个人简历
教育经历1990.9 2000.7 平原第一中学 理科2000.9 2003.9 协和医科大学 生物化学与分子生物学 博士1997.9 2000.9 山东师范大学 发育生物学 硕士1993.9 1997.7 山东师范大学 生物教育 学士工作经历2006.5 至今 大连理工大学 副教授2003.10 2006.5 关西医科大学 研究员专利 一种抗人淀粉样β肽的纳米抗体及其应用 一种重组蛋白A亲和配基的定点固定化方法 一种重组人IgE受体蛋白的制备方法及应用 一种对抗体具有广谱吸附能力的融合蛋白制备方法及应用 利用重组毕赤酵母生产蛋白A的方法 一种特异性清除甲状旁腺激素的血液净化吸附剂的制备方法 著作成果 Comprehensive Biotechnology, 2nd edition ，Volume 5: Medical Biotechnology and Healthcare/ Artificial Organs and Life Support Devices/ Blood Detoxication 科研项目 脑脊液微净化吸附去除脑实质Aβ可行性研究, 国家自然科学基金项目, 2016/08/17, 完成 催化氧化双环、稠环及卤代芳香烃的双加氧酶β亚基功能的研究, 主管部门科技项目, 2009/01/01-2011/08/31, 完成 研究阿尔茨海默病中淀粉样beta?肽聚集体作用蛋白的新方法, 主管部门科技项目, 2008/12/24-2011/12/31, 完成 利用固定化分子簇色谱技术研究Aβ寡聚体相互作用蛋白新方法, 国家自然科学基金项目, 2011/09/25-2014/12/31, 完成 治疗肝衰竭肾衰竭血液净化新技术及新产品, 省、市、自治区科技项目, 2018/01/01, 进行 高性能吸附剂关键技术研发及产业化, 国家科技部 , 2016/07/28, 进行 科研奖励 中国石油和化学工业科学技术奖 大连市科学技术进步奖
研究领域
"研究领域 疾病发生发展机理"
近期论文
[1]Zhang, Liuwei,Qian, Ming,Xia, Jing,Chen, Lili,Cui, Hongyan,Xia, Ying,Xu, Li,Wang, Jingyun,Peng, Xiaojun.A NIR fluorescent sensor with large Stokes shift for the real-time visualization of endogenous hydrogen peroxide in living cells[J],JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2019,370:12-17 [2]Xu, Li,Wang, Rou,Cao, Hanyu,Xu, Ting,Han, Lulu,Huang, Chundong,Jia, Lingyun.A facile method to oriented immobilization of His-tagged BirA on Co3+ -NTA agarose beads[J],ENZYME AND MICROBIAL TECHNOLOGY,2019,120:36-42 [3]Xu, Li,Song, Xiaoyu,Jia, Lingyun.A camelid nanobody against EGFR was easily obtained through refolding of inclusion body expressed in Escherichia coli[J],BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,2017,64(6):895-901 [4]臧柏林,贾凌云,任军,徐丽.冷冻法制备C端-C端连接的二价纳米抗体[A],中国化学会2017全国高分子学术论文报告会,2017,1 [5]臧柏林,任军,徐丽,贾凌云.一种重组蛋白A的定点固定化方法[A],2016,1-1 [6]Han, Lulu,Chu, Simin,Wei, Houliang,Ren, Jun,Xu, Li,Jia, Lingyun.Functionalized Magnetic Fe3O4-beta-Cyclodextran Nanoparticles for Efficient Removal of Bilirubin[J],JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(6):5537-5545 [7]贾凌云,任军,徐丽.Direct site-specific immobilization of protein A viaaldehyde-hydrazide conjugation[J],Journal of Chromatography B,2016,1008:132-138 [8]Bao, Xiaobo,Xu, Li,Lu, Xu,Jia, Lingyun.Optimization of dilution refolding conditions for a camelid single domain antibody against human beta-2-microglobulin[J],PROTEIN EXPRESSION AND PURIFICATION,2016,117:59-66 [9]Zang, Berlin,Ren, Jun,Xu, Li,Jia, Lingyun.Direct site-specific immobilization of protein A via aldehyde-hydrazide conjugation[J],JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICALAND LIFE SCIENCES,2016,1008:132-138 [10]Wang, Conggang,Cheng, Fang,Xu, Li,Jia, Lingyun.HSA targets multiple A beta 42 species and inhibits the seeding-mediated aggregation and cytotoxicity of A beta 42 aggregates[J],RSC ADVANCES,2016,6(75):71165-71175 [11]徐丽,王从纲,陈林丽,任军,谢健,贾凌云.