个人简历

个人简介
Personal Profile
1991年获得大连理工大学化学工程专业工学学士学位，2002年获得河北医科大学药物化学硕士学位，2006年获得中国协和医科大学生药学博士学位。1991-2006年在国家微生物药物工程技术中心、华北制药集团新药中心工作，高级工程师、室主任。1997-1999年日本北里研究所留学研究员、师从大村智、供田洋教授，2006年起调入大连理工大学生命科学与技术学院工作，副教授，博导，曾担任院长助理、副院长（2012-2016）。2013-2014年美国明尼苏达大学访问学者。
作为负责人、子课题负责人和技术骨干，承担科研项目近20项，包括国家科技部“十五”重大专项1项，国家重大新药创制重大专项3项，973子课题1项，国家自然科学基金面上项目1项，辽宁省教育厅重点实验室项目1项等。
已发表论文70余篇，其中SCI论文50篇，申请专利20余项，已授权17项。作为副主编和主要参加人员撰写学术专著2部，作为副主编编写“十三五规划教材”1部。
教育经历
1984.9 1987.7 石家庄市第一中学 无
2003.9 2006.7 中国协和医科大学 生药学 博士
1999.9 2001.7 河北医科大学 药物化学 硕士
1987.9 1991.7 大连理工大学 化学工程 学士
工作经历
2006.11 至今 大连理工大学 副教授
1997.5 1999.5 日本东京北里研究所 留学研究员
1991.7 2006.11 华北制药集团新药中心 室主任
专利
新鲜烟叶中多种产物的联产方法
一种利用烟叶残渣制备生物菌肥的方法
一种具有α‑糖苷酶抑制活性的药物组合物及其应用
一种预防或治疗脂肪肝的药物及其应用
预防或治疗前驱糖尿病的药物和药物组合物
一种废弃烟叶综合利用的方法
著作成果
生物制药工艺学
天然有机化合物核磁共振碳谱集
当科研成为一种职业
科研项目
香茅草油提取物的分析与鉴定, 省、市、自治区科技项目, 2018/06/01-2019/01/31, 完成
提取物ABC的降血糖活性评价, 企事业单位委托科技项目, 2016/10/01-2017/01/15, 完成
微生物次级代谢产物的活性评价, 其他课题, 2016/11/02, 进行
公斤级生物技术药物制备中试技术平台, 科技部重大专项, 2010/01/01-2010/01/01, 完成
微生物药物创新能力建设, 科技部重大专项, 2011/01/01-2012/01/01, 完成
双水相萃取分离越橘中花青素, 省、市、自治区科技项目, 2010/01/01-2013/02/04, 完成

研究领域

1. 降糖复方药物及功能食品及作用机制研究
2. 现代生物技术发现先导药物及其机制
3. 药物分离新技术、新方法研究"研究领域
1. 降糖复方药物及功能食品及作用机制研究
2. 现代生物技术发现先导药物及其机制
3. 药物分离新技术、新方法研究
1) Combined drugs or functional food in diabetes treamtmen and its mechanism
2) Discovery of leading compounds from natual product by modern biotechnology means.
3) New separation techniques to separate biological and chemical drugs"

近期论文

[1]Dai, Jian-Ying,Yang, Yu,Dong, Yue-Sheng,Xiu, Zhi-Long.Solid-state Co-cultivation of Bacillus subtilis, Bacillus mucilaginosus, and Paecilomyces lilacinus Using Tobacco Waste Residue[J],APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2020,190(3):1092-1105
[2]Ding, Qianzhi,Ma, Baiping,Zhang, Bowei,Zheng, Wei,Chen, Xiaojuan,Zhang, Jie,Yan, Renyi,Zhang, Tao,Yu, Liyan,Dong, Yuesheng.Liupao tea extract alleviates diabetes mellitus and modulates gut microbiota in rats induced by streptozotocin and high-fat, high-sugar diet[J],BIOMEDICINE & PHARMACOTHERAPY,2019,118:109262
[3]Wang Lulu,Quan Chunshan,Xu Yongbin,Chen Yuanyuan,Shang Fei,Liu Wei,Lan Jing,Gao Peng,Ha Nam-Chul,Nam Ki Hyun,Dong Yuesheng.Structural insight into the carboxylesterase BioH from Klebsiella pneumoniae[J],Biochemical and biophysical research communications,2019
[4]Dong, Yue-Sheng,Yang, Fan,Liu, Wen-Cai,Wang, Xu-Dong,Xing, Yan,Xiu, Zhi-Long.Separation and purification of wortmannilactone analogues by three-liquid-phase salting-out extraction coupled with column chromatography[J],SEPARATION AND PURIFICATION TECHNOLOGY,2019,224:397-404
