个人简历

教育经历
2008.9 2013.7 大连理工大学 生物化工 博士
2006.9 2008.6 大连理工大学 生物化工 硕士
2002.9 2006.6 大连理工大学 生物工程 学士
1999.9 2002.7 安阳一中
工作经历
2013.12 至今 大连理工大学 讲师
科研项目
2R,3R-丁二醇脱氢酶识别催化手性底物的结构和功能研究, 国家自然科学基金项目, 2015/08/18, 完成
仿生蛋白A血液净化材料及其制备方法, 企事业单位委托科技项目, 2014/12/05-2034/12/05, 进行

研究领域

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近期论文

[1]Peng, Qiang,Zang, Berlin,Zhao, Wei,Li, Da,Ren, Jun,Ji, Fangling,Jia, Lingyun.Efficient continuous-flow aldehyde tag conversion using immobilized formylglycine generating enzyme[J],CATALYSIS SCIENCE & TECHNOLOGY,2020,10(2):484-492
[2]Zang, Berlin,Ren, Jun,Li, Da,Huang, Chundong,Ma, Ha,Peng, Qiang,Ji, Fangling,Han, Lulu,Jia, Lingyun.Freezing-assisted synthesis of covalent C-C inked bivalent and bispecific nanobodies[J],ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(2):257-263
[3]袁文杰,姬芳玲,孜力汗,贾凌云.新工科形势下的生产实习与管理模式探索[J],高校生物学教学研究（电子版）,2018,8(6):31-34
[4]Zhang Yue,Ji Fangling,Wang Jingyun,Pu Zhongji,Jiang Bo,Bao Yongming.Purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from Psychrobacter sp. ZY124.[J],Extremophiles : life under extreme conditions,2018,22(2):287-300
[5]Ji, Fangling,Feng, Yanbin,Li, Mingyang,Yang, Yongliang,Wang, Tianqi,Wang, Jingyun,Bao, Yongming,Xue, Song.Studies on structure-function relationships of acetolactate decarboxylase from Enterobacter cloacae[J],RSC ADVANCES,2018,8(68):39066-39073
[6]Wang, Qingling,Ji, Fangling,Guo, Jianli,Wang, Yuepeng,Li, Yanyan,Wang, Jingyun,An, Lijia,Bao, Yongming.LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11[J],MICROBIOLOGICAL RESEARCH,2018,214:60-73
[7]Ji, Fangling,Bao, Yongming,Li, Mingyang,Feng, Yanbin,Wu, Sijin,Wang, Tianqi,Pu, Zhongji,Wang, Jingyun,Yang, Yongliang,Xue, Song.Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis.[J],Applied microbiology and biotechnology,2018,102(15):6479-6491
[8]Tang, Qin,Ji, Fangling,Wang, Jingyun,Guo, Lianying,Li, Yachen,Bao, Yongming.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,109:223-232
[9]Pu, Zhongji,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Sun, Wenhui,Bao, Yongming.Rational design of Meso-2,3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations[J],FEBS LETTERS,2017,591(20):3402-3413
[10]王蒙,孙文辉,姬芳玲,蒲中机,李寅生,包永明.人巨细胞病毒抗原表位的重组表达及免疫原性分析[J],中国生物工程杂志,2017,37(7):27-33
[11]Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Wang, Yuepeng,Zhang, Yue,Bao, Yongming.Metabolic engineering of Bacillus sp for diacetyl production[J],PROCESS BIOCHEMISTRY,2017,58:69-77
[12]Tang, Qin,Ji, Fangling,Sun, Wenhui,Wang, Jingyun,Guo, Jianli,Guo, Lianying,Li, Yachen,Bao, Yongming.Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects[J],PHYTOMEDICINE,2016,23(14):1778-1786
[13]Song, Ting,Wang, Ziqian,Ji, Fangling,Feng, Yingang,Fan, Yudan,Chai, Gaobo,Li, Xiangqian,Li, Zhiqiang,Zhang, Zhichao.Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination[J],ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(46):14248-14254
[14]Ji, Fangling,Li, Lu,Ma, Shuai,Wang, Jingyun,Bao, Yongming.Production of rhamnolipids with a high specificity by Pseudomonas aeruginosa M408 isolated from petroleum-contaminated soil using olive oil as sole carbon source[J],ANNALS OF MICROBIOLOGY,2016,66(3):1145-1156
[15]Tang, Qin,Ji, Fangling,Guo, Jianli,Wang, Jingyun,Li, Yachen,Bao, Yongming.Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin[J],BIOMEDICINE & PHARMACOTHERAPY,2016,82:693-703
[16]郝文博,姬芳玲,王静云,张悦,包永明.代谢工程改造枯草芽孢杆菌生产丁二酮[A],2016,1-1
[17]Wang, Qingling,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Lu,An, Lijia,Li, Yachen,Bao, Yongming.Characterization of a salt-activated protease with temperature-dependent secretion in Stenotrophomonas maltophilia FF11 isolated from frozen Antarctic krill[J],JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2016,43(6):829-840