通过分子簇获得不同聚集度的Aβ寡聚体及相互作用蛋白研究[A],2015全国老年痴呆与认知障碍相关疾病学术大会,2015,111-111 [12]Gao, Huipeng,Gao, Xiaorong,Cao, Yaming,Xu, Li,Jia, Lingyun.Influence of Hydroxypropyl-beta-cyclodextrin on the Extraction and Biodegradation of p,p '-DDT, o,p '-DDT, p,p '-DDD, and p,p '-DDE in Soils[J],WATER AIR AND SOIL POLLUTION,2015,226(7) [13]Wang, Conggang,Xu, Li,Cheng, Fang,Wang, Hanqi,Jia, Lingyun.Curcumin induces structural change and reduces the growth of amyloid-beta fibrils: a QCM-D study[J],RSC ADVANCES,2015,5(38):30197-30205 [14]Xu, Li,Wang, Conggang,Chen, Linli,Ren, Jun,Xie, Jian,Jia, Lingyun.Detection of A beta-interacting proteins via a novel A beta-adsorbents that use immobilized regular comb polymer[J],JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICALAND LIFE SCIENCES,2014,971:94-98 [15]Jia, Lingyun,Xu, Li,Gao, Bo,Gao, Huipeng.Remediation of DDTs-Contaminated Sediments through Retrievable Activated Carbon Fiber Felt[J],CLEAN-SOIL AIR WATER,2014,42(7):973-978 [16]Gao, Huipeng,Ma, Jing,Xu, Li,Jia, Lingyun.Hydroxypropyl-beta-cyclodextrin extractability and bioavailability of phenanthrene in humin and humic acid fractions from different soils and sediments[J],ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH,2014,21(14):8620-8630 [17]徐丽,任军,谢健,贾凌云.Detection of Aβ-interacting proteins via a novel Aβ-adsorbents that use immobilized regular comb polymer[J],J Chromatogr B Analyt Technol Biomed Life Sci,2014,971(1):94-98 [18]Wei, Houliang,Ren, Jun,Han, Bo,Xu, Li,Han, Lulu,Jia, Lingyun.Stability of polydopamine and poly(DOPA) melanin-like films on the surface of polymer membranes under strongly acidic and alkaline conditions[J],COLLOIDS AND SURFACES B-BIOINTERFACES,2013,110:22-28 [19]Gao, Huipeng,Xu, Li,Cao, Yaming,Ma, Jing,Jia, Lingyun.Effects of hydroxypropyl-beta-cyclodextrin and beta-cyclodextrin on the distribution and biodegradation of phenanthrene in NAPL-water system[J],INTERNATIONAL BIODETERIORATION & BIODEGRADATION,2013,83:105-111 [20]Hao, Jing,Xu, Li,He, Hongde,Du, Xiaojun,Jia, Lingyun.High-level expression of Staphylococcal Protein A in Pichia pastoris and purification and characterization of the recombinant protein[J],PROTEIN EXPRESSION AND PURIFICATION,2013,90(2):178-185 [21]Ma, Jing,Xu, Li,Jia, Lingyun.Characterization of pyrene degradation by Pseudomonas sp strain Jpyr-1 isolated from active sewage sludge[J],BIORESOURCE TECHNOLOGY,2013,140:15-21 [22]徐丽,贾凌云.Effects of hydroxypropyl-β-cyclodextrin and β-cyclodextrin on the distribution and biodegradation of phenanthrene in NAPL-water system[J],International Biodeterioration & Biodegradation,2013,83(1):105-111 [23]马静,曹亚明,徐丽,贾凌云.Pseudomonas sp. JM2菲降解酶基因解析[J],环境科学与技术,2013,36(12):15-19 [24]Wang, Zhi,Wei, Houliang,Jia, Lingyun,Xu, Li,Zou, Chunyi,Xie, Jian.Water-soluble adsorbent beta-cyclodextrin-grafted polyethyleneimine for removing bilirubin from plasma[J],TRANSFUSION AND APHERESIS SCIENCE,2012,47(2):159-165 [25]陈林丽,徐丽.Aβ聚集的影响因素和Aβ寡聚体的生理功能[J],中国老年学杂志,2012,32(17):3848-3850 [26]Wei, Houliang,Xu, Li,Ren, Jun,Jia, Lingyun.Adsorption of bilirubin to magnetic multi-walled carbon nanotubes as a potential application in bound solute