[5]Ren, Yixin,Qin, Yuanhua,Zhang, Xueqiang,Zheng, Lili,Dai, Xiaodong,Wu, Haiyan,Dong, Yuesheng,Cui, Yu.Killing the muscular larvae of Trichinella spiralis and the anti-fibrotic effect of the combination of Wortmannilatone F and recombinant G31P in a murine model of trichinellosis[J],BIOMEDICINE & PHARMACOTHERAPY,2018,108:934-940
[6]Chen, Jinli,Nam, Ki Hyun,Xu, Yongbin,Shang, Fei,Wang, Lulu,Zou, Linhai,Bu, Tingting,Jin, Liming,Dong, Yuesheng,Ha, Nam-Chul,Quan, Chunshan.Structural and Biochemical Analysis of the Citrate-Responsive Mechanism of the Regulatory Domain of Catabolite Control Protein E from Staphylococcus aureus[J],BIOCHEMISTRY,2018,57(42):6054-6060
[7]Shang, Fei,Quan, Chunshan,Xu, Yongbin,Chen, Jinli,Wang, Lulu,Jin, Liming,Zou, Linhai,Bu, Tingting,Dong, Yuesheng,Ha, Nam-Chul,Nam, Ki Hyun.Crystal structure of the nicotinamidase/pyrazinamidase PncA from Bacillus subtilis[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,503(4):2906-2911
[8]Zhang, Bowei,Xiu, Zhilong,Ma, Baiping,Yu, Liyan,Dong, Yuesheng,Sun, Wenlong,Yu, Na,Sun, Jin,Yu, Xiaoxia,Li, Xia,Xing, Yan,Yan, Dong,Ding, Qianzhi.Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats[J],JOURNAL OF FUNCTIONAL FOODS,2018,46:256-267
[9]胡春燕,王旭东,秦超,董悦生,修志龙.克拉维酸钾一步结晶工艺优化[J],高校化学工程学报,2018,32(4):910-917
[10]Chen, Jinli,Wang, Lulu,Shang, Fei,Dong, Yuesheng,Ha, Nam-Chul,Nam, Ki Hyun,Quan, Chunshan,Xu, Yongbin.Crystal structure of E. coli ZinT with one zinc-binding mode and complexed with citrate[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018,500(2):139-144
[11]Xing, Yan,Chen, Chaonan,Sun, Wenlong,Zhang, Bowei,Sang, Yuanbin,Xiu, Zhilong,Dong, Yuesheng.An environment-friendly approach to isolate and purify glucan from spent cells of recombinant Pichia pastoris and the bioactivity characterization of the purified glucan[J],ENGINEERING IN LIFE SCIENCES,2018,18(4):227-235
[12]Sun Wenlong,Zhang Bowei,Yu Xiaoxia,Zhuang Chunlin,Li Xia,Sun Jin,Xing Yan,Xiu Zhilong,Dong Yuesheng.Oroxin A from Oroxylum indicum prevents the progression from prediabetes to diabetes in streptozotocin and high-fat diet induced mice.[J],Phytomedicine : international journal of phytotherapy and phytopharmacology,2018,38:24-34
[13]Liu, Wen-Cai,Dong, Yue-Sheng,Ren, Yi-Xin,Hao, Ai-Yu,Yu, Sun,Shi, Xuan,Zhang, Xue-Qiang,Xing, Yan,Xiu, Zhi-Long,Cui, Yu.The activities of wortmannilactones against helminth electron transport chain enzymes, structure-activity relationships, and the effect on Trichinella spiralis infected mice.[J],The Journal of antibiotics,2018,71(8):731-740
[14]Zhang, Bo-wei,Xing, Yan,Wen, Chen,Yu, Xiao-xia,Sun, Wen-long,Xiu, Zhi-long,Dong, Yue-sheng.Pentacyclic triterpenes as alpha-glucosidase and alpha-amylase inhibitors: Structure-activity relationships and the synergism with acarbose[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(22):5065-5070
[15]王路路,权春善,许永斌,陈金利,吴懿,王冠天,董悦生.金黄色葡萄球菌arl双组分信号转导系统受体蛋白ArlSCA的表达、纯化及活性研究[J],中国生物工程杂志,2017,37(11):52-58
