个人简历

个人简介
Personal Profile
刘田，2014年入选辽宁省高等学校优秀人才支持计划和首批大连市青年科技之星，2015年入选大连理工大学星海学优青人才培养计划。2018年7月-2019年6月在新加坡南洋理工大学材料科学与工程学院访学一年。曾在J. Biol. Chem.、Biotechnol. Adv.及J. Agric. Food Chem.等期刊发表SCI论文40余篇。主持国家自然科学基金(2项)、国家重点研发计划子课题(2项)等项目，作为骨干参与国家杰出青年基金、国家自然科学基金重点项目等项目。曾获第13届国际生物技术大会青年科学家及学生奖等荣誉。常年招收博士及硕士研究生（学术型及专业型均可，有出国交流机会），欢迎联系及报考！
教育经历
2004.9 2009.9 大连理工大学 生物化工 博士
1999.9 2003.6 大连理工大学 生物工程 学士
1996.9 1999.6 沈阳市第五中学
专利
小檗碱及其衍生物作为己糖胺酶抑制剂的应用
高效几丁质酶突变体的制备方法及应用
春雷霉素及其衍生物为几丁质酶抑制剂的应用
小檗碱及其衍生物作为己糖胺酶抑制剂的应用
萘酰亚胺衍生物及其其用途
绿盲蝽多聚半乳糖醛酸酶的基因及其应用
著作成果
Bioprocess Sciences and Technology第16章：Insect chitin-remodeling enzymes:physiological roles, applications and preparation.
科研项目
基于钻蛀害虫的新靶标发掘与防治研究, 国家科技部 , 2017/07/24, 进行
基于靶标昆虫几丁质外切酶OfHex1的农药分子设计, 其他课题, 2016/06/01, 进行
组合酶法水解菌丝体生产功能糖的工艺开发, 企事业单位委托科技项目, 2016/01/01-2016/12/31, 完成
组合酶法水解真菌菌丝体制备壳寡糖, 企事业单位委托科技项目, 2014/07/01-2015/02/28, 完成
2014年大连市创新人才培育计划-青年科技之星, 省、市、自治区科技项目, 进行
2014年度辽宁省高等学校优秀人才支持计划（第二层次）, 省、市、自治区科技项目, 2014/07/11, 进行
其他奖励
教学质量优良奖 （2016年）
大连理工大学创业大赛优秀指导教师 （2018年）
教学质量优良奖 （2017年）
教学质量优良奖 （2015年）
大连理工大学第二批“星海优青” （2015年）
大连市青年科技之星 （2014年）

研究领域

昆虫学—表皮相关害虫防治靶标的发现及应用
生物材料学—受昆虫表皮启发的生物材料设计与应用
结构生物学—靶标结构功能研究及药物设计
酶工程—糖基水解酶的发现、改造及应用""

近期论文

[1]Liu Lin,Qu Mingbo,Liu Tian,Chen Qi,Guo Xingming,Yang Jun,Yang Qing.Biochemical characterization of three midgut chitin deacetylases of the Lepidopteran insect Bombyx mori[J],Journal of insect physiology,2019,113:42-48
[2]Wang, Jigang,Wang, Gang,Wu, Tingting,Wang, Di,Yuan, Yuyu,Wang, Jianren,Liu, Tian,Wang, Lili,Qiu, Jieshan.Quaternary Ammonium Compound Functionalized Activated Carbon Electrode for Capacitive Deionization Disinfection[J],ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2018,6(12):17204-17210
[3]Yang, Huibin,Liu, Tian,Qi, Huitang,Huang, Zhisong,Hao, Zesheng,Ying, Junwu,Yang, Qing,Qian, Xuhong.Design and synthesis of thiazolylhydrazone derivatives as inhibitors of chitinolytic N-acetyl-beta-D-hexosaminidase[J],BIOORGANIC & MEDICINAL CHEMISTRY,2018,26(20):5420-5426
[4]姜熙,刘田,杨青.几丁质酶抑制剂的发现[A],中国生物化学与分子生物学会第十二届全国会员代表大会暨2018年全国学术会议,2018,1
[5]Duan, Yanwei,Liu, Tian,Zhou, Yong,Dou, Tongyi,Yang, Qing.Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2018,293(40):15429-15438
[6]Dong, Yawen,Jiang, Xi,Liu, Tian,Ling, Yun,Yang, Qing,Zhang, Li,He, Xiongkui.Structure-Based Virtual Screening, Compound Synthesis, and Bioassay for the Design of Chitinase Inhibitors[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(13):3351-3357
[7]Liu, Tian,Duan, Yanwei,Yang, Qing.Revisiting glycoside hydrolase family 20 beta-N-acetyl-d-hexosaminidases: Crystal structures, physiological substrates and specific inhibitors.[J],Biotechnology advances,2018,36(4):1127-1138
[8]Liu, Tian,Zhu, Weixing,Wang, Jing,Zhou, Yong,Duan, Yanwei,Qu, Mingbo,Yang, Qing.The deduced role of a chitinase containing two nonsynergistic catalytic domains[J],ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY,2018,74(Pt 1):30-40
