个人简历

专利
用于致病微生物高通量快速检测的微流控芯片及其制备方法
用于血脑屏障药物通透性高通量筛选的微流控芯片及制备方法
一种基于固态双凝胶的微生物三维群落结构分析芯片及应用
用于体外溶血栓药物效果分析的双层微流控芯片及制备方法
一种收集昆虫蜻吐出液的方法及装置
一种昆虫蛹吐出液收集装置
科研项目
大肠癌SEPT9甲基化检测试剂盒开发 (RT-PCR法）, 企事业单位委托科技项目, 2016/10/19-2020/12/30, 进行
柞蚕核型多角体病毒编码的MicroRNA的挖掘与功能分析, 省、市、自治区科技项目, 2016/07/19, 进行
昆虫杆状病毒系统表达ppGalNAc-T4蛋白, 企事业单位委托科技项目, 2015/12/11-2017/12/31, 完成
基因工程改造秸秆产纤维素酶发酵生产生物质能源的关键技术研究, 省、市、自治区科技项目, 2011/01/01-2012/12/31, 完成
农业生物技术, 省、市、自治区科技项目, 2007/01/01-2009/12/31, 完成
新型蚊子相关细菌种类的分离与特征分析Isolationandcharacterizationofthenovelmosquito-associatedbacterialspeciesThorselliaanophelis, 2012/01/01, 完成

研究领域

"研究领域
昆虫发育与抗病机制
生物大分子的结构与功能"

近期论文

[1]Zhang, Cheng,Wu, Qiong,Huang, Huang,Chen, Xixi,Huang, Tianmiao,Li, Wenli,Liu, Yubo,Zhang, Jianing.Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells[J],JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,2019,75(4):549-559
[2]申宇,安利佳,李文利.球孢白僵菌侵染的柞蚕蛹体壁和脂肪体组织病理观察[J],昆虫学报,2018,61(8):923-931
[3]刘宇博,张娜娜,陈锦娇,朱彤,张嘉宁,李文利.O-连接N-乙酰葡糖胺转移酶抑制剂的筛选与活性分析[J],高等学校化学学报,2018,39(06):1185-1190
[4]史艳丽,刘宇博,吴思晋,刘亚军,张嘉宁,李文利.ApIV 3C蛋白酶抑制剂的虚拟筛选及活性测定[J],高等学校化学学报,2018,39(4):701-707
[5]刘宇博,张娜娜,陈锦娇,朱彤,张嘉宁,李文利.Discovery and Activity Verification of a O-GlcNAc Transferase Inhibitor by Structure-based Virtual Screening. [J],Chemical Journal of Chinese Universities,2018,39:1185-1190
[6]Liu Y.,Cao Y.,Pan X.,Shi M.,Wu Q.,Huang T.,Jiang H.,Li W.,Zhang J..O-GlcNAc elevation through activation of the hexosamine biosynthetic pathway enhances cancer cell chemoresistance.[J],Cell death & disease,2018,9(5)
[7]Huang, Huang,Liu, Yubo,Yu, Peishan,Qu, Jianhua,Guo, Yanjie,Li, Wenli,Wang, Shujing,Zhang, Jianing.MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3.[J],Scientific reports,2018,8(1):7366
[8]史艳丽,刘宇博,吴思晋,刘亚军,张嘉宁,李文利.Virtual Screening and Activity Verification of Novel Inhibitors of Apiv 3c Protease.[J],Chemical Journal of Chinese Universities,2018,39:701-707
[9]Liu, Yubo,Ren, Yang,Cao, Yu,Huang, Huang,Wu, Qiong,Li, Wenli,Wu, Sijin,Zhang, Jianing.Discovery of a Low Toxicity O-GlcNAc Transferase (OGT) Inhibitor by Structure-based Virtual Screening of Natural Products[J],SCIENTIFIC REPORTS,2017,7(1):12334
[10]张程,吴琼,黄天淼,黄煌,刘宇博,李文利,张嘉宁.小鼠肝癌细胞中Caveolin-1通过JNK、p38、ERK信号转导途径调控pofut1表达[A],2017第七届泛环渤海生物化学与分子生物学会学术交流会,2017,1
[11]黄天淼,吴琼,张程,黄煌,刘宇博,李文利,张嘉宁.N-乙酰氨基半乳糖转移酶8通过调控C1GALT1和COMSC影响乳腺癌的O-GalNAc糖基化修饰[A],2017第七届泛环渤海生物化学与分子生物学会学术交流会,2017,1
[12]吴琼,张程,黄天淼,黄煌,刘宇博,李文利,张嘉宁.ppGaINAc-T4调控人乳腺癌细胞转移潜能[A],2017第七届泛环渤海生物化学与分子生物学会学术交流会,2017,1
