining,Shi, Nannan,Cai, Shasha,Qiao, Xue,Chu, Peng,Wang, Hui,Long, Feida,Yang, Huaixin,Yang, Yongliang.De Novo Molecular Design of a Novel Octapeptide That Inhibits In Vivo Melanogenesis and Has Great Transdermal Ability[J],JOURNAL OF MEDICINAL CHEMISTRY,2018,61(15):6846-6857 \r
[6]Wang, Haina,Yang, Yongliang,Wang, Fuqiang,Wu, Sijin,Liu, Zhiheng,Li, Tingting,Mao, Lei,Zhang, Jie,Li, Cheng,Liu, Caigang.Traditional herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation[J],CHEMICO-BIOLOGICAL INTERACTIONS,2018,281:11-23 \r
[7]Li, Ming,Liu, Yinhui,Yuan, Jieli,Mao, Lei,Liu, Yu,Zheng, Xiliang,Wang, Erkang,Wang, Jin,Yang, Yongliang,Gao, Jiali,Tang, Yan,Liu, Meishuo,Wu, Sijin,Qu, Kunli,Long, Xiangyu,Li, Huajun,Liu, Min.Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells[J],FRONTIERS IN PHARMACOLOGY,2018,8(JAN):959 \r
[8]Ji, Fangling,Bao, Yongming,Li, Mingyang,Feng, Yanbin,Wu, Sijin,Wang, Tianqi,Pu, Zhongji,Wang, Jingyun,Yang, Yongliang,Xue, Song.Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis.[J],Applied microbiology and biotechnology,2018,102(15):6479-6491 \r
[9]Ji, Fangling,Feng, Yanbin,Li, Mingyang,Yang, Yongliang,Wang, Tianqi,Wang, Jingyun,Bao, Yongming,Xue, Song.Studies on structure-function relationships of acetolactate decarboxylase from Enterobacter cloacae[J],RSC ADVANCES,2018,8(68):39066-39073 \r
[10]Wu, Sijin,Zhang, Keren,Qin, Hongqiang,Niu, Mingshan,Zhao, Weijie,Ye, Mingliang,Zou, Hanfa,Yang, Yongliang.Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action[J],CHEMICAL BIOLOGY & DRUG DESIGN,2017,89(5):655-662 \r
[11]Hu, Xiaoqing,Cong, Ye,Luo, Huizhe,Wu, Sijin,Zhao, Liyuan,Liu, Quentin,Yang, Yongliang.Cancer Stem Cells Therapeutic Target Database: The First Comprehensive Database for Therapeutic Targets of Cancer Stem Cells[J],STEM CELLS TRANSLATIONAL MEDICINE,2017,6(2):331-334 \r
[12]Shao, Wen Yu,Yang, Yong Liang,Yan, Huan,Huang, Qian,Liu, Kai Jiang,Zhang, Shu.Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway[J],CANCER BIOLOGY & THERAPY,2017,18(1):26-35 \r
[13]Wu, Sijin,Luo , Huizhe,Wang, Haina,Zhao, Weijie,Hu, Qiwan,Yang, Yongliang.Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,478(3):1268-1273 \r
[14]Bi, H.,Yang, Y.,Wu, H.,Li, S.,Qu, X.,Wang, M.,Bai, X.,Xu, Z.,Ao, X.,Jia, Z.,Jiang, X..DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase[J],CELL DEATH & DISEASE,2015,6(9):e1891 \r
[15]Wei, Lin,Wang, Yipeng,Gao, Jiuxiang,Zhang, Shumin,Wu, Sijin,Xie, Zeping,Ling, Guiying,Kuang, Yi-Qun,Yang, Yongliang,Yu, Haining.Identification and Characterization of the First Cathelicidin from Sea Snakes with Potent Antimicrobial and Anti-inflammatory Activity and Special Mechanism[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2015,290(27):16633-16652 \r
[16]Yang, Yongliang,Niu, Mingshan,Ji, Xuefei,Zou, Libo,Wang, Jin,Li, Guohui,Zhao, Dongyu,Yu, Haoyang,Zheng, Xiliang,Peng, Xiangda,Zhang, Xiaoe,Fu, Ting,Hu, Xiaoqing.Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memory and cognitive deficits in rat model neurodegeneration[J],CHEMICAL SCIENCE,2015,6(5):2812-2821 \r
[17]Hou, Zhi-Jie,Long, Zi-Jie,Wang, Xue-Ting,Li, Guo-Hui,Wan, Xian-Yao,Zhang, Wei,Peng, Fei,Cui, Bai,Wu, Si-Jin,Zheng, Fei-Meng,Xu, Jie,Xu, Ling-Zhi,Yang, Yong-Liang.Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells[J],ONCOTARGET,2015,6(8):6326-6340 \r
[18]Cao, Longlong,Lin, Guangtan,Lin, Huizhong,Xie, Jianwei,Li, Ping,Hu, Xiaoqing,Zheng, Chaohui,Bu, Guojun,Zhang, Yun-wu,Xu, Huaxi,Yang, Yongliang,Zhou, Jiechao,Huang, Changming,Zhang, Jie,Zhang, Junrong,Wu, Sijin,Yang, Xintao,Zhao, Xin,Li, Huifang,Luo, Ming,Yu, Qian.Cyclin-Dependent Kinase 5 Decreases in Gastric Cancer and Its Nuclear Accumulation Suppresses Gastric Tumorigenesis[J],CLINICAL CANCER RESEARCH,2015,21(6):1419-1428 \r