[16]Xu, Yongbin,Jo, Inseong,Wang, Lulu,Chen, Jinli,Fan, Shengdi,Dong, Yuesheng,Quan, Chunshan,Ha, Nam-Chul.Hexameric assembly of membrane fusion protein YknX of the sporulation delaying efflux pump from Bacillus amyloliquefaciens[J],BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017,493(1):152-157
[17]Xu, Yongbin,Wang, Lulu,Chen, Jinli,Zhao, Jing,Fan, Shengdi,Dong, Yuesheng,Ha, Nam-Chul,Quan, Chunshan.Structural and Functional Analyses of Periplasmic 5 '-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Aeromonas hydrophila[J],BIOCHEMISTRY,2017,56(40):5347-5355
[18]Sun, Wenlong,Sun, Jin,Zhang, Bowei,Xing, Yan,Yu, Xiaoxia,Li, Xia,Xiu, Zhilong,Dong, Yuesheng.Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention[J],JOURNAL OF FUNCTIONAL FOODS,2017,37:339-353
[19]Zhang, Bo-wei,Li, Xia,Sun, Wen-long,Xing, Yan,Xiu, Zhi-long,Zhuang, Chun-lin,Dong, Yue-sheng.Dietary Flavonoids and Acarbose Synergistically Inhibit alpha-Glucosidase and Lower Postprandial Blood Glucose[J],JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2017,65(38):8319-8330
[20]Duan, Liying,Ye, Junwei,Sun, Wenlong,Wang, Shaoning,Gong, Wei-tao,Dong, Yuesheng,Ning, Guiling.A novel PTP1b inhibitor vanadium-flavone complex: synthesis and pharmacodynamic evaluation in streptozotocin-induced diabetic mice[J],MEDICINAL CHEMISTRY RESEARCH,2017,26(9):1863-1870
[21]Sun, Wenlong,Zhuang, Chunlin,Li, Xia,Zhang, Bowei,Lu, Xinhua,Zheng, Zhihui,Dong, Yuesheng.Varic acid analogues from fungus as PTP1B inhibitors: Biological evaluation and structure-activity relationships[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017,27(15):3382-3385
[22]Zhang, Bo-wei,Sang, Yuan-bin,Sun, Wen-long,Yu, He-shui,Ma, Bai-ping,Xiu, Zhi-long,Dong, Yue-sheng.Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study[J],BIOMEDICINE & PHARMACOTHERAPY,2017,91:890-898
[23]胡春燕,秦超,王旭东,董悦生,修志龙,李树有,冯涛,王启斌.克拉维酸在乙酸乙酯中的稳定性[J],高校化学工程学报,2017,31(2):270-275
[24]Sun, Wenlong,Sang, Yuanbin,Zhang, Bowei,Yu, Xiaoxia,Xu, Qinmin,Xiu, Zhilong,Dong, Yuesheng.Synergistic effects of acarbose and an Oroxylum indicum seed extract in streptozotocin and high-fat-diet induced prediabetic mice[J],BIOMEDICINE & PHARMACOTHERAPY,2017,87:160-170
[25]Zheng, Weilong,Wang, Xudong,Cao, Wenjing,Yang, Bowen,Mu, Ying,Dong, Yuesheng,Xiu, Zhilong.E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro[J],PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS,2017,117:47-53
[26]Sun, Wenlong,Xiu, Zhilong,Zhang, Bowei,Zheng, Haizhou,Zhuang, Chunlin,Li, Xia,Lu, Xinhua,Quan, Chunshan,Dong, Yuesheng,Zheng, Zhihui.Trivaric acid, a new inhibitor of PTP1b with potent beneficial effect on diabetes[J],LIFE SCIENCES,2017,169:52-64