[13]Li, Wenli,Lin, Lan,Terenius, Olle,Zhang, Zhengyao.Antheraea pernyi (Lepidoptera: Saturniidae) and Its Importance in Sericulture, Food Consumption, and Traditional Chinese Medicine[J],JOURNAL OF ECONOMIC ENTOMOLOGY,2017,110(4):1404-1411
[14]Liu, Yubo,Huang, Huang,Liu, Meijun,Wu, Qiong,Li, Wenli,Zhang, Jianing.MicroRNA-24-1 suppresses mouse hepatoma cell invasion and metastasis via directly targeting O-GlcNAc transferase[J],BIOMEDICINE & PHARMACOTHERAPY,2017,91:731-738
[15]Liu, Yubo,Huang, Huang,Cao, Yu,Wu, Qiong,Li, Wenli,Zhang, Jianing.Suppression of OGT by microRNA24 reduces FOXA1 stability and prevents breast cancer cells invasion[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,487(3):755-762
[16]Geng, Peng,Li, Wenli,de Miranda, Joachim R.,Qian, Zhou,An, Lijia,Terenius, Olle.Studies on the transmission and tissue distribution of Antheraea pernyi iflavirus in the Chinese oak silkmoth Antheraea pernyi[J],VIROLOGY,2017,502:171-175
[17]Jiang, Xiran,Zhou, Xiaoya,Liu, Qi,Zheng, Lulu,Yu, Ning,Li, Wenli.Expression of Acidothermus cellulolyticus thermostable cellulases in tobacco and rice plants[J],BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT,2017,31(1):23-28
[18]王乃红,耿鹏,李文利.柞蚕传染性软腐病病毒2C蛋白的表达纯化和酶活性分析[J],蚕业科学,2017,43(2):253-259
[19]蒋西然,章燕,秦红梅,冯智田,于宁,李文利,覃开蓉.微流控芯片技术在公共卫生监测中的应用[J],中国医疗设备,2016,31(8):5-8
[20]蒋西然,李文利,覃开蓉.微流控芯片技术在公共卫生检测中的应用[J],中国医疗设备,2016,31(8):6-8
[21]李文利.Expression of Acidothermus cellulolyticus thermostable cellulases in tobacco and rice plants[J],Biotechnology & Biotechnological Equipment,2016,30(12):23-28
[22]Dai, Yiming,Li, Wenli,An, Lijia.NMD mechanism and the functions of Upf proteins in plant[J],PLANT CELL REPORTS,2016,35(1):5-15
[23]Li, Peipei,Fan, Qi,Xing, Hua,Zhao, Zhenjun,Yang, Zhaoqing,Cao, Yaming,Li, Wenli,Yan, Guiyun,Sattabongkot, Jetsumon,Cui, Liwang.Genetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border area[J],ACTA TROPICA,2015,152:26-31
[24]蒋西然,覃开蓉,李灵,于宁,张馨跃,白莉娟,秦红梅,章燕,冯智田,李文利.微流控芯片快速检测空气气流中金黄葡萄球菌的研究[J],水动力学研究与进展A辑,2015,30(6):619-623
[25]王乃红,宋丽新,靳月琴,李文利.家蚕蛾吐出液溶茧酶的溶栓作用研究[J],中国蚕业,2015,36(4):48-53
[26]刘真英,李文利.密码子优化后的柞蚕溶菌酶在酵母中的表达及活性测定[J],微生物学通报,2015,43(2):292-300
[27]戴一明,安利佳,李文利.耐旱相关基因SiUPF3的克隆表达及生物信息学分析[J],植物生理学报,2015,51(4):509-516
[28]李文利.柞蚕核型多角体病毒内源性非编码小ＲNA 成熟体MD5 作用[J],蚕业科学,2015,41(1):71-79
[29]宋丽新,刘丹梅,李文利.柞蚕核型多角体病毒内源性非编码小RNA成熟体MD5作用的宿主靶基因及功能预测[J],蚕业科学,2015,41(1):72-79