[9]Wang, Di,Li, Anjie,Han, Hongyu,Liu, Tian,Yang, Qing.A potent chitinase from Bacillus subtilis for the efficient bioconversion of chitin-containing wastes.[J],International journal of biological macromolecules,2018,116:863-868
[10]Chen, Lei,Liu, Tian,Duan, Yanwei,Lu, Xinhua,Yang, Qing.Microbial Secondary Metabolite, Phlegmacin B-1, as a Novel Inhibitor of Insect Chitinolytic Enzymes[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(19):3851-3857
[11]Liu, Tian,Chen, Lei,Zhou, Yong,Jiang, Xi,Duan, Yanwei,Yang, Qing.Structure, Catalysis, and Inhibition of OfChi-h, the Lepidoptera-exclusive Insect Chitinase[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2017,292(6):2080-2088
[12]Jiang, Xi,Kumar, Ashutosh,Liu, Tian,Zhang, Kam Y. J.,Yang, Qing.A Novel Scaffold for Developing Specific or Broad-Spectrum Chitinase Inhibitors[J],JOURNAL OF CHEMICAL INFORMATION AND MODELING,2016,56(12):2413-2420
[13]Zhu, Weixing,Wang, Di,Liu, Tian,Yang, Qing.Production of N-Acetyl-D-glucosamine from Mycelial Waste by a Combination of Bacterial Chitinases and an Insect N-Acetyl-D-glucosaminidase[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(35):6738-6744
[14]姜熙,刘田,杨青.基于昆虫几丁质酶结构的抑制剂筛选[A],2016,1-1
[15]陈磊,刘田,段燕伟,杨青.基于昆虫糖基水解酶的抑制剂筛选[A],2016,1-1
[16]Kong, Hanchu,Chen, Wei,Liu, Tian,Lu, Huizhe,Yang, Qing,Dong, Yanhong,Liang, Xiaomei,Jin, Shuhui,Zhang, Jianjun.Synthesis of NAM-thiazoline derivatives as novel O-GlcNAcase inhibitors[J],CARBOHYDRATE RESEARCH,2016,429:54-61
[17]刘田,杨青.A novel scaffold for developing specific or broad-spectrum chitinase[J],Journal of Chemical Information and Modelling,2016,56(12):2413-2420
[18]刘田,杨青.Production of N-acetyl-D-glucosamine from mycelial waste by a combination of bacterial[J],Journal of Agricultural and Food Chemistry,2016,64(35):6738-6744
[19]段燕伟,刘田,杨青.昆虫I家族N-乙酰-D-己糖胺酶的结构、功能与抑制剂[J],中国科学. 化学,2016,46(11):1155-1164
[20]Liu, Tian,Xia, Meng,Zhang, Haitao,Zhou, Hao,Wang, Jing,Shen, Xu,Yang, Qing.Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic beta-acetylglucosaminidases[J],FEBS LETTERS,2015,589(1):110-116
[21]刘田,周豪,杨青.Exploring NAG-thiazoline and its derivatives as inhibitors of chitinolytic β-acetylglucosaminidases[J],FEBS Letters,2015,589(1)
[22]Liu, Tian,Guo, Peng,Zhou, Yong,Wang, Jing,Chen, Lei,Yang, Huibin,Qian, Xuhong,Yang, Qing.A crystal structure-guided rational design switching non-carbohydrate inhibitors' specificity between two beta-GlcNAcase homologs[J],SCIENTIFIC REPORTS,2014,4:6188
[23]屈明博,刘田,陈磊,陈琦,杨青.昆虫糖基水解酶20家族β-N-乙酰己糖胺酶研究进展[J],中国农业科学,2014,7:1303-1312
[24]Chen, Lei,Liu, Tian,Zhou, Yong,Chen, Qi,Shen, Xu,Yang, Qing.Structural characteristics of an insect group I chitinase, an enzyme indispensable to moulting[J],ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY,2014,70(Pt 4):932-942
[25]Liu, Tian,Chen, Lei,Ma, Qiang,Shen, Xu,Yang, Qing.Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors[J],CURRENT PHARMACEUTICAL DESIGN,2014,20(5):754-770
