个人简历

教育经历
2006.9 2012.9 大连理工大学 生物化工 博士
2002.9 2006.7 辽宁大学 生物技术 学士
1999.9 2002.7 大连市第一高中
工作经历
2014.12 至今 大连理工大学 讲师
2012.7 2014.12 大连理工大学 博士后
著作成果
诺贝尔奖中的生命科学（下）
诺贝尔奖中的生命科学（上）
科研项目
PES1的化学修饰对乳腺癌细胞增殖的调控机理, 国务院其他部门, 2013/08/01-2014/12/05, 完成
节律蛋白CLOCK在妇科肿瘤发生、发展中的作用, 国务院其他部门, 2012/01/01-2014/12/05, 完成
SUMO化修饰对PES1的调控及在乳腺癌发生发展中的作用, 国家自然科学基金项目, 2013/09/25-2016/12/31, 完成
科研奖励
辽宁省自然科学奖
辽宁省科学技术奖
大连市科技进步二等奖
辽宁省医学科技一等奖
其他奖励
化工与环境生命学部青年教师讲课竞赛 （2015年）

研究领域

肿瘤分子生物学
周期节律与肿瘤发生发展机制""

近期论文

[1]Chen Huan,Wang Miao,Wu Huijian,Xu Zhaowei,Li Xiahui,Yang Yangyang,Li Bowen,Li Yanan,Xia Kangkai,Wang Jian,Li Shujing.α-catenin SUMOylation increases IκBα stability and inhibits breast cancer progression[J],Oncogenesis,2018,7(3):28
[2]Jia Zhaojun,Wu Huijian,Wang Miao,Li Shujing,Li Xiahui,Bai Xiao-Yan,Xu Zhaowei,Yang Yangyang,Li Bowen,Li Yanan.U-box ubiquitin ligase PPIL2 suppresses breast cancer invasion and metastasis by altering cell morphology and promoting SNAI1 ubiquitination and degradation.[J],Cell death & disease,2018,9(2):63
[3]Chen, Huan,Wang, Miao,Wu, Huijian,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Wang, Jian,Li, Shujing.alpha-catenin SUMOylation increases IkappaBalpha stability and inhibits breast cancer progression.[J],Oncogenesis,2018,7(3)
[4]李淑晶.α-catenin SUMOylation increases IκBαstability and inhibits breast cancer progression[J],Oncogenesis,2018
[5]Bai, Xiao-Yan,Chen, Huan,Wu, Huijian,Li, Shujing,Wang, Miao,Li, Xiahui,Yang, Yangyang,Xu, Zhaowei,Li, Bowen,Li, Yanan,Xia, Kangkai.Kruppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion[J],CANCER LETTERS,2018,412(412):224-235
[6]Xu, Zhaowei,Wu, Huijian,Yang, Yangyang,Li, Bowen,Li, Yanan,Xia, Kangkai,Yang, Yuxi,Li, Xiahui,Wang, Miao,Li, Shujing.Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1.[J],Cell death & disease,2018,9(5):559
[7]李淑晶.Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breastcancer cell proliferation via deacetylase SIRT1[J],Cell death & disease,2018
[8]Wang, Miao,Chen, Huan,Wu, Huijian,Li, Shujing,Xu, Zhaowei,Li, Xiahui,Yang, Yangyang,Li, Bowen,Li, Yanan,Guo, Jing.SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling[J],ONCOTARGET,2017,8(52):89692-89706
[9]李霞辉,李淑晶,伍会健.近日节律对乳腺癌他莫昔芬耐药的影响[J],生命的化学,2017,37(3):313-318
[10]Li, Shujing,Wang, Miao,Qu, Xinjian,Xu, Zhaowei,Yang, Yangyang,Su, Qiming,Wu, Huijian.SUMOylation of PES1 upregulates its stability and function via inhibiting its ubiquitination[J],ONCOTARGET,2016,7(31):50507-50519
[11]Jiang, Xiao,Zhang, Mei,Bai, Xiao-Yan,Li, Shujing,Wu, Huijian.Association between 17q25.3-rs6465657 polymorphism and prostate cancer susceptibility: a meta-analysis based on 19 studies[J],ONCOTARGETS AND THERAPY,2016,9:4491-4503
[12]Ao, Xiang,Li, Shujing,Xu, Zhaowei,Yang, Yangyang,Chen, Min,Jiang, Xiao,Wu, Huijian.Sumoylation of TCF21 downregulates the transcriptional activity of estrogen receptor-alpha[J],ONCOTARGET,2016,7(18):26220-26234
[13]Bi, H.,Yang, Y.,Wu, H.,Li, S.,Qu, X.,Wang, M.,Bai, X.,Xu, Z.,Ao, X.,Jia, Z.,Jiang, X..DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase[J],CELL DEATH & DISEASE,2015,6(9):e1891
[14]Bai, Xiao-Yan,Li, Shujing,Wang, Miao,Qu, Xinjian,Hu, Gaolei,Xu, Zhaowei,Chen, Min,He, Guo-Wei,Wu, Huijian.Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A > G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis[J],ANNALS OF HUMAN GENETICS,2015,79(3):173-187