[27]董悦生,修志龙.E-configuration structures of EPA and DHA derived from Euphausia superba andtheirsignificant inhibitive effectson growth of human cancer cell lines in vitro[J],Prostaglandins, Leukotrienes and Essential Fatty Acids,2017,117(1):47-53
[28]Liu, Wen-Cai,Yang, Fan,Zhang, Ran,Shi, Xuan,Lu, Xin-Hua,Luan, Yu-Shi,Xiu, Zhi-Long,Dong, Yue-Sheng.Production of polyketides with anthelmintic activity by the fungus Talaromyces wortmannii using one strain-many compounds (OSMAC) method[J],PHYTOCHEMISTRY LETTERS,2016,18:157-161
[29]Liu, Wen-Cai,Wang, Yi-Yu,Liu, Jun-Hui,Ke, Ai-Bing,Zheng, Zhi-Hui,Lu, Xin-Hua,Luan, Yu-Shi,Xiu, Zhi-Long,Dong, Yue-Sheng.Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii[J],BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(21):5328-5333
[30]Dong, Yuesheng,Pang, Bofeng,Yu, Fang,Li, LingLing,Liu, Wencai,Xiu, Zhilong.Extraction and purification of IgG by hydrophilic organic solvent salting-out extraction[J],JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICALAND LIFE SCIENCES,2016,1012:137-143
[31]董悦生.Trivaric acid，一种潜在的治疗糖尿病的药物[A],2016年中国药学会学术年会,2016,1-4
[32]孙文龙,桑元斌,张博崴,于晓霞,徐亲民,修志龙,董悦生.木蝴蝶种子提取物和阿卡波糖协同干预链尿佐菌素和高脂高糖饮食诱导的小鼠前驱糖尿病[A],2015年中国药学大会暨第十五届中国药师周,2015,13
[33]董悦生,刘乐平,包永明,郝爱鱼,秦莹,温祖佳,修志龙.哈茨木霉CGMCC 2979生物转化栀子中的京尼平苷制备京尼平[J],催化学报,2014,35(9):1534-1546
[34]Huang, Liping,Shi, Yinghong,Wang, Ning,Dong, Yuesheng.Anaerobic/aerobic conditions and biostimulation for enhanced chlorophenols degradation in biocathode microbial fuel cells[J],BIODEGRADATION,2014,25(4):615-632
[35]杨宁,董悦生,刘文财,路新华,丁彦博,郑智慧.固态培养法提高放线菌次级代谢产物的多样性[J],中国抗生素杂志,2013,38(10):736-740
[36]杨宁,董悦生,路新华,丁彦博,郑智慧.固态培养法提高放线菌次级代谢产物的多样性[A],第四届全国微生物资源学术暨国家微生物资源平台运行服务研讨会,2012,76-76
[37]李原,刘文财,孙文龙,董悦生,阎浩林.蠕虫NADH-延胡索酸还原酶模型优化及沃特曼内酯F 的活性评价[J],中国医药生物技术,2012,07(4):276-280
[38]魏夺,董悦生,韩松,修志龙.纤维素酶催化与三液相萃取偶联制备盾叶薯蓣皂苷元[J],化工学报,2012,63(6):1877-1882
[39]Yuesheng Dong,Zhilong Xiu.Extraction and purification of recombinant human serum albumin from Pichia pastoris broths using aqueous two-phase system combined with hydrophobic interaction chromatography[A],15th International Biotechnology Symposium Daegu, Korea,2012,1(1):1-5
[40]董悦生,路新华,郑智慧,李原,刘文财,李业英.以电子传递链为作用靶点的微生物来源抗蠕虫药物研究进展[A],2011抗感染药物与耐药菌防控专题研讨会,2011,377-381
[41]郝爱鱼,刘英慧,赵丽元,毕秀玲,董悦生.酒石酸唑吡坦红外光谱鉴别方法的探讨[J],中国药品标准,2011,12(4):300-303
[42]尹哲媛,董悦生,路新华,李业英,张华,阎浩林.Wortmannilactone F产生菌邬氏黄丝曲霉F01Z0195的培养条件优化[J],中国抗生素杂志,2010,35(12):903-910
[43]Dong, Yuesheng,Teng, Hu,Qi, Shanshan,Liu, Lin,Wang, Hui,Zhao, Yangkun,Xiu, Zhilong.Pathways and kinetics analysis of biotransformation of Dioscorea zingiberensis by Aspergillus oryzae[J],BIOCHEMICAL ENGINEERING JOURNAL,2010,52(2-3):123-130
[44]董悦生,尹哲媛,初晓岚,路新华,张华,修志龙,阎浩林.培养条件对Wortmannilacton F及其类似物产量及种类的影响[A],2010,1-10
[45]董悦生,刘琳,王辉,修志龙.盐析萃取法提取分离盾叶薯蓣发酵液中甾体成分和虎杖发酵液中白藜芦醇[A],2010,1-8