dialysis[J],COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2012,405:38-44 [27]Ma, Jing,Xu, Li,Jia, Lingyun.Degradation of polycyclic aromatic hydrocarbons by Pseudomonas sp JM2 isolated from active sewage sludge of chemical plant[J],JOURNAL OF ENVIRONMENTAL SCIENCES,2012,24(12):2141-2148 [28]Wang, Zhi,Cao, Yaming,Wei, Houliang,Jia, Lingyun,Xu, Li,Xie, Jian.Bilirubin adsorption properties of water-soluble adsorbents with different cyclodextrin cavities in plasma dialysis system[J],COLLOIDS AND SURFACES B-BIOINTERFACES,2012,90(1):248-253 [29]徐丽,谢健,贾凌云.Homology modeling of naphthalene dioxygenase derived from JM2 and docking study with PAHs.[A],2012 [30]王智,陈书博,徐丽,谢健,贾凌云.胆红素吸附剂功能基组成及其吸附特性研究[J],离子交换与吸附,2011,27(6):511-520 [31]Gao, Bo,Liu, Wen-Bin,Jia, Ling-Yun,Xu, Li,Xie, Jian.Isolation and characterization of an Alcaligenes sp strain DG-5 capable of degrading DDTs under aerobic conditions[J],JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOODCONTAMINANTS AND AGRICULTURAL WASTES,2011,46(3):257-263 [32]胡顺利,贾凌云,高慧鹏,高波,谢健,徐丽.土壤中不同有机质对菲的吸附行为及生物可利用性的影响[J],环境科学学报,2011,31(2):341-348 [33]Cao, Yaming,Jia, Lingyun,Xu, Li,Xie, Jian.Analysis of different PCBs degradation abilities of biphenyl dioxygenase derived from Enterobacter sp. LY402 by molecular simulation[J],JOURNAL OF BIOTECHNOLOGY,2010,150:S230-S231 [34]Ren, Jun,Bai, Ying,Hao, Lan,Pi, Zhiqian,Xu, Li,Jia, Lingyun.Amelioration of Experimental Autoimmune Myasthenia Gravis Rats Using 4-Mercaptoethylpyridine-based Adsorbent[J],JOURNAL OF BIOTECHNOLOGY,2010,150:S446-S446 [35]Wang, Zhi,Cao, Yaming,Jia, Lingyun,Xu, Li,Xie, Jian.Analysis of interactions of bilirubin and cyclodextrin by docking and molecular dynamics[J],JOURNAL OF BIOTECHNOLOGY,2010,150:S445-S445 [36]孙嘉怡,任军,徐丽,贾凌云.猪肝中单胺氧化酶B的分离纯化[J],色谱,2010,28(9):872-876 [37]Ren, Jun,Pi, Zhiqian,Lin, Xue,Xu, Li,Xie, Jian,Jia, Lingyun.Effect of Structural Properties of Both Proteins and Stationary Phases to Adsorption Behavior of Proteins in Hydrophobic Interaction Chromatography[A],4th International Conference on Bioinformatics and BiomedicalEngineering (iCBBE),2010 [38]Ren, Jun,Pi, Zhiqian,Lin, Xue,Xu, Li,Xie, Jian,Jia, Lingyun,Ma, Yue,Wang, Yumei.An Adsorbent for Extracorporeal Elimination of Pathogenic Autoantibodies[A],4th International Conference on Bioinformatics and BiomedicalEngineering (iCBBE),2010 [39]贾凌云,徐丽.分子模拟技术在血液净化吸附材料设计合成中的应用[A],2010 [40]徐丽,贾凌云.Amelioration of Experimental Autoimmune Myasthenia Gravis Rats by Blood Purification Treatment using 4-Mercaptoethylpyridine (MEP) Based Adsorbent[A],2010 [41]谢健,徐丽,贾凌云.季铵化壳聚糖的制备及对血中胆红素吸附性能的应用，全国生物材料大会[A],2010 [42]徐丽,谢健,贾凌云.