[26]Chen, Qi,Guo, Peng,Xu, Lin,Liu, Tian,Qian, Xuhong,Yang, Qing.Exploring unsymmetrical dyads as efficient inhibitors against the insect beta-N-acetyl-D-hexosaminidase OfHex2[J],BIOCHIMIE,2014,97(1):152-162
[27]屈明博,刘田,陈磊,陈琦,杨青.昆虫糖基水解酶20家族beta-N-乙酰己糖胺酶研究进展[J],中国农业科学,2014,47(7):1303-1312
[28]刘田,周勇,杨青.A crystal structure-guided rational design switching non-carbohydrate inhibitors specificity between two β-GlcNAcase homologs.[J],Scientific Reports,2014,4(1):6188-6188
[29]Qu, Mingbo,Liu, Tian,Chen, Peng,Yang, Qing.A Sperm-Plasma beta-N-Acetyl-D-Hexosaminidase Interacting with a Chitinolytic beta-N-Acetyl-D-Hexosaminidase in Insect Molting Fluid[J],PLOS ONE,2013,8(8):e71738
[30]Guo, Peng,Chen, Qi,Liu, Tian,Xu, Lin,Yang, Qing,Qian, Xuhong.Development of Unsymmetrical Dyads As Potent Noncarbohydrate-Based Inhibitors against Human beta-N-Acetyl-D-hexosaminidase[J],ACS MEDICINAL CHEMISTRY LETTERS,2013,4(6):527-531
[31]刘田,陈磊,沈旭,杨青.Structural Insights into Chitinolytic Enzymes and Inhibition Mechanisms of Selective Inhibitors[A],第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会,2013,50-50
[32]Wu, Qingyue,Liu, Tian,Yang, Qing.Cloning, expression and biocharacterization of OfCht5, the chitinase from the insect Ostrinia furnacalis[J],INSECT SCIENCE,2013,20(2):147-157
[33]刘田,杨青.A Sperm–Plasma β-N-acetyl-D-hexosaminidase interacting with a chitinolytic β-N-acetyl-D-hexosaminidase in insect molting fluid.[J],PLoS One,2013,8(8):1-8
[34]Jia, Cang-Zhi,Liu, Tian,Wang, Zhi-Ping.O-GlcNAcPRED: a sensitive predictor to capture protein O-GlcNAcylation sites[J],MOLECULAR BIOSYSTEMS,2013,9(11):2909-2913
[35]Liu, Tian,Wu, Qingyue,Liu, Lin,Yang, Qing.Elimination of substrate inhibition of a beta-N-acetyl-D-hexosaminidase by single site mutation[J],PROCESS BIOCHEMISTRY,2013,48(1):103-108
[36]Liu, Tian,Zhou, Yong,Chen, Lei,Chen, Wei,Liu, Lin,Shen, Xu,Zhang, Wenqing,Zhang, Jianzhen,Yang, Qing.Structural Insights into Cellulolytic and Chitinolytic Enzymes Revealing Crucial Residues of Insect beta-N-acetyl-D-hexosaminidase[J],PLOS ONE,2012,7(12):e52225
[37]Liu, Fengyi,Liu, Tian,Qu, Mingbo,Yang, Qing.Molecular and Biochemical Characterization of a Novel beta-N-Acetyl-D-Hexosaminidase with Broad Substrate-Spectrum from the Aisan Corn Borer, Ostrinia Furnacalis[J],INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2012,8(8):1085-1096
[38]Wang, Yanli,Liu, Tian,Yang, Qing,Li, Zhong,Qian, Xuhong.A Modeling Study for Structure Features of beta-N-acetyl-D-hexosaminidase from Ostrinia furnacalis and its Novel Inhibitor Allosamidin: Species Selectivity and Multi-Target Characteristics[J],CHEMICAL BIOLOGY & DRUG DESIGN,2012,79(4):572-582
[39]Liu, Tian,Yan, Jun,Yang, Qing.Comparative Biochemistry of GH3, GH20 and GH84 beta-N-acetyl-D-hexosaminidases and Recent Progress in Selective Inhibitor Discovery[J],CURRENT DRUG TARGETS,2012,13(4):512-525
[40]Liu, Tian,Zhang, Haitao,Liu, Fengyi,Chen, Lei,Shen, Xu,Yang, Qing.Active-pocket size differentiating insectile from bacterial chitinolytic beta-N-acetyl-D-hexosaminidases[J],BIOCHEMICAL JOURNAL,2011,438(3):467-474