[30]Liu D.-M.,Li W.-L..Fluorescence tracking of exogenous DNA in genetic transformation of the chinese oak Silkmoth Antheraea Pernyi via sperm-mediated gene transfer[J],Journal of Donghua University (English Edition),2014,31(4):391-395
[31]余琴鸯,尹恒,安利佳,李文利.谷子逆境应答相关的钙依赖蛋白激酶基因SiCDPK1的克隆与表达[J],作物学报,2014,40(9):1531-1539
[32]孙风敏,韩焱,李文利.基于密码子优化的蛋白酶K在毕赤酵母中的表达及分离纯化[J],微生物学通报,2014,41(11):2198-2207
[33]Li, Peipei,Sirichaisinthop, Jeeraphat,Li, Shuying,Yan, Guiyun,Cui, Liwang,Fan, Qi,Zhao, Zhenjun,Wang, Ying,Xing, Hua,Parker, Daniel M.,Yang, Zhaoqing,Baum, Elizabeth,Li, Wenli,Sattabongkot, Jetsumon.Nested PCR detection of malaria directly using blood filter paper samples from epidemiological surveys[J],MALARIA JOURNAL,2014,13(1)
[34]尹恒,余琴鸯,安利佳,李文利.一个快速响应干旱的F-box基因的克隆和表达分析[J],作物学报,2014,40(6):1027-1034
[35]Geng, Peng,Li, Wenli,Lin, Lan,de Miranda, Joachim R.,Emrich, Scott,An, Lijia,Terenius, Olle.Genetic Characterization of a Novel Iflavirus Associated with Vomiting Disease in the Chinese Oak Silkmoth Antheraea pernyi[J],PLOS ONE,2014,9(3):e92107
[36]Geng, Peng,Lin, Lan,Li, Yuan,Fan, Qi,Wang, Naihong,Song, Lixin,Li, Wenli.A novel fibrin(ogen)olytic trypsin-like protease from Chinese oak silkworm (Antheraea pernyi): Purification and characterization[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,445(1):64-70
[37]Yu, Qinyang,An, Lijia,Li, Wenli.The CBL-CIPK network mediates different signaling pathways in plants[J],PLANT CELL REPORTS,2014,33(2):203-214
[38]刘丹梅,安利佳,李文利.新型柞蚕双元基因转移载体的构建及在Ｓｆ９ 细胞中的表达[J],蚕业科学,2014,40(1):38-44
[39]李文利,安利佳.The CBL–CIPK network mediates different signaling pathwaysin plants[J],Plant Cell Rep,2014,14(33):203-214
[40]李文利,安利佳.Structural and Functional Characterization of the Actin-1 Gene Promoter From theAntheraea pernyi (Lepidoptera: Saturniidae)[J],Journal of Insect Science,2014,14(3):1-7
[41]Liu, Danmei,Geng, Peng,Jiang, Xiran,An, Lijia,Li, Wenli.Structural and Functional Characterization of the Actin-1 Gene Promoter From the Antheraea pernyi (Lepidoptera: Saturniidae)[J],JOURNAL OF INSECT SCIENCE,2014,14:173
[42]李文利.柞蚕核型多角体病毒基因组编码VmiRNA的预测与功能分析/[J],中国畜牧兽医文摘,2014,8:58-58
[43]李文利,刘媛,李凤娟,李亚洁.柞蚕免疫相关基因Apdorsal 的克隆鉴定与表达分析[J],蚕业科学,2014,40(1):32-37
[44]李文利,韩焱,方素云.ApNPV 诱导柞蚕脂肪体和中肠组织中3 个脂肪酶基因的表达及表达载体构建[J],蚕业科学,2014,40(4):639-647
[45]耿鹏,周倩,安利佳,Olle Terenius,李文利.柞蚕传染性软腐病病毒(Iflavirus)功能蛋白的基因克隆和结构分析[J],蚕业科学,2014,40(5):843-850
[46]王乃红,宋丽新,靳月琴,李文利.家蚕溶茧酶收集方法的建立及活性测定[J],北方蚕业,2013,3:9-12
[47]李文利,林澜,王乃红,栾雨时.柞蚕核型多角体病毒基因组编码VmiRNA的预测与功能分析[J],蚕业科学,2013,39(2):324-332
