个人简历

教育经历
2001.9 2004.7 大连理工大学 生物化工 博士
1989.9 1992.7 长春中医学院 中药 硕士
1985.9 1989.7 长春中医学院 中药 学士
1982.9 1985.7 吉林省辽源矿务局第一高中 无
工作经历
2004.7 至今 大连理工大学 教师
1992.9 2001.9 大连海洋药业公司 工作
专利
黄芩素与10-羟基喜树碱的药物组合物及其应用
7-环己基甲基-5-（2’-氨基）苯基白杨素及其制备方法和应用
梓醇的制备新方法和含它的药物组合物及用途
黄芩素与10-羟基喜树碱的药物组合物及其应用
著作成果
生物化学
生物化学
科研项目
新型小动物红外自动追踪系统的开发, 企事业单位委托科技项目, 2015/10/15-2019/03/31, 完成
多棘海盘车氨基多糖的抗肿瘤活性研究, 省、市、自治区科技项目, 2010/01/01, 完成
五味子醇乙抗阿尔茨海默病的活性研究, 省、市、自治区科技项目, 2008/01/01, 完成
抗老年性痴呆国家一类新药“意泰“的研究, 企事业单位委托科技项目, 2007/05/01-2008/12/01, 完成
抗老年性痴呆一类新药梓醇的开发, 企事业单位委托科技项目, 2010/06/01-2012/12/30, 完成
梓醇抗小鼠帕金森病作用及机制研究, 省、市、自治区科技项目, 2007/01/01-2009/12/31, 完成
科研奖励
辽宁省科技进步奖
大连市科学技术奖励

研究领域

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近期论文

[1]Zang, Berlin,Ren, Jun,Li, Da,Huang, Chundong,Ma, Ha,Peng, Qiang,Ji, Fangling,Han, Lulu,Jia, Lingyun.Freezing-assisted synthesis of covalent C-C inked bivalent and bispecific nanobodies[J],ORGANIC & BIOMOLECULAR CHEMISTRY,2019,17(2):257-263
[2]Xu, Li,Wang, Rou,Cao, Hanyu,Xu, Ting,Han, Lulu,Huang, Chundong,Jia, Lingyun.A facile method to oriented immobilization of His-tagged BirA on Co3+ -NTA agarose beads[J],ENZYME AND MICROBIAL TECHNOLOGY,2019,120:36-42
[3]Yang, Liwei,Sun, He,Jiang, Wenning,Xu, Ting,Song, Bing,Peng, Ruilian,Han, Lulu,Jia, Lingyun.A Chemical Method for Specific Capture of Circulating Tumor Cells Using Label-Free Polyphenol-Functionalized Films[J],CHEMISTRY OF MATERIALS,2018,30(13):4372-4382
[4]Yang, Liwei,Han, Lulu,Jia, Lingyun.Galloyl groups-regulated fibrinogen conformation: Understanding antiplatelet adhesion on tannic acid coating[J],ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,2018,255
[5]Li Jingyu,Han Lulu,Liu Shuxin,He Sai,Cao Yaming,Xie Jian,Jia Lingyun.Removal of indoxyl sulfate by water-soluble poly-cyclodextrins in dialysis.[J],Colloids and surfaces. B, Biointerfaces,2018,164:406-413
[6]韩璐璐,贾凌云.Galloyl groups-regulated fibrinogen conformation: Understanding antiplatelet adhesion on tannic acid coating[A],ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,2018,255:495-495
[7]Han, Lulu,Liu, Qi,Yang, Liwei,Ye, Tong,He, Zhien,Jia, Lingyun.Facile Oriented Immobilization of Histidine-Tagged Proteins on Nonfouling Cobalt Polyphenolic Self-Assembly Surfaces[J],ACS BIOMATERIALS SCIENCE & ENGINEERING,2017,3(12):3328-3337
[8]Yang, Liwei,Han, Lulu,Jia, Lingyun.Novel platelet-repellent polyphenolic surfaces and their micropattern for platelet adhesion detection[J],ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY,2017,253
[9]Yang, Liwei,Han, Lulu,Jia, Lingyun.A Novel Platelet-Repellent Polyphenolic Surface and Its Micropattern for Platelet Adhesion Detection[J],ACS APPLIED MATERIALS & INTERFACES,2016,8(40):26570-26577
[10]韩璐璐,韦厚良,贾凌云.自组装石墨烯凝胶对血液中胆红素的去除[A],2016,1-1
[11]杨立为,韩璐璐,贾凌云.基于单宁酸自组装膜循环肿瘤细胞高效捕捉与无损释放[A],2016,1-1
[12]Han, Lulu,Chu, Simin,Wei, Houliang,Ren, Jun,Xu, Li,Jia, Lingyun.Functionalized Magnetic Fe3O4-beta-Cyclodextran Nanoparticles for Efficient Removal of Bilirubin[J],JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(6):5537-5545