环糊精与胆红素相互作用的分子模拟与实验研究[A],2010 [43]贾凌云,徐丽,谢健.Analysis of PCBs degradation abilities of biphenyl dioxygenase derived from Enterobacter sp. LY402 by molecular simulation[A],2010 [44]贾凌云,徐丽,谢健.Analysis of interactions between bilirubin and cyclodextrin by docking and molecular dynamics[A],2010 [45]Ren, Jun,Jia, Lingyun,Xu, Li,Lin, Xue,Pi, Zhiqian,Xie, Jian.Removal of autoantibodies by 4-mercaptoethylpyridine-based adsorbent[J],JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICALAND LIFE SCIENCES,2009,877(11-12):1200-1204 [46]Gao, Bo,Jia, Lingyun,Xu, Li,Xie, Jian.Biodegradation of organochlorine pesticides adsorbed on activated carbon fiber felt[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S699-S699 [47]Gao, Bo,Jia, Lingyun,Xu, Li,Xie, Jian.Aerobic degradation of dieldrin by Enterobacter sp LY402[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S698-S698 [48]Ma, Jing,Gao, HuiPeng,Jia, LingYun,Xu, Li,Xie, Jian.Isolation and characterization of PAHs degrading bacteria from activated sludge[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S697-S698 [49]Wang, Zhi,Xu, Li,Xie, Jian,Jia, Ling-Yun.Cephalin: An effective ligand for LDL-C adsorbent[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S429-S430 [50]Xu, Li,Jia, Ling-Yun,Xie, Jian.A novel biosurfactant sucrose laurate enhances biodegradation of high chlorinated PCBs[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S701-S701 [51]Zhang, Xiao-Rui,Xu, Li,Xie, Jian,Jia, Ling-Yun.A novel endotoxin adsorbent with branch ligand[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S436-S437 [52]Jia, Ling-Yun,Xu, Jin-Jing,Zheng, Ai-Ping,Xu, Li.Biodegradation properties and metabolic pathway of PCBs in Enterobacter sp LY402[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S701-S702 [53]Jia, Ling-Yun,Xu, Li,Xie, Jian.Effects of Tween-80 on microbial degradation of 2,3 ',4,4 '-tetrachlorinated biphenyl[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S701-S701 [54]闫妍,谢健,徐丽,贾凌云.Enterobacter sp.LY402在液相体系中好氧降解氯丹的研究[J],安徽农业科学,2008,36(23):10122-10123,10139 [55]Jia Ling-Yun,Zheng, Ai-Ping,Xu, Li,Huang, Xiao-Dong,Zhang, Qing,Yang, Feng-Lin.Isolation and characterization of comprehensive polychlorinated biphenyl-degrading bacterium, Enterobacter sp LY402[J],JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2008,18(5):952-957 [56]贾凌云,徐丽.Characterization of a novel polychlorinated biphenyl- degrading bacterium[A],2008 [57]贾凌云,徐丽.Biodegradation properties and metabolic pathway of PCBs in Enterobacter sp. LY402.[A],2008 [58]贾凌云,徐丽,谢健.Biodegradation of organochlorine pesticides adsorbed on activated carbon fiber felt.[A],2008 [59]贾凌云,徐丽,谢健.Aerobic degradation of dieldrin by Enterobacter sp. LY402.[A],2008 [60]贾凌云,徐丽,谢健.Study of hydrophobic interaction between immobilized ligands and proteins using an improved docking method.[A],2008 [61]贾凌云,徐丽,谢健.Isolation and characterization of PAHs degrading bacteria fromactivated sludge.[A],2008 [62]贾凌云,徐丽,谢健.Effects of Tween-80 on microbial degradation of 23’44’-tetrachlorinated biphenyl.[A],Journal of biotechnology,2008 [63]徐丽,谢健,贾凌云.A novel endotoxin adsorbent with branch ligand.[A],2008 [64]徐丽,谢健,贾凌云.Cephalin: An effective ligand for LDL-C adsorbent.[A],2008 [65]徐丽,贾凌云,谢健.A novel biosurfactant sucrose laurate enhances biodegradation of high chlorinated PCBs[A],Journal of biotechnology,2008
