个人简历

史向阳，1970年8月生，化学化工与生物工程学院，生物科学与技术研究所教授，博士生导师。2008年回国前，在美国密歇根大学历任博士后研究员、第二级副研究员、研究员和研究助理教授。美国化学会、中国化学会、中国生物材料委员会会员，上海市生物物理学会理事，北京生理科学会再生医学专业委员会秘书长、副主任委员。兼任美国密歇根大学医学和生物科学纳米技术研究所客座研究员，首届葡萄牙马德拉大学“邀请纳米技术主任（Invited Chair in Nanotechnology），Wiley-VCH期刊 Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol.副主编，美国化学会期刊 Bioconjugate Chem.编委；也是Nat. Nanotechnol.、Nat. Commun.和 J. Am. Chem. Soc.等84个国际杂志审稿人

研究领域

"""""1.生物纳米技术：以各种基于树状大分子或生物相容性高分子修饰或组装的多种纳米颗粒为医学平台，研究各种癌症的早期诊断、多模态诊断、治疗、联合治疗及诊疗一体化\r
2.新型纳米材料和纳米复合材料的合成、组装、表面修饰、性能、及其在生物医学中的应用\r
3.静电纺纳米纤维在生物医学和环境科学中的应用"

近期论文

Jingchao Li, Shige Wang, Xiangyang Shi,* Mingwu Shen*. Aqueous-phase synthesis of iron oxide nanoparticles and composites for cancer diagnosis and therapy. Adv. Colloid Interface Sci. 2017, 249, 374–385 (impact factor 9.922, citation #14). \r
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Lizhou Lin#, Yu Fan#, Feng Gao, Lifang Jin, Dan Li, Wenjie Sun, Fan Li, Peng Qin, Qiusheng Shi*, Xiangyang Shi*, Lianfang Du*.UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy. Theranostics 2018, 8(7), 1923-1939 (impact factor 8.579, citation #24).\r
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Serge Mignani*, João Rodrigues*, Helena Tomas, Maria Zablocka, Xiangyang Shi, Anne-Marie Caminade, Jean-Pierre Majoral*. Dendrimers in combination with natural products and analogues as anti-cancer agents. Chem. Soc. Rev. 2018, 47, 514-532 (citation # 41, Impact factor 42.846).\r
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Benqing Zhou#, Ruizhi Wang#, Lingzhou Zhao, Peng Wang, Xin Li, István Bányai,* Qiang Ouyang*, Xiangyang Shi, and Mingwu Shen*. 99mTc-Labeled RGD−Polyethylenimine Conjugates with Entrapped Gold Nanoparticles in the Cavities for Dual-Mode SPECT/CT Imaging of Hepatic Carcinoma. ACS Appl. Mater. Interfaces 2018, 10 (7), 6146–6154 (impact factor 8.758, citation #11).\r
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Jean-Pierre Majoral*, Maria Zablocka*, Anne-Marie Caminade, Piotr Balczewski, Xiangyang Shi, Serge Mignani*. Interactions gold/phosphorus dendrimers. Versatile ways to hybrid organic-metallic macromolecules. Coord. Chem. Rev. 2018, 358, 80-91 (impact factor 15.367, citation #7).\r
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Yong Hu, Serge Mignani, Jean-Pierre Majoral, Mingwu Shen*, and Xiangyang Shi*. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 2018, 47, 1874-1900 (citation # 89, Impact factor 42.846).\r
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Zheng Qiao, Mingwu Shen, Yunchao Xiao, Meifang Zhu, Serge Mignani, Jean-Pierre Majoral, Xiangyang Shi*. Organic/inorganic nanohybrids formed using electrospun polymer nanofibers as nanoreactors. Coord. Chem. Rev. 2018, 372, 31-51 (impact factor 15.367, citation #5).\r
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Jingyi Zhu#, Hongsheng Li#, Zhijuan Xiong, Mingwu Shen, Peter S. Conti, Xiangyang Shi*, Kai Chen*. Polyethyleneimine-coated manganese oxide nanoparticles for targeted tumor PET/MR imaging. ACS Appl. Mater. Interfaces 2018, 10(41), 34954-34964 (impact factor 8.758, citation #14).\r
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Serge Mignani*, João Rodrigues, Helena Tomas, René Roy, Xiangyang Shi, Jean-Pierre Majoral*. Bench-to-bedside translation of dendrimers: Reality or utopia? A concise analysis. Adv. Drug Deliver. Rev. 2018, 136–137, 73–81 (impact factor 13.300, citation # 12).\r
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Shiyi Lu, Xin Li, Jiulong Zhang, Chen Peng,* Mingwu Shen,* and Xiangyang Shi*. Dendrimer-Stabilized Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Multimode Imaging-Guided Combination Therapy of Tumors. Adv. Sci. 2018, 5, 1801612 (citation #19, Impact factor 15.840).\r
