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王淼
2023-05-09 16:51
  • 王淼
  • 王淼 - 博士 副教授 硕导-大连理工大学-生物工程学院-个人资料

近期热点

资料介绍

个人简历


人简介
Personal Profile
承担科研项目情况:
主持:
⑴AIB1促进乳腺癌转移的分子机制及临床检测意义,国家自然科学青年科学基金,项目号:81301504,时间:2014-01—2016-12。
⑵SRC-3在乳腺癌转移中的作用及其机制研究,中国博士后科学基金面上资助,项目号:2012M510797,时间:2012-05—2013-11。
⑶AIB1促乳腺癌转移的分子机制,中国博士后科学基金第六批特别资助,项目号:2013T60275,时间:2013-06—2013-11。
参加:
⑴SUMO化修饰对PES的调控及在乳腺癌发生发展中的作用,国家自然科学基金委员会,项目号:31301159,时间:2014-01—2016-12。
⑶SUMO化修饰对AhR的调控及在乳腺癌发生、发展中的作用,国家自然科学基金委员会,项目号:31271500,时间:2013-01—2016-12。
⑷TSP50抑制激活素信号转导途径的机制及其与乳腺癌发生相关性的研究,国家自然科学基金委员会,项目号:30672068,时间:2007-01—2009-12。
⑸结肠癌抑制基因SLC5A8表达调控机制及其中药表达激活剂筛选研究,国家自然科学基金委员会,项目号:30873409,时间:2009-01—2009-12。
⑹抗乳腺癌药物筛选模型的制备及抗乳腺癌中药新药筛选,吉林省科技厅,项目号:200805131,时间:2008-01—2010-12。
⑺TSP50在乳腺癌发生中的作用及其机制的研究,吉林省科技厅,项目号:20050114,时间:2005-01—2007-12。
⑻乳腺癌双重特异性早期诊断试剂盒,吉林省科技厅,项目号:20060923-01,时间:2006-10—2008-12。
⑼密环菌发酵技术及生产工艺的研究-密环菌DNA指纹研究,科技部,项目号:2007BAI38B06-02-1,时间:2007-12—2010-12。
⑽中药有效成分和药物分子作用靶标的计算机虚拟筛选,吉林省中医药管理局,项目号:2010pt067,时间:2010-12—2011-12。
奖励:
辽宁省医学科技奖,一等奖,排名第三,2016年
辽宁省自然科学奖,二等奖,排名第三,2014年
大连市科技进步奖,一等奖,排名第四,2013年
大连市科技进步奖,二等奖,排名第三,2016年
发明专利:
人睾丸特异性蛋白50基因表达调节剂筛选系统及筛选其基因表达调节剂的方法,专利号:200510016593.
教育经历
2007.9 2010.7 东北师范大学 植物学 博士
2004.9 2007.7 东北师范大学 细胞生物学 硕士
2000.9 2004.7 东北师范大学 生物技术 学士
1997.9 2000.7 长春外国语学校
工作经历
2013.11 至今 大连理工大学
2011.9 2013.11 化工环境生命学部博士后流动站

研究领域


研究方向:
肿瘤分子生物学
肿瘤细胞侵袭转移发生机制
癌基因抑癌基因在肿瘤发生发展中的作用""