[48]李凤娟,李亚洁,李文利.昆虫免疫防御分子Hemolin的研究进展[J],生命科学研究,2012,16(1):90-94
[49]李凤娟,姜德富,李喜升,王凤成,李文利.柞蚕模式识别受体betaGRP的基因克隆及序列特征和诱导表达谱分析[J],蚕业科学,2012,38(3):449-455
[50]李文利.cDNA Cloning and Expression Analysis of Pattern RecognitionProteins from the Chinese Oak Silkmoth, Antheraea pernyi[J],Insects,2012,3(3):1093-1104
[51]李凤娟,姜德富,李喜升,李文利.柞蚕模式识别受体βGRP 的基因克隆及序列特征和诱导表达[J],蚕业科学,2012,38(3):449-455
[52]Sun, Shou-Hui,Li, Yu-Ping,Zheng, Ya-Nan,Xu, Xiao-Rui,Jin, Xiang-Dong,Wu, Song,Li, Wen-Li,Liu, Yan-Qun.Molecular Cloning, Expression Pattern, and Phylogenetic Analysis of a Selenophosphate synthetase Gene From Antheraea pernyi (Lepidoptera: Saturniidae)[J],ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA,2011,104(6):1373-1379
[53]Jiang, Xi-ran,Zhou, Xiao-ya,Jiang, Wen-yan,Gao, Xiao-rong,Li, Wen-li.Expressions of thermostable bacterial cellulases in tobacco plant[J],BIOTECHNOLOGY LETTERS,2011,33(9):1797-1803
[54]刘丹梅,王芬,李文利.蜘蛛拖牵丝蛋白基因的克隆与表达[J],基因组学与应用生物学,2011,30(1):16-20
[55]李文利.Cloning and Expression of Spider Dragline Silk Protein Gene in Escherichia coli and Eukaryotic Cell[J],Molecular Entomology,2011,2(1):1-5
[56]蒋西然,刘纪文,李文利.嗜热菌在纤维素乙醇中的研究进展及应用前景[J],生命科学研究,2010,14(5):449-455
[57]Han, Yan,Niu, Mingshan,An, Lijia,Li, Wenli.Involvement of TLR21 in baculovirus-induced interleukin-12 gene expression in avian macrophage-like cell line HD11[J],VETERINARY MICROBIOLOGY,2010,144(1-2):75-81
[58]Zhang, Yu,Jiang, Bo,Li, Wenli,Zhou, Cheng,Ji, Fangling,Xie, Qun,Sun, Xiaojiao,An, Lijia,Bao, Yongming.Mechanisms of Analgesic Action of Gln49-PLA(2) from Gloydius ussurensis Snake Venom[J],APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2010,160(3):773-779
[59]贺建华,李文利,魏立君,夏秀英.人β淀粉样蛋白基因植物表达载体的构建及转化[J],华北农学报,2009,24(z1):23-26
[60]蒋西然,李文利.纤维素乙醇基因工程研究进展[J],中国生物工程杂志,2009,29(7):127-133
[61]Han, Yan,Niu, Mingshan,An, Lijia,Li, Wenli.Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-kappa B pathways[J],INTERNATIONAL IMMUNOPHARMACOLOGY,2009,9(7-8):817-823
[62]韩焱,牛铭山,李文利,安利佳.柞蚕杆状病毒诱导鸡异嗜白细胞脱粒效应的信号转导通路[J],蚕业科学,2009,35(2):403-407
[63]Xu, Shurong,Liu, Danmei,Li, Wenli.Upregulated proteins associated with fibroin synthesis in posterior silk glands of Antheraea pernyi fifth instar larvae[J],COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS,2009,4(2):105-110
[64]徐淑荣,刘丹梅,李文利.柞蚕谷胱甘肽硫转移酶-theta基因(GSTT)的克隆及其在5龄幼虫丝腺中的表达规律[J],蚕业科学,2009,35(1):66-70
[65]李文利.Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-κB pathways[J],International Immunopharmacology,2009,9(7):817-823