[13]贾凌云,韩璐璐.Functionalized Magnetic Fe3O4-beta-Cyclodextran Nanoparticals for Efficient Removal of Bilirubin[J],JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,6(16):5537-5545
[14]贾凌云,韩璐璐.Coating process and stability of metal-polyphenol film[J],Colloids and Surfaces A: Physicochemical and Engineering Aspects,2016,484(484):197-205
[15]Yang, Liwei,Han, Lulu,Ren, Jun,Wei, Houliang,Jia, Lingyun.Coating process and stability of metal-polyphenol film[J],COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2015,484:197-205
[16]Wei, Houliang,Han, Lulu,Tang, Yongchao,Ren, Jun,Zhao, Zongbin,Jia, Lingyun.Highly flexible heparin-modified chitosan/graphene oxide hybrid hydrogel as a super bilirubin adsorbent with excellent hemocompatibility[J],JOURNAL OF MATERIALS CHEMISTRY B,2015,3(8):1646-1654
[17]Wei, Houliang,Han, Lulu,Ren, Jun,Jia, Lingyun.Anticoagulant Surface Coating Using Composite Polysaccharides with Embedded Heparin-Releasing Mesoporous Silica[J],ACS APPLIED MATERIALS & INTERFACES,2013,5(23):12571-12578
[18]Wei, Houliang,Ren, Jun,Han, Bo,Xu, Li,Han, Lulu,Jia, Lingyun.Stability of polydopamine and poly(DOPA) melanin-like films on the surface of polymer membranes under strongly acidic and alkaline conditions[J],COLLOIDS AND SURFACES B-BIOINTERFACES,2013,110:22-28
[21]Zhao, Xin-Qing,Jiao, Wen-Ce,Jiang, Bo,Yuan, Wen-Jie,Yang, Tian-Hong,Hao, Shuang.Screening and identification of actinobacteria from marine sediments: Investigation of potential producers for antimicrobial agents and type I polyketides[J],WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,2009,25(5):859-866
[22]Bi, Jing,Jiang, Bo,Hao, Shuang,Zhang, Aihong,Dong, Yuesheng,Jiang, Tao,An, Lijia.Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons[J],NEUROCHEMISTRY INTERNATIONAL,2009,54(3-4):264-270
[23]Zhu, Yanxia,Liu, Tianqing,Song, Kedong,Jiang, Bo,Ma, Xuehu,Cui, Zhanfeng.Collagen-chitosan polymer as a scaffold for the proliferation of human adipose tissue-derived stem cells[J],JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2009,20(3):799-808
[24]Sun, Li-Hui,Jiang, Bo,Xiu, Zhi-Long.Aqueous two-phase extraction of 2,3-butanediol from fermentation broths by isopropanol/ammonium sulfate system[J],BIOTECHNOLOGY LETTERS,2009,31(3):371-376
[25]包永明,安利佳,姜波.Effects ofcatalpolonmitochondrialfunctionandworkingmemoryinmice[J],Experimental and ToxicologicPathology 61(2009),2009,61(12):461-467
[26]梁建华,杜静,xuliandeng,姜波.Catalpol protects primary cultured cortical neurons induced by Ab1–42 through a[J],Neurochemistry International,2009,55(8):741-746
[27]Jiang, Bo,Li, Zhi-Gang,Dai, Jian-Ying,Zhang, Dai-Jia,Xiu, Zhi-Long.Aqueous two-phase extraction of 2,3-butanediol from fermentation broths using an ethanol/phosphate system[J],PROCESS BIOCHEMISTRY,2009,44(1):112-117
[28]Bi, Jing,Wang, Xiao-bo,Chen, Lei,Hao, Shuang,An, Li-jia,Jiang, Bo,Guo, Lei.Catalpol protects mesencephalic neurons against MPTP induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity[J],TOXICOLOGY IN VITRO,2008,22(8):1883-1889
[29]Sun, Li-Hui,Jiang, Bo,Xiu, Zhi-Long.Aqueous two-phase extraction for the recovery of 2,3-butanediol by isopropanol/ammonium sulphate system[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S499-S500
