个人简历

高雪娇，女，博士，副教授，硕士研究生导师。
毕业于“双一流”高校吉林大学，获得“吉林大学十佳研究生”称号。2019年入选东北农业大学东农学者-学术骨干，目前主持国家自然科学基金1项，中国博士后科学基金面上项目1项。先后发表SCI论文20余篇，其中，中科院一区文章3篇、二区文章2篇。目前担任fish & shellfish immunology，Biological trace element research，inflammation，food&funtion等期刊审稿人。

主要学习工作经历
2019/8~至 今 东北农业大学 基础兽医学 副教授
2017/8~2019/7 湖北大学 生命科学 博士后
2014/9~2017/7 吉林大学 临床兽医学 博 士
2009/9~2012/7 东北农业大学 临床兽医学 硕 士
2004/9~2009/7 东北农业大学 动物医学 学 士

研究领域

主要从事营养元素对动物天然免疫防御系统的调控研究，分析确定微量元素在禽类、反刍动物及水生鱼类等免疫功能调控过程中发挥的重要作用及相关机制。

近期论文

1.Gao XJ，B. Tang, H. Liang, L. Yi, Z. Wei. Selenium deficiency induced an inflammatory response by the HSP60 - TLR2-MAPKs signalling pathway in the liver of carp. Fish & Shellfish Immunology, 2019, 87: 688-694. (一区，IF=3.387. )
2.Gao XJ，B. Tang, H. Liang, L. Yi, Z. Wei. Selenium deficiency inhibits micRNA-146a to promote ROS-induced inflammation via regulation of the MAPK pathway in the head kidney of carp. Fish & Shellfish Immunology, 2019, 91: 284-292. (一区，IF=3.387. )
3.Jing H, Gao X, Xu L, Lin H, Zhang Z. H2S promotes a glycometabolism disorder by disturbing the Th1/Th2 balance during LPS-induced inflammation in the skeletal muscles of chickens. Chemosphere. 2019 May; 222:124-131.（二区，IF =5.351）(Co-first author)
4.Gao X, Guo M, Zhang Z, Shen P, Yang Z, Zhang N. Baicalin promotes the bacteriostatic activity of lysozyme on S. aureus in mammary glands and neutrophilic granulocytes in mice. Oncotarget. 2017, 8(12):19894-19901.（一区，IF =5.165）
5.Gao XJ，B. Tang, H. Liang, L. Yi, Z. Wei. The protective effect of Nigeglanine on Dextran Sulfate Sodium-Induced Experimental Colitis in Mice and Caco-2 cells. journal of cellular physiology, 2019.5.14 DOI: 10.1002/jcp.28909 (二区，IF=3.923. )
6.Gao XJ, Wang TC, Zhang ZC, Cao YG, Zhang NS, Guo MY. Brazilin plays an anti-inflammatory role with regulating Toll-like receptor 2 and TLR 2 downstream pathways in Staphylococcus aureus-induced mastitis in mice. Int Immunopharmacol. 2015 , 27(1):130-7. （三区，IF =3.056）
7.Gao X, Zhang Z, Li Y, Shen P, Hu X, Cao Y, Zhang N. Selenium Deficiency Facilitates Inflammation Following S. aureus Infection by Regulating TLR2-Related Pathways in the Mouse Mammary Gland. Biol Trace Elem Res. 2016, 172(2): 449-457 . （三区，IF =2.325）
8.Gao X, Zhang Z, Xing H, Yu J, Zhang N, Xu S. Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract. Biol Trace Elem Res. 2016, 173(1): 210-218 . （三区，IF =2.325）
9.Gao X, Zhang Z, Li Y, Hu X, Shen P, Fu Y, Cao Y, Zhang N. Selenium Deficiency Deteriorate the Inflammation of S. aureus Infection via Regulating NF-κB and PPAR-γ in Mammary Gland of Mice.Biol Trace Elem Res. 2016, 172(1): 140-147 .（三区，IF =2.325）
10.Gao XJ, Guo MY, Zhang ZC, Wang TC, Cao YG, Zhang NS. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis.Inflammation. 2015; 38(3):1142-50. （三区， IF =2.709）
11.Gao, X, Xing, H., Li, S., Li, J., Ying, T., Xu, S. Selenium regulates gene expression of Selenoprotein W in chicken gastrointestinal tract. Biol Trace Elem Res.2012, 145(2):181-8.（三区，IF =2.325）
12.Zhang, Z., Gao, X., Cao, Y., Jiang, H., Wang, T., Song, X., Guo, M., Zhang, N. Selenium Deficiency Facilitates Inflammation Through the Regulation of TLR4 and TLR4-Related Signaling Pathways in the Mice Uterus. Inflammation. 2015,38 (3): 1347-1356. (Co-first author) （三区，IF =2.709） (Co-first author)
13.Wang, W., Gao, X., Guo, M., Zhang, W., Song, X., Wang, T., Zhang, Z., Jiang, H., Cao, Y., Zhang, N. Leptospira interrogans induces uterine inflammatory responses and abnormal expression of extracellular matrix proteins in dogs. Microb Pathog. 2014,75:1-6. (Co-first author) （三区，IF =2.323） (Co-first author)
14.Xu T, Gao X, Liu G. The Antagonistic Effect of Selenium on Lead Toxicity Is Related to the Ion Profile in Chicken Liver. Biol Trace Elem Res. 2016 Feb; 169(2):365-73. （三区， IF =2.325）
15.Guo M, Gao X, Zhang N, Qiu C, Li C, Deng G. Effects of Se on the Diversity of SelT Synthesis and Distribution in Different Smooth Muscle Tissues in Rats. Biol Trace Elem Res. 2016 170(2):340-347.（三区，IF =2.325）
16.Xing H, Wang Z, Gao X, Chen D, Wang L, Li S, Xu S. Atrazine and chlorpyrifos exposure induces liver autophagic response in common carp. Ecotoxicol Environ Saf. 2015 Mar;113: 52-8..027 （三区，IF =4.000）
17.Xing H, Li S, Wang Z, Gao X, Xu S, Wang X. Histopathological changes and antioxidant response in brain and kidney of common carp exposed to atrazine and chlorpyrifos. Chemosphere. 2012 Jul;88(4):377-83. （二区，IF =4.551）
18.Xing H, Wang X, Sun G, Gao X, Xu S, Wang X. Effects of atrazine and chlorpyrifos on activity and transcription of glutathione S-transferase in common carp (Cyprinus carpio L.). Environ Toxicol Pharmacol. 2012;33(2):233-44. (三区，IF =2.721)
19.Yu D, Li JL, Zhang JL, Gao XJ, Xu S. Effects of dietary selenium on selenoprotein W gene expression in the chicken immune organs.Biol Trace Elem Res. 2011 Dec; 144(1-3):678-87. （三区，IF =2.325）
20.Hu X, Fu Y, Tian Y, Zhang Z, Zhang W, Gao X, Lu X, Cao Y, Zhang N. The anti-inflammatory effect of TR6 on LPS-induced mastitis in mice.Int Immunopharmacol. 2016 Jan; 30:150-6. （三区，IF =3.056）.
21.Hu X, Tian Y, Wang T, Zhang W, Wang W, Gao X, Qu S, Cao Y, Zhang N.TRAM-Derived Decoy Peptides inhibits the inflammatory response in mouse mammary epithelial cells and a mastitis model in mice. Eur J Pharmacol. 2015 Oct 5; 764:607-12. （三区, IF =3.04）