[18]王南,唐琴,姬芳玲,窦佳,包永明.天山雪莲细胞培养物对RANKL诱导破骨细胞的影响[J],中成药,2016,38(1):1-6
[19]郝文博,姬芳玲,王静云,张悦,王天琪,车文实,包永明.D194 G突变对meso-2,3-丁二醇脱氢酶催化特性的影响[J],中国生物工程杂志,2016,36(1):47-54
[20]Li, Lu,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Yachen,Bao, Yongming.Efficient mono-acylation of fructose by lipase-catalyzed esterification in ionic liquid co-solvents[J],CARBOHYDRATE RESEARCH,2015,416:51-58
[1]Peng, Qiang,Zang, Berlin,Zhao, Wei,Li, Da,Ren, Jun,Ji, Fangling,Jia, Lingyun.Efficient continuous-flow aldehyde tag conversion using immobilized formylglycine generating enzyme[J],CATALYSIS SCIENCE & TECHNOLOGY,2020,10(2):484-492
[2]Zang, Berlin,Ren, Jun,Li, Da,Huang, Chundong,Ma, Ha,Peng, Qiang,Ji, Fangling,Han, Lulu,Jia, Lingyun.Freezing-assisted synthesis of covalent C-C inked bivalent and bispecific nanobodies[J],ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(2):257-263
[3]袁文杰,姬芳玲,孜力汗,贾凌云.新工科形势下的生产实习与管理模式探索[J],高校生物学教学研究（电子版）,2018,8(6):31-34
[4]Zhang Yue,Ji Fangling,Wang Jingyun,Pu Zhongji,Jiang Bo,Bao Yongming.Purification and characterization of a novel organic solvent-tolerant and cold-adapted lipase from Psychrobacter sp. ZY124.[J],Extremophiles : life under extreme conditions,2018,22(2):287-300
[5]Ji, Fangling,Feng, Yanbin,Li, Mingyang,Yang, Yongliang,Wang, Tianqi,Wang, Jingyun,Bao, Yongming,Xue, Song.Studies on structure-function relationships of acetolactate decarboxylase from Enterobacter cloacae[J],RSC ADVANCES,2018,8(68):39066-39073
[6]Wang, Qingling,Ji, Fangling,Guo, Jianli,Wang, Yuepeng,Li, Yanyan,Wang, Jingyun,An, Lijia,Bao, Yongming.LotS/LotR/Clp, a novel signal pathway responding to temperature, modulating protease expression via c-di-GMP mediated manner in Stenotrophomonas maltophilia FF11[J],MICROBIOLOGICAL RESEARCH,2018,214:60-73
[7]Ji, Fangling,Bao, Yongming,Li, Mingyang,Feng, Yanbin,Wu, Sijin,Wang, Tianqi,Pu, Zhongji,Wang, Jingyun,Yang, Yongliang,Xue, Song.Structural and enzymatic characterization of acetolactate decarboxylase from Bacillus subtilis.[J],Applied microbiology and biotechnology,2018,102(15):6479-6491
[8]Tang, Qin,Ji, Fangling,Wang, Jingyun,Guo, Lianying,Li, Yachen,Bao, Yongming.Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin[J],EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2017,109:223-232
[9]Pu, Zhongji,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Sun, Wenhui,Bao, Yongming.Rational design of Meso-2,3-butanediol dehydrogenase by molecular dynamics simulation and experimental evaluations[J],FEBS LETTERS,2017,591(20):3402-3413
[10]王蒙,孙文辉,姬芳玲,蒲中机,李寅生,包永明.人巨细胞病毒抗原表位的重组表达及免疫原性分析[J],中国生物工程杂志,2017,37(7):27-33
[11]Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Wang, Yuepeng,Zhang, Yue,Bao, Yongming.Metabolic engineering of Bacillus sp for diacetyl production[J],PROCESS BIOCHEMISTRY,2017,58:69-77
[12]Tang, Qin,Ji, Fangling,Sun, Wenhui,Wang, Jingyun,Guo, Jianli,Guo, Lianying,Li, Yachen,Bao, Yongming.Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects[J],PHYTOMEDICINE,2016,23(14):1778-1786
[13]Song, Ting,Wang, Ziqian,Ji, Fangling,Feng, Yingang,Fan, Yudan,Chai, Gaobo,Li, Xiangqian,Li, Zhiqiang,Zhang, Zhichao.Deactivation of Mcl-1 by Dual-Function Small-Molecule Inhibitors Targeting the Bcl-2 Homology 3 Domain and Facilitating Mcl-1 Ubiquitination[J],ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(46):14248-14254
[14]Ji, Fangling,Li, Lu,Ma, Shuai,Wang, Jingyun,Bao, Yongming.Production of rhamnolipids with a high specificity by Pseudomonas aeruginosa M408 isolated from petroleum-contaminated soil using olive oil as sole carbon source[J],ANNALS OF MICROBIOLOGY,2016,66(3):1145-1156