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Jianzhi Zhu#, Zhicong Li#, Changchang Zhang, Lizhou Lin, Shoupeng Cao, Hailong Che, Xiangyang Shi*, Han Wang*, Jan C. M. van Hest*. Single enzyme loaded nanoparticles for combinational ultrasound-guided focused ultrasound ablation and hypoxia-relieved chemotherapy. Theranostics 2019, 9(26), 8048-8060 (impact factor 8.579, citation #0).\r
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Yu Fan, Jiulong Zhang, Menghan Shi, Dan Li, Chunhua Lu, Xueyan Cao, Chen Peng*, Serge Mignani*, Jean-Pierre Majoral*, Xiangyang Shi*. PAMAM Dendrimer-Coordinated Copper(II) Complexes as a Theranostic Nanoplatform for Radiotherapy-Enhanced MR Imaging and Chemotherapy of Tumors and Tumor Metastasis. Nano Lett. 2019, 19, 1216−1226 (citation # 6, Impact factor 11.238).\r
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Chao Cai, Xin Li, Yue Wang, Mengxue Liu, Xiangyang Shi*, Jindong Xia*, Mingwu Shen*. Polydopamine-Coated Gold Core/Hollow Mesoporous Silica Shell Particles as a Nanoplatform for Multimode Imaging and Photothermal Therapy of Tumors. Chem. Eng. J. 2019, 362, 842-850 (Impact factor 10.652, citation #9).\r
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Jinyuan Liu, Zhijuan Xiong, Jiulong Zhang, Chen Peng*, Barbara Klajnert-Maculewicz*, Mingwu Shen*, Xiangyang Shi*. Zwitterionic Gadolinium (III)-Complexed Dendrimer-Entrapped Gold Nanoparticles for Enhanced Computed Tomography/Magnetic Resonance Imaging of Lung Cancer Metastasis. ACS Appl. Mater. Interfaces 2019, 11, 15212-15221 (impact factor 8.758, citation #8).\r
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Xin Li#, Shiyi Lu#, Zuogang Xiong, Yong Hu, Dan Ma, Wenqi Lou, Chen Peng*, Mingwu Shen*, Xiangyang Shi*. Light-Addressable Nanoclusters of Ultrasmall Iron Oxide Nanoparticles for Enhanced and Dynamic Magnetic Resonance Imaging of Arthritis. Adv. Sci. 2019, 6, 1901800 (citation # 3, Impact factor 15.840).\r
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Lingxi Xing#, Xin Li#, Zehua Xing#, Fan Li, Mingwu Shen, Hong Wang*, Xiangyang Shi*, Lianfang Du*. Silica/Gold Nanoplatform combined with a Thermosensitive Gel for Imaging-guided Interventional Therapy in PDX of Pancreatic Cancer. Chem. Eng. J. 2020, 382, 122949 (Impact factor 10.652, citation #0).\r
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Ni Zhang, Yue Wang, Changchang Zhang, Yu Fan, Du Li, Xueyan Cao, Jindong Xia, Xiangyang Shi, Rui Guo*. LDH-Stabilized Ultrasmall Iron Oxide Nanoparticles as a Platform for Hyaluronidase-Promoted MR Imaging and Chemotherapy of Tumors. Theranostics 2020, 10, 2791-2802 (impact factor 8.579, citation #0).\r
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Changchang Zhang, Wenjie Sun, Yue Wang, Fang Xu, Jiao Qu, Jindong Xia, Mingwu Shen*, Xiangyang Shi*. Gd-/CuS-Loaded Functional Nanogels for MR/PA Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Appl. Mater. Interfaces 2020, 12, 9107-9117 (impact factor 8.758, citation #0).\r
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Fang Xu#, Jianzhi Zhu#, Lizhou Lin#, Changchang Zhang, Wenjie Sun, Yu Fan, Fangfang Yin, Jan C. M. van Hest, Han Wang, Lianfang Du* and Xiangyang Shi*. Redox-responsive PVCL nanogels loaded with MnO2 nanoparticles and doxorubicin for imaging-guided and UTMD-promoted chemotherapy of tumors. Theranostics 2020, 10(10), 4349-4358 (impact factor 8.579, citation #0). \r
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Ningning Song, Lingzhou Zhao, Xiaoying Xu, Meilin Zhu, Changcun Liu, Na Sun, Jiqin Yang,* Xiangyang Shi,* Jinhua Zhao*. LyP-1-modified multifunctional dendrimers for targeted anti-tumor and anti-metastasis therapy. ACS Appl. Mater. Interfaces 2020, 12, 12395-12406 (impact factor 8.758, citation #0).\r
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Yu Fan#, Wenzhi Tu#, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu*, Xiangyang Shi*. Targeted Tumor Hypoxia Dual Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer-Based Nanosensitizers. Adv. Funct. Mater. 2020, 30, 1909285 (impact factor 16.836, citation #0).