近期论文


[1]Song, Xu,Huang, Liping,Lu, Hong,Zhou, Peng,Wang, Miao,Li, Ning.An external magnetic field for efficient acetate production from inorganic carbon in Serratia marcescens catalyzed cathode of microbial electrosynthesis system[J],BIOCHEMICAL ENGINEERING JOURNAL,2020,155
[2]Chen Huan,Wang Miao,Wu Huijian,Xu Zhaowei,Li Xiahui,Yang Yangyang,Li Bowen,Li Yanan,Xia Kangkai,Wang Jian,Li Shujing.α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression[J],Oncogenesis,2018,7(3):28
[3]Jia Zhaojun,Wu Huijian,Wang Miao,Li Shujing,Li Xiahui,Bai Xiao-Yan,Xu Zhaowei,Yang Yangyang,Li Bowen,Li Yanan.U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation.[J],Cell death & disease,2018,9(2):63
[4]Wang, Miao,Yang, Yuxi,Xu, Jian,Bai, Wen,Ren, Xueli,Wu, Huijian.CircRNAs as biomarkers of cancer: a meta-analysis.[J],BMC cancer,2018,18(1):303
[5]Chen, Huan,Wang, Miao,Wu, Huijian,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Wang, Jian,Li, Shujing.alpha-catenin SUMOylation increases IkappaBalpha stability and inhibits breast cancer progression.[J],Oncogenesis,2018,7(3)
[6]Bai, Xiao-Yan,Chen, Huan,Wu, Huijian,Li, Shujing,Wang, Miao,Li, Xiahui,Yang, Yangyang,Xu, Zhaowei,Li, Bowen,Li, Yanan,Xia, Kangkai.Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion[J],CANCER LETTERS,2018,412(412):224-235
[7]Xu, Zhaowei,Wu, Huijian,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Yang, Yuxi,Li, Xiahui,Wang, Miao,Li, Shujing.Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1.[J],Cell death & disease,2018,9(5):559
[8]Wang, Miao,Chen, Huan,Wu, Huijian,Li, Shujing,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Guo, Jing.SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling[J],ONCOTARGET,2017,8(52):89692-89706
[9]陈欢,王淼,伍会健.上皮-间质转化在肿瘤侵袭、转移及化疗耐药中的研究进展[J],中国细胞生物学学报,2017,39(7):978-983
[10]孙静静,王淼,伍会健.TRIM在肿瘤发生发展中的作用[J],中国细胞生物学学报,2017,39(1):106-113
[11]王淼.Krüppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion[J],Cancer letter,2017,412:224-235
[12]Li, Shujing,Wang, Miao,Qu, Xinjian,Xu, Zhaowei,Yang, Yangyang,Su, Qiming,Wu, Huijian.SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination[J],ONCOTARGET,2016,7(31):50507-50519
[13]Bi, H.,Yang, Y.,Wu, H.,Li, S.,Qu, X.,Wang, M.,Bai, X.,Xu, Z.,Ao, X.,Jia, Z.,Jiang, X..DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase[J],CELL DEATH & DISEASE,2015,6(9):e1891
[14]Bai, Xiao-Yan,Qu, Xinjian,Jiang, Xiao,Xu, Zhaowei,Yang, Yangyang,Su, Qiming,Wang, Miao,Wu, Huijian.Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects[J],JOURNAL OF CANCER,2015,6(9):913-921
[15]Bai, Xiao-Yan,Li, Shujing,Wang, Miao,Qu, Xinjian,Hu, Gaolei,Xu, Zhaowei,Chen, Min,He, Guo-Wei,Wu, Huijian.Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A > G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis[J],ANNALS OF HUMAN GENETICS,2015,79(3):173-187
[16]Zhao, F.,Wang, M.,Li, S.,Bai, X.,Bi, H.,Liu, Y.,Ao, X.,Jia, Z.,Wu, H..DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis[J],ONCOGENESIS,2015,4(3):e143
[17]张梅,王淼,伍会健.SUMO化修饰系统及其在肿瘤发展中的作用[J],中国细胞生物学学报,2015,37(10):1458-1464
[18]王淼.Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518AG Polymorphism with Susceptibility to Coronary Artery Disease A Meta-Analysis[J],Annals of Human Genetics,2015,3(79):173-187
[19]王淼.跨校区网络同步教学课程模式探索—“细胞生物学”课程改革[J],中国细胞生物学学报,2015,5(37):715-719
[20]王淼,李淑晶,伍会健.跨校区网络同步教学课程模式探索 细胞生物学课程改革[J],中国细胞生物学学报,2015,37(5):715-719
[21]Bi, Hailian,Li, Shujing,Wang, Miao,Jia, Zhaojun,Chang, Alan K.,Pang, Pengsha,Wu, Huijian.SUMOylation of GPS2 protein regulates its transcription-suppressing function[J],MOLECULAR BIOLOGY OF THE CELL,2014,25(16):2499-2508
[22]Xiao, Liyun,Chang, Alan K.,Zang, Ming-Xi,Bi, Hailian,Li, Shujing,Wang, Miao,Xing, Xinrong,Wu, Huijian.Induction of the CLOCK Gene by E2-ER alpha Signaling Promotes the Proliferation of Breast Cancer Cells[J],PLOS ONE,2014,9(5):e95878
[23]白晓彦,王淼,伍会健.一氧化氮相关的内皮功能障碍与高血压[J],生命的化学,2014,34(6):744-748
[24]王淼.Induction of the CLOCK Gene by E2-ERa Signaling[J],PLOS ONE,2014,9(5):1-13
[25]Li, S.,Wu, H.,Wang, M.,Ao, X.,Chang, A. K.,Yang, C.,Zhao, F.,Bi, H.,Liu, Y.,Xiao, L..CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha[J],ONCOGENE,2013,32(41):4883-4891
[26]Wang, Miao,Zhao, Feng,Li, Shujing,Chang, Alan K.,Jia, Zhaojun,Chen, Yixuan,Xu, Feihong,Pan, Hongming,Wu, Huijian.AIB1 Cooperates with ER alpha to Promote Epithelial Mesenchymal Transition in Breast Cancer through SNAI1 Activation[J],PLOS ONE,2013,8(6):e65556
[27]Yang, Chunhua,Li, Shen,Wu, Huijian,Li, Shujing,Wang, Miao,Chang, Alan K.,Liu, Ying,Zhao, Feng,Xiao, Liyun,Han, Lin,Wang, Dao.PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha[J],MOLECULAR CANCER,2013,12(1):21
[28]王淼.AIB1 cooperates with ERα to promote epithelial mesenchymal transition in breast cancer through SNAI1 activation[J],PLoS One,2013,8(6):1-13
[29]王淼..Steroid Receptor Co-activator-3 promotes breast cancer cell invasion and metastasis through SNAI1 expression[A],遗传学为人类造福——全球华人遗传学大会,2013
[30]Xing, Xinrong,Wu, Huijian,Bi, Hailian,Chang, Alan K.,Zang, Ming-Xi,Wang, Miao,Ao, Xiang,Li, Shen,Pan, Hongming,Guo, Qianping.SUMOylation of AhR modulates its activity and stability through inhibiting its ubiquitination[J],JOURNAL OF CELLULAR PHYSIOLOGY,2012,227(12):3812-3819

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