个人简历

2000年，本科毕业于东北师大化学专业\r
2006年，博士毕业于东北师大有机化学专业。同年，获得德国洪堡基金会的研究奖学金，赴德国波恩大学从事博士后研究\r
2008年底回国，在东北师大开始独立的课题研究，工作集中在发展新的有机反应，尤其是银催化的合成转化\r
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经历\r
1996.09 - 2000.07 东北师范大学 化学 学士\r
2000.09 - 2006.07 东北师范大学 有机化学 博士\r
2006.08 - 2008.12 德国波恩大学凯库勒研究所 博士后\r
2005.07 - 2008.12 东北师范大学化学学院 讲师\r
2009.1-东北师范大学化学学院 副教授，教授\r
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荣誉\r
2006 德国洪堡基金会研究奖学金\r
2014 Thieme Chemistry Journals Award\r
2015 国家自然科学基金委“优青”\r
2016 教育部“长江学者奖励计划”青年学者\r
2018 吉林省科学技术奖自然科学一等奖\r
2019 牛顿高级学者 药明康德生命化学研究奖

研究领域

"""""银催化有机合成与理论研究\r
过渡金属催化是现代有机合成化学发展的重要推动力，发展新催化剂和新反应是这一前沿领域极为重要的研究内容。多变价、强配位的过渡金属占据主导地位，如：铑、钌、钯、铱、铜、金等，这些金属催化活性高，普遍应用于催化有机合成反应；难变价、弱配位的过渡金属则催化活性低，建立这类金属催化的有机反应比较困难，但是往往呈现催化的独特性，所以探索这类金属的催化潜力十分必要。银就是这样的一类过渡金属，银离子最外层5s为空轨道，又拥有充满的4d(10)轨道，这样的电子结构与轨道特征使得银呈现出显著的特性：它是唯一正一价稳定的过渡金属，与质子具有一定的相似性，一些有机银试剂可以看作是相应的酸等当物；有机银中间体一般不稳定，易于发生脱银质子化；是温和的单电子氧化剂和较弱的路易斯酸；与配体相互作用较弱，存在可逆性；具有生物友好性等。总的来说，银的性质可以用“温和”来概括，这也导致银的催化活性不高，银催化化学发展缓慢，对银的作用缺乏深刻认识，一般泛泛地归结为单电子氧化剂、σ-或π-路易斯酸等，造成对其真正作用的忽视。因此，建立银催化的独特反应体系并揭示其催化原理是过渡金属催化研究的重要问题，也是难点问题。过去十余年间，毕锡和课题组聚焦于银催化性能的探索，开展了银催化有机合成与理论研究，取得了系列创新性成果：建立了具有原始创新性的银催化炔烃氢叠氮化反应，并进一步拓展至炔烃系列多组分反应，被国际同行称为“毕的银催化炔烃氢叠氮化方法学（Bi's Ag(I) catalysed hydroazidation methodology）”；发现了银对异氰以及donor-型重氮的优异活化性能，建立了一系列银催化的卡宾反应；在理论上，归纳总结出银的类质子性和弱配位活化，形成了对银的新认知。这些研究工作丰富了银的催化化学，提升了银的合成用途，展现了银的催化潜力。"