[19]张晓娥,杨永亮.XPO1/CRM1介导的核质运输与疾病治疗[J],生命的化学,2015,35(4):525-530 \r
[20]杨永亮.Computational discovery and experimental verification of tyrosine kinase inhibitor pazopanib for the reversal of memoery and cognitive deficts in rat model neurodegeneration[J],Chemical Science,2015,6(1):2812-2821 \r
[21]Che, J.,Wang, L. L.,Wang, X. T.,Yang, G. J.,Yang, Y.,Xu, W. P.,Xu, Y. P..Characterization of Nitrifying Bacterial Community in a Mariculture Wastewater Treatment Using SBR System[J],ISRAELI JOURNAL OF AQUACULTURE-BAMIDGEH,2015,67 \r
[22]Guo, Liyong,Yan, Zhiqiang,Zheng, Xiliang,Hu, Liang,Yang, Yongliang,Wang, Jin.A comparison of various optimization algorithms of protein-ligand docking programs by fitness accuracy[J],JOURNAL OF MOLECULAR MODELING,2014,20(7) \r
[23]Liu, Yu,Yang, Yongliang.Empirical study of L-Sequence: The basic h-index sequence for cumulative publications with consideration of the yearly citation performance[J],JOURNAL OF INFORMETRICS,2014,8(3):478-485 \r
[24]Niu, Mingshan,Hu, Jin,Wu, Sijin,Zhang, Xiaoe,Xu, Huaxi,Zhang, Yunwu,Zhang, Jie,Yang, Yongliang.Structural Bioinformatics-Based Identification of EGFR Inhibitor Gefitinib as a Putative Lead Compound for BACE[J],CHEMICAL BIOLOGY & DRUG DESIGN,2014,83(1):81-88 \r
[25]Niu, Mingshan,Wu, Sijin,Mao, Lei,Yang, Yongliang.CRM1 Is a Cellular Target of Curcumin: New Insights for the Myriad of Biological Effects of an Ancient Spice[J],TRAFFIC,2013,14(10):1042-1052 \r
[26]Yang, Yongliang,Wang, Jin.Rational Drug Design with the Aid of Molecular Modeling and Bioinformatics[J],CURRENT PHARMACEUTICAL DESIGN,2013,19(12):2245-2245 \r
[27]Mao, Lei,Yang, Yongliang.Targeting the Nuclear Transport Machinery by Rational Drug Design[J],CURRENT PHARMACEUTICAL DESIGN,2013,19(12):2318-2325 \r
[28]Liu, Yu,Zhao, Lei,Li, Wentao,Zhao, Dongyu,Song, Miao,Yang, Yongliang.FIPSDock: A new molecular docking technique driven by fully informed swarm optimization algorithm[J],JOURNAL OF COMPUTATIONAL CHEMISTRY,2013,34(1):67-75 \r
[29]Lang, Haijing,Huang, Xudong,Yang, Yongliang.Identification of Putative Molecular Imaging Probes for BACE-1 by Accounting for Protein Flexibility in Virtual Screening[J],JOURNAL OF ALZHEIMERS DISEASE,2012,29(2):351-359 \r
[30]Chen, Min,Wang, Kai,Zhang, Liang,Li, Cheng,Yang, Yongliang.The Discovery of Putative Urine Markers for the Specific Detection of Prostate Tumor by Integrative Mining of Public Genomic Profiles[J],PLOS ONE,2011,6(12):e28552 \r
[31]Yang, Yongliang,Wang, Ketai,Li, Wentao,Adelstein, S. James,Kassis, Amin I..Human Placental Alkaline Phosphatase-Mediated Hydrolysis Correlates Tightly with the Electrostatic Contribution from Tail Group[J],CHEMICAL BIOLOGY & DRUG DESIGN,2011,78(6):923-931 \r
[32]Liu, Yu,Li, Wentao,Zhao, Lei,Yang, Yongliang.Momentum Particle Swarm Optimization for Molecular Docking[J],2011 International Conference on Intelligent Computing and InformationScience (ICICIS 2011),2011,14(3,SI):939-944 \r
[33]Yang, You,Liu, Tian,Yang, Yongliang,Wu, Qingyue,Yang, Qing,Yu, Biao.Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-D-glucosamine-(1 -> 4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 beta-N-Acetyl-D-hexosaminidases[J],CHEMBIOCHEM,2011,12(3):457-467 \r
[34]刘田,杨永亮,杨青.Synthesis, evaluation, and mechanism of N,N,N-Tri-methyl-D-glucosamine-β-1,4-chitooligosaccharides as selective inhibitors of glycosyl hydrolase family 20 β-N-acetyl-D-hexosaminidases.[J],CHEMBIOCHEM,2011,12:457-467.,2011,12:457-467 \r
[35]杨永亮.General approach to identifying potential targets for cancer imaging by integrated bioinformatics analysis of publicly available genomic profiles[J],Molecular Imaging,2010