[41]Jia, Cangzhi,Liu, Tian,Chang, Alan K.,Zhai, Yingying.Prediction of mitochondrial proteins of malaria parasite using bi-profile Bayes feature extraction[J],BIOCHIMIE,2011,93(4):778-782
[42]Yang, You,Liu, Tian,Yang, Yongliang,Wu, Qingyue,Yang, Qing,Yu, Biao.Synthesis, Evaluation, and Mechanism of N,N,N-Trimethyl-D-glucosamine-(1 -> 4)-chitooligosaccharides as Selective Inhibitors of Glycosyl Hydrolase Family 20 beta-N-Acetyl-D-hexosaminidases[J],CHEMBIOCHEM,2011,12(3):457-467
[43]施倩,刘鹏飞,刘田,杨青,徐晓勇.含氟N,N'-二芳基异硫脲的合成及昆虫β-N-乙酰己糖胺酶抑制活性研究[J],现代农药,2011,10(1):16-20,23
[44]Liu, Tian,Zhang, Haitao,Liu, Fengyi,Wu, Qingyue,Shen, Xu,Yang, Qing.Structural Determinants of an Insect beta-N-Acetyl-D-hexosaminidase Specialized as a Chitinolytic Enzyme[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(6):4049-4058
[45]Qu, Mingbo,Liu, Tian,Yang, Jun,Yang, Qing.The gene, expression pattern and subcellular localization of chitin synthase B from the insect Ostrinia furnacalis[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2011,404(1):302-307
[46]刘田,杨青.Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases.[J],Biochemical Journal, 2011,438(3): 467-474,2011,438(3):467-474
[47]刘田,杨青.Structural determinants of an insect β-N-acetyl-D-hexosaminidase specialized as a chitinolytic enzyme.[J],JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286:4049-4058.,2011,286(1):4049-4058
[48]刘田,杨永亮,杨青.Synthesis, evaluation, and mechanism of N,N,N-Tri-methyl-D-glucosamine-β-1,4-chitooligosaccharides as selective inhibitors of glycosyl hydrolase family 20 β-N-acetyl-D-hexosaminidases.[J],CHEMBIOCHEM,2011,12:457-467.,2011,12:457-467
[49]Liu, Tian,Jia, Cangzhi.A high-accuracy protein structural class prediction algorithm using predicted secondary structural information[J],JOURNAL OF THEORETICAL BIOLOGY,2010,267(3):272-275
[50]Liu, Tian,Liu, Fengyi,Yang, Qing,Yang, Jun.Expression, purification and characterization of the chitinolytic beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis[J],PROTEIN EXPRESSION AND PURIFICATION,2009,68(1):99-103
[51]Jia, Cangzhi,Liu, Tian,Zhang, Xiangde,Fu, Haoyue,Yang, Qing.Alignment-free Comparison of Protein Sequences Based on Reduced Amino Acid Alphabets[J],JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2009,26(6):763-769
[52]Jia, Cangzhi,Liu, Tian,Zhang, Xiangde,Yan, Shijun.Protein Secondary Structure Class Assignment on the Basis of a New Graphic Representation[J],INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY,2009,109(4):819-825
[53]Yang, Qing,Liu, Tian,Liu, Fengyi,Qu, Mingbo,Qian, Xuhong.A novel beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis (Guenee)[J],FEBS JOURNAL,2008,275(22):5690-5702
[54]Liu, Tian,Qu, Mingbo,Yang, Qing,Yang, Jun,Qian, Xuhong.Cloning and expression of two novel beta-N-acetyl-D-hexosaminidases from the insect Ostrinia furnacalis (Guenee)[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S109-S109