[15]Tang, Qin,Ji, Fangling,Guo, Jianli,Wang, Jingyun,Li, Yachen,Bao, Yongming.Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin[J],BIOMEDICINE & PHARMACOTHERAPY,2016,82:693-703
[16]郝文博,姬芳玲,王静云,张悦,包永明.代谢工程改造枯草芽孢杆菌生产丁二酮[A],2016,1-1
[17]Wang, Qingling,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Lu,An, Lijia,Li, Yachen,Bao, Yongming.Characterization of a salt-activated protease with temperature-dependent secretion in Stenotrophomonas maltophilia FF11 isolated from frozen Antarctic krill[J],JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY,2016,43(6):829-840
[18]王南,唐琴,姬芳玲,窦佳,包永明.天山雪莲细胞培养物对RANKL诱导破骨细胞的影响[J],中成药,2016,38(1):1-6
[19]郝文博,姬芳玲,王静云,张悦,王天琪,车文实,包永明.D194 G突变对meso-2,3-丁二醇脱氢酶催化特性的影响[J],中国生物工程杂志,2016,36(1):47-54
[20]Li, Lu,Ji, Fangling,Wang, Jingyun,Jiang, Bo,Li, Yachen,Bao, Yongming.Efficient mono-acylation of fructose by lipase-catalyzed esterification in ionic liquid co-solvents[J],CARBOHYDRATE RESEARCH,2015,416:51-58
[21]王南,唐琴,姬芳玲,许青,包永明.天山雪莲愈伤组织提取物对人成骨肉瘤细胞MG-63增殖及分化的影响[J],中草药,2015,46(19):2900-2907
[22]Li, Lu,Ji, Fangling,Wang, Jingyun,Li, Yachen,Bao, Yongming.Esterification degree of fructose laurate exerted by Candida antarctica lipase B in organic solvents[J],ENZYME AND MICROBIAL TECHNOLOGY,2015,69:46-53
[23]姬芳玲,包永明,王静云.New bifunctional-pullulan-based micelles with good biocompatibility for efficient co-delivery of cancer-suppressing p53gene and doxorubicin to cancer cells[J],RSC Advances,2015,5(5):94719-94731
[24]Chen, Lili,Wang, Xiaohong,Ji, Fangling,Bao, Yongming,Wang, Jingyun,Wang, Xianwu,Guo, Lianying,Li, Yachen.New bifunctional-pullulan-based micelles with good biocompatibility for efficient co-delivery of cancer-suppressing p53 gene and doxorubicin to cancer cells[J],RSC ADVANCES,2015,5(115):94719-94731
[25]Wang, Jingyun,Ji, Fangling,Xing, Jishuang,Cui, Shuang,Bao, Yongming,Hao, Wenbo.Lipase Immobilization onto the Surface of PGMA-b-PDMAEMA-grafted Magnetic Nanoparticles Prepared via Atom Transfer Radical Polymerization[J],CHINESE JOURNAL OF CHEMICAL ENGINEERING,2014,22(11-12):1333-1339
[26]Hao, Wenbo,Ji, Fangling,Wang, Jingyun,Zhang, Yue,Wang, Tianqi,Bao, Yongming.Biochemical characterization of unusual meso-2,3-butanediol dehydrogenase from a strain of Bacillus subtilis[J],JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC,2014,109:184-190
[27]包永明,王天琪,姬芳玲.细菌3-羟基丁酮及氧化还原产物代谢的研究进展[J],微生物学杂志,2014,34(4):1-6
[28]王静云,姬芳玲,包永明.Lipase Immobilization onto the Surface of PGMA-b-PDMAEMA-grafted[J],Chinese Journal of Chemical Engineering,2014,22(11):1333-1339
[29]Ji, Fangling,Koharudin, Leonardus M. I.,Jung, Jinwon,Gronenborn, Angela M..Crystal structure of the cataract-causing P23T D-crystallin mutant[J],PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2013,81(9):1493-1498
[30]Ji, Fangling,Jung, Jinwon,Koharudin, Leonardus M. I.,Gronenborn, Angela M..The Human W42R gamma D-Crystallin Mutant Structure Provides a Link between Congenital and Age-related Cataracts[J],JOURNAL OF BIOLOGICAL CHEMISTRY,2013,288(1):99-109
[31]Ji, Fangling,Jung, Jinwon,Gronenborn, Angela M..Structural and Biochemical Characterization of the Childhood Cataract-Associated R76S Mutant of Human gamma D-Crystallin[J],BIOCHEMISTRY,2012,51(12):2588-2596
[32]Zhang, Yu,Jiang, Bo,Li, Wenli,Zhou, Cheng,Ji, Fangling,Xie, Qun,Sun, Xiaojiao,An, Lijia,Bao, Yongming.Mechanisms of Analgesic Action of Gln49-PLA(2) from Gloydius ussurensis Snake Venom[J],APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2010,160(3):773-779
[33]窦佳,蔡河,姬芳玲,崔文举,王静云,包永明,安利佳.Gln49-磷脂酶A2基因工程定点突变及酶活性分析[J],中国生物工程杂志,2007,27(5):21-27