个人简历
个人简介Personal Profile在大连理工大学分别获得学士、硕士和博士学位。2002.10-2004.10 美国西北大学化学系博士后。2001年7月至今在大连理工大学生命科学与技术学院任教，2015年聘为教授。围绕重大疾病相关的生物活性分子实时、动态、高灵敏的可视化检测及面向重大疾病治疗及检测的新型纳米载体和标记技术开展研究，获2项国家自然科学基金资助，发表研究论文50余篇，授权专利4项。教育经历1981.9 1984.7 山西大同矿务局一中 无1998.9 2001.6 大连理工大学 生物化工 博士1988.9 1991.7 大连理工大学 应用化学 硕士1984.9 1988.7 大连理工大学 煤化工 学士工作经历2001.7 至今 大连理工大学 教授1991.7 1998.8 辽宁省外贸开发区公司 业务员专利 噁嗪类化合物在制备近红外荧光探针中的应用 噁嗪类化合物及其应用 一种基于普鲁兰多糖的用于超声控制释放的纳米药物载体、药物载体系统及制备方法 肝靶向智能超声响应释药的载药载体、制备方法及其应用 噁嗪类化合物在制备近红外荧光探针中的应用 一类具有抗癌活性的苯并双萘醌衍生物 科研项目 肌红蛋白与细胞色素b5之间电子转移的研究, 主管部门科技项目, 2006/01/01-2008/03/31, 完成 典型高效生物催化剂及其反应体系的开发, 国家“973”项目 , 2008/08/21-2013/08/31, 完成 光诱导肌红蛋白的去氧、结合氧及传能机制研究, 国家自然科学基金项目, 2009/01/01-2011/12/31, 完成 活细胞（组织）线粒体微环境粘度可视化双光子比例荧光染料, 国家自然科学基金项目, 2013/09/25-2017/12/31, 完成 活细胞内酸泡质子可视化荧光染料探针, 国家自然科学基金项目, 2008/09/25-2011/12/31, 完成 生物分子检测及医学诊断用菁荧光标记染料, 省、市、自治区科技项目, 2007/01/01-2010/09/17, 完成
研究领域
研究方向用于肿瘤治疗的诊疗一体化多功能纳米材料药物/基因递送智能纳米材料与疾病相关的活细胞内离子、活性分子的荧光可视化选择性识别""
近期论文
[1]Gurram, Bhaskar,Li, Miao,Fan, Jiangli,Wang, Jingyun,Peng, Xiaojun.Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells[J],FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2020,14(1):41-52 [2]Shi, Chao,Sun, Wen,Du, Jianjun,Long, Saran,Wang, Jingyun,Peng, Xiaojun,Li, Mingle,Zhang, Zhen,Yao, Qichao,Shao, Kun,Xu, Feng,Xu, Ning,Li, Haidong,Fan, Jiangli.Catalase-based liposomal for reversing immunosuppressive tumor microenvironment and enhanced cancer chemo-photodynamic therapy[J],BIOMATERIALS,2020,233:119755 [3]Guo, Jianli,Wang, Qingling,Zhang, Yue,Sun, Wenhui,Zhang, Shuangzhe,Li, Yachen,Wang, Jingyun,Bao, Yongming.Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer[J],PHARMACOLOGICAL RESEARCH,2019,147:104387 [4]Xia, Jing,Chen, Qixian,Wang, Jingyun,Peng, Xiaojun,Li, Jiaxin,Yao, Qichao,Meng, Zhipeng,Qian, Ming,Cui, Hongyan,Zhang, Liuwei,Li, Yachen,Wu, Suli.Mitochondria specific oxidative injury by near-infrared energy transfer nanoclusters for amplified photodynamic potency[J],JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,557:45-54 [5]Wang, Jingyun,Xia, Ying,Liu, Huiying,Xia, Jing,Qian, Ming,Zhang, Liuwei,Chen, Lili,Chen, Qixian.Poly(lactobionamidoethyl methacrylate)-based amphiphiles with ultrasound-labile components in manufacture of drug delivery nanoparticulates for augmented cytotoxic efficacy to hepatocellular carcinoma[J],JOURNAL OF COLLOID AND INTERFACE SCIENCE,2019,551:1-9 [6]陈丽丽,姬芳玲,包永明,夏菁,王静云.药物/基因共载的普鲁兰多糖基阳离子纳米胶束在肿瘤治疗中的应用[A],2016,1-1 [7]Qian, Ming,Zhang, Liuwei,Wang, Jingyun,Peng, Xiaojun.A red-emitting fluorescent probe with large Stokes shift for real-time tracking of cysteine over glutathione and homocysteine in living cells[J],SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2019,214:469-475 [8]Gebremedhin, Kalayou H.,Li, Mingle,Gao, Fengli,Gurram, Bhaskar,Fan, Jiangli,Wang, Jingyun,Li, Yaming,Peng, Xiaojun.Benzo[a]phenoselenazine-based NIR photosensitizer for tumor-targeting photodynamic therapy via lysosomal-disruption pathway[J],DYES AND PIGMENTS,2019,170 [9]Li, Haidong,Peng, Xiaojun,Li, Yueqing,Yao, Qichao,Fan, Jiangli,Sun, Wen,Long, Saran,Shao, Kun,Du, Jianjun,Wang, Jingyun.In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe[J],CHEMICAL SCIENCE,2019,10(6):1619-1625 [10]Guo, Jianli,Tang, Qin,Wang, Qingling,Sun, Wenhui,Pu, Zhongji,Wang, Jingyun,Bao, Yongming.Pifithrin-alpha enhancing anticancer effect of topotecan on p53-expressing cancer cells[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2019,128:61-72 [11]Li, Haidong,Fan, Jiangli,Long, Saran,Du, Jianjun,Wang, Jingyun,Peng, Xiaojun.A fluorescent and colorimetric probe for imaging the mitochondrial sulfur dioxide in living cells[J],SENSORS AND ACTUATORS B-CHEMICAL,2018,273:899-905 [12]Sun, Peng,Li, Zhen,Wang, Jingyun,Gao, Hui,Yang, Xi,Wu, Sudong,Liu, Deqiang,Chen, Qixian.Transcellular delivery of messenger RNA payloads by a cationic supramolecular MOF platform[J],CHEMICAL COMMUNICATIONS,2018,54(80):11304-11307 [13]Li, Haidong,Peng, Xiaojun,Yao, Qichao,Xu, Feng,Xu, Ning,Sun, Wen,Long, Saran,Du, Jianjun,Fan, Jiangli,Wang, Jingyun.Lighting-Up Tumor for Assisting Resection via Spraying NIR Fluorescent Probe of gamma-Glutamyltranspeptidas[J],FRONTIERS IN CHEMISTRY,2018,6:485 [14]Yao, Qichao,Li, Haidong,Xian, Liman,Xu, Feng,Xia, Jing,Fan, Jiangli,Du, Jianjun,Wang, Jingyun,Peng, Xiaojun.Differentiating RNA from DNA by a molecular fluorescent probe based on the \