近期论文

Site-Selective C−H Allylation of Alkanes: Facile Access to Allylic Quaternary sp3-Carbon Centers Yong Yang, Shaopeng Liu, Shuang Li, Zhaohong Liu, Peiqiu Liao, Paramasivam Sivaguru, Ying Lu, Jiaojiao Gao, Xihe Bi* Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202214519\r
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Silver-Catalyzed Vinylcarbene Insertion into C–C Bonds of 1,3-Diketones with Vinyl-N-triftosylhydrazones Yong Wu, Yongquan Ning*, Xinyue Han, Peiqiu Liao, Ying Xia, Paramasivam Sivaguru, and Xihe Bi* Org. Lett. 2022, DOI: 10.1021/acs.orglett.2c03176\r
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Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy Linxuan Li, Xinyu Zhang, Yongquan Ning, Xiaolong Zhang, Binbin Liu, Zhansong Zhang, Paramasivam Sivaguru, Giuseppe Zanoni, Shuang Li, Edward A. Anderson, Xihe Bi* Nat. Commun. 2022, 13, 4280\r
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Defluorinative Carboimination of Trifluoromethyl Ketones Xiaolong Zhang, Yongquan Ning, Zhaohong Liu, Shuang Li, Giuseppe Zanoni, and Xihe Bi* ACS Catal. 2022, 12, 8802–8810\r
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Silver-catalyzed site-selective C(sp3)−H benzylation of ethers with N-triftosylhydrazones Zhaohong Liu, Hongwei Wang, Paramasivam Sivaguru, Steven P. Nolan, Qingmin Song, Weijie Yu, Xinyu Jiang, Edward A. Anderson, Xihe Bi* Nat. Commun. 2022, 13, 1674\r
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The merger of vinyl-N-triftosylhydrazones and silver catalysis to enable stereoselective vinylcyclopropanation of alkenes Yong Yang, Zhaohong Liu, Qingmin Song, Paramasivam Sivaguru, Giuseppe Zanoni, Kuan Wang, Qiaowei Bi, Xihe Bi* Chem Catalysis 2022, 2, 563-57780A Carbene Strategy for Progressive (Deutero)Hydrodefluorination of Fluoroalkyl Ketones.Xiaolong Zhang, Xinyu Zhang, Qingmin Song, Paramasivam Sivaguru, Zikun Wang, Giuseppe Zanoni and Xihe Bi* Angew. Chem. Int. Ed. 2021, 7, e202116190\r
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Catalytic Asymmetric C(sp3)–H Carbene Insertion Approach to Access Enantioenriched 3-Fluoroalkyl 2,3-Dihydrobenzofurans Xinyu Zhang, Paramasivam Sivaguru, Giuseppe Zanoni, Xinyue Han, Minghui Tong，and Xihe Bi* ACS Catal. 2021, 11, 14293–14301\r
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Synthetic exploration of sulfinyl radicals using sulfinyl sulfones Zikun Wang, Zhansong Zhang, Wanjun Zhao, Paramasivam Sivaguru, Giuseppe Zanoni,Yingying Wang, Edward A. Anderson & Xihe Bi* Nat. Commun. 2021, 12, 5244\r
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Fluoroalkyl N-Triftosylhydrazones as Easily Decomposable Diazo Surrogates for Asymmetric [2 + 1] Cycloaddition: Synthesis of Chiral Fluoroalkyl Cyclopropenes and Cyclopropanes Xinyu Zhang, Chunqi Tian, Zhanjing Wang, Paramasivam Sivaguru, Steven P. Nolan, and Xihe Bi* ACS Catal. 2021, 11, 8527–8537\r
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Silver-catalyzed Unstrained C(CO)–alkyl Bond Scission via [3+2]/retro-[3+2] Cycloaddition of Ketones with N-isocyanoiminotriphenylphosphorane Zikun Wang, Linxuan Li, Xueying Zhang, and Xihe Bi* Sci. China Chem. 2021, 64, 1157-1163\r
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Computational Insights into Different Mechanisms for Ag‐, Cu‐, and Pd‐Catalyzed Cyclopropanation of Alkenes and Sulfonyl Hydrazones Yong Wu, Shanshan Cao, Iskander Douair, Laurent Maron*, and Xihe Bi* Chem. Eur. J. 2021, 27, 5999-6006\r
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Palladium(II)-Catalyzed Cross-Coupling of Diazo Compounds and Isocyanides to Access Ketenimines Zhaohong Liu, Shanshan Cao, Jiayi Wu, Giuseppe Zanoni, Paramasivam Sivaguru, and Xihe Bi* ACS Catal. 2020, 10, 12881-12887\r
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Site-selective C-H Benzylation of Alkanes with N-triftosylhydrazones Leading to Alkyl Aromatics Zhaohong Liu, Shanshan Cao, Weijie Yu, Jiayi Wu, Fanhua Yi, Edward A. Anderson, and Xihe Bi* Chem 2020, 6, 2110-2124\r
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Computational Studies on Reaction Mechanism of the Catalyst-Controlled Selective Insertion of Metal Carbenoids into C-C and C-H Bonds of 1,3-Dicarbonyl Compounds Shanshan Cao, Zhaohong Liu*, Haiyan Yuan, Liu Yang, Jingping Zhang*, and Xihe Bi* Chin. J. Org. Chem. 2020, 40, 2468-2475\r
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AgN3-Catalyzed Hydroazidation of Terminal Alkynes and Mechanistic Studies Shanshan Cao, Qinghe Ji, Huaizhi Li, Maolin Pang*, Haiyan Yuan, Jingping Zhang*, and Xihe Bi*J. Am. Chem. Soc. 2020, 142, 7083-7091\r
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Synthesis of β-Difluoroalkyl Azides via Elusive 1,2-Azide Migration Yongquan Ning, Paramasivam Sivaguru, Giuseppe Zanoni, Edward A. Anderson, Xihe Bi* Chem 2020, 6, 486-496\r
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Difluoroacetaldehyde N-Triftosylhydrazone (DFHZ-Tfs) as a Bench-Stable Crystalline Diazo Surrogate for Diazoacetaldehyde and Difluorodiazoethane Yongquan Ning, Xinyu Zhang, Yi Gai, Yuanqing Dong, Paramasivam Sivaguru, Yingying Wang, Bhoomireddy Rajendra Prasad Reddy, Giuseppe Zanoni, Xihe Bi* Angew. Chem. Int. Ed. 2020, 59, 6473-6481\r
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Neighbouring Carbonyl Group-assisted Sequential 1,2-Azide and 1,4-Oxygen Migrations of Vinyl Azides Leading to α-Azido Ketones Yi Gai, Yongquan Ning, Paramasivam Sivaguru, Xiaomeng Li, Yue Zhao, Jiayi Wu, and Xihe Bi* Sci. China Chem. 2020, 63, 460–466\r
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Cycloaddition of Trifluoroacetaldehyde N-Triftosylhydrazone (TFHZ-Tfs) with Alkynes for Synthesizing 3-Trifluoromethylpyrazoles Hongwei Wang, Yongquan Ning, Yue Sun, Paramasivam Sivaguru, and Xihe Bi* Org. Lett. 2020, 22, 2012-2016\r
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