[46]Liu, Lin,Dong, Yue-sheng,Xiu, Zhi-long.Three-liquid-phase extraction of diosgenin and steroidal saponins from fermentation of Dioscorea zingibernsis C. H. Wright[J],PROCESS BIOCHEMISTRY,2010,45(5):752-756
[47]戴建英,孙亚琴,孙丽慧,李丹,董悦生,修志龙.生物基化学品2,3-丁二醇的研究进展[J],过程工程学报,2010,10(1):200-208
[48]王辉,董悦生,秦建全,王亚俊,修志龙.虎杖发酵液中白藜芦醇的分离纯化工艺研究[J],中草药,2010,41(2):223-227
[49]X. Lu, Q, Y. Gu, J. He, C. Huo, Y. Dong, Y. Ma, X. Ren, A. Ke, Zhang, H, Z. Zheng.Two new members of mycophenolic acid family from Penicillium brevicompactum Dierckx[J],J. Antibiot,2009,62:527-529
[50]董悦生.卡斯帕酶-3抑制剂的高通量筛选及活性化合物F03ZA-575的初步研究[J],中国医药生物技术,2010,5(5):361-366
[51]Y. Dong,L Liu,Y Qin,A Hao,Y Bao.Biotransformation of geniposide in to genipin by CGMCC 2979[J],Chinese Journal of Catalysis,2014,35(9):1534-1546
[52]Liu, Lin,Dong, Yue-Sheng,Qi, Shan-Shan,Wang, Hui,Xiu, Zhi-Long.Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum[J],APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2010,85(4):933-940
[53]王元好,董悦生,修志龙.梯度洗脱高效液相色谱法快速测定1,3-丙二醇发酵液中有机酸[J],食品与发酵工业,2010,36(1):126-130
[54]董悦生.真菌F01-994产生的对谷胱苷肽转移酶具有抑制作用的活性化合物的研究[J],中国抗生素杂志,2010,35(10):743-746
[55]刘琳,董悦生,修志龙.微波辅助双水相提取盾叶薯蓣中的皂苷成分[J],过程工程学报,2009,9(6):1147-1152
[56]董悦生,齐珊珊,刘琳,修志龙.米曲霉直接转化盾叶薯蓣生产薯蓣皂苷元[J],过程工程学报,2009,9(5):993-998
[57]Bi, Jing,Jiang, Bo,Hao, Shuang,Zhang, Aihong,Dong, Yuesheng,Jiang, Tao,An, Lijia.Catalpol attenuates nitric oxide increase via ERK signaling pathways induced by rotenone in mesencephalic neurons[J],NEUROCHEMISTRY INTERNATIONAL,2009,54(3-4):264-270
[58]Dong, Yuesheng,Lin, Jie,Lu, Xinhua,Zheng, Zhihui,Ren, Xiao,Zhang, Hun,He, Jiangong,Yang, Junshan.Cathepsin B Inhibitory Tetraene Lactones from the Fungus Talaromyces wortmannii[J],HELVETICA CHIMICA ACTA,2009,92(3):567-574
[59]刘国兴,王元好,孙丽慧,戴建英,孙亚琴,董悦生,修志龙.盾叶薯蓣糖化液发酵生产2,3-丁二醇[J],过程工程学报,2009,9(1):95-100
[60]Wang, Hui,Dong, Yuesheng,Xiu, Zhi-Long.Microwave-assisted aqueous two-phase extraction of piceid, resveratrol and emodin from Polygonum cuspidatum by ethanol/ammonium sulphate systems[J],BIOTECHNOLOGY LETTERS,2008,30(12):2079-2084
[61]齐珊珊,董悦生,刘琳,修志龙.米曲霉转化盾叶薯蓣中的甾体皂苷生成薯蓣皂苷元的工艺优化[A],2008中国药学会学术年会暨第八届中国药师周,2008,1-9
[62]郭永学,张华,董悦生,修志龙.丹酚酸B的水解动力学及降解机理[A],2008中国药学会学术年会暨第八届中国药师周,2008,1-16
[63]Qi, Shanshan,Dong, Yuesheng,Zhao, Yangkun,Xiu, Zhilong.Identification and quantification of steroidal saponins and aglycone during biotransformation of Dioscorea zingiberensis by Aspergillus oryzae[J],JOURNAL OF BIOTECHNOLOGY,2008,136:S370-S370
[64]修志龙,李志刚,江波,孙丽慧,王辉,郭永学,张华,张江红,董悦生.新型双水相萃取技术[A],第五届全国化学工程与生物化工年会,2008,1007-1008
[65]董悦生,刘琳,齐珊珊,孔珊,修志龙.木霉DL3012转化盾叶薯蓣中甾体皂苷生成薯蓣皂苷元的工艺优化[A],第五届全国化工年会论文集中国化工学会,2008,1-10
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现任中国生物化学与分子生物学会工业生物化学与分子生物学分会理事，中国医药生物技术协会酶工程与发酵工程专业委员会委员，大连药学会科技创新专业委员会委员等社会兼职。