[15]Zhao, F.,Wang, M.,Li, S.,Bai, X.,Bi, H.,Liu, Y.,Ao, X.,Jia, Z.,Wu, H..DACH1 inhibits SNAI1-mediated epithelial-mesenchymal transition and represses breast carcinoma metastasis[J],ONCOGENESIS,2015,4(3):e143
[16]Cui, Xiaoneng,Zhao, Jianzhang,Lou, Zhangrong,Li, Shujing,Wu, Huijian,Han, Ke-li.Switching of the Triplet Excited State of Rhodamine/Naphthaleneimide Dyads: An Experimental and Theoretical Study[J],JOURNAL OF ORGANIC CHEMISTRY,2015,80(1):568-581
[17]王淼,李淑晶,伍会健.跨校区网络同步教学课程模式探索 细胞生物学课程改革[J],中国细胞生物学学报,2015,37(5):715-719
[18]杨杨杨,李淑晶,伍会健.F-box蛋白家族在肿瘤发生中的作用[J],中国细胞生物学学报,2015,37(8):1180-1186
[19]李淑晶.Association of Monocyte Chemoattractant Protein-1(MCP-1)-2518AG Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis[J],Annals of Human Genetics,2015,79(3):137-187
[20]Zhao, Jianzhang,Huang, Ling,Cui, Xiaoneng,Li, Shujing,Wu, Huijian.Maximizing the thiol-activated photodynamic and fluorescence imaging functionalities of theranostic reagents by modularization of Bodipy-based dyad triplet photosensitizers[J],JOURNAL OF MATERIALS CHEMISTRY B,2015,3(47):9194-9211
[21]陈敏,李淑晶,伍会健.泛素化与SUMO化对DNA损伤应答的调控作用简[J],生命的化学,2015,35(6):801-806
[22]Bi, Hailian,Li, Shujing,Wang, Miao,Jia, Zhaojun,Chang, Alan K.,Pang, Pengsha,Wu, Huijian.SUMOylation of GPS2 protein regulates its transcription-suppressing function[J],MOLECULAR BIOLOGY OF THE CELL,2014,25(16):2499-2508
[23]Xiao, Liyun,Chang, Alan K.,Zang, Ming-Xi,Bi, Hailian,Li, Shujing,Wang, Miao,Xing, Xinrong,Wu, Huijian.Induction of the CLOCK Gene by E2-ER alpha Signaling Promotes the Proliferation of Breast Cancer Cells[J],PLOS ONE,2014,9(5):e95878
[24]Li N.,Song Y.,Yu W.,Lv G.,Ma X.,Zhang Y.,Liu Y.,Xiu Z.,Tan M.,Li S.,Guo X.,Wang Y.,Chen L..Improved islet purity by the hypertonic-hypotonic method[J],International Journal of Artificial Organs,2014,37(6):477-485
[25]Li, S.,Wu, H.,Wang, M.,Ao, X.,Chang, A. K.,Yang, C.,Zhao, F.,Bi, H.,Liu, Y.,Xiao, L..CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha[J],ONCOGENE,2013,32(41):4883-4891
[26]Li, Shujing,Ao, Xiang,Wu, Huijian.The role of circadian rhythm in breast cancer[J],CHINESE JOURNAL OF CANCER RESEARCH,2013,25(4):442-450
[27]Wang, Miao,Zhao, Feng,Li, Shujing,Chang, Alan K.,Jia, Zhaojun,Chen, Yixuan,Xu, Feihong,Pan, Hongming,Wu, Huijian.AIB1 Cooperates with ER alpha to Promote Epithelial Mesenchymal Transition in Breast Cancer through SNAI1 Activation[J],PLOS ONE,2013,8(6):e65556
[28]Yang, Chunhua,Li, Shen,Wu, Huijian,Li, Shujing,Wang, Miao,Chang, Alan K.,Liu, Ying,Zhao, Feng,Xiao, Liyun,Han, Lin,Wang, Dao.PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha[J],MOLECULAR CANCER,2013,12(1):21
[29]Li, Shujing,Chang, Alan K.,Xiao, Liyun,Zhang, Yuanyuan,Wu, Huijian,Yang, Chunhua,Hong, Yongde,Bi, Hailian,Zhao, Feng,Liu, Ying,Ao, Xiang,Pang, Pengsha,Xing, Xinrong.The transcriptional activity of co-activator AIB1 is regulated by the SUMO E3 Ligase PIAS1[J],BIOLOGY OF THE CELL,2012,104(5):287-296
[30]Hong, Yongde,Wu, Huijian,Xing, Xinrong,Li, Shujing,Bi, Hailian,Yang, Chunhua,Zhao, Feng,Liu, Ying,Ao, Xiang,Chang, Alan K..SUMOylation of DEC1 Protein Regulates Its Transcriptional Activity and Enhances Its Stability[J],PLOS ONE,2011,6(8):e23046
[31]李淑晶,毕海连,伍会健.泛素连接酶APC/C和SCF复合物与肿瘤的关系[J],北京大学学报（医学版）,2010,42(2):243-封3
[32]敖翔,李淑晶,伍会健.周期节律与肿瘤关系的分子机理[J],中国生物化学与分子生物学报,2010,26(11):998-1002
[33]李淑晶,刘文栋,伍会健.二恶英对雌激素受体的干扰作用[J],生命科学,2008,20(5):764-767
[34]杨春华,李淑晶,伍会健.PTEN对ERα转录活性的调节[A],东北三省生物化学与分子生物学学会2008年学术交流会,2008,1
[35]李淑晶,程智逵,伍会健.SUMO在转录中的抑制作用[J],中国生物化学与分子生物学报,2007,23(7):525-530