[66]Niu, Mingshan,Han, Yan,Li, Wenli.Baculovirus up-regulates antiviral systems and induces protection against infectious bronchitis virus challenge in neonatal chicken[J],INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(12):1609-1615
[67]冷春玲,李文利.柞蚕核型多角体病毒IE-1基因启动子的克隆与分析[J],华北农学报,2008,23(5):147-150
[68]Liu, Danmei,Li, Wenli,An, Lijia.Construct of a dual-marker transfer vector mediated by transposon piggybac and its expression in hela cells[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S233-S234
[69]Yan, Han,Niu, Mingshan,Li, Wenli,An, Lijia.Insect baculoviruse selectively up-regulates TLRS expression and induces the innate immune response via p38-dependent, ERK-independent pathways in avian macrophage cells (HD11)[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S256-S257
[70]Niu, Mingshan,Li, Wenli,Han, Yan,An, Lijia.Baculovirus induces protective antiviral innate immune responses in neonatal chicken[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S256-S256
[71]Yang, Guoling,Zhang, Mingli,Li, Wenli,An, Lijia.Direct species identification of common pathogenic dermatophyte fungi in clinical specimens by semi-nested PCR and restriction fragment length polymorphism[J],MYCOPATHOLOGIA,2008,166(4):203-208
[72]金礼吉,李文利,徐永平,安利佳.Isolation of genomic sequences flanking the fibroin gene of Antheraea pernyi by using thermal asymmetric interlaced PCR[J],Journal of Biotechnology, 第13届国际生物技术大会,2008,136:230-230
[73]李文利,安利佳.Construct of a dual-marker transfer vector mediated by transposon piggybac and its expression in hela cells[A],2008,252-260
[74]李文利,安利佳.Insect baculoviruse selectively up-regulates TLRS expression and induces the innate immune response via p38-dependent, ERK-independent pathways in avian macrophage cells (HD11)[A],2008,252-260
[75]李文利,安利佳.Baculovirus induces protective antiviral innate immune responses in neonatal chicken[A],2008,252-260
[76]张明莉,杨国玲,李文利,安利佳.半巢式PCR-RFLP法快速鉴定临床标本中的皮肤癣菌[J],中国皮肤性病学杂志,2007,21(12):729-732
[77]杨国玲,杜迎春,张明莉,李文利,安利佳.传代对红色毛癣菌表型和核糖体基因影响的研究[J],中国皮肤性病学杂志,2007,21(5):263-266
[78]杨国玲,孙晓岩,李文利,安利佳.AP-PCR快速鉴定甲真菌病病原菌的研究[J],中国真菌学杂志,2007,2(2):89-91
[79]李志强,于凤泉,田春晖,孙富余,李文利.辽宁省不同地域稻水象甲分子遗传差异及其意义研究[J],辽宁农业科学,2006,1:1-3
[80]李文利,金礼吉,范琦,安利佳.柞蚕丝素基因 5′端部分序列的克隆及结构分析[J],中国农业科学,2002,35(2):218-221
[81]李文利,范琦,高晓蓉,迟彦,安利佳.β-1,3葡聚糖酶与糖体失活蛋白融合基因的制备及表达载体的构建[J],生物技术,2001,11(3):1-5
[82]高晓蓉,安利佳,范琦,李文利,康晓慧.大豆β-1,3-葡聚糖酶基因的研究初报[J],农业生物技术学报,2000,03:240-247