[30]Zhang, Xiuli,Jiang, Bo,Wang, Jingyun,An, Lijia.Comparison of techniques for the extraction of the neuroprotective drug catalpol from Rehmannia glutinosa Libosch[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S471-S471
[31]Bi, Jing,Jiang, Tao,Hao, Shuang,Jiang, Bo.Catalpol protects mesencephalic neurons against MPTP-induced neurotoxicity via attenuation of mitochondrial dysfunction and MAO-B activity[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S81-S82
[32]Jiang, Bo,Li, Zhigang,Zhang, Daijia,Xiu, Zhilong.Separation of 2,3-butanediol from fermentation broths with ethanol/phosphate aqueous two-phase system[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S500-S501
[33]Bi, Jing,Jiang, Bo,Liu, Jian Hui,Lei, Chen,Zhang, Xiu Li,An, Li-Jia.Protective effects of catalpol against H2O2-induced oxidative stress in astrocytes primary cultures[J],NEUROSCIENCE LETTERS,2008,442(3):224-227
[34]真国辉,姜波,安利佳.线粒体复合物Ⅰ抑制与帕金森病[J],中国老年学杂志,2008,28(15):1555-1557
[35]Zhang, Xiu-li,An, Li-jia,Bao, Yong-ming,Wang, Jing-yun,Jiang, Bo.D-galactose administration induces memory loss and energy metabolism disturbance in mice: Protective effects of catalpol[J],FOOD AND CHEMICAL TOXICOLOGY,2008,46(8):2888-2894
[36]Jiang, Bo,Zhang, Huang,Bi, Jing,Zhang, Xiu Li.Neuroprotective activities of catalpol on MPP+/MPTP-induced neurotoxicity[J],NEUROLOGICAL RESEARCH,2008,30(6):639-644
[37]Zhang, Xluli,Zhang, Aihong,Jiang, Bo,Bao, Yongming,Wang, Jingyun,An, Lijia.Further pharmacological evidence of the neuroprotective effect of catalpol from Rehmannia glutinosa[J],PHYTOMEDICINE,2008,15(6-7):484-490
[38]姜涛,张爱红,赵荣国,姜波.梓醇对鱼藤酮损伤小鼠的记忆、抗氧化能力的影响及安全性评价[J],现代生物医学进展,2008,8(6):1039-1041,1045
[39]Jiang, L. L.,Song, K. D.,Jiang, B.,Liu, T. Q.,Ma, X. H.,Cui, Z. F..Expansion of human adipose-derived stem cells in spinner flasks[J],TISSUE ENGINEERING PART A,2008,14(5):734-734
[40]Li, Yachen,Bao, Yongming,Jiang, Bo,Wang, Zhuo,Liu, Yuxin,Zhang, Cen,An, Lijia.Catalpol protects primary cultured astrocytes from in vitro ischemia-induced damage[J],INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE,2008,26(3-4):309-317
[41]Liu, Ye-Ming,Jiang, Bo,Bao, Yong-Ming,An, Li-Jia.Protocatechuic acid inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells[J],TOXICOLOGY IN VITRO,2008,22(2):430-437
[42]Wang, Zhuo,An, Li-Jia,Duan, Yan-Long,Li, Ya-Chen,Jiang, Bo.Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury[J],NEUROLOGICAL RESEARCH,2008,30(1):106-112
[43]张秀丽,王静云,姜波,常妍,安利佳.大孔吸附树脂分离纯化地黄中梓醇工艺的研究[J],中国生物工程杂志,2008,28(1):65-69
[44]Jiang, Bo,Du, Jing,Jian-hui, Liu,Bao, Yong-Ming,An, Li-Jia.Catalpol attenuates the neurotoxicity induced by beta-amyloid(1-42) in cortical neuron-glia cultures[J],BRAIN RESEARCH,2008,1188:139-147
[45]汪卓,安利佳,段延龙,李亚晨,姜波.梓醇对氧糖剥夺诱导PC12细胞凋亡的保护作用[J],现代生物医学进展,2006,6(12):31-33
[46]真国辉,姜波,包永明,李东霞,安利佳.菟丝子黄酮类组分对H2O2损伤PC12细胞的保护作用[J],中药材,2006,29(10):1051-1055
[47]安利佳,李志刚,姜波.帕金森病与细胞凋亡[J],中国现代医学杂志,2006,16(7):1032-1036
[48]李志刚,姜波,包永明,安利佳.菟丝子提取物对MPP+诱导的PC12细胞凋亡的保护作用[J],中成药,2006,28(2):219-222
[49]刘建辉,姜波,包永明,安利佳.菟丝子提取物在PC12细胞株中的神经营养因子样活性[J],生物化学与生物物理进展,2003,30(2):226-230